Putative glycerol-3-phosphate acyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerol-3-phosphate acyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H3I0_LEIBR

TriTrypDb:

LbrM.03.0090 , LBRM2903_030005800

Length:

717

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H3I0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3I0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004366	glycerol-3-phosphate O-acyltransferase activity	6	6
GO:0008374	O-acyltransferase activity	5	6
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	6
GO:0102420	sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity	5	6
GO:0016287	glycerone-phosphate O-acyltransferase activity	7	2
GO:0016407	acetyltransferase activity	5	2
GO:0016413	O-acetyltransferase activity	6	2
GO:0043772	acyl-phosphate glycerol-3-phosphate acyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	46	50	PF00656	0.765
CLV_NRD_NRD_1	107	109	PF00675	0.453
CLV_NRD_NRD_1	133	135	PF00675	0.494
CLV_NRD_NRD_1	414	416	PF00675	0.534
CLV_NRD_NRD_1	469	471	PF00675	0.476
CLV_NRD_NRD_1	529	531	PF00675	0.493
CLV_NRD_NRD_1	660	662	PF00675	0.312
CLV_NRD_NRD_1	711	713	PF00675	0.410
CLV_PCSK_KEX2_1	107	109	PF00082	0.440
CLV_PCSK_KEX2_1	414	416	PF00082	0.513
CLV_PCSK_KEX2_1	469	471	PF00082	0.476
CLV_PCSK_KEX2_1	529	531	PF00082	0.475
CLV_PCSK_KEX2_1	564	566	PF00082	0.376
CLV_PCSK_KEX2_1	660	662	PF00082	0.305
CLV_PCSK_KEX2_1	710	712	PF00082	0.418
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.533
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.401
CLV_PCSK_PC7_1	706	712	PF00082	0.458
CLV_PCSK_SKI1_1	110	114	PF00082	0.423
CLV_PCSK_SKI1_1	167	171	PF00082	0.471
CLV_PCSK_SKI1_1	415	419	PF00082	0.506
CLV_PCSK_SKI1_1	512	516	PF00082	0.615
CLV_PCSK_SKI1_1	529	533	PF00082	0.365
CLV_PCSK_SKI1_1	564	568	PF00082	0.312
CLV_PCSK_SKI1_1	584	588	PF00082	0.446
CLV_PCSK_SKI1_1	610	614	PF00082	0.458
CLV_PCSK_SKI1_1	7	11	PF00082	0.432
CLV_PCSK_SKI1_1	712	716	PF00082	0.496
CLV_PCSK_SKI1_1	93	97	PF00082	0.424
DEG_APCC_DBOX_1	129	137	PF00400	0.649
DEG_APCC_DBOX_1	609	617	PF00400	0.307
DEG_APCC_DBOX_1	637	645	PF00400	0.596
DEG_SPOP_SBC_1	76	80	PF00917	0.742
DOC_CYCLIN_RxL_1	509	519	PF00134	0.426
DOC_MAPK_gen_1	130	138	PF00069	0.620
DOC_MAPK_gen_1	247	257	PF00069	0.321
DOC_MAPK_gen_1	265	273	PF00069	0.199
DOC_MAPK_gen_1	387	396	PF00069	0.284
DOC_MAPK_gen_1	414	422	PF00069	0.309
DOC_MAPK_gen_1	488	497	PF00069	0.213
DOC_MAPK_gen_1	529	536	PF00069	0.246
DOC_MAPK_MEF2A_6	610	617	PF00069	0.258
DOC_MAPK_MEF2A_6	638	645	PF00069	0.509
DOC_MAPK_NFAT4_5	638	646	PF00069	0.507
DOC_PP1_RVXF_1	160	167	PF00149	0.475
DOC_PP1_RVXF_1	203	210	PF00149	0.246
DOC_PP1_RVXF_1	438	445	PF00149	0.361
DOC_PP1_RVXF_1	5	12	PF00149	0.676
DOC_PP1_RVXF_1	582	588	PF00149	0.551
DOC_PP4_FxxP_1	216	219	PF00568	0.258
DOC_PP4_FxxP_1	400	403	PF00568	0.298
DOC_PP4_FxxP_1	617	620	PF00568	0.334
DOC_USP7_MATH_1	212	216	PF00917	0.246
DOC_USP7_MATH_1	26	30	PF00917	0.767
DOC_USP7_MATH_1	284	288	PF00917	0.341
DOC_USP7_MATH_1	39	43	PF00917	0.638
DOC_USP7_MATH_1	5	9	PF00917	0.730
DOC_USP7_MATH_1	55	59	PF00917	0.698
DOC_USP7_MATH_1	61	65	PF00917	0.706
DOC_USP7_MATH_1	75	79	PF00917	0.602
DOC_USP7_MATH_1	85	89	PF00917	0.647
DOC_USP7_MATH_1	95	99	PF00917	0.642
DOC_USP7_UBL2_3	93	97	PF12436	0.630
DOC_WW_Pin1_4	24	29	PF00397	0.720
DOC_WW_Pin1_4	37	42	PF00397	0.725
DOC_WW_Pin1_4	398	403	PF00397	0.302
DOC_WW_Pin1_4	63	68	PF00397	0.643
DOC_WW_Pin1_4	69	74	PF00397	0.632
LIG_14-3-3_CanoR_1	101	107	PF00244	0.670
LIG_14-3-3_CanoR_1	144	150	PF00244	0.490
LIG_14-3-3_CanoR_1	226	232	PF00244	0.307
LIG_14-3-3_CanoR_1	288	297	PF00244	0.307
LIG_14-3-3_CanoR_1	369	374	PF00244	0.327
LIG_14-3-3_CanoR_1	440	445	PF00244	0.208
LIG_14-3-3_CanoR_1	565	574	PF00244	0.588
LIG_14-3-3_CanoR_1	638	642	PF00244	0.585
LIG_Actin_WH2_2	146	164	PF00022	0.529
LIG_Actin_WH2_2	547	563	PF00022	0.483
LIG_Actin_WH2_2	622	640	PF00022	0.396
LIG_APCC_ABBA_1	338	343	PF00400	0.246
LIG_APCC_ABBA_1	603	608	PF00400	0.457
LIG_APCC_ABBAyCdc20_2	512	518	PF00400	0.371
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_BIR_III_1	1	5	PF00653	0.621
LIG_BIR_III_3	1	5	PF00653	0.621
LIG_BRCT_BRCA1_1	162	166	PF00533	0.474
LIG_BRCT_BRCA1_1	480	484	PF00533	0.399
LIG_BRCT_BRCA1_1	7	11	PF00533	0.687
LIG_DLG_GKlike_1	698	705	PF00625	0.604
LIG_EH1_1	534	542	PF00400	0.315
LIG_FHA_1	296	302	PF00498	0.271
LIG_FHA_1	348	354	PF00498	0.246
LIG_FHA_1	431	437	PF00498	0.284
LIG_FHA_1	54	60	PF00498	0.697
LIG_FHA_1	609	615	PF00498	0.298
LIG_FHA_1	638	644	PF00498	0.617
LIG_FHA_2	288	294	PF00498	0.314
LIG_FHA_2	66	72	PF00498	0.625
LIG_LIR_Apic_2	213	219	PF02991	0.258
LIG_LIR_Apic_2	398	403	PF02991	0.301
LIG_LIR_Gen_1	261	271	PF02991	0.318
LIG_LIR_Gen_1	322	332	PF02991	0.246
LIG_LIR_Gen_1	390	400	PF02991	0.342
LIG_LIR_Gen_1	463	471	PF02991	0.295
LIG_LIR_Gen_1	481	491	PF02991	0.314
LIG_LIR_Gen_1	492	502	PF02991	0.302
LIG_LIR_Gen_1	600	606	PF02991	0.359
LIG_LIR_Nem_3	163	169	PF02991	0.380
LIG_LIR_Nem_3	261	266	PF02991	0.318
LIG_LIR_Nem_3	322	328	PF02991	0.246
LIG_LIR_Nem_3	390	396	PF02991	0.336
LIG_LIR_Nem_3	438	442	PF02991	0.358
LIG_LIR_Nem_3	447	451	PF02991	0.336
LIG_LIR_Nem_3	463	467	PF02991	0.300
LIG_LIR_Nem_3	481	487	PF02991	0.308
LIG_LIR_Nem_3	492	497	PF02991	0.279
LIG_LIR_Nem_3	600	604	PF02991	0.359
LIG_MLH1_MIPbox_1	162	166	PF16413	0.474
LIG_NBox_RRM_1	587	597	PF00076	0.193
LIG_NRBOX	510	516	PF00104	0.426
LIG_Pex14_2	396	400	PF04695	0.374
LIG_Pex14_2	444	448	PF04695	0.269
LIG_Pex14_2	583	587	PF04695	0.551
LIG_Rb_pABgroove_1	404	412	PF01858	0.402
LIG_SH2_CRK	325	329	PF00017	0.248
LIG_SH2_CRK	439	443	PF00017	0.371
LIG_SH2_CRK	452	456	PF00017	0.293
LIG_SH2_NCK_1	325	329	PF00017	0.246
LIG_SH2_PTP2	624	627	PF00017	0.299
LIG_SH2_SRC	382	385	PF00017	0.385
LIG_SH2_SRC	452	455	PF00017	0.336
LIG_SH2_STAP1	315	319	PF00017	0.282
LIG_SH2_STAP1	325	329	PF00017	0.197
LIG_SH2_STAT3	675	678	PF00017	0.587
LIG_SH2_STAT5	165	168	PF00017	0.290
LIG_SH2_STAT5	382	385	PF00017	0.299
LIG_SH2_STAT5	393	396	PF00017	0.269
LIG_SH2_STAT5	464	467	PF00017	0.293
LIG_SH2_STAT5	494	497	PF00017	0.221
LIG_SH2_STAT5	535	538	PF00017	0.419
LIG_SH2_STAT5	557	560	PF00017	0.535
LIG_SH2_STAT5	624	627	PF00017	0.299
LIG_SH2_STAT5	686	689	PF00017	0.515
LIG_SH3_3	230	236	PF00018	0.246
LIG_SH3_3	294	300	PF00018	0.270
LIG_SH3_3	304	310	PF00018	0.232
LIG_SH3_3	38	44	PF00018	0.623
LIG_SH3_3	544	550	PF00018	0.304
LIG_Sin3_3	588	595	PF02671	0.232
LIG_SUMO_SIM_anti_2	168	173	PF11976	0.246
LIG_SUMO_SIM_anti_2	611	618	PF11976	0.356
LIG_SUMO_SIM_anti_2	626	632	PF11976	0.299
LIG_SUMO_SIM_par_1	611	618	PF11976	0.387
LIG_SUMO_SIM_par_1	626	632	PF11976	0.299
LIG_TRAF2_1	12	15	PF00917	0.704
LIG_TRAF2_1	122	125	PF00917	0.650
LIG_TRAF2_1	291	294	PF00917	0.351
LIG_TRAF2_1	68	71	PF00917	0.740
LIG_TYR_ITIM	555	560	PF00017	0.480
LIG_UBA3_1	352	356	PF00899	0.299
LIG_WRC_WIRS_1	445	450	PF05994	0.457
LIG_WRC_WIRS_1	598	603	PF05994	0.383
MOD_CK1_1	264	270	PF00069	0.463
MOD_CK1_1	287	293	PF00069	0.446
MOD_CK1_1	50	56	PF00069	0.735
MOD_CK1_1	568	574	PF00069	0.461
MOD_CK1_1	646	652	PF00069	0.415
MOD_CK1_1	701	707	PF00069	0.535
MOD_CK1_1	78	84	PF00069	0.554
MOD_CK2_1	287	293	PF00069	0.338
MOD_CK2_1	39	45	PF00069	0.516
MOD_CK2_1	65	71	PF00069	0.612
MOD_CK2_1	9	15	PF00069	0.590
MOD_GlcNHglycan	258	261	PF01048	0.342
MOD_GlcNHglycan	315	318	PF01048	0.444
MOD_GlcNHglycan	459	462	PF01048	0.494
MOD_GlcNHglycan	480	483	PF01048	0.539
MOD_GlcNHglycan	93	96	PF01048	0.648
MOD_GSK3_1	102	109	PF00069	0.593
MOD_GSK3_1	284	291	PF00069	0.401
MOD_GSK3_1	309	316	PF00069	0.379
MOD_GSK3_1	343	350	PF00069	0.299
MOD_GSK3_1	440	447	PF00069	0.458
MOD_GSK3_1	5	12	PF00069	0.525
MOD_GSK3_1	50	57	PF00069	0.628
MOD_GSK3_1	503	510	PF00069	0.391
MOD_GSK3_1	604	611	PF00069	0.388
MOD_GSK3_1	61	68	PF00069	0.538
MOD_GSK3_1	694	701	PF00069	0.462
MOD_GSK3_1	75	82	PF00069	0.421
MOD_GSK3_1	91	98	PF00069	0.593
MOD_N-GLC_1	455	460	PF02516	0.377
MOD_N-GLC_2	335	337	PF02516	0.315
MOD_NEK2_1	106	111	PF00069	0.517
MOD_NEK2_1	145	150	PF00069	0.365
MOD_NEK2_1	198	203	PF00069	0.406
MOD_NEK2_1	227	232	PF00069	0.317
MOD_NEK2_1	313	318	PF00069	0.368
MOD_NEK2_1	444	449	PF00069	0.445
MOD_NEK2_1	560	565	PF00069	0.409
MOD_NEK2_1	567	572	PF00069	0.429
MOD_NEK2_1	597	602	PF00069	0.341
MOD_NEK2_1	623	628	PF00069	0.285
MOD_NEK2_1	637	642	PF00069	0.372
MOD_NEK2_1	643	648	PF00069	0.380
MOD_NEK2_2	212	217	PF00069	0.284
MOD_NEK2_2	5	10	PF00069	0.497
MOD_PIKK_1	503	509	PF00454	0.375
MOD_PIKK_1	646	652	PF00454	0.573
MOD_PK_1	369	375	PF00069	0.334
MOD_PKA_1	415	421	PF00069	0.402
MOD_PKA_2	106	112	PF00069	0.586
MOD_PKA_2	287	293	PF00069	0.434
MOD_PKA_2	478	484	PF00069	0.511
MOD_PKA_2	503	509	PF00069	0.387
MOD_PKA_2	637	643	PF00069	0.275
MOD_Plk_1	14	20	PF00069	0.510
MOD_Plk_1	167	173	PF00069	0.315
MOD_Plk_1	212	218	PF00069	0.299
MOD_Plk_1	295	301	PF00069	0.335
MOD_Plk_1	347	353	PF00069	0.299
MOD_Plk_1	455	461	PF00069	0.364
MOD_Plk_1	5	11	PF00069	0.540
MOD_Plk_1	568	574	PF00069	0.455
MOD_Plk_4	145	151	PF00069	0.291
MOD_Plk_4	167	173	PF00069	0.372
MOD_Plk_4	348	354	PF00069	0.299
MOD_Plk_4	378	384	PF00069	0.342
MOD_Plk_4	440	446	PF00069	0.466
MOD_Plk_4	597	603	PF00069	0.285
MOD_Plk_4	623	629	PF00069	0.300
MOD_Plk_4	698	704	PF00069	0.547
MOD_ProDKin_1	24	30	PF00069	0.682
MOD_ProDKin_1	37	43	PF00069	0.691
MOD_ProDKin_1	398	404	PF00069	0.385
MOD_ProDKin_1	63	69	PF00069	0.573
MOD_SUMO_rev_2	676	685	PF00179	0.544
TRG_DiLeu_BaLyEn_6	463	468	PF01217	0.468
TRG_DiLeu_BaLyEn_6	639	644	PF01217	0.526
TRG_DiLeu_BaLyEn_6	666	671	PF01217	0.520
TRG_ENDOCYTIC_2	325	328	PF00928	0.293
TRG_ENDOCYTIC_2	329	332	PF00928	0.295
TRG_ENDOCYTIC_2	393	396	PF00928	0.416
TRG_ENDOCYTIC_2	439	442	PF00928	0.489
TRG_ENDOCYTIC_2	464	467	PF00928	0.364
TRG_ENDOCYTIC_2	494	497	PF00928	0.474
TRG_ENDOCYTIC_2	557	560	PF00928	0.485
TRG_ENDOCYTIC_2	624	627	PF00928	0.285
TRG_ER_diArg_1	106	108	PF00400	0.494
TRG_ER_diArg_1	388	391	PF00400	0.366
TRG_ER_diArg_1	468	470	PF00400	0.345
TRG_ER_diArg_1	528	530	PF00400	0.369
TRG_ER_diArg_1	709	712	PF00400	0.523
TRG_NES_CRM1_1	423	438	PF08389	0.441
TRG_Pf-PMV_PEXEL_1	208	213	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	449	453	PF00026	0.348
TRG_Pf-PMV_PEXEL_1	565	569	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	655	659	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I239	Leptomonas seymouri	73%	99%
A0A0S4JH62	Bodo saltans	54%	98%
A0A1X0P8Y7	Trypanosomatidae	56%	100%
A0A3R7K7V0	Trypanosoma rangeli	56%	100%
A0A3S5H521	Leishmania donovani	93%	100%
D0A214	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9ACF5	Leishmania major	92%	100%
E9AG27	Leishmania infantum	93%	100%
E9AJP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P32784	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	94%
P36148	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	97%
Q9P7P0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
V5B455	Trypanosoma cruzi	57%	100%