Putative cytochrome c oxidase assembly protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase assembly protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H3I2_LEIBR

TriTrypDb:

LbrM.03.0110 , LBRM2903_030006000

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	7
GO:0016020	membrane	2	7
GO:0019866	organelle inner membrane	4	7
GO:0031090	organelle membrane	3	7
GO:0031966	mitochondrial membrane	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4H3I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3I2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	7
GO:0005507	copper ion binding	6	7
GO:0016491	oxidoreductase activity	2	2
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	25	27	PF00675	0.507
CLV_NRD_NRD_1	3	5	PF00675	0.368
CLV_NRD_NRD_1	45	47	PF00675	0.415
CLV_PCSK_KEX2_1	3	5	PF00082	0.356
CLV_PCSK_KEX2_1	44	46	PF00082	0.441
CLV_PCSK_PC7_1	40	46	PF00082	0.545
CLV_PCSK_SKI1_1	122	126	PF00082	0.424
CLV_PCSK_SKI1_1	168	172	PF00082	0.423
CLV_PCSK_SKI1_1	216	220	PF00082	0.424
DEG_Nend_Nbox_1	1	3	PF02207	0.598
DOC_CKS1_1	102	107	PF01111	0.235
DOC_MAPK_gen_1	122	129	PF00069	0.219
DOC_MAPK_gen_1	165	173	PF00069	0.224
DOC_MAPK_MEF2A_6	122	129	PF00069	0.231
DOC_PP1_RVXF_1	124	130	PF00149	0.238
DOC_PP2B_LxvP_1	82	85	PF13499	0.278
DOC_PP4_FxxP_1	102	105	PF00568	0.232
DOC_USP7_UBL2_3	122	126	PF12436	0.224
DOC_WW_Pin1_4	101	106	PF00397	0.235
DOC_WW_Pin1_4	247	252	PF00397	0.447
LIG_14-3-3_CanoR_1	128	137	PF00244	0.224
LIG_14-3-3_CanoR_1	165	171	PF00244	0.224
LIG_FHA_1	134	140	PF00498	0.224
LIG_FHA_1	182	188	PF00498	0.224
LIG_LIR_Apic_2	99	105	PF02991	0.238
LIG_LIR_Gen_1	67	77	PF02991	0.290
LIG_LIR_Gen_1	80	89	PF02991	0.251
LIG_LIR_Nem_3	235	239	PF02991	0.221
LIG_LIR_Nem_3	67	72	PF02991	0.290
LIG_LIR_Nem_3	80	86	PF02991	0.251
LIG_PCNA_yPIPBox_3	216	227	PF02747	0.238
LIG_Pex14_2	65	69	PF04695	0.278
LIG_PTB_Apo_2	230	237	PF02174	0.224
LIG_SH2_CRK	9	13	PF00017	0.598
LIG_SH2_CRK	90	94	PF00017	0.238
LIG_SH2_GRB2like	186	189	PF00017	0.224
LIG_SH2_NCK_1	176	180	PF00017	0.224
LIG_SH2_STAT5	103	106	PF00017	0.204
LIG_SH2_STAT5	176	179	PF00017	0.223
LIG_SH2_STAT5	186	189	PF00017	0.213
LIG_SH2_STAT5	213	216	PF00017	0.233
LIG_SH2_STAT5	234	237	PF00017	0.219
LIG_SH2_STAT5	245	248	PF00017	0.356
LIG_SH2_STAT5	9	12	PF00017	0.704
LIG_SH2_STAT5	90	93	PF00017	0.232
LIG_SH3_2	22	27	PF14604	0.645
LIG_SH3_3	149	155	PF00018	0.247
LIG_SH3_3	19	25	PF00018	0.710
LIG_SH3_3	203	209	PF00018	0.224
LIG_SUMO_SIM_anti_2	147	152	PF11976	0.238
LIG_TYR_ITIM	7	12	PF00017	0.596
LIG_WW_3	23	27	PF00397	0.723
MOD_CDK_SPK_2	247	252	PF00069	0.372
MOD_CK1_1	13	19	PF00069	0.654
MOD_CK1_1	166	172	PF00069	0.224
MOD_CK1_1	174	180	PF00069	0.224
MOD_CK2_1	30	36	PF00069	0.761
MOD_Cter_Amidation	42	45	PF01082	0.486
MOD_GlcNHglycan	160	163	PF01048	0.415
MOD_GlcNHglycan	18	21	PF01048	0.503
MOD_GlcNHglycan	31	35	PF01048	0.526
MOD_GlcNHglycan	50	53	PF01048	0.326
MOD_GlcNHglycan	66	69	PF01048	0.179
MOD_GSK3_1	26	33	PF00069	0.696
MOD_GSK3_1	64	71	PF00069	0.432
MOD_GSK3_1	73	80	PF00069	0.265
MOD_N-GLC_1	163	168	PF02516	0.424
MOD_N-GLC_1	232	237	PF02516	0.396
MOD_NEK2_1	171	176	PF00069	0.221
MOD_NEK2_1	77	82	PF00069	0.289
MOD_PKA_1	26	32	PF00069	0.717
MOD_PKB_1	46	54	PF00069	0.716
MOD_Plk_1	166	172	PF00069	0.238
MOD_Plk_1	232	238	PF00069	0.196
MOD_Plk_4	232	238	PF00069	0.190
MOD_Plk_4	77	83	PF00069	0.304
MOD_ProDKin_1	101	107	PF00069	0.235
TRG_DiLeu_BaEn_1	147	152	PF01217	0.224
TRG_ENDOCYTIC_2	234	237	PF00928	0.224
TRG_ENDOCYTIC_2	9	12	PF00928	0.597
TRG_ER_diArg_1	2	4	PF00400	0.580
TRG_ER_diArg_1	44	46	PF00400	0.711
TRG_ER_FFAT_2	60	71	PF00635	0.475
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWR6	Leptomonas seymouri	81%	95%
A0A0S4JH88	Bodo saltans	75%	100%
A0A1X0P9J0	Trypanosomatidae	77%	100%
A0A3R7N777	Trypanosoma rangeli	77%	100%
A1BA38	Paracoccus denitrificans (strain Pd 1222)	34%	100%
A3KMZ6	Bos taurus	40%	89%
A3PGX7	Cereibacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)	37%	100%
A5EAA0	Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)	29%	100%
A5VP42	Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)	36%	100%
A6U6U8	Sinorhizobium medicae (strain WSM419)	29%	100%
A6WWG2	Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37)	35%	100%
A7IPB8	Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)	36%	100%
A9M8Z5	Brucella canis (strain ATCC 23365 / NCTC 10854)	36%	100%
B0CKF6	Brucella suis (strain ATCC 23445 / NCTC 10510)	36%	100%
C0RHH8	Brucella melitensis biotype 2 (strain ATCC 23457)	36%	100%
C3MHJ5	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	30%	100%
D0A217	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	88%	100%
O21243	Reclinomonas americana	45%	100%
P08303	Paracoccus denitrificans	34%	100%
P19516	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	84%
P56939	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	35%	100%
P56940	Cereibacter sphaeroides	36%	100%
Q11KD0	Chelativorans sp. (strain BNC1)	33%	100%
Q167V9	Roseobacter denitrificans (strain ATCC 33942 / OCh 114)	35%	100%
Q1GE51	Ruegeria sp. (strain TM1040)	35%	100%
Q1QHV9	Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)	32%	100%
Q1RJ56	Rickettsia bellii (strain RML369-C)	35%	100%
Q3J5F7	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	36%	100%
Q4UM75	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	35%	100%
Q54HM6	Dictyostelium discoideum	36%	81%
Q5LNX9	Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)	36%	100%
Q5R7U6	Pongo abelii	37%	91%
Q6P8I6	Mus musculus	43%	92%
Q8G261	Brucella suis biovar 1 (strain 1330)	36%	100%
Q8GWR0	Arabidopsis thaliana	38%	88%
Q8YFQ7	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	36%	100%
Q92IL2	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	34%	100%
Q92RG6	Rhizobium meliloti (strain 1021)	30%	100%
Q9Y6N1	Homo sapiens	41%	91%
Q9ZDM3	Rickettsia prowazekii (strain Madrid E)	34%	100%