Mediator complex subunit 23

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3H9_LEIBR

TriTrypDb:

LbrM.03.0080 , LBRM2903_030005700

Length:

830

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3H9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3H9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	418	420	PF00675	0.472
CLV_NRD_NRD_1	432	434	PF00675	0.522
CLV_NRD_NRD_1	487	489	PF00675	0.580
CLV_NRD_NRD_1	540	542	PF00675	0.545
CLV_NRD_NRD_1	56	58	PF00675	0.447
CLV_NRD_NRD_1	762	764	PF00675	0.652
CLV_NRD_NRD_1	825	827	PF00675	0.613
CLV_PCSK_KEX2_1	432	434	PF00082	0.522
CLV_PCSK_KEX2_1	487	489	PF00082	0.580
CLV_PCSK_KEX2_1	540	542	PF00082	0.547
CLV_PCSK_KEX2_1	56	58	PF00082	0.447
CLV_PCSK_KEX2_1	762	764	PF00082	0.652
CLV_PCSK_KEX2_1	827	829	PF00082	0.696
CLV_PCSK_PC1ET2_1	827	829	PF00082	0.696
CLV_PCSK_PC7_1	483	489	PF00082	0.552
CLV_PCSK_SKI1_1	244	248	PF00082	0.531
CLV_PCSK_SKI1_1	327	331	PF00082	0.480
CLV_PCSK_SKI1_1	344	348	PF00082	0.384
CLV_PCSK_SKI1_1	372	376	PF00082	0.392
CLV_PCSK_SKI1_1	419	423	PF00082	0.415
CLV_PCSK_SKI1_1	583	587	PF00082	0.441
CLV_PCSK_SKI1_1	655	659	PF00082	0.483
CLV_PCSK_SKI1_1	748	752	PF00082	0.379
CLV_PCSK_SKI1_1	771	775	PF00082	0.541
CLV_Separin_Metazoa	484	488	PF03568	0.550
CLV_Separin_Metazoa	537	541	PF03568	0.581
DEG_APCC_DBOX_1	418	426	PF00400	0.472
DEG_APCC_DBOX_1	654	662	PF00400	0.505
DEG_APCC_DBOX_1	74	82	PF00400	0.579
DEG_APCC_DBOX_1	747	755	PF00400	0.410
DEG_Nend_UBRbox_2	1	3	PF02207	0.637
DOC_ANK_TNKS_1	486	493	PF00023	0.567
DOC_CDC14_PxL_1	248	256	PF14671	0.453
DOC_CYCLIN_RxL_1	369	379	PF00134	0.527
DOC_CYCLIN_RxL_1	607	617	PF00134	0.583
DOC_CYCLIN_yCln2_LP_2	282	288	PF00134	0.578
DOC_CYCLIN_yCln2_LP_2	774	780	PF00134	0.508
DOC_MAPK_gen_1	419	427	PF00069	0.473
DOC_MAPK_gen_1	502	509	PF00069	0.512
DOC_MAPK_gen_1	56	65	PF00069	0.402
DOC_MAPK_gen_1	746	755	PF00069	0.385
DOC_MAPK_MEF2A_6	502	511	PF00069	0.532
DOC_MAPK_MEF2A_6	56	65	PF00069	0.518
DOC_MAPK_MEF2A_6	655	662	PF00069	0.476
DOC_MAPK_MEF2A_6	746	755	PF00069	0.385
DOC_MAPK_NFAT4_5	748	756	PF00069	0.482
DOC_PP1_RVXF_1	342	348	PF00149	0.479
DOC_PP1_RVXF_1	581	587	PF00149	0.495
DOC_PP1_RVXF_1	608	615	PF00149	0.560
DOC_PP2B_LxvP_1	350	353	PF13499	0.468
DOC_PP2B_LxvP_1	685	688	PF13499	0.563
DOC_USP7_MATH_1	118	122	PF00917	0.703
DOC_USP7_MATH_1	15	19	PF00917	0.623
DOC_USP7_MATH_1	585	589	PF00917	0.490
DOC_USP7_MATH_1	688	692	PF00917	0.630
DOC_USP7_MATH_1	87	91	PF00917	0.524
DOC_USP7_UBL2_3	794	798	PF12436	0.626
DOC_USP7_UBL2_3	82	86	PF12436	0.568
DOC_USP7_UBL2_3	823	827	PF12436	0.683
DOC_WW_Pin1_4	412	417	PF00397	0.481
DOC_WW_Pin1_4	643	648	PF00397	0.498
LIG_14-3-3_CanoR_1	16	22	PF00244	0.674
LIG_14-3-3_CanoR_1	197	205	PF00244	0.428
LIG_14-3-3_CanoR_1	411	416	PF00244	0.417
LIG_14-3-3_CanoR_1	590	597	PF00244	0.481
LIG_14-3-3_CanoR_1	690	694	PF00244	0.628
LIG_14-3-3_CanoR_1	768	774	PF00244	0.548
LIG_Actin_WH2_2	90	108	PF00022	0.574
LIG_BIR_III_4	36	40	PF00653	0.572
LIG_BRCT_BRCA1_1	462	466	PF00533	0.455
LIG_BRCT_BRCA1_1	633	637	PF00533	0.515
LIG_Clathr_ClatBox_1	188	192	PF01394	0.663
LIG_Clathr_ClatBox_1	461	465	PF01394	0.513
LIG_eIF4E_1	778	784	PF01652	0.397
LIG_FAT_LD_1	512	520	PF03623	0.533
LIG_FHA_1	25	31	PF00498	0.579
LIG_FHA_1	291	297	PF00498	0.424
LIG_FHA_1	360	366	PF00498	0.487
LIG_FHA_1	468	474	PF00498	0.466
LIG_FHA_1	557	563	PF00498	0.449
LIG_FHA_1	603	609	PF00498	0.432
LIG_FHA_1	666	672	PF00498	0.369
LIG_FHA_1	716	722	PF00498	0.440
LIG_FHA_2	304	310	PF00498	0.524
LIG_FHA_2	654	660	PF00498	0.509
LIG_FHA_2	695	701	PF00498	0.539
LIG_FHA_2	799	805	PF00498	0.674
LIG_Integrin_RGD_1	665	667	PF01839	0.605
LIG_LIR_Gen_1	171	182	PF02991	0.603
LIG_LIR_Gen_1	259	270	PF02991	0.461
LIG_LIR_Gen_1	299	308	PF02991	0.397
LIG_LIR_Gen_1	361	371	PF02991	0.484
LIG_LIR_Gen_1	392	403	PF02991	0.558
LIG_LIR_Gen_1	504	512	PF02991	0.526
LIG_LIR_Gen_1	683	688	PF02991	0.566
LIG_LIR_LC3C_4	386	390	PF02991	0.543
LIG_LIR_Nem_3	171	177	PF02991	0.575
LIG_LIR_Nem_3	184	189	PF02991	0.569
LIG_LIR_Nem_3	259	265	PF02991	0.451
LIG_LIR_Nem_3	299	305	PF02991	0.396
LIG_LIR_Nem_3	336	340	PF02991	0.291
LIG_LIR_Nem_3	361	366	PF02991	0.492
LIG_LIR_Nem_3	392	398	PF02991	0.479
LIG_LIR_Nem_3	465	471	PF02991	0.488
LIG_LIR_Nem_3	504	508	PF02991	0.550
LIG_LIR_Nem_3	653	657	PF02991	0.425
LIG_LIR_Nem_3	683	687	PF02991	0.557
LIG_LIR_Nem_3	769	773	PF02991	0.432
LIG_LIR_Nem_3	775	781	PF02991	0.423
LIG_LYPXL_yS_3	471	474	PF13949	0.280
LIG_LYPXL_yS_3	778	781	PF13949	0.423
LIG_NRBOX	421	427	PF00104	0.472
LIG_NRBOX	550	556	PF00104	0.508
LIG_NRBOX	750	756	PF00104	0.484
LIG_Pex14_1	178	182	PF04695	0.595
LIG_Pex14_1	582	586	PF04695	0.424
LIG_Pex14_1	591	595	PF04695	0.443
LIG_PTB_Apo_2	264	271	PF02174	0.491
LIG_PTB_Apo_2	608	615	PF02174	0.560
LIG_PTB_Phospho_1	264	270	PF10480	0.489
LIG_Rb_LxCxE_1	184	204	PF01857	0.674
LIG_REV1ctd_RIR_1	219	228	PF16727	0.543
LIG_SH2_CRK	270	274	PF00017	0.419
LIG_SH2_SRC	595	598	PF00017	0.305
LIG_SH2_STAP1	125	129	PF00017	0.650
LIG_SH2_STAP1	169	173	PF00017	0.680
LIG_SH2_STAP1	270	274	PF00017	0.404
LIG_SH2_STAP1	578	582	PF00017	0.291
LIG_SH2_STAT3	182	185	PF00017	0.543
LIG_SH2_STAT5	182	185	PF00017	0.555
LIG_SH2_STAT5	230	233	PF00017	0.490
LIG_SH2_STAT5	250	253	PF00017	0.426
LIG_SH2_STAT5	262	265	PF00017	0.412
LIG_SH2_STAT5	578	581	PF00017	0.401
LIG_SH2_STAT5	595	598	PF00017	0.443
LIG_SH2_STAT5	67	70	PF00017	0.494
LIG_SH2_STAT5	684	687	PF00017	0.550
LIG_SH3_3	174	180	PF00018	0.695
LIG_SH3_3	329	335	PF00018	0.483
LIG_SH3_3	504	510	PF00018	0.536
LIG_SH3_3	774	780	PF00018	0.381
LIG_Sin3_3	423	430	PF02671	0.473
LIG_SUMO_SIM_anti_2	127	134	PF11976	0.425
LIG_SUMO_SIM_anti_2	656	662	PF11976	0.511
LIG_SUMO_SIM_par_1	303	309	PF11976	0.470
LIG_SUMO_SIM_par_1	559	567	PF11976	0.551
LIG_SUMO_SIM_par_1	667	673	PF11976	0.428
LIG_TYR_ITIM	172	177	PF00017	0.612
LIG_TYR_ITIM	682	687	PF00017	0.487
LIG_UBA3_1	220	224	PF00899	0.587
LIG_UBA3_1	789	794	PF00899	0.537
LIG_WRC_WIRS_1	202	207	PF05994	0.539
LIG_WW_1	334	337	PF00397	0.535
MOD_CDC14_SPxK_1	646	649	PF00782	0.362
MOD_CDK_SPxK_1	643	649	PF00069	0.359
MOD_CDK_SPxxK_3	412	419	PF00069	0.477
MOD_CK1_1	200	206	PF00069	0.636
MOD_CK1_1	24	30	PF00069	0.531
MOD_CK1_1	373	379	PF00069	0.524
MOD_CK1_1	401	407	PF00069	0.532
MOD_CK1_1	447	453	PF00069	0.477
MOD_CK1_1	702	708	PF00069	0.498
MOD_CK2_1	303	309	PF00069	0.449
MOD_CK2_1	653	659	PF00069	0.510
MOD_CK2_1	798	804	PF00069	0.714
MOD_Cter_Amidation	54	57	PF01082	0.543
MOD_GlcNHglycan	134	138	PF01048	0.670
MOD_GlcNHglycan	141	144	PF01048	0.634
MOD_GlcNHglycan	147	150	PF01048	0.508
MOD_GlcNHglycan	205	208	PF01048	0.644
MOD_GlcNHglycan	400	403	PF01048	0.555
MOD_GlcNHglycan	440	443	PF01048	0.708
MOD_GlcNHglycan	449	452	PF01048	0.546
MOD_GlcNHglycan	703	707	PF01048	0.492
MOD_GlcNHglycan	89	92	PF01048	0.594
MOD_GSK3_1	113	120	PF00069	0.721
MOD_GSK3_1	135	142	PF00069	0.556
MOD_GSK3_1	196	203	PF00069	0.625
MOD_GSK3_1	397	404	PF00069	0.558
MOD_GSK3_1	443	450	PF00069	0.635
MOD_GSK3_1	456	463	PF00069	0.309
MOD_GSK3_1	572	579	PF00069	0.602
MOD_GSK3_1	585	592	PF00069	0.369
MOD_GSK3_1	631	638	PF00069	0.511
MOD_GSK3_1	67	74	PF00069	0.469
MOD_GSK3_1	732	739	PF00069	0.502
MOD_GSK3_1	87	94	PF00069	0.287
MOD_LATS_1	242	248	PF00433	0.610
MOD_N-GLC_1	572	577	PF02516	0.374
MOD_NEK2_1	113	118	PF00069	0.654
MOD_NEK2_1	135	140	PF00069	0.452
MOD_NEK2_1	156	161	PF00069	0.505
MOD_NEK2_1	191	196	PF00069	0.574
MOD_NEK2_1	216	221	PF00069	0.555
MOD_NEK2_1	303	308	PF00069	0.389
MOD_NEK2_1	370	375	PF00069	0.446
MOD_NEK2_1	398	403	PF00069	0.549
MOD_NEK2_1	443	448	PF00069	0.624
MOD_NEK2_1	467	472	PF00069	0.418
MOD_NEK2_1	498	503	PF00069	0.625
MOD_NEK2_1	589	594	PF00069	0.496
MOD_NEK2_1	631	636	PF00069	0.517
MOD_NEK2_1	642	647	PF00069	0.469
MOD_NEK2_1	714	719	PF00069	0.545
MOD_NEK2_1	736	741	PF00069	0.481
MOD_NEK2_2	585	590	PF00069	0.460
MOD_NEK2_2	77	82	PF00069	0.573
MOD_PIKK_1	15	21	PF00454	0.588
MOD_PIKK_1	444	450	PF00454	0.425
MOD_PIKK_1	736	742	PF00454	0.539
MOD_PIKK_1	91	97	PF00454	0.567
MOD_PK_1	154	160	PF00069	0.355
MOD_PK_1	197	203	PF00069	0.504
MOD_PKA_2	118	124	PF00069	0.670
MOD_PKA_2	15	21	PF00069	0.608
MOD_PKA_2	196	202	PF00069	0.410
MOD_PKA_2	443	449	PF00069	0.622
MOD_PKA_2	569	575	PF00069	0.592
MOD_PKA_2	589	595	PF00069	0.401
MOD_PKA_2	689	695	PF00069	0.615
MOD_Plk_1	191	197	PF00069	0.627
MOD_Plk_1	317	323	PF00069	0.542
MOD_Plk_1	702	708	PF00069	0.402
MOD_Plk_2-3	460	466	PF00069	0.512
MOD_Plk_4	191	197	PF00069	0.501
MOD_Plk_4	216	222	PF00069	0.528
MOD_Plk_4	303	309	PF00069	0.282
MOD_Plk_4	405	411	PF00069	0.492
MOD_Plk_4	631	637	PF00069	0.479
MOD_ProDKin_1	412	418	PF00069	0.478
MOD_ProDKin_1	643	649	PF00069	0.495
MOD_SUMO_for_1	793	796	PF00179	0.544
MOD_SUMO_rev_2	571	577	PF00179	0.610
MOD_SUMO_rev_2	822	829	PF00179	0.687
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.664
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.502
TRG_DiLeu_LyEn_5	560	565	PF01217	0.370
TRG_ENDOCYTIC_2	169	172	PF00928	0.600
TRG_ENDOCYTIC_2	174	177	PF00928	0.571
TRG_ENDOCYTIC_2	250	253	PF00928	0.465
TRG_ENDOCYTIC_2	262	265	PF00928	0.380
TRG_ENDOCYTIC_2	270	273	PF00928	0.212
TRG_ENDOCYTIC_2	337	340	PF00928	0.451
TRG_ENDOCYTIC_2	471	474	PF00928	0.367
TRG_ENDOCYTIC_2	678	681	PF00928	0.386
TRG_ENDOCYTIC_2	684	687	PF00928	0.425
TRG_ENDOCYTIC_2	733	736	PF00928	0.383
TRG_ENDOCYTIC_2	778	781	PF00928	0.423
TRG_ER_diArg_1	486	488	PF00400	0.571
TRG_ER_diArg_1	539	541	PF00400	0.539
TRG_ER_diArg_1	56	59	PF00400	0.421
TRG_ER_diArg_1	619	622	PF00400	0.629
TRG_ER_diArg_1	625	628	PF00400	0.580
TRG_ER_diArg_1	826	829	PF00400	0.722
TRG_NES_CRM1_1	271	284	PF08389	0.434
TRG_NES_CRM1_1	294	309	PF08389	0.547
TRG_NES_CRM1_1	552	567	PF08389	0.563
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	594	599	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	734	738	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAX1	Leptomonas seymouri	65%	93%
A0A0S4JH32	Bodo saltans	27%	96%
A0A1X0PA13	Trypanosomatidae	33%	100%
A0A422N7I6	Trypanosoma rangeli	34%	100%
A0A451EJL3	Leishmania donovani	90%	100%
D0A213	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ACF4	Leishmania major	90%	100%
E9AG26	Leishmania infantum	90%	100%
E9AJP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%