DNA primase large subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA primase large subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H3I1_LEIBR

TriTrypDb:

LbrM.03.0100 , LBRM2903_030005900

Length:

567

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	12
GO:0005658	alpha DNA polymerase:primase complex	4	12
GO:0005739	mitochondrion	5	1
GO:0030880	RNA polymerase complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0042575	DNA polymerase complex	3	12
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

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Expansion

Sequence features

A4H3I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3I1

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	1
GO:0006261	DNA-templated DNA replication	6	1
GO:0006269	DNA replication, synthesis of RNA primer	6	12
GO:0006270	DNA replication initiation	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	2
GO:0003896	DNA primase activity	7	1
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	1
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016779	nucleotidyltransferase activity	4	2
GO:0034062	5'-3' RNA polymerase activity	5	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	93	97	PF00656	0.699
CLV_NRD_NRD_1	118	120	PF00675	0.679
CLV_NRD_NRD_1	221	223	PF00675	0.522
CLV_NRD_NRD_1	359	361	PF00675	0.338
CLV_NRD_NRD_1	514	516	PF00675	0.364
CLV_NRD_NRD_1	89	91	PF00675	0.552
CLV_PCSK_KEX2_1	118	120	PF00082	0.679
CLV_PCSK_KEX2_1	221	223	PF00082	0.522
CLV_PCSK_KEX2_1	252	254	PF00082	0.405
CLV_PCSK_KEX2_1	359	361	PF00082	0.338

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDE0	Leptomonas seymouri	80%	98%
A0A0S4JD25	Bodo saltans	53%	100%
A0A1X0P8Q6	Trypanosomatidae	57%	96%
A0A3R7RF31	Trypanosoma rangeli	56%	99%
A0A3S7WNM4	Leishmania donovani	88%	100%
D0A216	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	98%
E9ACF6	Leishmania major	88%	100%
E9AG28	Leishmania infantum	88%	100%
E9AJP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O74761	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%

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