LeishMANIAdb
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Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Calponin-homology (CH) domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H3I3_LEIBR
TriTrypDb:
LbrM.03.0120 , LBRM2903_030006100
Length:
898

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3I3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3I3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 444 448 PF00656 0.747
CLV_C14_Caspase3-7 632 636 PF00656 0.816
CLV_NRD_NRD_1 190 192 PF00675 0.759
CLV_NRD_NRD_1 315 317 PF00675 0.698
CLV_NRD_NRD_1 479 481 PF00675 0.563
CLV_NRD_NRD_1 685 687 PF00675 0.601
CLV_NRD_NRD_1 7 9 PF00675 0.611
CLV_NRD_NRD_1 71 73 PF00675 0.480
CLV_NRD_NRD_1 834 836 PF00675 0.817
CLV_NRD_NRD_1 841 843 PF00675 0.714
CLV_PCSK_KEX2_1 111 113 PF00082 0.595
CLV_PCSK_KEX2_1 189 191 PF00082 0.757
CLV_PCSK_KEX2_1 315 317 PF00082 0.698
CLV_PCSK_KEX2_1 479 481 PF00082 0.803
CLV_PCSK_KEX2_1 685 687 PF00082 0.541
CLV_PCSK_KEX2_1 71 73 PF00082 0.565
CLV_PCSK_PC1ET2_1 111 113 PF00082 0.595
CLV_PCSK_PC7_1 311 317 PF00082 0.829
CLV_PCSK_SKI1_1 184 188 PF00082 0.684
CLV_PCSK_SKI1_1 479 483 PF00082 0.668
CLV_PCSK_SKI1_1 504 508 PF00082 0.706
CLV_PCSK_SKI1_1 72 76 PF00082 0.308
CLV_PCSK_SKI1_1 816 820 PF00082 0.551
CLV_PCSK_SKI1_1 871 875 PF00082 0.839
CLV_PCSK_SKI1_1 9 13 PF00082 0.567
DEG_APCC_DBOX_1 76 84 PF00400 0.329
DEG_SCF_FBW7_1 429 434 PF00400 0.589
DEG_SPOP_SBC_1 233 237 PF00917 0.795
DEG_SPOP_SBC_1 310 314 PF00917 0.611
DEG_SPOP_SBC_1 371 375 PF00917 0.639
DOC_CYCLIN_yClb5_NLxxxL_5 533 540 PF00134 0.675
DOC_CYCLIN_yCln2_LP_2 76 82 PF00134 0.579
DOC_MAPK_gen_1 71 82 PF00069 0.418
DOC_MAPK_MEF2A_6 71 80 PF00069 0.414
DOC_MAPK_NFAT4_5 75 83 PF00069 0.578
DOC_MIT_MIM_1 67 77 PF04212 0.567
DOC_PP1_RVXF_1 857 863 PF00149 0.575
DOC_PP2B_LxvP_1 76 79 PF13499 0.571
DOC_PP4_FxxP_1 82 85 PF00568 0.571
DOC_USP7_MATH_1 228 232 PF00917 0.811
DOC_USP7_MATH_1 233 237 PF00917 0.772
DOC_USP7_MATH_1 259 263 PF00917 0.707
DOC_USP7_MATH_1 310 314 PF00917 0.763
DOC_USP7_MATH_1 318 322 PF00917 0.836
DOC_USP7_MATH_1 348 352 PF00917 0.820
DOC_USP7_MATH_1 371 375 PF00917 0.560
DOC_USP7_MATH_1 385 389 PF00917 0.492
DOC_USP7_MATH_1 416 420 PF00917 0.667
DOC_USP7_MATH_1 431 435 PF00917 0.576
DOC_USP7_MATH_1 495 499 PF00917 0.571
DOC_USP7_MATH_1 598 602 PF00917 0.839
DOC_USP7_MATH_1 611 615 PF00917 0.484
DOC_USP7_MATH_1 625 629 PF00917 0.555
DOC_USP7_MATH_1 763 767 PF00917 0.742
DOC_USP7_MATH_1 808 812 PF00917 0.566
DOC_USP7_MATH_1 863 867 PF00917 0.616
DOC_WW_Pin1_4 226 231 PF00397 0.829
DOC_WW_Pin1_4 255 260 PF00397 0.623
DOC_WW_Pin1_4 306 311 PF00397 0.628
DOC_WW_Pin1_4 425 430 PF00397 0.847
DOC_WW_Pin1_4 481 486 PF00397 0.838
DOC_WW_Pin1_4 545 550 PF00397 0.501
DOC_WW_Pin1_4 617 622 PF00397 0.736
DOC_WW_Pin1_4 834 839 PF00397 0.611
LIG_14-3-3_CanoR_1 17 23 PF00244 0.620
LIG_14-3-3_CanoR_1 181 187 PF00244 0.562
LIG_14-3-3_CanoR_1 263 269 PF00244 0.849
LIG_14-3-3_CanoR_1 300 305 PF00244 0.756
LIG_14-3-3_CanoR_1 356 362 PF00244 0.691
LIG_14-3-3_CanoR_1 479 485 PF00244 0.693
LIG_14-3-3_CanoR_1 581 588 PF00244 0.712
LIG_14-3-3_CanoR_1 613 622 PF00244 0.811
LIG_14-3-3_CanoR_1 688 694 PF00244 0.623
LIG_14-3-3_CanoR_1 77 83 PF00244 0.327
LIG_14-3-3_CanoR_1 816 821 PF00244 0.554
LIG_14-3-3_CanoR_1 859 863 PF00244 0.678
LIG_14-3-3_CanoR_1 871 877 PF00244 0.796
LIG_Actin_WH2_2 76 91 PF00022 0.471
LIG_BRCT_BRCA1_1 115 119 PF00533 0.629
LIG_BRCT_BRCA1_1 277 281 PF00533 0.609
LIG_CaM_IQ_9 677 693 PF13499 0.648
LIG_CaM_NSCaTE_8 558 565 PF13499 0.674
LIG_FHA_1 126 132 PF00498 0.461
LIG_FHA_1 137 143 PF00498 0.465
LIG_FHA_1 156 162 PF00498 0.473
LIG_FHA_1 264 270 PF00498 0.859
LIG_FHA_1 330 336 PF00498 0.655
LIG_FHA_1 356 362 PF00498 0.651
LIG_FHA_1 431 437 PF00498 0.623
LIG_FHA_1 513 519 PF00498 0.720
LIG_FHA_1 523 529 PF00498 0.579
LIG_FHA_1 607 613 PF00498 0.562
LIG_FHA_1 732 738 PF00498 0.656
LIG_FHA_1 872 878 PF00498 0.845
LIG_FHA_1 97 103 PF00498 0.499
LIG_FHA_2 171 177 PF00498 0.576
LIG_FHA_2 524 530 PF00498 0.737
LIG_FHA_2 601 607 PF00498 0.583
LIG_FHA_2 710 716 PF00498 0.557
LIG_FHA_2 801 807 PF00498 0.499
LIG_Integrin_RGD_1 442 444 PF01839 0.813
LIG_LIR_Apic_2 81 85 PF02991 0.482
LIG_LIR_Gen_1 94 105 PF02991 0.555
LIG_LIR_Nem_3 24 29 PF02991 0.599
LIG_LIR_Nem_3 278 284 PF02991 0.616
LIG_LIR_Nem_3 67 73 PF02991 0.415
LIG_LIR_Nem_3 687 693 PF02991 0.625
LIG_LIR_Nem_3 724 730 PF02991 0.656
LIG_LIR_Nem_3 94 100 PF02991 0.560
LIG_NRBOX 402 408 PF00104 0.691
LIG_NRBOX 872 878 PF00104 0.845
LIG_PCNA_yPIPBox_3 397 411 PF02747 0.673
LIG_Pex14_1 66 70 PF04695 0.566
LIG_Pex14_2 115 119 PF04695 0.554
LIG_Pex14_2 39 43 PF04695 0.559
LIG_PTB_Apo_2 37 44 PF02174 0.564
LIG_PTB_Apo_2 646 653 PF02174 0.440
LIG_PTB_Phospho_1 646 652 PF10480 0.442
LIG_SH2_CRK 26 30 PF00017 0.581
LIG_SH2_NCK_1 820 824 PF00017 0.548
LIG_SH2_STAP1 458 462 PF00017 0.691
LIG_SH2_STAP1 820 824 PF00017 0.707
LIG_SH2_STAT5 104 107 PF00017 0.452
LIG_SH2_STAT5 130 133 PF00017 0.596
LIG_SH3_2 250 255 PF14604 0.737
LIG_SH3_3 148 154 PF00018 0.647
LIG_SH3_3 247 253 PF00018 0.847
LIG_SH3_3 344 350 PF00018 0.721
LIG_SH3_3 423 429 PF00018 0.732
LIG_SH3_3 486 492 PF00018 0.800
LIG_SH3_3 615 621 PF00018 0.690
LIG_SH3_CIN85_PxpxPR_1 250 255 PF14604 0.601
LIG_Sin3_3 138 145 PF02671 0.576
LIG_TRAF2_1 173 176 PF00917 0.633
LIG_TRAF2_1 712 715 PF00917 0.681
LIG_WRC_WIRS_1 11 16 PF05994 0.565
LIG_WW_3 252 256 PF00397 0.804
MOD_CDK_SPK_2 306 311 PF00069 0.617
MOD_CDK_SPK_2 427 432 PF00069 0.833
MOD_CDK_SPK_2 545 550 PF00069 0.501
MOD_CDK_SPxxK_3 425 432 PF00069 0.845
MOD_CDK_SPxxK_3 545 552 PF00069 0.489
MOD_CK1_1 194 200 PF00069 0.799
MOD_CK1_1 229 235 PF00069 0.628
MOD_CK1_1 24 30 PF00069 0.595
MOD_CK1_1 258 264 PF00069 0.852
MOD_CK1_1 270 276 PF00069 0.650
MOD_CK1_1 309 315 PF00069 0.765
MOD_CK1_1 317 323 PF00069 0.746
MOD_CK1_1 324 330 PF00069 0.601
MOD_CK1_1 357 363 PF00069 0.646
MOD_CK1_1 370 376 PF00069 0.561
MOD_CK1_1 475 481 PF00069 0.684
MOD_CK1_1 483 489 PF00069 0.813
MOD_CK1_1 498 504 PF00069 0.524
MOD_CK1_1 620 626 PF00069 0.742
MOD_CK1_1 628 634 PF00069 0.602
MOD_CK1_1 783 789 PF00069 0.465
MOD_CK1_1 811 817 PF00069 0.660
MOD_CK1_1 858 864 PF00069 0.832
MOD_CK1_1 886 892 PF00069 0.593
MOD_CK2_1 170 176 PF00069 0.582
MOD_CK2_1 600 606 PF00069 0.586
MOD_CK2_1 709 715 PF00069 0.679
MOD_Cter_Amidation 6 9 PF01082 0.598
MOD_GlcNHglycan 114 118 PF01048 0.636
MOD_GlcNHglycan 193 196 PF01048 0.779
MOD_GlcNHglycan 231 234 PF01048 0.652
MOD_GlcNHglycan 25 29 PF01048 0.336
MOD_GlcNHglycan 280 284 PF01048 0.644
MOD_GlcNHglycan 316 319 PF01048 0.865
MOD_GlcNHglycan 323 326 PF01048 0.643
MOD_GlcNHglycan 364 367 PF01048 0.715
MOD_GlcNHglycan 369 372 PF01048 0.612
MOD_GlcNHglycan 416 419 PF01048 0.811
MOD_GlcNHglycan 433 436 PF01048 0.575
MOD_GlcNHglycan 438 441 PF01048 0.579
MOD_GlcNHglycan 449 452 PF01048 0.419
MOD_GlcNHglycan 497 500 PF01048 0.796
MOD_GlcNHglycan 595 598 PF01048 0.744
MOD_GlcNHglycan 600 603 PF01048 0.735
MOD_GlcNHglycan 615 618 PF01048 0.718
MOD_GlcNHglycan 622 625 PF01048 0.797
MOD_GlcNHglycan 821 824 PF01048 0.640
MOD_GlcNHglycan 863 866 PF01048 0.710
MOD_GlcNHglycan 883 888 PF01048 0.501
MOD_GSK3_1 126 133 PF00069 0.492
MOD_GSK3_1 17 24 PF00069 0.530
MOD_GSK3_1 228 235 PF00069 0.722
MOD_GSK3_1 255 262 PF00069 0.785
MOD_GSK3_1 263 270 PF00069 0.742
MOD_GSK3_1 275 282 PF00069 0.526
MOD_GSK3_1 287 294 PF00069 0.807
MOD_GSK3_1 306 313 PF00069 0.538
MOD_GSK3_1 314 321 PF00069 0.677
MOD_GSK3_1 324 331 PF00069 0.571
MOD_GSK3_1 355 362 PF00069 0.765
MOD_GSK3_1 367 374 PF00069 0.751
MOD_GSK3_1 410 417 PF00069 0.687
MOD_GSK3_1 427 434 PF00069 0.635
MOD_GSK3_1 52 59 PF00069 0.593
MOD_GSK3_1 589 596 PF00069 0.569
MOD_GSK3_1 613 620 PF00069 0.702
MOD_GSK3_1 626 633 PF00069 0.642
MOD_GSK3_1 689 696 PF00069 0.616
MOD_GSK3_1 701 708 PF00069 0.436
MOD_GSK3_1 742 749 PF00069 0.666
MOD_GSK3_1 883 890 PF00069 0.582
MOD_N-GLC_1 255 260 PF02516 0.778
MOD_N-GLC_1 362 367 PF02516 0.568
MOD_NEK2_1 155 160 PF00069 0.631
MOD_NEK2_1 339 344 PF00069 0.578
MOD_NEK2_1 354 359 PF00069 0.536
MOD_NEK2_1 367 372 PF00069 0.501
MOD_NEK2_1 407 412 PF00069 0.710
MOD_NEK2_1 582 587 PF00069 0.609
MOD_NEK2_1 689 694 PF00069 0.618
MOD_PIKK_1 201 207 PF00454 0.703
MOD_PIKK_1 300 306 PF00454 0.869
MOD_PIKK_1 464 470 PF00454 0.687
MOD_PIKK_1 56 62 PF00454 0.548
MOD_PIKK_1 611 617 PF00454 0.812
MOD_PIKK_1 731 737 PF00454 0.657
MOD_PIKK_1 746 752 PF00454 0.522
MOD_PIKK_1 769 775 PF00454 0.442
MOD_PK_1 89 95 PF00069 0.494
MOD_PKA_2 16 22 PF00069 0.622
MOD_PKA_2 262 268 PF00069 0.849
MOD_PKA_2 310 316 PF00069 0.711
MOD_PKA_2 321 327 PF00069 0.675
MOD_PKA_2 355 361 PF00069 0.677
MOD_PKA_2 410 416 PF00069 0.499
MOD_PKA_2 431 437 PF00069 0.598
MOD_PKA_2 472 478 PF00069 0.494
MOD_PKA_2 800 806 PF00069 0.527
MOD_PKA_2 858 864 PF00069 0.579
MOD_PKB_1 189 197 PF00069 0.771
MOD_PKB_1 206 214 PF00069 0.582
MOD_Plk_1 125 131 PF00069 0.537
MOD_Plk_1 362 368 PF00069 0.776
MOD_Plk_1 642 648 PF00069 0.710
MOD_Plk_1 783 789 PF00069 0.582
MOD_Plk_2-3 10 16 PF00069 0.571
MOD_Plk_4 126 132 PF00069 0.548
MOD_Plk_4 136 142 PF00069 0.384
MOD_Plk_4 402 408 PF00069 0.691
MOD_Plk_4 693 699 PF00069 0.492
MOD_Plk_4 78 84 PF00069 0.494
MOD_Plk_4 872 878 PF00069 0.845
MOD_Plk_4 96 102 PF00069 0.334
MOD_ProDKin_1 226 232 PF00069 0.831
MOD_ProDKin_1 255 261 PF00069 0.622
MOD_ProDKin_1 306 312 PF00069 0.627
MOD_ProDKin_1 425 431 PF00069 0.842
MOD_ProDKin_1 481 487 PF00069 0.840
MOD_ProDKin_1 545 551 PF00069 0.493
MOD_ProDKin_1 617 623 PF00069 0.736
MOD_ProDKin_1 834 840 PF00069 0.614
MOD_SUMO_rev_2 235 244 PF00179 0.600
MOD_SUMO_rev_2 629 639 PF00179 0.578
TRG_AP2beta_CARGO_1 67 77 PF09066 0.315
TRG_DiLeu_BaEn_1 532 537 PF01217 0.670
TRG_DiLeu_BaEn_1 777 782 PF01217 0.586
TRG_DiLeu_BaEn_4 642 648 PF01217 0.613
TRG_ENDOCYTIC_2 183 186 PF00928 0.656
TRG_ENDOCYTIC_2 26 29 PF00928 0.582
TRG_ENDOCYTIC_2 652 655 PF00928 0.491
TRG_ENDOCYTIC_2 727 730 PF00928 0.646
TRG_ER_diArg_1 188 191 PF00400 0.738
TRG_ER_diArg_1 254 257 PF00400 0.619
TRG_ER_diArg_1 292 295 PF00400 0.860
TRG_ER_diArg_1 46 49 PF00400 0.615
TRG_ER_diArg_1 549 552 PF00400 0.699
TRG_ER_diArg_1 684 686 PF00400 0.645
TRG_ER_diArg_1 70 72 PF00400 0.565
TRG_ER_diArg_1 720 723 PF00400 0.610
TRG_NES_CRM1_1 510 522 PF08389 0.471
TRG_Pf-PMV_PEXEL_1 21 25 PF00026 0.623

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H523 Leishmania donovani 74% 100%
E9ACF8 Leishmania major 75% 100%
E9AG30 Leishmania infantum 74% 100%
E9AJP6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS