Putative ABC transporter protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transporter protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H3I8_LEIBR

TriTrypDb:

LbrM.03.0170 , LBRM2903_030006600

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3I8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.304
CLV_NRD_NRD_1	155	157	PF00675	0.466
CLV_NRD_NRD_1	158	160	PF00675	0.458
CLV_NRD_NRD_1	176	178	PF00675	0.544
CLV_NRD_NRD_1	705	707	PF00675	0.481
CLV_NRD_NRD_1	715	717	PF00675	0.447
CLV_PCSK_FUR_1	156	160	PF00082	0.461
CLV_PCSK_KEX2_1	123	125	PF00082	0.632
CLV_PCSK_KEX2_1	148	150	PF00082	0.479
CLV_PCSK_KEX2_1	158	160	PF00082	0.446
CLV_PCSK_KEX2_1	178	180	PF00082	0.348
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.632
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.479
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.446
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.348
CLV_PCSK_SKI1_1	123	127	PF00082	0.503
CLV_PCSK_SKI1_1	165	169	PF00082	0.466
CLV_PCSK_SKI1_1	214	218	PF00082	0.356
CLV_PCSK_SKI1_1	327	331	PF00082	0.320
CLV_PCSK_SKI1_1	356	360	PF00082	0.252
CLV_PCSK_SKI1_1	361	365	PF00082	0.252
CLV_PCSK_SKI1_1	405	409	PF00082	0.301
CLV_PCSK_SKI1_1	540	544	PF00082	0.384
CLV_PCSK_SKI1_1	638	642	PF00082	0.270
DEG_APCC_DBOX_1	404	412	PF00400	0.334
DEG_APCC_DBOX_1	610	618	PF00400	0.252
DEG_APCC_DBOX_1	637	645	PF00400	0.252
DEG_MDM2_SWIB_1	390	398	PF02201	0.311
DEG_Nend_UBRbox_2	1	3	PF02207	0.382
DEG_SCF_FBW7_1	588	593	PF00400	0.295
DOC_CKS1_1	273	278	PF01111	0.265
DOC_CYCLIN_RxL_1	356	368	PF00134	0.270
DOC_MAPK_FxFP_2	499	502	PF00069	0.365
DOC_MAPK_gen_1	716	722	PF00069	0.268
DOC_MAPK_JIP1_4	648	654	PF00069	0.252
DOC_MAPK_MEF2A_6	204	212	PF00069	0.362
DOC_PP1_RVXF_1	63	69	PF00149	0.404
DOC_PP4_FxxP_1	364	367	PF00568	0.270
DOC_PP4_FxxP_1	499	502	PF00568	0.365
DOC_PP4_FxxP_1	646	649	PF00568	0.252
DOC_USP7_MATH_1	523	527	PF00917	0.498
DOC_USP7_MATH_2	101	107	PF00917	0.499
DOC_USP7_UBL2_3	129	133	PF12436	0.663
DOC_USP7_UBL2_3	153	157	PF12436	0.497
DOC_USP7_UBL2_3	160	164	PF12436	0.439
DOC_USP7_UBL2_3	189	193	PF12436	0.441
DOC_USP7_UBL2_3	392	396	PF12436	0.383
DOC_USP7_UBL2_3	717	721	PF12436	0.489
DOC_WW_Pin1_4	254	259	PF00397	0.252
DOC_WW_Pin1_4	272	277	PF00397	0.252
DOC_WW_Pin1_4	341	346	PF00397	0.270
DOC_WW_Pin1_4	586	591	PF00397	0.289
LIG_14-3-3_CanoR_1	107	114	PF00244	0.704
LIG_14-3-3_CanoR_1	124	128	PF00244	0.488
LIG_14-3-3_CanoR_1	179	187	PF00244	0.408
LIG_14-3-3_CanoR_1	8	18	PF00244	0.412
LIG_Actin_WH2_2	15	33	PF00022	0.479
LIG_AP2alpha_1	461	465	PF02296	0.416
LIG_APCC_ABBA_1	525	530	PF00400	0.478
LIG_BRCT_BRCA1_1	403	407	PF00533	0.309
LIG_BRCT_BRCA1_1	507	511	PF00533	0.408
LIG_BRCT_BRCA1_1	593	597	PF00533	0.252
LIG_Clathr_ClatBox_1	651	655	PF01394	0.252
LIG_deltaCOP1_diTrp_1	141	145	PF00928	0.491
LIG_eIF4E_1	676	682	PF01652	0.361
LIG_FAT_LD_1	38	46	PF03623	0.373
LIG_FHA_1	182	188	PF00498	0.521
LIG_FHA_1	219	225	PF00498	0.320
LIG_FHA_1	240	246	PF00498	0.252
LIG_FHA_1	344	350	PF00498	0.252
LIG_FHA_1	374	380	PF00498	0.252
LIG_FHA_1	395	401	PF00498	0.296
LIG_FHA_1	413	419	PF00498	0.252
LIG_FHA_1	557	563	PF00498	0.320
LIG_FHA_1	587	593	PF00498	0.328
LIG_FHA_1	61	67	PF00498	0.348
LIG_FHA_1	656	662	PF00498	0.252
LIG_FHA_1	83	89	PF00498	0.521
LIG_FHA_2	137	143	PF00498	0.531
LIG_FHA_2	273	279	PF00498	0.330
LIG_FHA_2	281	287	PF00498	0.330
LIG_FHA_2	434	440	PF00498	0.416
LIG_FHA_2	47	53	PF00498	0.512
LIG_FHA_2	498	504	PF00498	0.440
LIG_LIR_Apic_2	500	504	PF02991	0.340
LIG_LIR_Apic_2	645	649	PF02991	0.293
LIG_LIR_Gen_1	170	176	PF02991	0.427
LIG_LIR_Gen_1	257	265	PF02991	0.252
LIG_LIR_Gen_1	311	321	PF02991	0.252
LIG_LIR_Gen_1	380	390	PF02991	0.293
LIG_LIR_Gen_1	427	438	PF02991	0.356
LIG_LIR_Gen_1	508	519	PF02991	0.368
LIG_LIR_Gen_1	70	77	PF02991	0.493
LIG_LIR_Nem_3	170	175	PF02991	0.425
LIG_LIR_Nem_3	257	262	PF02991	0.252
LIG_LIR_Nem_3	311	316	PF02991	0.252
LIG_LIR_Nem_3	380	385	PF02991	0.293
LIG_LIR_Nem_3	427	433	PF02991	0.356
LIG_LIR_Nem_3	508	514	PF02991	0.346
LIG_LIR_Nem_3	526	531	PF02991	0.355
LIG_LIR_Nem_3	70	74	PF02991	0.477
LIG_LIR_Nem_3	709	715	PF02991	0.379
LIG_PCNA_yPIPBox_3	299	313	PF02747	0.384
LIG_Pex14_1	386	390	PF04695	0.294
LIG_Pex14_2	382	386	PF04695	0.291
LIG_Pex14_2	390	394	PF04695	0.312
LIG_Pex14_2	461	465	PF04695	0.416
LIG_Pex14_2	497	501	PF04695	0.513
LIG_Pex14_2	708	712	PF04695	0.341
LIG_SH2_CRK	231	235	PF00017	0.252
LIG_SH2_SRC	118	121	PF00017	0.616
LIG_SH2_STAP1	118	122	PF00017	0.484
LIG_SH2_STAP1	172	176	PF00017	0.425
LIG_SH2_STAP1	199	203	PF00017	0.428
LIG_SH2_STAT5	426	429	PF00017	0.397
LIG_SH2_STAT5	54	57	PF00017	0.498
LIG_SH2_STAT5	629	632	PF00017	0.252
LIG_SH2_STAT5	67	70	PF00017	0.357
LIG_SH2_STAT5	688	691	PF00017	0.385
LIG_SH3_3	489	495	PF00018	0.511
LIG_SUMO_SIM_anti_2	219	227	PF11976	0.279
LIG_SUMO_SIM_anti_2	274	281	PF11976	0.330
LIG_SUMO_SIM_anti_2	368	374	PF11976	0.252
LIG_SUMO_SIM_anti_2	397	402	PF11976	0.278
LIG_SUMO_SIM_anti_2	510	516	PF11976	0.243
LIG_SUMO_SIM_anti_2	539	545	PF11976	0.387
LIG_SUMO_SIM_par_1	219	227	PF11976	0.320
LIG_SUMO_SIM_par_1	368	374	PF11976	0.252
LIG_SUMO_SIM_par_1	396	402	PF11976	0.284
LIG_SUMO_SIM_par_1	650	656	PF11976	0.252
LIG_SUMO_SIM_par_1	679	684	PF11976	0.271
LIG_TRAF2_1	101	104	PF00917	0.597
LIG_TRAF2_1	449	452	PF00917	0.511
MOD_CDC14_SPxK_1	344	347	PF00782	0.270
MOD_CDK_SPxK_1	341	347	PF00069	0.270
MOD_CK1_1	102	108	PF00069	0.633
MOD_CK1_1	182	188	PF00069	0.569
MOD_CK1_1	50	56	PF00069	0.465
MOD_CK2_1	272	278	PF00069	0.307
MOD_CK2_1	280	286	PF00069	0.277
MOD_CK2_1	433	439	PF00069	0.416
MOD_CK2_1	46	52	PF00069	0.503
MOD_CK2_1	507	513	PF00069	0.501
MOD_CK2_1	590	596	PF00069	0.252
MOD_CK2_1	681	687	PF00069	0.287
MOD_CK2_1	72	78	PF00069	0.578
MOD_CK2_1	9	15	PF00069	0.492
MOD_GlcNHglycan	109	112	PF01048	0.673
MOD_GlcNHglycan	149	152	PF01048	0.516
MOD_GlcNHglycan	322	325	PF01048	0.292
MOD_GlcNHglycan	349	352	PF01048	0.286
MOD_GlcNHglycan	507	510	PF01048	0.442
MOD_GlcNHglycan	565	568	PF01048	0.320
MOD_GlcNHglycan	619	622	PF01048	0.331
MOD_GlcNHglycan	631	634	PF01048	0.220
MOD_GlcNHglycan	74	77	PF01048	0.371
MOD_GSK3_1	103	110	PF00069	0.594
MOD_GSK3_1	123	130	PF00069	0.389
MOD_GSK3_1	132	139	PF00069	0.529
MOD_GSK3_1	181	188	PF00069	0.665
MOD_GSK3_1	194	201	PF00069	0.537
MOD_GSK3_1	343	350	PF00069	0.267
MOD_GSK3_1	399	406	PF00069	0.297
MOD_GSK3_1	46	53	PF00069	0.434
MOD_GSK3_1	586	593	PF00069	0.294
MOD_GSK3_1	613	620	PF00069	0.282
MOD_GSK3_1	95	102	PF00069	0.555
MOD_N-GLC_1	112	117	PF02516	0.409
MOD_N-GLC_1	197	202	PF02516	0.488
MOD_N-GLC_1	300	305	PF02516	0.320
MOD_N-GLC_1	701	706	PF02516	0.263
MOD_N-GLC_1	81	86	PF02516	0.489
MOD_N-GLC_2	410	412	PF02516	0.307
MOD_N-GLC_2	556	558	PF02516	0.252
MOD_NEK2_1	127	132	PF00069	0.557
MOD_NEK2_1	147	152	PF00069	0.333
MOD_NEK2_1	433	438	PF00069	0.416
MOD_NEK2_1	474	479	PF00069	0.416
MOD_NEK2_1	497	502	PF00069	0.556
MOD_NEK2_1	597	602	PF00069	0.252
MOD_NEK2_1	689	694	PF00069	0.316
MOD_NEK2_1	81	86	PF00069	0.442
MOD_NEK2_2	118	123	PF00069	0.619
MOD_NEK2_2	412	417	PF00069	0.221
MOD_NEK2_2	523	528	PF00069	0.374
MOD_PIKK_1	335	341	PF00454	0.384
MOD_PKA_1	123	129	PF00069	0.511
MOD_PKA_1	99	105	PF00069	0.530
MOD_PKA_2	123	129	PF00069	0.719
MOD_PKB_1	177	185	PF00069	0.554
MOD_Plk_1	103	109	PF00069	0.498
MOD_Plk_1	118	124	PF00069	0.489
MOD_Plk_1	141	147	PF00069	0.485
MOD_Plk_1	433	439	PF00069	0.416
MOD_Plk_1	536	542	PF00069	0.252
MOD_Plk_1	701	707	PF00069	0.358
MOD_Plk_2-3	141	147	PF00069	0.563
MOD_Plk_4	123	129	PF00069	0.511
MOD_Plk_4	240	246	PF00069	0.371
MOD_Plk_4	327	333	PF00069	0.295
MOD_Plk_4	394	400	PF00069	0.339
MOD_Plk_4	50	56	PF00069	0.416
MOD_Plk_4	507	513	PF00069	0.414
MOD_Plk_4	523	529	PF00069	0.318
MOD_Plk_4	550	556	PF00069	0.252
MOD_Plk_4	565	571	PF00069	0.252
MOD_ProDKin_1	254	260	PF00069	0.252
MOD_ProDKin_1	272	278	PF00069	0.252
MOD_ProDKin_1	341	347	PF00069	0.270
MOD_ProDKin_1	586	592	PF00069	0.289
MOD_SUMO_rev_2	141	150	PF00179	0.548
MOD_SUMO_rev_2	161	167	PF00179	0.314
MOD_SUMO_rev_2	75	81	PF00179	0.449
TRG_DiLeu_BaEn_1	286	291	PF01217	0.252
TRG_DiLeu_BaEn_1	293	298	PF01217	0.252
TRG_DiLeu_BaEn_1	366	371	PF01217	0.252
TRG_DiLeu_BaEn_1	414	419	PF01217	0.384
TRG_DiLeu_BaEn_3	170	176	PF01217	0.458
TRG_DiLeu_BaEn_4	103	109	PF01217	0.630
TRG_DiLeu_BaEn_4	293	299	PF01217	0.252
TRG_ENDOCYTIC_2	172	175	PF00928	0.421
TRG_ENDOCYTIC_2	231	234	PF00928	0.252
TRG_ENDOCYTIC_2	313	316	PF00928	0.252
TRG_ENDOCYTIC_2	430	433	PF00928	0.429
TRG_ER_diArg_1	176	179	PF00400	0.527
TRG_ER_diArg_1	353	356	PF00400	0.277
TRG_NES_CRM1_1	206	222	PF08389	0.361
TRG_NES_CRM1_1	608	622	PF08389	0.252
TRG_NLS_Bipartite_1	159	181	PF00514	0.459
TRG_NLS_MonoCore_2	155	160	PF00514	0.541
TRG_NLS_MonoExtC_3	155	160	PF00514	0.541
TRG_NLS_MonoExtN_4	153	160	PF00514	0.540
TRG_NLS_MonoExtN_4	571	577	PF00514	0.270
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.252
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	361	366	PF00026	0.252

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VBH0	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	42%	100%
A0A0H2VFI8	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	30%	100%
A0A0N0P4L2	Leptomonas seymouri	85%	100%
A0A0N1I593	Leptomonas seymouri	37%	100%
A0A0N1PAH6	Leptomonas seymouri	41%	100%
A0A0S4IYK6	Bodo saltans	30%	100%
A0A0S4JRN6	Bodo saltans	36%	100%
A0A1X0P0L3	Trypanosomatidae	36%	100%
A0A1X0P688	Trypanosomatidae	42%	100%
A0A1X0P8V9	Trypanosomatidae	72%	100%
A0A3Q8IHB5	Leishmania donovani	36%	100%
A0A3R7LWT1	Trypanosoma rangeli	43%	100%
A0A3S5H525	Leishmania donovani	94%	100%
A0A3S7WVI6	Leishmania donovani	41%	100%
A0A422N7J4	Trypanosoma rangeli	71%	100%
A0A422NHP3	Trypanosoma rangeli	39%	100%
A4HA37	Leishmania braziliensis	41%	100%
A4HL68	Leishmania braziliensis	36%	100%
A4HRS7	Leishmania infantum	94%	100%
A4HYA0	Leishmania infantum	41%	100%
A4I8P8	Leishmania infantum	36%	100%
D0A0N6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A223	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
D0A4N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ACG3	Leishmania major	93%	100%
E9AJQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AS32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B3L1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
O05519	Bacillus subtilis (strain 168)	31%	100%
O06476	Bacillus subtilis (strain 168)	30%	100%
O31716	Bacillus subtilis (strain 168)	32%	100%
O34512	Bacillus subtilis (strain 168)	31%	100%
O42943	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
O59672	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	98%
P0A9U3	Escherichia coli (strain K12)	33%	100%
P0A9U4	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	33%	100%
P0A9U5	Escherichia coli O157:H7	33%	100%
P0A9W3	Escherichia coli (strain K12)	31%	100%
P0A9W4	Escherichia coli O157:H7	31%	100%
P0A9W5	Shigella flexneri	31%	100%
P23212	Staphylococcus epidermidis	28%	100%
P25256	Streptomyces fradiae	32%	100%
P40024	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
P43535	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	96%
P43672	Escherichia coli (strain K12)	31%	100%
P44808	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	39%	100%
P45127	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	30%	100%
P63389	Escherichia coli (strain K12)	41%	100%
P63390	Escherichia coli O157:H7	41%	100%
P9WQK2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	29%	100%
P9WQK3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
Q2K0S7	Rhizobium etli (strain CFN 42 / ATCC 51251)	24%	100%
Q2KJA2	Bos taurus	41%	100%
Q45978	Caulobacter vibrioides (strain ATCC 19089 / CB15)	30%	100%
Q4Q4I8	Leishmania major	37%	100%
Q4QDE1	Leishmania major	41%	100%
Q57242	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	33%	100%
Q5R9Z5	Pongo abelii	38%	100%
Q66H39	Rattus norvegicus	38%	100%
Q6MG08	Rattus norvegicus	41%	86%
Q6P542	Mus musculus	40%	86%
Q6YRJ4	Onion yellows phytoplasma (strain OY-M)	22%	100%
Q737I0	Bacillus cereus (strain ATCC 10987 / NRS 248)	22%	100%
Q73P93	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	24%	100%
Q767L0	Sus scrofa	41%	90%
Q7YR37	Pan troglodytes	41%	90%
Q81N53	Bacillus anthracis	25%	100%
Q81PZ8	Bacillus anthracis	22%	100%
Q8H0V6	Arabidopsis thaliana	48%	100%
Q8K268	Mus musculus	38%	100%
Q8K9I3	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	28%	100%
Q8NE71	Homo sapiens	41%	86%
Q8SRV5	Encephalitozoon cuniculi (strain GB-M1)	39%	100%
Q8T6B7	Dictyostelium discoideum	38%	100%
Q99LE6	Mus musculus	41%	100%
Q9FIB4	Arabidopsis thaliana	29%	100%
Q9FJH6	Arabidopsis thaliana	44%	100%
Q9LV93	Arabidopsis thaliana	28%	100%
Q9M1H3	Arabidopsis thaliana	39%	100%
Q9NUQ8	Homo sapiens	38%	100%
Q9UG63	Homo sapiens	41%	100%
Q9USH9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	88%
V5AVV7	Trypanosoma cruzi	39%	100%
V5BD93	Trypanosoma cruzi	74%	100%
V5DFD4	Trypanosoma cruzi	42%	100%