Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3K2_LEIBR

TriTrypDb:

LbrM.03.0310 , LBRM2903_030008100

Length:

946

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H3K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3K2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.533
CLV_C14_Caspase3-7	699	703	PF00656	0.430
CLV_NRD_NRD_1	178	180	PF00675	0.417
CLV_NRD_NRD_1	214	216	PF00675	0.503
CLV_NRD_NRD_1	361	363	PF00675	0.691
CLV_NRD_NRD_1	392	394	PF00675	0.601
CLV_NRD_NRD_1	408	410	PF00675	0.412
CLV_NRD_NRD_1	443	445	PF00675	0.468
CLV_NRD_NRD_1	716	718	PF00675	0.518
CLV_NRD_NRD_1	763	765	PF00675	0.377
CLV_NRD_NRD_1	832	834	PF00675	0.592
CLV_PCSK_FUR_1	441	445	PF00082	0.564
CLV_PCSK_KEX2_1	178	180	PF00082	0.393
CLV_PCSK_KEX2_1	214	216	PF00082	0.546
CLV_PCSK_KEX2_1	231	233	PF00082	0.417
CLV_PCSK_KEX2_1	294	296	PF00082	0.579
CLV_PCSK_KEX2_1	320	322	PF00082	0.562
CLV_PCSK_KEX2_1	392	394	PF00082	0.551
CLV_PCSK_KEX2_1	443	445	PF00082	0.589
CLV_PCSK_KEX2_1	716	718	PF00082	0.381
CLV_PCSK_KEX2_1	832	834	PF00082	0.628
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.455
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.579
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.600
CLV_PCSK_SKI1_1	126	130	PF00082	0.497
CLV_PCSK_SKI1_1	195	199	PF00082	0.617
CLV_PCSK_SKI1_1	25	29	PF00082	0.420
CLV_PCSK_SKI1_1	320	324	PF00082	0.613
CLV_PCSK_SKI1_1	459	463	PF00082	0.440
CLV_PCSK_SKI1_1	644	648	PF00082	0.264
CLV_PCSK_SKI1_1	94	98	PF00082	0.504
CLV_Separin_Metazoa	2	6	PF03568	0.509
CLV_Separin_Metazoa	602	606	PF03568	0.267
DEG_APCC_DBOX_1	641	649	PF00400	0.381
DEG_APCC_DBOX_1	738	746	PF00400	0.443
DEG_APCC_DBOX_1	93	101	PF00400	0.502
DEG_Nend_UBRbox_2	1	3	PF02207	0.375
DOC_CYCLIN_RxL_1	22	32	PF00134	0.540
DOC_MAPK_gen_1	132	142	PF00069	0.558
DOC_MAPK_gen_1	390	400	PF00069	0.640
DOC_MAPK_gen_1	640	647	PF00069	0.356
DOC_MAPK_gen_1	713	723	PF00069	0.446
DOC_PP1_RVXF_1	535	541	PF00149	0.527
DOC_SPAK_OSR1_1	257	261	PF12202	0.544
DOC_USP7_MATH_1	374	378	PF00917	0.631
DOC_USP7_MATH_1	442	446	PF00917	0.339
DOC_USP7_MATH_1	554	558	PF00917	0.491
DOC_USP7_MATH_1	614	618	PF00917	0.369
DOC_USP7_MATH_1	68	72	PF00917	0.349
DOC_USP7_MATH_1	837	841	PF00917	0.594
DOC_USP7_MATH_1	867	871	PF00917	0.658
DOC_USP7_MATH_1	887	891	PF00917	0.415
DOC_USP7_UBL2_3	231	235	PF12436	0.526
DOC_USP7_UBL2_3	294	298	PF12436	0.542
DOC_USP7_UBL2_3	665	669	PF12436	0.302
DOC_WW_Pin1_4	853	858	PF00397	0.767
LIG_14-3-3_CanoR_1	101	111	PF00244	0.538
LIG_14-3-3_CanoR_1	321	328	PF00244	0.581
LIG_14-3-3_CanoR_1	331	336	PF00244	0.551
LIG_14-3-3_CanoR_1	362	368	PF00244	0.606
LIG_14-3-3_CanoR_1	441	450	PF00244	0.571
LIG_14-3-3_CanoR_1	475	482	PF00244	0.409
LIG_14-3-3_CanoR_1	5	13	PF00244	0.593
LIG_14-3-3_CanoR_1	563	571	PF00244	0.516
LIG_14-3-3_CanoR_1	609	616	PF00244	0.510
LIG_14-3-3_CanoR_1	624	630	PF00244	0.277
LIG_14-3-3_CanoR_1	70	80	PF00244	0.422
LIG_14-3-3_CanoR_1	809	813	PF00244	0.471
LIG_Actin_WH2_2	548	565	PF00022	0.515
LIG_CaM_IQ_9	241	257	PF13499	0.551
LIG_FHA_1	112	118	PF00498	0.624
LIG_FHA_1	206	212	PF00498	0.509
LIG_FHA_1	274	280	PF00498	0.532
LIG_FHA_1	362	368	PF00498	0.539
LIG_FHA_1	468	474	PF00498	0.316
LIG_FHA_1	485	491	PF00498	0.520
LIG_FHA_1	506	512	PF00498	0.539
LIG_FHA_1	656	662	PF00498	0.444
LIG_FHA_1	723	729	PF00498	0.427
LIG_FHA_1	770	776	PF00498	0.522
LIG_FHA_1	834	840	PF00498	0.546
LIG_FHA_1	879	885	PF00498	0.465
LIG_FHA_2	103	109	PF00498	0.536
LIG_FHA_2	147	153	PF00498	0.528
LIG_FHA_2	184	190	PF00498	0.458
LIG_FHA_2	194	200	PF00498	0.451
LIG_FHA_2	401	407	PF00498	0.632
LIG_FHA_2	483	489	PF00498	0.486
LIG_LIR_Gen_1	19	28	PF02991	0.403
LIG_LIR_Gen_1	732	743	PF02991	0.425
LIG_LIR_Nem_3	19	23	PF02991	0.403
LIG_LIR_Nem_3	732	738	PF02991	0.408
LIG_MYND_1	11	15	PF01753	0.540
LIG_NRBOX	124	130	PF00104	0.505
LIG_NRBOX	22	28	PF00104	0.547
LIG_PCNA_yPIPBox_3	305	318	PF02747	0.505
LIG_PCNA_yPIPBox_3	621	630	PF02747	0.512
LIG_RPA_C_Fungi	143	155	PF08784	0.400
LIG_RPA_C_Fungi	666	678	PF08784	0.543
LIG_SH2_CRK	735	739	PF00017	0.464
LIG_SH2_STAP1	569	573	PF00017	0.442
LIG_SH2_STAT3	414	417	PF00017	0.620
LIG_SH2_STAT3	620	623	PF00017	0.345
LIG_SH2_STAT5	124	127	PF00017	0.473
LIG_SH2_STAT5	652	655	PF00017	0.507
LIG_SH3_3	881	887	PF00018	0.743
LIG_SH3_3	918	924	PF00018	0.725
LIG_SH3_4	930	937	PF00018	0.576
LIG_SUMO_SIM_anti_2	484	493	PF11976	0.384
LIG_SUMO_SIM_anti_2	598	606	PF11976	0.490
LIG_SUMO_SIM_par_1	469	474	PF11976	0.313
LIG_TRAF2_1	180	183	PF00917	0.323
LIG_TRAF2_1	343	346	PF00917	0.568
LIG_TRAF2_1	463	466	PF00917	0.448
LIG_TRAF2_1	750	753	PF00917	0.617
LIG_TRAF2_1	778	781	PF00917	0.487
LIG_WW_3	920	924	PF00397	0.475
MOD_CK1_1	334	340	PF00069	0.544
MOD_CK1_1	505	511	PF00069	0.523
MOD_CK1_1	632	638	PF00069	0.302
MOD_CK1_1	692	698	PF00069	0.550
MOD_CK1_1	71	77	PF00069	0.541
MOD_CK2_1	146	152	PF00069	0.438
MOD_CK2_1	183	189	PF00069	0.526
MOD_CK2_1	193	199	PF00069	0.520
MOD_CK2_1	400	406	PF00069	0.596
MOD_CK2_1	482	488	PF00069	0.399
MOD_CK2_1	632	638	PF00069	0.324
MOD_CK2_1	71	77	PF00069	0.497
MOD_CK2_1	771	777	PF00069	0.523
MOD_Cter_Amidation	390	393	PF01082	0.431
MOD_GlcNHglycan	304	308	PF01048	0.498
MOD_GlcNHglycan	313	317	PF01048	0.505
MOD_GlcNHglycan	376	379	PF01048	0.459
MOD_GlcNHglycan	616	619	PF01048	0.500
MOD_GlcNHglycan	7	10	PF01048	0.647
MOD_GlcNHglycan	844	847	PF01048	0.618
MOD_GlcNHglycan	889	892	PF01048	0.648
MOD_GSK3_1	107	114	PF00069	0.586
MOD_GSK3_1	327	334	PF00069	0.575
MOD_GSK3_1	362	369	PF00069	0.592
MOD_GSK3_1	625	632	PF00069	0.382
MOD_GSK3_1	833	840	PF00069	0.665
MOD_GSK3_1	851	858	PF00069	0.681
MOD_N-GLC_1	146	151	PF02516	0.545
MOD_N-GLC_1	873	878	PF02516	0.613
MOD_N-GLC_1	894	899	PF02516	0.603
MOD_NEK2_1	26	31	PF00069	0.558
MOD_NEK2_1	303	308	PF00069	0.587
MOD_NEK2_1	372	377	PF00069	0.714
MOD_NEK2_1	408	413	PF00069	0.510
MOD_NEK2_1	467	472	PF00069	0.542
MOD_NEK2_1	667	672	PF00069	0.530
MOD_NEK2_1	771	776	PF00069	0.478
MOD_NEK2_1	873	878	PF00069	0.452
MOD_NEK2_2	68	73	PF00069	0.444
MOD_PIKK_1	337	343	PF00454	0.549
MOD_PIKK_1	556	562	PF00454	0.483
MOD_PIKK_1	564	570	PF00454	0.496
MOD_PIKK_1	59	65	PF00454	0.457
MOD_PIKK_1	787	793	PF00454	0.299
MOD_PIKK_1	856	862	PF00454	0.473
MOD_PK_1	198	204	PF00069	0.487
MOD_PK_1	331	337	PF00069	0.550
MOD_PKA_1	231	237	PF00069	0.534
MOD_PKA_1	320	326	PF00069	0.535
MOD_PKA_1	362	368	PF00069	0.468
MOD_PKA_2	205	211	PF00069	0.472
MOD_PKA_2	231	237	PF00069	0.452
MOD_PKA_2	320	326	PF00069	0.573
MOD_PKA_2	361	367	PF00069	0.691
MOD_PKA_2	408	414	PF00069	0.462
MOD_PKA_2	442	448	PF00069	0.564
MOD_PKA_2	482	488	PF00069	0.534
MOD_PKA_2	494	500	PF00069	0.530
MOD_PKA_2	578	584	PF00069	0.403
MOD_PKA_2	586	592	PF00069	0.387
MOD_PKA_2	608	614	PF00069	0.388
MOD_PKA_2	632	638	PF00069	0.422
MOD_PKA_2	808	814	PF00069	0.463
MOD_Plk_1	107	113	PF00069	0.589
MOD_Plk_1	136	142	PF00069	0.470
MOD_Plk_1	198	204	PF00069	0.620
MOD_Plk_1	270	276	PF00069	0.625
MOD_Plk_1	312	318	PF00069	0.474
MOD_Plk_1	894	900	PF00069	0.480
MOD_Plk_1	910	916	PF00069	0.504
MOD_Plk_4	136	142	PF00069	0.615
MOD_Plk_4	270	276	PF00069	0.592
MOD_Plk_4	408	414	PF00069	0.514
MOD_Plk_4	625	631	PF00069	0.270
MOD_Plk_4	632	638	PF00069	0.243
MOD_Plk_4	808	814	PF00069	0.326
MOD_Plk_4	868	874	PF00069	0.472
MOD_ProDKin_1	853	859	PF00069	0.767
MOD_SUMO_for_1	293	296	PF00179	0.583
MOD_SUMO_for_1	343	346	PF00179	0.415
MOD_SUMO_for_1	506	509	PF00179	0.530
MOD_SUMO_for_1	583	586	PF00179	0.290
MOD_SUMO_rev_2	224	233	PF00179	0.456
MOD_SUMO_rev_2	291	300	PF00179	0.560
MOD_SUMO_rev_2	445	450	PF00179	0.543
TRG_DiLeu_BaEn_1	313	318	PF01217	0.585
TRG_DiLeu_BaEn_1	486	491	PF01217	0.524
TRG_DiLeu_BaEn_1	599	604	PF01217	0.358
TRG_DiLeu_BaEn_4	137	143	PF01217	0.554
TRG_DiLeu_BaEn_4	794	800	PF01217	0.487
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.415
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.366
TRG_ENDOCYTIC_2	181	184	PF00928	0.405
TRG_ENDOCYTIC_2	20	23	PF00928	0.536
TRG_ENDOCYTIC_2	735	738	PF00928	0.416
TRG_ER_diArg_1	213	215	PF00400	0.483
TRG_ER_diArg_1	392	394	PF00400	0.661
TRG_ER_diArg_1	440	443	PF00400	0.582
TRG_ER_diArg_1	492	495	PF00400	0.501
TRG_ER_diArg_1	537	540	PF00400	0.525
TRG_ER_diArg_1	641	644	PF00400	0.368
TRG_ER_diArg_1	648	651	PF00400	0.383
TRG_ER_diArg_1	671	674	PF00400	0.515
TRG_ER_diArg_1	715	717	PF00400	0.533
TRG_ER_diArg_1	903	906	PF00400	0.642
TRG_NES_CRM1_1	639	654	PF08389	0.494
TRG_NES_CRM1_1	699	711	PF08389	0.541
TRG_NLS_Bipartite_1	443	463	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	525	530	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	539	543	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	675	679	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	906	910	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ56	Leptomonas seymouri	25%	100%
A0A0N1I2V1	Leptomonas seymouri	63%	92%
A0A0S4JDB4	Bodo saltans	26%	100%
A0A0S4JMK5	Bodo saltans	33%	100%
A0A0S4KGN1	Bodo saltans	25%	99%
A0A1X0P9K9	Trypanosomatidae	38%	98%
A0A381MLP4	Leishmania infantum	25%	100%
A0A3Q8IAS8	Leishmania donovani	25%	100%
A0A3R7L4Y2	Trypanosoma rangeli	37%	98%
A0A3S5H534	Leishmania donovani	78%	91%
A0A451EJK4	Leishmania donovani	25%	100%
A4HRU2	Leishmania infantum	78%	91%
A8HUA1	Chlamydomonas reinhardtii	25%	100%
B2RW38	Mus musculus	27%	100%
C9ZJ55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	92%
D0A240	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ACE4	Leishmania major	26%	100%
E9ACH7	Leishmania major	79%	100%
E9ACX3	Leishmania major	26%	100%
E9AJN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AJR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	94%
V5A873	Trypanosoma cruzi	25%	100%
V5BCD1	Trypanosoma cruzi	37%	90%
V5D614	Trypanosoma cruzi	25%	100%