LeishMANIAdb
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FYVE-type domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
FYVE-type domain-containing protein
Gene product:
FYVE zinc finger/Apolipoprotein A1/A4/E domain containing protein, putative
Species:
Leishmania braziliensis
UniProt:
A4H3J9_LEIBR
TriTrypDb:
LbrM.03.0280 , LBRM2903_030007700 * , LBRM2903_030007800 *
Length:
1439

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0000795 synaptonemal complex 3 2
GO:0005576 extracellular region 2 6
GO:0099086 synaptonemal structure 2 2
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4H3J9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 6
GO:0006810 transport 3 6
GO:0006869 lipid transport 5 6
GO:0006996 organelle organization 4 2
GO:0007130 synaptonemal complex assembly 4 2
GO:0008152 metabolic process 1 6
GO:0009987 cellular process 1 2
GO:0016043 cellular component organization 3 2
GO:0019538 protein metabolic process 3 6
GO:0022402 cell cycle process 2 2
GO:0022414 reproductive process 1 2
GO:0022607 cellular component assembly 4 2
GO:0042157 lipoprotein metabolic process 4 6
GO:0043170 macromolecule metabolic process 3 6
GO:0044238 primary metabolic process 2 6
GO:0051179 localization 1 6
GO:0051234 establishment of localization 2 6
GO:0051276 chromosome organization 5 2
GO:0070192 chromosome organization involved in meiotic cell cycle 3 2
GO:0070193 synaptonemal complex organization 6 2
GO:0071702 organic substance transport 4 6
GO:0071704 organic substance metabolic process 2 6
GO:0071840 cellular component organization or biogenesis 2 2
GO:1901564 organonitrogen compound metabolic process 3 6
GO:1903046 meiotic cell cycle process 2 2
Molecular functions
Term Name Level Count
GO:0005488 binding 1 6
GO:0008289 lipid binding 2 6
GO:0043167 ion binding 2 5
GO:0043169 cation binding 3 5
GO:0046872 metal ion binding 4 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 1248 1252 PF00656 0.513
CLV_NRD_NRD_1 1129 1131 PF00675 0.411
CLV_NRD_NRD_1 1309 1311 PF00675 0.511
CLV_NRD_NRD_1 1368 1370 PF00675 0.484
CLV_NRD_NRD_1 1423 1425 PF00675 0.442
CLV_NRD_NRD_1 870 872 PF00675 0.668
CLV_NRD_NRD_1 926 928 PF00675 0.497
CLV_PCSK_KEX2_1 1129 1131 PF00082 0.411
CLV_PCSK_KEX2_1 1200 1202 PF00082 0.549
CLV_PCSK_KEX2_1 1309 1311 PF00082 0.511
CLV_PCSK_KEX2_1 1368 1370 PF00082 0.484
CLV_PCSK_KEX2_1 1423 1425 PF00082 0.442
CLV_PCSK_KEX2_1 870 872 PF00082 0.668
CLV_PCSK_KEX2_1 926 928 PF00082 0.497
CLV_PCSK_PC1ET2_1 1200 1202 PF00082 0.517
CLV_PCSK_PC7_1 1364 1370 PF00082 0.484
CLV_PCSK_SKI1_1 1056 1060 PF00082 0.428
CLV_PCSK_SKI1_1 1200 1204 PF00082 0.539
CLV_PCSK_SKI1_1 1210 1214 PF00082 0.498
CLV_PCSK_SKI1_1 1242 1246 PF00082 0.494
CLV_PCSK_SKI1_1 133 137 PF00082 0.544
CLV_PCSK_SKI1_1 1343 1347 PF00082 0.516
CLV_PCSK_SKI1_1 1390 1394 PF00082 0.549
CLV_PCSK_SKI1_1 929 933 PF00082 0.491
CLV_Separin_Metazoa 1136 1140 PF03568 0.427
DEG_APCC_DBOX_1 1389 1397 PF00400 0.547
DEG_APCC_DBOX_1 176 184 PF00400 0.308
DEG_APCC_DBOX_1 889 897 PF00400 0.291
DEG_APCC_DBOX_1 928 936 PF00400 0.299
DEG_SPOP_SBC_1 1087 1091 PF00917 0.584
DEG_SPOP_SBC_1 90 94 PF00917 0.505
DOC_ANK_TNKS_1 1138 1145 PF00023 0.464
DOC_CKS1_1 105 110 PF01111 0.598
DOC_CKS1_1 124 129 PF01111 0.510
DOC_CKS1_1 1375 1380 PF01111 0.580
DOC_CYCLIN_RxL_1 1236 1248 PF00134 0.470
DOC_MAPK_gen_1 1056 1065 PF00069 0.427
DOC_MAPK_gen_1 1206 1215 PF00069 0.511
DOC_USP7_MATH_1 103 107 PF00917 0.597
DOC_USP7_MATH_1 1087 1091 PF00917 0.624
DOC_USP7_MATH_1 1092 1096 PF00917 0.581
DOC_USP7_MATH_1 1185 1189 PF00917 0.523
DOC_USP7_MATH_1 1238 1242 PF00917 0.461
DOC_USP7_MATH_1 90 94 PF00917 0.492
DOC_WW_Pin1_4 104 109 PF00397 0.573
DOC_WW_Pin1_4 1088 1093 PF00397 0.587
DOC_WW_Pin1_4 123 128 PF00397 0.533
DOC_WW_Pin1_4 1291 1296 PF00397 0.618
DOC_WW_Pin1_4 1328 1333 PF00397 0.491
DOC_WW_Pin1_4 1374 1379 PF00397 0.576
DOC_WW_Pin1_4 91 96 PF00397 0.513
LIG_14-3-3_CanoR_1 1075 1081 PF00244 0.483
LIG_14-3-3_CanoR_1 1086 1092 PF00244 0.568
LIG_14-3-3_CanoR_1 1334 1342 PF00244 0.638
LIG_14-3-3_CanoR_1 140 148 PF00244 0.482
LIG_14-3-3_CanoR_1 258 267 PF00244 0.291
LIG_14-3-3_CanoR_1 297 306 PF00244 0.291
LIG_14-3-3_CanoR_1 336 345 PF00244 0.291
LIG_14-3-3_CanoR_1 375 384 PF00244 0.291
LIG_14-3-3_CanoR_1 414 423 PF00244 0.291
LIG_14-3-3_CanoR_1 491 500 PF00244 0.291
LIG_14-3-3_CanoR_1 530 539 PF00244 0.291
LIG_14-3-3_CanoR_1 569 578 PF00244 0.291
LIG_14-3-3_CanoR_1 608 617 PF00244 0.291
LIG_14-3-3_CanoR_1 647 656 PF00244 0.291
LIG_14-3-3_CanoR_1 686 695 PF00244 0.291
LIG_14-3-3_CanoR_1 725 734 PF00244 0.291
LIG_14-3-3_CanoR_1 764 773 PF00244 0.291
LIG_14-3-3_CanoR_1 803 812 PF00244 0.291
LIG_14-3-3_CanoR_1 842 851 PF00244 0.291
LIG_14-3-3_CanoR_1 870 876 PF00244 0.416
LIG_14-3-3_CanoR_1 890 894 PF00244 0.250
LIG_Actin_WH2_2 1041 1058 PF00022 0.483
LIG_Actin_WH2_2 176 193 PF00022 0.308
LIG_Actin_WH2_2 914 931 PF00022 0.291
LIG_BRCT_BRCA1_1 23 27 PF00533 0.308
LIG_BRCT_BRCA1_1 28 32 PF00533 0.293
LIG_eIF4E_1 1118 1124 PF01652 0.442
LIG_FHA_1 1157 1163 PF00498 0.485
LIG_FHA_1 124 130 PF00498 0.554
LIG_FHA_1 1323 1329 PF00498 0.507
LIG_FHA_1 1361 1367 PF00498 0.480
LIG_FHA_1 1375 1381 PF00498 0.622
LIG_FHA_1 191 197 PF00498 0.322
LIG_FHA_1 46 52 PF00498 0.351
LIG_FHA_1 972 978 PF00498 0.322
LIG_FHA_2 1263 1269 PF00498 0.532
LIG_FHA_2 142 148 PF00498 0.516
LIG_FHA_2 243 249 PF00498 0.291
LIG_FHA_2 282 288 PF00498 0.291
LIG_FHA_2 321 327 PF00498 0.291
LIG_FHA_2 360 366 PF00498 0.291
LIG_FHA_2 399 405 PF00498 0.291
LIG_FHA_2 476 482 PF00498 0.291
LIG_FHA_2 515 521 PF00498 0.291
LIG_FHA_2 554 560 PF00498 0.291
LIG_FHA_2 593 599 PF00498 0.291
LIG_FHA_2 632 638 PF00498 0.291
LIG_FHA_2 671 677 PF00498 0.291
LIG_FHA_2 710 716 PF00498 0.291
LIG_FHA_2 749 755 PF00498 0.291
LIG_FHA_2 788 794 PF00498 0.291
LIG_FHA_2 827 833 PF00498 0.291
LIG_FHA_2 890 896 PF00498 0.270
LIG_FHA_2 994 1000 PF00498 0.493
LIG_LIR_Apic_2 1286 1292 PF02991 0.559
LIG_LIR_Gen_1 1070 1080 PF02991 0.434
LIG_LIR_Gen_1 1176 1186 PF02991 0.478
LIG_LIR_Gen_1 1344 1351 PF02991 0.499
LIG_LIR_Nem_3 1070 1076 PF02991 0.564
LIG_LIR_Nem_3 1176 1181 PF02991 0.488
LIG_LIR_Nem_3 1339 1345 PF02991 0.558
LIG_LIR_Nem_3 1420 1425 PF02991 0.494
LIG_LIR_Nem_3 24 28 PF02991 0.308
LIG_PCNA_PIPBox_1 1359 1368 PF02747 0.475
LIG_PCNA_yPIPBox_3 858 869 PF02747 0.291
LIG_Pex14_2 28 32 PF04695 0.279
LIG_REV1ctd_RIR_1 25 35 PF16727 0.322
LIG_SH2_CRK 1178 1182 PF00017 0.472
LIG_SH2_CRK 1230 1234 PF00017 0.452
LIG_SH2_GRB2like 55 58 PF00017 0.348
LIG_SH2_SRC 1347 1350 PF00017 0.492
LIG_SH2_SRC 84 87 PF00017 0.435
LIG_SH2_STAP1 119 123 PF00017 0.559
LIG_SH2_STAP1 1347 1351 PF00017 0.491
LIG_SH2_STAT3 56 59 PF00017 0.279
LIG_SH2_STAT5 1178 1181 PF00017 0.473
LIG_SH2_STAT5 1365 1368 PF00017 0.556
LIG_SH2_STAT5 84 87 PF00017 0.508
LIG_SH3_1 1289 1295 PF00018 0.551
LIG_SH3_3 107 113 PF00018 0.601
LIG_SH3_3 1081 1087 PF00018 0.522
LIG_SH3_3 121 127 PF00018 0.527
LIG_SH3_3 1289 1295 PF00018 0.755
LIG_SH3_3 1297 1303 PF00018 0.735
LIG_SH3_3 1375 1381 PF00018 0.574
LIG_SUMO_SIM_par_1 1061 1067 PF11976 0.421
LIG_SxIP_EBH_1 45 54 PF03271 0.348
LIG_TRAF2_1 1030 1033 PF00917 0.522
LIG_TRAF2_1 1153 1156 PF00917 0.412
LIG_TRAF2_1 1318 1321 PF00917 0.468
LIG_TRAF2_1 973 976 PF00917 0.315
LIG_TRAF2_1 984 987 PF00917 0.492
LIG_TYR_ITIM 1345 1350 PF00017 0.489
MOD_CDK_SPK_2 1374 1379 PF00069 0.576
MOD_CDK_SPxK_1 1328 1334 PF00069 0.488
MOD_CDK_SPxK_1 91 97 PF00069 0.569
MOD_CDK_SPxxK_3 1291 1298 PF00069 0.615
MOD_CK1_1 1071 1077 PF00069 0.479
MOD_CK1_1 1090 1096 PF00069 0.549
MOD_CK1_1 1098 1104 PF00069 0.473
MOD_CK1_1 125 131 PF00069 0.565
MOD_CK2_1 1158 1164 PF00069 0.488
MOD_CK2_1 1262 1268 PF00069 0.529
MOD_CK2_1 1315 1321 PF00069 0.530
MOD_CK2_1 219 225 PF00069 0.308
MOD_CK2_1 242 248 PF00069 0.308
MOD_CK2_1 258 264 PF00069 0.261
MOD_CK2_1 281 287 PF00069 0.308
MOD_CK2_1 297 303 PF00069 0.261
MOD_CK2_1 320 326 PF00069 0.308
MOD_CK2_1 336 342 PF00069 0.261
MOD_CK2_1 359 365 PF00069 0.308
MOD_CK2_1 375 381 PF00069 0.261
MOD_CK2_1 398 404 PF00069 0.308
MOD_CK2_1 414 420 PF00069 0.261
MOD_CK2_1 475 481 PF00069 0.308
MOD_CK2_1 491 497 PF00069 0.285
MOD_CK2_1 514 520 PF00069 0.308
MOD_CK2_1 530 536 PF00069 0.261
MOD_CK2_1 553 559 PF00069 0.308
MOD_CK2_1 569 575 PF00069 0.261
MOD_CK2_1 592 598 PF00069 0.308
MOD_CK2_1 608 614 PF00069 0.261
MOD_CK2_1 631 637 PF00069 0.308
MOD_CK2_1 647 653 PF00069 0.308
MOD_CK2_1 670 676 PF00069 0.308
MOD_CK2_1 686 692 PF00069 0.261
MOD_CK2_1 709 715 PF00069 0.308
MOD_CK2_1 725 731 PF00069 0.261
MOD_CK2_1 748 754 PF00069 0.308
MOD_CK2_1 764 770 PF00069 0.261
MOD_CK2_1 787 793 PF00069 0.308
MOD_CK2_1 803 809 PF00069 0.261
MOD_CK2_1 826 832 PF00069 0.308
MOD_CK2_1 842 848 PF00069 0.261
MOD_CK2_1 889 895 PF00069 0.279
MOD_CK2_1 951 957 PF00069 0.343
MOD_CK2_1 970 976 PF00069 0.309
MOD_CK2_1 993 999 PF00069 0.493
MOD_Cter_Amidation 1127 1130 PF01082 0.419
MOD_GlcNHglycan 1035 1038 PF01048 0.480
MOD_GlcNHglycan 1076 1079 PF01048 0.646
MOD_GlcNHglycan 1094 1097 PF01048 0.513
MOD_GlcNHglycan 1238 1241 PF01048 0.469
MOD_GlcNHglycan 1372 1375 PF01048 0.654
MOD_GlcNHglycan 168 171 PF01048 0.594
MOD_GlcNHglycan 371 374 PF01048 0.279
MOD_GlcNHglycan 487 490 PF01048 0.279
MOD_GlcNHglycan 604 607 PF01048 0.279
MOD_GlcNHglycan 643 646 PF01048 0.279
MOD_GlcNHglycan 79 82 PF01048 0.450
MOD_GlcNHglycan 87 90 PF01048 0.513
MOD_GSK3_1 1063 1070 PF00069 0.637
MOD_GSK3_1 1086 1093 PF00069 0.610
MOD_GSK3_1 109 116 PF00069 0.601
MOD_GSK3_1 1095 1102 PF00069 0.559
MOD_GSK3_1 118 125 PF00069 0.559
MOD_GSK3_1 1283 1290 PF00069 0.617
MOD_GSK3_1 1370 1377 PF00069 0.585
MOD_GSK3_1 181 188 PF00069 0.318
MOD_GSK3_1 254 261 PF00069 0.308
MOD_GSK3_1 293 300 PF00069 0.308
MOD_GSK3_1 332 339 PF00069 0.308
MOD_GSK3_1 371 378 PF00069 0.308
MOD_GSK3_1 40 47 PF00069 0.279
MOD_GSK3_1 410 417 PF00069 0.308
MOD_GSK3_1 487 494 PF00069 0.308
MOD_GSK3_1 526 533 PF00069 0.308
MOD_GSK3_1 565 572 PF00069 0.308
MOD_GSK3_1 604 611 PF00069 0.308
MOD_GSK3_1 643 650 PF00069 0.308
MOD_GSK3_1 682 689 PF00069 0.308
MOD_GSK3_1 721 728 PF00069 0.308
MOD_GSK3_1 760 767 PF00069 0.308
MOD_GSK3_1 799 806 PF00069 0.308
MOD_GSK3_1 838 845 PF00069 0.308
MOD_GSK3_1 85 92 PF00069 0.538
MOD_N-GLC_1 175 180 PF02516 0.573
MOD_N-GLC_1 181 186 PF02516 0.312
MOD_NEK2_1 1076 1081 PF00069 0.526
MOD_NEK2_1 1158 1163 PF00069 0.594
MOD_NEK2_1 1253 1258 PF00069 0.525
MOD_NEK2_1 136 141 PF00069 0.526
MOD_NEK2_1 1400 1405 PF00069 0.549
MOD_NEK2_1 190 195 PF00069 0.337
MOD_NEK2_1 27 32 PF00069 0.351
MOD_NEK2_1 41 46 PF00069 0.280
MOD_NEK2_1 437 442 PF00069 0.279
MOD_NEK2_1 85 90 PF00069 0.493
MOD_NEK2_1 979 984 PF00069 0.610
MOD_PIKK_1 101 107 PF00454 0.652
MOD_PIKK_1 113 119 PF00454 0.561
MOD_PIKK_1 1200 1206 PF00454 0.488
MOD_PIKK_1 1254 1260 PF00454 0.528
MOD_PIKK_1 206 212 PF00454 0.343
MOD_PKA_1 1200 1206 PF00069 0.488
MOD_PKA_2 1033 1039 PF00069 0.479
MOD_PKA_2 1074 1080 PF00069 0.520
MOD_PKA_2 1179 1185 PF00069 0.479
MOD_PKA_2 1200 1206 PF00069 0.488
MOD_PKA_2 1333 1339 PF00069 0.554
MOD_PKA_2 889 895 PF00069 0.279
MOD_Plk_1 1098 1104 PF00069 0.497
MOD_Plk_1 185 191 PF00069 0.335
MOD_Plk_1 212 218 PF00069 0.308
MOD_Plk_2-3 880 886 PF00069 0.308
MOD_Plk_4 1068 1074 PF00069 0.485
MOD_Plk_4 1099 1105 PF00069 0.488
MOD_Plk_4 1107 1113 PF00069 0.421
MOD_Plk_4 1158 1164 PF00069 0.462
MOD_Plk_4 47 53 PF00069 0.351
MOD_Plk_4 951 957 PF00069 0.308
MOD_ProDKin_1 104 110 PF00069 0.569
MOD_ProDKin_1 1088 1094 PF00069 0.586
MOD_ProDKin_1 123 129 PF00069 0.532
MOD_ProDKin_1 1291 1297 PF00069 0.616
MOD_ProDKin_1 1328 1334 PF00069 0.488
MOD_ProDKin_1 1374 1380 PF00069 0.576
MOD_ProDKin_1 91 97 PF00069 0.521
MOD_SUMO_for_1 1058 1061 PF00179 0.433
MOD_SUMO_rev_2 164 169 PF00179 0.516
MOD_SUMO_rev_2 908 916 PF00179 0.344
TRG_DiLeu_BaEn_1 1001 1006 PF01217 0.457
TRG_DiLeu_BaEn_1 1136 1141 PF01217 0.470
TRG_DiLeu_BaEn_4 185 191 PF01217 0.381
TRG_DiLeu_BaEn_4 923 929 PF01217 0.308
TRG_DiLeu_BaLyEn_6 1239 1244 PF01217 0.477
TRG_DiLeu_LyEn_5 1136 1141 PF01217 0.470
TRG_ENDOCYTIC_2 1178 1181 PF00928 0.473
TRG_ENDOCYTIC_2 1230 1233 PF00928 0.458
TRG_ENDOCYTIC_2 1342 1345 PF00928 0.668
TRG_ENDOCYTIC_2 1347 1350 PF00928 0.595
TRG_ENDOCYTIC_2 68 71 PF00928 0.322
TRG_ER_diArg_1 1129 1131 PF00400 0.411
TRG_ER_diArg_1 1308 1310 PF00400 0.540
TRG_ER_diArg_1 1367 1369 PF00400 0.482
TRG_ER_diArg_1 1422 1424 PF00400 0.448
TRG_ER_diArg_1 869 871 PF00400 0.483
TRG_ER_diArg_1 926 929 PF00400 0.332
TRG_ER_diArg_1 966 969 PF00400 0.381
TRG_ER_diArg_1 980 983 PF00400 0.446
TRG_NES_CRM1_1 1136 1149 PF08389 0.459
TRG_Pf-PMV_PEXEL_1 1018 1022 PF00026 0.511
TRG_Pf-PMV_PEXEL_1 1025 1029 PF00026 0.535
TRG_Pf-PMV_PEXEL_1 1129 1133 PF00026 0.432
TRG_Pf-PMV_PEXEL_1 1139 1143 PF00026 0.457
TRG_Pf-PMV_PEXEL_1 1152 1156 PF00026 0.429
TRG_Pf-PMV_PEXEL_1 1394 1398 PF00026 0.538
TRG_Pf-PMV_PEXEL_1 140 145 PF00026 0.494
TRG_Pf-PMV_PEXEL_1 919 923 PF00026 0.308
TRG_Pf-PMV_PEXEL_1 926 930 PF00026 0.284
TRG_Pf-PMV_PEXEL_1 958 962 PF00026 0.308
TRG_Pf-PMV_PEXEL_1 983 987 PF00026 0.520

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H530 Leishmania donovani 61% 90%
A4H3R9 Leishmania braziliensis 94% 100%
A4HRT8 Leishmania infantum 61% 67%
E9AJR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 55% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS