Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H3K0_LEIBR

TriTrypDb:

LbrM.03.0290 , LBRM2903_030007900

Length:

1000

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3K0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1
GO:0035091	phosphatidylinositol binding	4	1
GO:1901981	phosphatidylinositol phosphate binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.559
CLV_C14_Caspase3-7	453	457	PF00656	0.604
CLV_C14_Caspase3-7	496	500	PF00656	0.545
CLV_C14_Caspase3-7	504	508	PF00656	0.478
CLV_C14_Caspase3-7	834	838	PF00656	0.560
CLV_C14_Caspase3-7	87	91	PF00656	0.549
CLV_MEL_PAP_1	645	651	PF00089	0.500
CLV_NRD_NRD_1	169	171	PF00675	0.606
CLV_NRD_NRD_1	212	214	PF00675	0.653
CLV_NRD_NRD_1	369	371	PF00675	0.548
CLV_NRD_NRD_1	475	477	PF00675	0.545
CLV_NRD_NRD_1	493	495	PF00675	0.520
CLV_NRD_NRD_1	647	649	PF00675	0.607
CLV_NRD_NRD_1	920	922	PF00675	0.552
CLV_PCSK_KEX2_1	169	171	PF00082	0.606
CLV_PCSK_KEX2_1	212	214	PF00082	0.653
CLV_PCSK_KEX2_1	369	371	PF00082	0.554
CLV_PCSK_KEX2_1	475	477	PF00082	0.545
CLV_PCSK_KEX2_1	493	495	PF00082	0.520
CLV_PCSK_KEX2_1	647	649	PF00082	0.604
CLV_PCSK_KEX2_1	919	921	PF00082	0.561
CLV_PCSK_PC7_1	915	921	PF00082	0.551
CLV_PCSK_SKI1_1	108	112	PF00082	0.512
CLV_PCSK_SKI1_1	145	149	PF00082	0.547
CLV_PCSK_SKI1_1	46	50	PF00082	0.450
CLV_PCSK_SKI1_1	476	480	PF00082	0.538
CLV_PCSK_SKI1_1	558	562	PF00082	0.519
CLV_PCSK_SKI1_1	576	580	PF00082	0.579
DEG_APCC_DBOX_1	105	113	PF00400	0.519
DEG_APCC_DBOX_1	283	291	PF00400	0.590
DEG_MDM2_SWIB_1	111	119	PF02201	0.505
DEG_SPOP_SBC_1	259	263	PF00917	0.515
DEG_SPOP_SBC_1	56	60	PF00917	0.562
DOC_CDC14_PxL_1	241	249	PF14671	0.517
DOC_CDC14_PxL_1	735	743	PF14671	0.540
DOC_CDC14_PxL_1	752	760	PF14671	0.407
DOC_CKS1_1	125	130	PF01111	0.516
DOC_CKS1_1	559	564	PF01111	0.518
DOC_CKS1_1	597	602	PF01111	0.530
DOC_CKS1_1	734	739	PF01111	0.551
DOC_CKS1_1	77	82	PF01111	0.551
DOC_CKS1_1	865	870	PF01111	0.624
DOC_CKS1_1	989	994	PF01111	0.486
DOC_CYCLIN_RxL_1	104	114	PF00134	0.519
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.552
DOC_MAPK_DCC_7	612	621	PF00069	0.503
DOC_MAPK_gen_1	101	111	PF00069	0.513
DOC_MAPK_gen_1	369	376	PF00069	0.660
DOC_MAPK_gen_1	763	770	PF00069	0.495
DOC_MAPK_MEF2A_6	369	378	PF00069	0.448
DOC_MAPK_MEF2A_6	612	621	PF00069	0.503
DOC_PP1_RVXF_1	106	112	PF00149	0.518
DOC_PP2B_LxvP_1	242	245	PF13499	0.544
DOC_PP2B_LxvP_1	322	325	PF13499	0.342
DOC_PP2B_LxvP_1	423	426	PF13499	0.629
DOC_PP2B_LxvP_1	873	876	PF13499	0.521
DOC_PP2B_LxvP_1	908	911	PF13499	0.621
DOC_PP4_FxxP_1	295	298	PF00568	0.496
DOC_PP4_FxxP_1	525	528	PF00568	0.525
DOC_USP7_MATH_1	157	161	PF00917	0.604
DOC_USP7_MATH_1	172	176	PF00917	0.533
DOC_USP7_MATH_1	178	182	PF00917	0.595
DOC_USP7_MATH_1	183	187	PF00917	0.584
DOC_USP7_MATH_1	189	193	PF00917	0.595
DOC_USP7_MATH_1	27	31	PF00917	0.536
DOC_USP7_MATH_1	310	314	PF00917	0.350
DOC_USP7_MATH_1	361	365	PF00917	0.462
DOC_USP7_MATH_1	404	408	PF00917	0.524
DOC_USP7_MATH_1	536	540	PF00917	0.608
DOC_USP7_MATH_1	541	545	PF00917	0.575
DOC_USP7_MATH_1	600	604	PF00917	0.557
DOC_USP7_MATH_1	82	86	PF00917	0.592
DOC_USP7_MATH_1	822	826	PF00917	0.587
DOC_USP7_MATH_1	852	856	PF00917	0.539
DOC_USP7_MATH_1	857	861	PF00917	0.600
DOC_USP7_MATH_1	880	884	PF00917	0.600
DOC_USP7_MATH_1	91	95	PF00917	0.572
DOC_USP7_MATH_1	979	983	PF00917	0.400
DOC_WW_Pin1_4	121	126	PF00397	0.483
DOC_WW_Pin1_4	155	160	PF00397	0.609
DOC_WW_Pin1_4	228	233	PF00397	0.524
DOC_WW_Pin1_4	271	276	PF00397	0.618
DOC_WW_Pin1_4	524	529	PF00397	0.455
DOC_WW_Pin1_4	558	563	PF00397	0.528
DOC_WW_Pin1_4	570	575	PF00397	0.522
DOC_WW_Pin1_4	596	601	PF00397	0.622
DOC_WW_Pin1_4	729	734	PF00397	0.566
DOC_WW_Pin1_4	76	81	PF00397	0.617
DOC_WW_Pin1_4	812	817	PF00397	0.577
DOC_WW_Pin1_4	864	869	PF00397	0.642
DOC_WW_Pin1_4	92	97	PF00397	0.597
DOC_WW_Pin1_4	950	955	PF00397	0.579
DOC_WW_Pin1_4	988	993	PF00397	0.479
LIG_14-3-3_CanoR_1	480	489	PF00244	0.534
LIG_14-3-3_CanoR_1	581	589	PF00244	0.543
LIG_14-3-3_CanoR_1	634	644	PF00244	0.537
LIG_14-3-3_CanoR_1	647	652	PF00244	0.523
LIG_14-3-3_CanoR_1	686	695	PF00244	0.542
LIG_14-3-3_CanoR_1	704	710	PF00244	0.567
LIG_14-3-3_CanoR_1	724	734	PF00244	0.535
LIG_14-3-3_CanoR_1	765	771	PF00244	0.487
LIG_14-3-3_CanoR_1	809	814	PF00244	0.530
LIG_14-3-3_CanoR_1	861	866	PF00244	0.645
LIG_14-3-3_CanoR_1	937	946	PF00244	0.566
LIG_EVH1_1	322	326	PF00568	0.354
LIG_EVH1_2	323	327	PF00568	0.373
LIG_FHA_1	133	139	PF00498	0.528
LIG_FHA_1	335	341	PF00498	0.514
LIG_FHA_1	555	561	PF00498	0.608
LIG_FHA_1	843	849	PF00498	0.563
LIG_FHA_1	886	892	PF00498	0.562
LIG_FHA_1	939	945	PF00498	0.522
LIG_FHA_2	528	534	PF00498	0.485
LIG_FHA_2	559	565	PF00498	0.520
LIG_FHA_2	58	64	PF00498	0.613
LIG_FHA_2	87	93	PF00498	0.621
LIG_LIR_Apic_2	557	562	PF02991	0.556
LIG_LIR_Gen_1	631	640	PF02991	0.547
LIG_LIR_Gen_1	750	760	PF02991	0.523
LIG_LIR_Gen_1	965	974	PF02991	0.471
LIG_LIR_Nem_3	121	126	PF02991	0.483
LIG_LIR_Nem_3	631	635	PF02991	0.555
LIG_LIR_Nem_3	750	755	PF02991	0.538
LIG_LYPXL_SIV_4	876	884	PF13949	0.522
LIG_MYND_3	665	669	PF01753	0.539
LIG_Pex14_1	777	781	PF04695	0.474
LIG_Pex14_2	111	115	PF04695	0.506
LIG_Rb_pABgroove_1	736	744	PF01858	0.615
LIG_SH2_CRK	123	127	PF00017	0.587
LIG_SH2_NCK_1	123	127	PF00017	0.501
LIG_SH2_NCK_1	88	92	PF00017	0.549
LIG_SH2_PTP2	559	562	PF00017	0.555
LIG_SH2_PTP2	752	755	PF00017	0.523
LIG_SH2_SRC	489	492	PF00017	0.556
LIG_SH2_STAP1	742	746	PF00017	0.562
LIG_SH2_STAP1	877	881	PF00017	0.524
LIG_SH2_STAT5	123	126	PF00017	0.513
LIG_SH2_STAT5	328	331	PF00017	0.426
LIG_SH2_STAT5	519	522	PF00017	0.428
LIG_SH2_STAT5	559	562	PF00017	0.555
LIG_SH2_STAT5	683	686	PF00017	0.527
LIG_SH2_STAT5	752	755	PF00017	0.523
LIG_SH2_STAT5	842	845	PF00017	0.609
LIG_SH2_STAT5	88	91	PF00017	0.548
LIG_SH2_STAT5	922	925	PF00017	0.532
LIG_SH3_3	122	128	PF00018	0.599
LIG_SH3_3	168	174	PF00018	0.573
LIG_SH3_3	272	278	PF00018	0.614
LIG_SH3_3	317	323	PF00018	0.451
LIG_SH3_3	660	666	PF00018	0.548
LIG_SH3_3	707	713	PF00018	0.625
LIG_SH3_3	731	737	PF00018	0.633
LIG_SH3_3	750	756	PF00018	0.443
LIG_SH3_3	862	868	PF00018	0.544
LIG_SH3_3	951	957	PF00018	0.561
LIG_SH3_3	986	992	PF00018	0.573
LIG_SUMO_SIM_par_1	692	697	PF11976	0.520
LIG_SUMO_SIM_par_1	959	965	PF11976	0.484
LIG_SxIP_EBH_1	887	897	PF03271	0.555
LIG_TRAF2_1	384	387	PF00917	0.478
LIG_TRAF2_1	561	564	PF00917	0.571
LIG_TRAF2_1	697	700	PF00917	0.558
LIG_TRAF2_1	798	801	PF00917	0.512
LIG_WW_1	325	328	PF00397	0.385
LIG_WW_3	910	914	PF00397	0.506
MOD_CDC14_SPxK_1	158	161	PF00782	0.552
MOD_CDC14_SPxK_1	573	576	PF00782	0.508
MOD_CDK_SPxK_1	155	161	PF00069	0.547
MOD_CDK_SPxK_1	570	576	PF00069	0.510
MOD_CK1_1	155	161	PF00069	0.554
MOD_CK1_1	271	277	PF00069	0.611
MOD_CK1_1	334	340	PF00069	0.513
MOD_CK1_1	407	413	PF00069	0.528
MOD_CK1_1	448	454	PF00069	0.535
MOD_CK1_1	462	468	PF00069	0.520
MOD_CK1_1	527	533	PF00069	0.506
MOD_CK1_1	57	63	PF00069	0.599
MOD_CK1_1	664	670	PF00069	0.613
MOD_CK1_1	759	765	PF00069	0.386
MOD_CK1_1	812	818	PF00069	0.550
MOD_CK1_1	864	870	PF00069	0.612
MOD_CK1_1	882	888	PF00069	0.519
MOD_CK2_1	380	386	PF00069	0.577
MOD_CK2_1	448	454	PF00069	0.541
MOD_CK2_1	558	564	PF00069	0.520
MOD_CK2_1	57	63	PF00069	0.599
MOD_CK2_1	694	700	PF00069	0.525
MOD_CK2_1	86	92	PF00069	0.550
MOD_GlcNHglycan	154	157	PF01048	0.600
MOD_GlcNHglycan	185	188	PF01048	0.594
MOD_GlcNHglycan	193	196	PF01048	0.625
MOD_GlcNHglycan	221	224	PF01048	0.533
MOD_GlcNHglycan	333	336	PF01048	0.509
MOD_GlcNHglycan	357	360	PF01048	0.635
MOD_GlcNHglycan	409	412	PF01048	0.547
MOD_GlcNHglycan	450	453	PF01048	0.535
MOD_GlcNHglycan	504	507	PF01048	0.501
MOD_GlcNHglycan	538	541	PF01048	0.606
MOD_GlcNHglycan	543	546	PF01048	0.585
MOD_GlcNHglycan	602	605	PF01048	0.595
MOD_GlcNHglycan	637	640	PF01048	0.551
MOD_GlcNHglycan	680	683	PF01048	0.582
MOD_GlcNHglycan	707	710	PF01048	0.532
MOD_GlcNHglycan	73	76	PF01048	0.624
MOD_GlcNHglycan	743	747	PF01048	0.468
MOD_GlcNHglycan	758	761	PF01048	0.423
MOD_GlcNHglycan	833	836	PF01048	0.614
MOD_GlcNHglycan	854	857	PF01048	0.551
MOD_GlcNHglycan	873	876	PF01048	0.546
MOD_GlcNHglycan	977	980	PF01048	0.436
MOD_GSK3_1	132	139	PF00069	0.531
MOD_GSK3_1	155	162	PF00069	0.603
MOD_GSK3_1	327	334	PF00069	0.498
MOD_GSK3_1	403	410	PF00069	0.596
MOD_GSK3_1	450	457	PF00069	0.557
MOD_GSK3_1	459	466	PF00069	0.579
MOD_GSK3_1	554	561	PF00069	0.549
MOD_GSK3_1	570	577	PF00069	0.568
MOD_GSK3_1	596	603	PF00069	0.600
MOD_GSK3_1	678	685	PF00069	0.541
MOD_GSK3_1	725	732	PF00069	0.566
MOD_GSK3_1	805	812	PF00069	0.540
MOD_GSK3_1	82	89	PF00069	0.576
MOD_GSK3_1	857	864	PF00069	0.616
MOD_GSK3_1	871	878	PF00069	0.573
MOD_GSK3_1	882	889	PF00069	0.544
MOD_GSK3_1	940	947	PF00069	0.616
MOD_GSK3_1	948	955	PF00069	0.575
MOD_GSK3_1	975	982	PF00069	0.397
MOD_LATS_1	492	498	PF00433	0.549
MOD_LATS_1	973	979	PF00433	0.380
MOD_N-GLC_1	214	219	PF02516	0.540
MOD_N-GLC_1	445	450	PF02516	0.535
MOD_N-GLC_1	468	473	PF02516	0.546
MOD_N-GLC_2	37	39	PF02516	0.490
MOD_NEK2_1	227	232	PF00069	0.526
MOD_NEK2_1	247	252	PF00069	0.488
MOD_NEK2_1	270	275	PF00069	0.522
MOD_NEK2_1	336	341	PF00069	0.466
MOD_NEK2_1	344	349	PF00069	0.500
MOD_NEK2_1	459	464	PF00069	0.548
MOD_NEK2_1	546	551	PF00069	0.513
MOD_NEK2_1	938	943	PF00069	0.496
MOD_OFUCOSY	341	348	PF10250	0.508
MOD_PIKK_1	162	168	PF00454	0.571
MOD_PIKK_1	235	241	PF00454	0.502
MOD_PIKK_1	398	404	PF00454	0.582
MOD_PIKK_1	460	466	PF00454	0.593
MOD_PIKK_1	694	700	PF00454	0.525
MOD_PIKK_1	842	848	PF00454	0.566
MOD_PIKK_1	875	881	PF00454	0.606
MOD_PIKK_1	979	985	PF00454	0.409
MOD_PK_1	204	210	PF00069	0.637
MOD_PK_1	861	867	PF00069	0.629
MOD_PKA_1	647	653	PF00069	0.510
MOD_PKA_2	381	387	PF00069	0.617
MOD_PKA_2	390	396	PF00069	0.558
MOD_PKA_2	454	460	PF00069	0.560
MOD_PKA_2	580	586	PF00069	0.543
MOD_PKA_2	647	653	PF00069	0.566
MOD_PKA_2	673	679	PF00069	0.562
MOD_PKA_2	725	731	PF00069	0.567
MOD_PKA_2	823	829	PF00069	0.531
MOD_PKA_2	886	892	PF00069	0.553
MOD_Plk_1	204	210	PF00069	0.538
MOD_Plk_1	630	636	PF00069	0.566
MOD_Plk_1	742	748	PF00069	0.560
MOD_Plk_2-3	928	934	PF00069	0.545
MOD_Plk_4	454	460	PF00069	0.538
MOD_Plk_4	546	552	PF00069	0.575
MOD_Plk_4	747	753	PF00069	0.527
MOD_Plk_4	766	772	PF00069	0.410
MOD_Plk_4	962	968	PF00069	0.491
MOD_ProDKin_1	121	127	PF00069	0.488
MOD_ProDKin_1	155	161	PF00069	0.612
MOD_ProDKin_1	228	234	PF00069	0.523
MOD_ProDKin_1	271	277	PF00069	0.616
MOD_ProDKin_1	524	530	PF00069	0.463
MOD_ProDKin_1	558	564	PF00069	0.528
MOD_ProDKin_1	570	576	PF00069	0.522
MOD_ProDKin_1	596	602	PF00069	0.625
MOD_ProDKin_1	729	735	PF00069	0.566
MOD_ProDKin_1	76	82	PF00069	0.614
MOD_ProDKin_1	812	818	PF00069	0.579
MOD_ProDKin_1	864	870	PF00069	0.642
MOD_ProDKin_1	92	98	PF00069	0.589
MOD_ProDKin_1	950	956	PF00069	0.569
MOD_ProDKin_1	988	994	PF00069	0.482
TRG_DiLeu_BaEn_1	105	110	PF01217	0.527
TRG_DiLeu_BaEn_1	454	459	PF01217	0.637
TRG_DiLeu_BaEn_4	387	393	PF01217	0.518
TRG_DiLeu_LyEn_5	105	110	PF01217	0.527
TRG_ENDOCYTIC_2	123	126	PF00928	0.599
TRG_ENDOCYTIC_2	752	755	PF00928	0.539
TRG_ER_diArg_1	106	109	PF00400	0.525
TRG_ER_diArg_1	169	171	PF00400	0.606
TRG_ER_diArg_1	212	214	PF00400	0.653
TRG_ER_diArg_1	369	371	PF00400	0.542
TRG_ER_diArg_1	475	477	PF00400	0.545
TRG_ER_diArg_1	647	649	PF00400	0.547
TRG_ER_diArg_1	912	915	PF00400	0.571
TRG_ER_diArg_1	919	921	PF00400	0.550
TRG_Pf-PMV_PEXEL_1	809	813	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	921	925	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H531	Leishmania donovani	56%	100%
A4HRT9	Leishmania infantum	56%	100%
E9ACH5	Leishmania major	55%	93%
E9AJR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%