LeishMANIAdb
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Alanine--glyoxylate transaminase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Alanine--glyoxylate transaminase
Gene product:
2-aminoethylphosphonate:pyruvateaminotransferas e-like protein
Species:
Leishmania braziliensis
UniProt:
A4H3H7_LEIBR
TriTrypDb:
LbrM.03.0060 , LBRM2903_030005500 *
Length:
381

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3H7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3H7

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 12
GO:0008152 metabolic process 1 12
GO:0009056 catabolic process 2 12
GO:0009987 cellular process 1 12
GO:0019634 organic phosphonate metabolic process 4 12
GO:0019637 organophosphate metabolic process 3 12
GO:0019700 organic phosphonate catabolic process 5 12
GO:0044237 cellular metabolic process 2 12
GO:0046434 organophosphate catabolic process 4 12
GO:0071704 organic substance metabolic process 2 12
GO:1901575 organic substance catabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0008453 alanine-glyoxylate transaminase activity 5 11
GO:0008483 transaminase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016769 transferase activity, transferring nitrogenous groups 3 12
GO:0047304 2-aminoethylphosphonate-pyruvate transaminase activity 5 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 161 163 PF00675 0.236
CLV_NRD_NRD_1 211 213 PF00675 0.237
CLV_NRD_NRD_1 281 283 PF00675 0.232
CLV_NRD_NRD_1 296 298 PF00675 0.232
CLV_PCSK_KEX2_1 161 163 PF00082 0.236
CLV_PCSK_KEX2_1 211 213 PF00082 0.236
CLV_PCSK_SKI1_1 223 227 PF00082 0.275
CLV_PCSK_SKI1_1 23 27 PF00082 0.416
CLV_PCSK_SKI1_1 283 287 PF00082 0.195
CLV_PCSK_SKI1_1 361 365 PF00082 0.339
CLV_PCSK_SKI1_1 6 10 PF00082 0.407
CLV_PCSK_SKI1_1 85 89 PF00082 0.254
CLV_Separin_Metazoa 158 162 PF03568 0.460
DEG_APCC_DBOX_1 43 51 PF00400 0.515
DOC_CKS1_1 9 14 PF01111 0.368
DOC_MAPK_DCC_7 197 207 PF00069 0.515
DOC_MAPK_FxFP_2 105 108 PF00069 0.355
DOC_MAPK_gen_1 104 112 PF00069 0.395
DOC_MAPK_gen_1 282 290 PF00069 0.400
DOC_MAPK_gen_1 32 42 PF00069 0.294
DOC_MAPK_MEF2A_6 104 112 PF00069 0.479
DOC_MAPK_MEF2A_6 223 231 PF00069 0.460
DOC_PP1_RVXF_1 30 37 PF00149 0.460
DOC_PP1_RVXF_1 4 11 PF00149 0.422
DOC_PP2B_PxIxI_1 202 208 PF00149 0.515
DOC_PP4_FxxP_1 105 108 PF00568 0.355
DOC_PP4_MxPP_1 1 4 PF00568 0.353
DOC_SPAK_OSR1_1 344 348 PF12202 0.357
DOC_USP7_MATH_1 124 128 PF00917 0.509
DOC_USP7_MATH_1 210 214 PF00917 0.364
DOC_USP7_MATH_1 366 370 PF00917 0.351
DOC_USP7_UBL2_3 93 97 PF12436 0.515
DOC_WW_Pin1_4 242 247 PF00397 0.412
DOC_WW_Pin1_4 8 13 PF00397 0.428
LIG_14-3-3_CanoR_1 211 215 PF00244 0.416
LIG_14-3-3_CanoR_1 223 228 PF00244 0.453
LIG_14-3-3_CanoR_1 270 275 PF00244 0.431
LIG_APCC_ABBA_1 290 295 PF00400 0.415
LIG_BIR_III_4 237 241 PF00653 0.355
LIG_BRCT_BRCA1_1 238 242 PF00533 0.470
LIG_BRCT_BRCA1_1 75 79 PF00533 0.515
LIG_deltaCOP1_diTrp_1 313 321 PF00928 0.478
LIG_FHA_1 135 141 PF00498 0.472
LIG_FHA_1 145 151 PF00498 0.426
LIG_FHA_1 224 230 PF00498 0.433
LIG_FHA_1 243 249 PF00498 0.418
LIG_FHA_1 289 295 PF00498 0.441
LIG_FHA_1 57 63 PF00498 0.432
LIG_FHA_2 352 358 PF00498 0.275
LIG_GBD_Chelix_1 250 258 PF00786 0.315
LIG_LIR_Gen_1 287 294 PF02991 0.385
LIG_LIR_Gen_1 57 62 PF02991 0.358
LIG_LIR_Nem_3 175 180 PF02991 0.412
LIG_LIR_Nem_3 287 293 PF02991 0.363
LIG_LIR_Nem_3 342 348 PF02991 0.370
LIG_LIR_Nem_3 57 61 PF02991 0.358
LIG_SH2_CRK 322 326 PF00017 0.434
LIG_SH2_GRB2like 324 327 PF00017 0.515
LIG_SH2_STAP1 339 343 PF00017 0.248
LIG_SH2_STAT5 100 103 PF00017 0.463
LIG_SH2_STAT5 322 325 PF00017 0.475
LIG_SH3_3 1 7 PF00018 0.454
LIG_SH3_3 189 195 PF00018 0.515
LIG_SH3_3 241 247 PF00018 0.520
LIG_SH3_3 305 311 PF00018 0.452
LIG_SUMO_SIM_par_1 225 230 PF11976 0.457
LIG_SUMO_SIM_par_1 45 51 PF11976 0.505
LIG_WRC_WIRS_1 233 238 PF05994 0.515
MOD_CK2_1 120 126 PF00069 0.495
MOD_CK2_1 210 216 PF00069 0.374
MOD_CK2_1 335 341 PF00069 0.454
MOD_GlcNHglycan 122 125 PF01048 0.273
MOD_GlcNHglycan 174 177 PF01048 0.273
MOD_GlcNHglycan 237 241 PF01048 0.248
MOD_GlcNHglycan 50 53 PF01048 0.309
MOD_GlcNHglycan 65 68 PF01048 0.276
MOD_GlcNHglycan 90 93 PF01048 0.278
MOD_GSK3_1 120 127 PF00069 0.449
MOD_GSK3_1 223 230 PF00069 0.442
MOD_GSK3_1 232 239 PF00069 0.465
MOD_GSK3_1 24 31 PF00069 0.431
MOD_GSK3_1 335 342 PF00069 0.486
MOD_GSK3_1 88 95 PF00069 0.502
MOD_N-GLC_2 196 198 PF02516 0.208
MOD_NEK2_1 120 125 PF00069 0.469
MOD_NEK2_1 227 232 PF00069 0.474
MOD_NEK2_1 236 241 PF00069 0.442
MOD_NEK2_1 288 293 PF00069 0.446
MOD_NEK2_1 88 93 PF00069 0.454
MOD_NEK2_2 339 344 PF00069 0.312
MOD_NEK2_2 74 79 PF00069 0.515
MOD_PKA_1 297 303 PF00069 0.419
MOD_PKA_2 210 216 PF00069 0.384
MOD_Plk_1 133 139 PF00069 0.478
MOD_Plk_1 227 233 PF00069 0.532
MOD_Plk_1 56 62 PF00069 0.484
MOD_Plk_4 124 130 PF00069 0.525
MOD_Plk_4 320 326 PF00069 0.457
MOD_Plk_4 348 354 PF00069 0.453
MOD_Plk_4 74 80 PF00069 0.444
MOD_ProDKin_1 242 248 PF00069 0.412
MOD_ProDKin_1 8 14 PF00069 0.438
MOD_SUMO_rev_2 111 120 PF00179 0.505
MOD_SUMO_rev_2 295 300 PF00179 0.446
TRG_AP2beta_CARGO_1 287 297 PF09066 0.355
TRG_ENDOCYTIC_2 322 325 PF00928 0.433
TRG_ER_diArg_1 160 162 PF00400 0.436
TRG_Pf-PMV_PEXEL_1 212 216 PF00026 0.251
TRG_PTS1 378 381 PF00515 0.542

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IGF3 Leptomonas seymouri 75% 100%
A0A0S4JG24 Bodo saltans 56% 95%
A0A0S4JM51 Bodo saltans 40% 81%
A0A1X0NXQ0 Trypanosomatidae 41% 96%
A0A1X0P8N5 Trypanosomatidae 59% 99%
A0A422NWJ2 Trypanosoma rangeli 42% 95%
A0A451EJL1 Leishmania donovani 86% 100%
A0KJL8 Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049) 34% 100%
A0LMC0 Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB) 37% 100%
A0RBE9 Bacillus thuringiensis (strain Al Hakam) 33% 100%
A1B8Z3 Paracoccus denitrificans (strain Pd 1222) 26% 96%
A1SY89 Psychromonas ingrahamii (strain 37) 36% 100%
A1UZE5 Burkholderia mallei (strain SAVP1) 35% 100%
A2S233 Burkholderia mallei (strain NCTC 10229) 35% 100%
A3MCV7 Burkholderia mallei (strain NCTC 10247) 35% 100%
A3NGW6 Burkholderia pseudomallei (strain 668) 35% 100%
A3P2G7 Burkholderia pseudomallei (strain 1106a) 35% 100%
A5F049 Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) 34% 100%
A5W695 Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) 35% 100%
A6L4N0 Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC 11154) 33% 100%
A6TFW2 Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) 35% 100%
A7GMM0 Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98) 33% 100%
A9MWZ9 Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) 34% 100%
A9VKQ3 Bacillus mycoides (strain KBAB4) 34% 100%
B0KIG1 Pseudomonas putida (strain GB-1) 38% 100%
B1HPR6 Lysinibacillus sphaericus (strain C3-41) 31% 100%
B1JBM5 Pseudomonas putida (strain W619) 37% 100%
B1Z0T3 Burkholderia ambifaria (strain MC40-6) 35% 100%
B2JLS3 Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815) 37% 100%
B3RBH4 Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1) 35% 100%
B4SWS3 Salmonella newport (strain SL254) 34% 100%
B4T9C6 Salmonella heidelberg (strain SL476) 34% 100%
B4TMB1 Salmonella schwarzengrund (strain CVM19633) 34% 100%
B5BDA1 Salmonella paratyphi A (strain AKU_12601) 33% 100%
B5EXH1 Salmonella agona (strain SL483) 34% 100%
B5FKT6 Salmonella dublin (strain CT_02021853) 34% 100%
B5QTH9 Salmonella enteritidis PT4 (strain P125109) 34% 100%
B5R6T2 Salmonella gallinarum (strain 287/91 / NCTC 13346) 34% 100%
B7HH81 Bacillus cereus (strain B4264) 32% 100%
B7HK48 Bacillus cereus (strain AH187) 32% 100%
B7IN19 Bacillus cereus (strain G9842) 32% 100%
B7JFQ9 Bacillus cereus (strain AH820) 33% 100%
B9IUR6 Bacillus cereus (strain Q1) 33% 100%
C0Q7V5 Salmonella paratyphi C (strain RKS4594) 34% 100%
C1EM34 Bacillus cereus (strain 03BB102) 33% 100%
C3LAM8 Bacillus anthracis (strain CDC 684 / NRRL 3495) 33% 100%
C3LVL9 Vibrio cholerae serotype O1 (strain M66-2) 34% 100%
C3P4E3 Bacillus anthracis (strain A0248) 33% 100%
E9ACF2 Leishmania major 87% 100%
E9AG24 Leishmania infantum 86% 100%
E9AJP0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
O25436 Helicobacter pylori (strain ATCC 700392 / 26695) 24% 100%
O35423 Mus musculus 23% 92%
P09139 Rattus norvegicus 24% 92%
P14776 Synechococcus sp. (strain PCC 6716) 25% 99%
P16421 Anabaena cylindrica 25% 99%
P21549 Homo sapiens 22% 97%
P31029 Callithrix jacchus 24% 92%
P31030 Oryctolagus cuniculus 25% 97%
P41689 Felis catus 22% 92%
P43567 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 99%
P55819 Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) 25% 95%
P96060 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 34% 100%
Q02JF1 Pseudomonas aeruginosa (strain UCBPP-PA14) 37% 100%
Q0IG34 Aedes aegypti 23% 95%
Q0JZT9 Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) 35% 100%
Q122G2 Polaromonas sp. (strain JS666 / ATCC BAA-500) 33% 100%
Q128B2 Polaromonas sp. (strain JS666 / ATCC BAA-500) 36% 100%
Q13P97 Paraburkholderia xenovorans (strain LB400) 36% 100%
Q13YI7 Paraburkholderia xenovorans (strain LB400) 33% 98%
Q1BQZ3 Burkholderia cenocepacia (strain AU 1054) 35% 100%
Q1I7U0 Pseudomonas entomophila (strain L48) 37% 100%
Q2SHM3 Hahella chejuensis (strain KCTC 2396) 37% 100%
Q2T3K6 Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264) 35% 100%
Q39AP8 Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383) 35% 100%
Q39BS5 Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383) 36% 100%
Q3JH97 Burkholderia pseudomallei (strain 1710b) 35% 100%
Q3K9Y3 Pseudomonas fluorescens (strain Pf0-1) 37% 100%
Q46NS0 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) 38% 100%
Q46UV8 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) 35% 100%
Q4K9L8 Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) 37% 100%
Q56YA5 Arabidopsis thaliana 24% 95%
Q57SD3 Salmonella choleraesuis (strain SC-B67) 34% 100%
Q58369 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 27% 99%
Q5L9Q0 Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow) 36% 100%
Q5PFR0 Salmonella paratyphi A (strain ATCC 9150 / SARB42) 33% 100%
Q62CM5 Burkholderia mallei (strain ATCC 23344) 35% 100%
Q63E45 Bacillus cereus (strain ZK / E33L) 33% 100%
Q63NF6 Burkholderia pseudomallei (strain K96243) 35% 100%
Q64PZ3 Bacteroides fragilis (strain YCH46) 37% 100%
Q6HLM0 Bacillus thuringiensis subsp. konkukian (strain 97-27) 33% 100%
Q73BH8 Bacillus cereus (strain ATCC 10987 / NRS 248) 33% 100%
Q7MF44 Vibrio vulnificus (strain YJ016) 35% 100%
Q7PRG3 Anopheles gambiae 23% 96%
Q81G81 Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) 32% 100%
Q81TE0 Bacillus anthracis 33% 100%
Q87JL4 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) 34% 100%
Q88KT0 Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) 36% 100%
Q88YN9 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) 32% 100%
Q8D3M4 Vibrio vulnificus (strain CMCP6) 35% 100%
Q8RLU1 Bacillus cereus 32% 100%
Q8RSQ4 Pseudomonas putida 37% 100%
Q8Z8W6 Salmonella typhi 34% 100%
Q92UV9 Rhizobium meliloti (strain 1021) 35% 99%
Q9I434 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 37% 100%
Q9KLY7 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 34% 100%
Q9X1C0 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 26% 99%
Q9ZLA7 Helicobacter pylori (strain J99 / ATCC 700824) 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS