zf-C2H2_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of acetyl-transferase ESCO, putative

Species:

Leishmania braziliensis

UniProt:

A4H3J0_LEIBR

TriTrypDb:

LbrM.03.0190 , LBRM2903_030006800

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3J0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.583
CLV_C14_Caspase3-7	291	295	PF00656	0.561
CLV_C14_Caspase3-7	497	501	PF00656	0.649
CLV_C14_Caspase3-7	503	507	PF00656	0.682
CLV_NRD_NRD_1	100	102	PF00675	0.279
CLV_NRD_NRD_1	111	113	PF00675	0.586
CLV_NRD_NRD_1	13	15	PF00675	0.643
CLV_NRD_NRD_1	130	132	PF00675	0.591
CLV_NRD_NRD_1	185	187	PF00675	0.691
CLV_NRD_NRD_1	243	245	PF00675	0.445
CLV_NRD_NRD_1	323	325	PF00675	0.525
CLV_NRD_NRD_1	334	336	PF00675	0.458
CLV_NRD_NRD_1	345	347	PF00675	0.407
CLV_NRD_NRD_1	55	57	PF00675	0.607
CLV_PCSK_FUR_1	108	112	PF00082	0.595
CLV_PCSK_FUR_1	128	132	PF00082	0.523
CLV_PCSK_KEX2_1	100	102	PF00082	0.279
CLV_PCSK_KEX2_1	110	112	PF00082	0.574
CLV_PCSK_KEX2_1	13	15	PF00082	0.643
CLV_PCSK_KEX2_1	130	132	PF00082	0.591
CLV_PCSK_KEX2_1	184	186	PF00082	0.694
CLV_PCSK_KEX2_1	322	324	PF00082	0.509
CLV_PCSK_KEX2_1	334	336	PF00082	0.451
CLV_PCSK_KEX2_1	345	347	PF00082	0.407
CLV_PCSK_KEX2_1	373	375	PF00082	0.628
CLV_PCSK_KEX2_1	55	57	PF00082	0.605
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.628
CLV_PCSK_PC7_1	180	186	PF00082	0.688
CLV_PCSK_SKI1_1	216	220	PF00082	0.362
CLV_PCSK_SKI1_1	311	315	PF00082	0.418
CLV_PCSK_SKI1_1	346	350	PF00082	0.535
DEG_APCC_DBOX_1	310	318	PF00400	0.421
DEG_APCC_DBOX_1	79	87	PF00400	0.491
DEG_Nend_Nbox_1	1	3	PF02207	0.476
DEG_ODPH_VHL_1	141	154	PF01847	0.379
DEG_SPOP_SBC_1	398	402	PF00917	0.453
DOC_CKS1_1	378	383	PF01111	0.399
DOC_CYCLIN_RxL_1	249	260	PF00134	0.455
DOC_CYCLIN_yCln2_LP_2	358	364	PF00134	0.299
DOC_MAPK_gen_1	244	251	PF00069	0.447
DOC_MAPK_gen_1	55	63	PF00069	0.505
DOC_MAPK_HePTP_8	241	253	PF00069	0.356
DOC_MAPK_MEF2A_6	244	253	PF00069	0.349
DOC_MAPK_MEF2A_6	293	302	PF00069	0.368
DOC_MAPK_MEF2A_6	323	332	PF00069	0.485
DOC_MAPK_MEF2A_6	55	63	PF00069	0.505
DOC_MAPK_RevD_3	229	245	PF00069	0.321
DOC_PP2B_LxvP_1	22	25	PF13499	0.501
DOC_USP7_MATH_1	126	130	PF00917	0.650
DOC_USP7_MATH_1	16	20	PF00917	0.500
DOC_USP7_MATH_1	277	281	PF00917	0.636
DOC_USP7_MATH_1	468	472	PF00917	0.560
DOC_WW_Pin1_4	165	170	PF00397	0.648
DOC_WW_Pin1_4	200	205	PF00397	0.588
DOC_WW_Pin1_4	224	229	PF00397	0.519
DOC_WW_Pin1_4	25	30	PF00397	0.518
DOC_WW_Pin1_4	257	262	PF00397	0.453
DOC_WW_Pin1_4	270	275	PF00397	0.456
DOC_WW_Pin1_4	283	288	PF00397	0.452
DOC_WW_Pin1_4	294	299	PF00397	0.372
DOC_WW_Pin1_4	357	362	PF00397	0.460
DOC_WW_Pin1_4	377	382	PF00397	0.400
LIG_14-3-3_CanoR_1	130	140	PF00244	0.636
LIG_14-3-3_CanoR_1	144	152	PF00244	0.351
LIG_14-3-3_CanoR_1	345	353	PF00244	0.459
LIG_14-3-3_CanoR_1	383	387	PF00244	0.502
LIG_BRCT_BRCA1_1	119	123	PF00533	0.474
LIG_FHA_1	145	151	PF00498	0.345
LIG_FHA_1	203	209	PF00498	0.565
LIG_FHA_1	258	264	PF00498	0.424
LIG_FHA_1	284	290	PF00498	0.693
LIG_FHA_1	295	301	PF00498	0.481
LIG_FHA_1	65	71	PF00498	0.521
LIG_FHA_2	201	207	PF00498	0.673
LIG_FHA_2	289	295	PF00498	0.502
LIG_FHA_2	347	353	PF00498	0.406
LIG_FHA_2	364	370	PF00498	0.403
LIG_FHA_2	492	498	PF00498	0.603
LIG_FHA_2	64	70	PF00498	0.291
LIG_LIR_Gen_1	230	238	PF02991	0.275
LIG_LIR_Nem_3	217	222	PF02991	0.646
LIG_LIR_Nem_3	230	235	PF02991	0.318
LIG_LIR_Nem_3	258	262	PF02991	0.473
LIG_NRBOX	2	8	PF00104	0.624
LIG_NRBOX	252	258	PF00104	0.487
LIG_NRBOX	309	315	PF00104	0.426
LIG_PCNA_TLS_4	383	390	PF02747	0.521
LIG_Pex14_2	123	127	PF04695	0.466
LIG_Pex14_2	232	236	PF04695	0.272
LIG_SH2_NCK_1	446	450	PF00017	0.529
LIG_SH2_STAP1	446	450	PF00017	0.547
LIG_SH2_STAT5	457	460	PF00017	0.374
LIG_SH2_STAT5	493	496	PF00017	0.616
LIG_SH3_1	284	290	PF00018	0.481
LIG_SH3_2	378	383	PF14604	0.399
LIG_SH3_3	137	143	PF00018	0.505
LIG_SH3_3	18	24	PF00018	0.676
LIG_SH3_3	215	221	PF00018	0.518
LIG_SH3_3	284	290	PF00018	0.556
LIG_SH3_3	315	321	PF00018	0.421
LIG_SH3_3	375	381	PF00018	0.571
LIG_SH3_3	483	489	PF00018	0.502
LIG_SUMO_SIM_par_1	252	258	PF11976	0.432
LIG_TRAF2_1	366	369	PF00917	0.333
LIG_TRFH_1	20	24	PF08558	0.504
LIG_WRC_WIRS_1	386	391	PF05994	0.452
MOD_CDK_SPxK_1	377	383	PF00069	0.400
MOD_CK1_1	172	178	PF00069	0.562
MOD_CK1_1	214	220	PF00069	0.565
MOD_CK1_1	224	230	PF00069	0.637
MOD_CK1_1	273	279	PF00069	0.464
MOD_CK1_1	32	38	PF00069	0.603
MOD_CK1_1	401	407	PF00069	0.587
MOD_CK1_1	499	505	PF00069	0.575
MOD_CK2_1	224	230	PF00069	0.556
MOD_CK2_1	357	363	PF00069	0.461
MOD_GlcNHglycan	120	123	PF01048	0.579
MOD_GlcNHglycan	158	161	PF01048	0.443
MOD_GlcNHglycan	294	297	PF01048	0.614
MOD_GlcNHglycan	395	398	PF01048	0.582
MOD_GSK3_1	118	125	PF00069	0.674
MOD_GSK3_1	156	163	PF00069	0.513
MOD_GSK3_1	165	172	PF00069	0.653
MOD_GSK3_1	198	205	PF00069	0.639
MOD_GSK3_1	25	32	PF00069	0.503
MOD_GSK3_1	273	280	PF00069	0.685
MOD_GSK3_1	288	295	PF00069	0.565
MOD_GSK3_1	336	343	PF00069	0.565
MOD_GSK3_1	363	370	PF00069	0.386
MOD_GSK3_1	385	392	PF00069	0.596
MOD_GSK3_1	393	400	PF00069	0.576
MOD_GSK3_1	496	503	PF00069	0.526
MOD_N-GLC_1	172	177	PF02516	0.771
MOD_N-GLC_2	237	239	PF02516	0.477
MOD_NEK2_1	117	122	PF00069	0.476
MOD_NEK2_1	171	176	PF00069	0.745
MOD_NEK2_1	222	227	PF00069	0.503
MOD_NEK2_1	389	394	PF00069	0.528
MOD_NEK2_1	54	59	PF00069	0.692
MOD_NEK2_1	61	66	PF00069	0.644
MOD_NEK2_2	469	474	PF00069	0.411
MOD_PIKK_1	175	181	PF00454	0.599
MOD_PIKK_1	399	405	PF00454	0.447
MOD_PIKK_1	61	67	PF00454	0.629
MOD_PKA_2	175	181	PF00069	0.697
MOD_PKA_2	239	245	PF00069	0.490
MOD_PKA_2	382	388	PF00069	0.384
MOD_PKA_2	54	60	PF00069	0.635
MOD_Plk_1	16	22	PF00069	0.525
MOD_Plk_1	208	214	PF00069	0.605
MOD_Plk_1	463	469	PF00069	0.389
MOD_Plk_2-3	500	506	PF00069	0.702
MOD_Plk_4	35	41	PF00069	0.498
MOD_Plk_4	385	391	PF00069	0.585
MOD_Plk_4	510	516	PF00069	0.543
MOD_ProDKin_1	165	171	PF00069	0.647
MOD_ProDKin_1	200	206	PF00069	0.586
MOD_ProDKin_1	224	230	PF00069	0.504
MOD_ProDKin_1	25	31	PF00069	0.520
MOD_ProDKin_1	257	263	PF00069	0.451
MOD_ProDKin_1	270	276	PF00069	0.461
MOD_ProDKin_1	283	289	PF00069	0.452
MOD_ProDKin_1	294	300	PF00069	0.354
MOD_ProDKin_1	357	363	PF00069	0.458
MOD_ProDKin_1	377	383	PF00069	0.400
TRG_DiLeu_BaEn_1	230	235	PF01217	0.267
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.604
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.402
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.459
TRG_ER_diArg_1	100	102	PF00400	0.385
TRG_ER_diArg_1	108	111	PF00400	0.621
TRG_ER_diArg_1	127	130	PF00400	0.600
TRG_ER_diArg_1	184	186	PF00400	0.813
TRG_ER_diArg_1	321	324	PF00400	0.602
TRG_ER_diArg_1	54	56	PF00400	0.708

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD4	Leptomonas seymouri	32%	73%
A0A1X0P9N7	Trypanosomatidae	27%	100%
A0A3R7KHE5	Trypanosoma rangeli	25%	100%
A0A3S5H526	Leishmania donovani	65%	71%
A4HRS9	Leishmania infantum	65%	71%
E9ACG5	Leishmania major	66%	100%
E9AJQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%