Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3I4_LEIBR

TriTrypDb:

LbrM.03.0130 , LBRM2903_030006200

Length:

869

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	5
GO:0042995	cell projection	2	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	5
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4H3I4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3I4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.537
CLV_NRD_NRD_1	152	154	PF00675	0.531
CLV_NRD_NRD_1	256	258	PF00675	0.624
CLV_NRD_NRD_1	461	463	PF00675	0.536
CLV_NRD_NRD_1	475	477	PF00675	0.535
CLV_NRD_NRD_1	546	548	PF00675	0.551
CLV_NRD_NRD_1	568	570	PF00675	0.642
CLV_NRD_NRD_1	681	683	PF00675	0.779
CLV_NRD_NRD_1	722	724	PF00675	0.640
CLV_PCSK_FUR_1	150	154	PF00082	0.525
CLV_PCSK_FUR_1	846	850	PF00082	0.507
CLV_PCSK_KEX2_1	152	154	PF00082	0.531
CLV_PCSK_KEX2_1	256	258	PF00082	0.624
CLV_PCSK_KEX2_1	297	299	PF00082	0.742
CLV_PCSK_KEX2_1	461	463	PF00082	0.627
CLV_PCSK_KEX2_1	465	467	PF00082	0.618
CLV_PCSK_KEX2_1	475	477	PF00082	0.535
CLV_PCSK_KEX2_1	510	512	PF00082	0.597
CLV_PCSK_KEX2_1	546	548	PF00082	0.551
CLV_PCSK_KEX2_1	568	570	PF00082	0.642
CLV_PCSK_KEX2_1	681	683	PF00082	0.779
CLV_PCSK_KEX2_1	722	724	PF00082	0.640
CLV_PCSK_KEX2_1	848	850	PF00082	0.628
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.585
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.659
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.597
CLV_PCSK_PC1ET2_1	848	850	PF00082	0.628
CLV_PCSK_PC7_1	461	467	PF00082	0.539
CLV_PCSK_SKI1_1	155	159	PF00082	0.370
CLV_PCSK_SKI1_1	208	212	PF00082	0.704
CLV_PCSK_SKI1_1	25	29	PF00082	0.554
CLV_PCSK_SKI1_1	294	298	PF00082	0.693
CLV_PCSK_SKI1_1	492	496	PF00082	0.608
CLV_PCSK_SKI1_1	682	686	PF00082	0.664
CLV_PCSK_SKI1_1	722	726	PF00082	0.637
CLV_PCSK_SKI1_1	854	858	PF00082	0.691
CLV_Separin_Metazoa	339	343	PF03568	0.580
CLV_Separin_Metazoa	92	96	PF03568	0.480
DEG_APCC_DBOX_1	11	19	PF00400	0.487
DEG_APCC_DBOX_1	154	162	PF00400	0.520
DEG_APCC_DBOX_1	87	95	PF00400	0.497
DEG_COP1_1	372	381	PF00400	0.543
DEG_Kelch_Keap1_1	562	567	PF01344	0.495
DEG_Nend_Nbox_1	1	3	PF02207	0.402
DEG_SPOP_SBC_1	319	323	PF00917	0.556
DEG_SPOP_SBC_1	421	425	PF00917	0.598
DOC_ANK_TNKS_1	764	771	PF00023	0.547
DOC_CKS1_1	204	209	PF01111	0.687
DOC_CKS1_1	383	388	PF01111	0.713
DOC_CKS1_1	760	765	PF01111	0.544
DOC_CYCLIN_RxL_1	679	689	PF00134	0.669
DOC_CYCLIN_yCln2_LP_2	308	314	PF00134	0.561
DOC_CYCLIN_yCln2_LP_2	793	796	PF00134	0.519
DOC_MAPK_gen_1	306	315	PF00069	0.565
DOC_MAPK_gen_1	722	729	PF00069	0.480
DOC_PP2B_LxvP_1	308	311	PF13499	0.556
DOC_PP2B_LxvP_1	793	796	PF13499	0.519
DOC_PP4_FxxP_1	798	801	PF00568	0.528
DOC_USP7_MATH_1	183	187	PF00917	0.512
DOC_USP7_MATH_1	219	223	PF00917	0.689
DOC_USP7_MATH_1	23	27	PF00917	0.507
DOC_USP7_MATH_1	263	267	PF00917	0.710
DOC_USP7_MATH_1	269	273	PF00917	0.641
DOC_USP7_MATH_1	318	322	PF00917	0.592
DOC_USP7_MATH_1	379	383	PF00917	0.729
DOC_USP7_MATH_1	419	423	PF00917	0.598
DOC_USP7_MATH_1	572	576	PF00917	0.547
DOC_USP7_MATH_1	597	601	PF00917	0.727
DOC_USP7_MATH_1	607	611	PF00917	0.730
DOC_USP7_MATH_1	613	617	PF00917	0.626
DOC_USP7_MATH_1	623	627	PF00917	0.647
DOC_USP7_MATH_1	675	679	PF00917	0.647
DOC_USP7_MATH_1	688	692	PF00917	0.561
DOC_USP7_MATH_1	785	789	PF00917	0.614
DOC_USP7_MATH_1	801	805	PF00917	0.716
DOC_USP7_MATH_1	841	845	PF00917	0.562
DOC_USP7_UBL2_3	854	858	PF12436	0.595
DOC_WW_Pin1_4	132	137	PF00397	0.495
DOC_WW_Pin1_4	203	208	PF00397	0.647
DOC_WW_Pin1_4	344	349	PF00397	0.662
DOC_WW_Pin1_4	382	387	PF00397	0.712
DOC_WW_Pin1_4	398	403	PF00397	0.704
DOC_WW_Pin1_4	422	427	PF00397	0.795
DOC_WW_Pin1_4	61	66	PF00397	0.323
DOC_WW_Pin1_4	615	620	PF00397	0.853
DOC_WW_Pin1_4	621	626	PF00397	0.767
DOC_WW_Pin1_4	749	754	PF00397	0.616
DOC_WW_Pin1_4	759	764	PF00397	0.612
DOC_WW_Pin1_4	797	802	PF00397	0.684
DOC_WW_Pin1_4	835	840	PF00397	0.753
LIG_14-3-3_CanoR_1	114	119	PF00244	0.472
LIG_14-3-3_CanoR_1	29	35	PF00244	0.534
LIG_14-3-3_CanoR_1	36	40	PF00244	0.435
LIG_14-3-3_CanoR_1	46	52	PF00244	0.292
LIG_14-3-3_CanoR_1	475	485	PF00244	0.538
LIG_14-3-3_CanoR_1	496	503	PF00244	0.416
LIG_14-3-3_CanoR_1	514	524	PF00244	0.597
LIG_14-3-3_CanoR_1	533	538	PF00244	0.347
LIG_14-3-3_CanoR_1	681	685	PF00244	0.766
LIG_14-3-3_CanoR_1	717	721	PF00244	0.568
LIG_14-3-3_CanoR_1	78	83	PF00244	0.482
LIG_14-3-3_CanoR_1	803	808	PF00244	0.700
LIG_Actin_WH2_2	242	258	PF00022	0.563
LIG_Actin_WH2_2	33	48	PF00022	0.341
LIG_Actin_WH2_2	481	498	PF00022	0.552
LIG_Actin_WH2_2	787	805	PF00022	0.612
LIG_Clathr_ClatBox_1	165	169	PF01394	0.504
LIG_DLG_GKlike_1	78	85	PF00625	0.480
LIG_eIF4E_1	34	40	PF01652	0.475
LIG_FHA_1	102	108	PF00498	0.602
LIG_FHA_1	110	116	PF00498	0.408
LIG_FHA_1	133	139	PF00498	0.526
LIG_FHA_1	303	309	PF00498	0.661
LIG_FHA_1	438	444	PF00498	0.727
LIG_FHA_1	641	647	PF00498	0.614
LIG_FHA_1	672	678	PF00498	0.658
LIG_FHA_1	828	834	PF00498	0.742
LIG_FHA_2	172	178	PF00498	0.560
LIG_FHA_2	223	229	PF00498	0.579
LIG_FHA_2	359	365	PF00498	0.715
LIG_FHA_2	4	10	PF00498	0.490
LIG_FHA_2	499	505	PF00498	0.624
LIG_FHA_2	534	540	PF00498	0.494
LIG_FHA_2	543	549	PF00498	0.405
LIG_FHA_2	571	577	PF00498	0.547
LIG_FHA_2	823	829	PF00498	0.719
LIG_GBD_Chelix_1	646	654	PF00786	0.632
LIG_GBD_Chelix_1	676	684	PF00786	0.655
LIG_GSK3_LRP6_1	839	845	PF00069	0.535
LIG_LIR_Apic_2	61	65	PF02991	0.331
LIG_LIR_Gen_1	33	40	PF02991	0.561
LIG_LIR_Gen_1	73	83	PF02991	0.465
LIG_LIR_Nem_3	33	37	PF02991	0.551
LIG_LIR_Nem_3	73	79	PF02991	0.573
LIG_PCNA_TLS_4	722	729	PF02747	0.637
LIG_Rb_pABgroove_1	858	866	PF01858	0.467
LIG_RPA_C_Fungi	542	554	PF08784	0.543
LIG_SH2_CRK	34	38	PF00017	0.595
LIG_SH2_CRK	395	399	PF00017	0.699
LIG_SH2_GRB2like	179	182	PF00017	0.654
LIG_SH2_NCK_1	179	183	PF00017	0.575
LIG_SH2_NCK_1	34	38	PF00017	0.474
LIG_SH2_PTP2	62	65	PF00017	0.322
LIG_SH2_SRC	179	182	PF00017	0.654
LIG_SH2_STAP1	179	183	PF00017	0.648
LIG_SH2_STAP1	538	542	PF00017	0.547
LIG_SH2_STAT3	538	541	PF00017	0.548
LIG_SH2_STAT5	122	125	PF00017	0.625
LIG_SH2_STAT5	62	65	PF00017	0.322
LIG_SH3_1	622	628	PF00018	0.582
LIG_SH3_2	625	630	PF14604	0.582
LIG_SH3_3	141	147	PF00018	0.609
LIG_SH3_3	230	236	PF00018	0.702
LIG_SH3_3	338	344	PF00018	0.813
LIG_SH3_3	622	628	PF00018	0.598
LIG_SH3_3	733	739	PF00018	0.560
LIG_SH3_3	757	763	PF00018	0.614
LIG_SH3_3	793	799	PF00018	0.659
LIG_SH3_3	833	839	PF00018	0.728
LIG_SH3_3	84	90	PF00018	0.350
LIG_SUMO_SIM_anti_2	824	834	PF11976	0.644
LIG_SUMO_SIM_par_1	164	169	PF11976	0.507
LIG_SUMO_SIM_par_1	200	206	PF11976	0.563
LIG_SUMO_SIM_par_1	756	762	PF11976	0.565
LIG_SUMO_SIM_par_1	824	834	PF11976	0.723
LIG_TRAF2_2	432	437	PF00917	0.521
LIG_TRAF2_2	740	745	PF00917	0.738
LIG_TYR_ITIM	393	398	PF00017	0.721
LIG_UBA3_1	502	510	PF00899	0.595
LIG_WRC_WIRS_1	534	539	PF05994	0.540
LIG_WW_1	340	343	PF00397	0.547
LIG_WW_3	339	343	PF00397	0.580
LIG_WW_3	762	766	PF00397	0.538
LIG_WW_3	794	798	PF00397	0.523
MOD_CDC14_SPxK_1	347	350	PF00782	0.672
MOD_CDC14_SPxK_1	425	428	PF00782	0.730
MOD_CDC14_SPxK_1	627	630	PF00782	0.722
MOD_CDC14_SPxK_1	800	803	PF00782	0.541
MOD_CDK_SPK_2	203	208	PF00069	0.686
MOD_CDK_SPxK_1	344	350	PF00069	0.676
MOD_CDK_SPxK_1	422	428	PF00069	0.731
MOD_CDK_SPxK_1	624	630	PF00069	0.724
MOD_CDK_SPxK_1	759	765	PF00069	0.568
MOD_CDK_SPxK_1	797	803	PF00069	0.538
MOD_CDK_SPxxK_3	615	622	PF00069	0.737
MOD_CDK_SPxxK_3	839	846	PF00069	0.533
MOD_CK1_1	164	170	PF00069	0.517
MOD_CK1_1	186	192	PF00069	0.674
MOD_CK1_1	222	228	PF00069	0.621
MOD_CK1_1	283	289	PF00069	0.652
MOD_CK1_1	322	328	PF00069	0.630
MOD_CK1_1	372	378	PF00069	0.651
MOD_CK1_1	382	388	PF00069	0.716
MOD_CK1_1	422	428	PF00069	0.767
MOD_CK1_1	498	504	PF00069	0.503
MOD_CK1_1	512	518	PF00069	0.603
MOD_CK1_1	562	568	PF00069	0.501
MOD_CK1_1	585	591	PF00069	0.551
MOD_CK1_1	618	624	PF00069	0.786
MOD_CK1_1	626	632	PF00069	0.660
MOD_CK1_1	689	695	PF00069	0.703
MOD_CK1_1	842	848	PF00069	0.525
MOD_CK2_1	222	228	PF00069	0.711
MOD_CK2_1	359	365	PF00069	0.558
MOD_CK2_1	498	504	PF00069	0.503
MOD_CK2_1	533	539	PF00069	0.496
MOD_CK2_1	542	548	PF00069	0.405
MOD_CK2_1	561	567	PF00069	0.552
MOD_CK2_1	8	14	PF00069	0.475
MOD_CK2_1	822	828	PF00069	0.731
MOD_CK2_1	841	847	PF00069	0.526
MOD_DYRK1A_RPxSP_1	749	753	PF00069	0.554
MOD_GlcNHglycan	324	327	PF01048	0.702
MOD_GlcNHglycan	412	415	PF01048	0.810
MOD_GlcNHglycan	511	514	PF01048	0.600
MOD_GlcNHglycan	561	564	PF01048	0.620
MOD_GlcNHglycan	599	602	PF01048	0.667
MOD_GlcNHglycan	609	612	PF01048	0.630
MOD_GlcNHglycan	613	616	PF01048	0.729
MOD_GlcNHglycan	687	691	PF01048	0.670
MOD_GlcNHglycan	787	790	PF01048	0.551
MOD_GlcNHglycan	805	808	PF01048	0.657
MOD_GlcNHglycan	833	836	PF01048	0.627
MOD_GlcNHglycan	865	868	PF01048	0.512
MOD_GSK3_1	130	137	PF00069	0.525
MOD_GSK3_1	182	189	PF00069	0.653
MOD_GSK3_1	238	245	PF00069	0.769
MOD_GSK3_1	269	276	PF00069	0.702
MOD_GSK3_1	297	304	PF00069	0.813
MOD_GSK3_1	318	325	PF00069	0.731
MOD_GSK3_1	397	404	PF00069	0.710
MOD_GSK3_1	533	540	PF00069	0.543
MOD_GSK3_1	557	564	PF00069	0.516
MOD_GSK3_1	603	610	PF00069	0.575
MOD_GSK3_1	611	618	PF00069	0.704
MOD_GSK3_1	624	631	PF00069	0.709
MOD_GSK3_1	671	678	PF00069	0.678
MOD_GSK3_1	797	804	PF00069	0.665
MOD_GSK3_1	827	834	PF00069	0.775
MOD_GSK3_1	835	842	PF00069	0.719
MOD_GSK3_1	859	866	PF00069	0.626
MOD_N-GLC_1	250	255	PF02516	0.626
MOD_N-GLC_1	30	35	PF02516	0.454
MOD_N-GLC_1	671	676	PF02516	0.509
MOD_NEK2_1	130	135	PF00069	0.508
MOD_NEK2_1	280	285	PF00069	0.561
MOD_NEK2_1	30	35	PF00069	0.454
MOD_NEK2_1	313	318	PF00069	0.730
MOD_NEK2_1	397	402	PF00069	0.660
MOD_NEK2_1	436	441	PF00069	0.630
MOD_NEK2_1	443	448	PF00069	0.483
MOD_NEK2_1	45	50	PF00069	0.323
MOD_NEK2_1	537	542	PF00069	0.546
MOD_NEK2_1	557	562	PF00069	0.666
MOD_NEK2_1	654	659	PF00069	0.638
MOD_NEK2_1	671	676	PF00069	0.631
MOD_NEK2_1	680	685	PF00069	0.730
MOD_NEK2_1	72	77	PF00069	0.443
MOD_NEK2_1	8	13	PF00069	0.473
MOD_NEK2_1	802	807	PF00069	0.551
MOD_NEK2_1	863	868	PF00069	0.504
MOD_NEK2_2	379	384	PF00069	0.645
MOD_NEK2_2	811	816	PF00069	0.568
MOD_NEK2_2	859	864	PF00069	0.456
MOD_PIKK_1	219	225	PF00454	0.684
MOD_PIKK_1	45	51	PF00454	0.489
MOD_PIKK_1	476	482	PF00454	0.537
MOD_PIKK_1	483	489	PF00454	0.473
MOD_PIKK_1	537	543	PF00454	0.470
MOD_PIKK_1	771	777	PF00454	0.671
MOD_PKA_1	297	303	PF00069	0.707
MOD_PKA_2	186	192	PF00069	0.765
MOD_PKA_2	297	303	PF00069	0.807
MOD_PKA_2	35	41	PF00069	0.484
MOD_PKA_2	45	51	PF00069	0.362
MOD_PKA_2	495	501	PF00069	0.570
MOD_PKA_2	515	521	PF00069	0.603
MOD_PKA_2	557	563	PF00069	0.607
MOD_PKA_2	585	591	PF00069	0.551
MOD_PKA_2	680	686	PF00069	0.663
MOD_PKA_2	716	722	PF00069	0.566
MOD_PKA_2	77	83	PF00069	0.476
MOD_PKA_2	802	808	PF00069	0.701
MOD_Plk_1	250	256	PF00069	0.559
MOD_Plk_1	273	279	PF00069	0.673
MOD_Plk_1	280	286	PF00069	0.611
MOD_Plk_1	30	36	PF00069	0.458
MOD_Plk_1	332	338	PF00069	0.574
MOD_Plk_1	379	385	PF00069	0.707
MOD_Plk_1	483	489	PF00069	0.544
MOD_Plk_1	603	609	PF00069	0.554
MOD_Plk_1	671	677	PF00069	0.585
MOD_Plk_1	72	78	PF00069	0.450
MOD_Plk_1	827	833	PF00069	0.678
MOD_Plk_2-3	822	828	PF00069	0.716
MOD_Plk_4	161	167	PF00069	0.517
MOD_Plk_4	443	449	PF00069	0.572
MOD_Plk_4	498	504	PF00069	0.617
MOD_Plk_4	533	539	PF00069	0.543
MOD_Plk_4	827	833	PF00069	0.747
MOD_Plk_4	859	865	PF00069	0.719
MOD_ProDKin_1	132	138	PF00069	0.490
MOD_ProDKin_1	203	209	PF00069	0.647
MOD_ProDKin_1	344	350	PF00069	0.664
MOD_ProDKin_1	382	388	PF00069	0.712
MOD_ProDKin_1	398	404	PF00069	0.704
MOD_ProDKin_1	422	428	PF00069	0.798
MOD_ProDKin_1	61	67	PF00069	0.328
MOD_ProDKin_1	615	621	PF00069	0.854
MOD_ProDKin_1	624	630	PF00069	0.715
MOD_ProDKin_1	749	755	PF00069	0.611
MOD_ProDKin_1	759	765	PF00069	0.615
MOD_ProDKin_1	797	803	PF00069	0.687
MOD_ProDKin_1	835	841	PF00069	0.749
MOD_SUMO_for_1	601	604	PF00179	0.533
TRG_DiLeu_BaEn_1	552	557	PF01217	0.558
TRG_DiLeu_BaLyEn_6	198	203	PF01217	0.530
TRG_DiLeu_LyEn_5	552	557	PF01217	0.558
TRG_ENDOCYTIC_2	34	37	PF00928	0.587
TRG_ENDOCYTIC_2	395	398	PF00928	0.724
TRG_ENDOCYTIC_2	531	534	PF00928	0.545
TRG_ER_diArg_1	150	153	PF00400	0.541
TRG_ER_diArg_1	255	257	PF00400	0.617
TRG_ER_diArg_1	416	419	PF00400	0.740
TRG_ER_diArg_1	460	462	PF00400	0.547
TRG_ER_diArg_1	475	477	PF00400	0.535
TRG_ER_diArg_1	553	556	PF00400	0.558
TRG_ER_diArg_1	568	570	PF00400	0.548
TRG_ER_diArg_1	583	586	PF00400	0.507
TRG_ER_diArg_1	680	682	PF00400	0.780
TRG_ER_diArg_1	722	724	PF00400	0.741
TRG_NES_CRM1_1	480	493	PF08389	0.546
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	547	552	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	682	687	PF00026	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H524	Leishmania donovani	70%	94%
E9ACF9	Leishmania major	71%	100%
E9AG31	Leishmania infantum	71%	94%
E9AJP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	94%