Phosphoglycan beta 1,3 galactosyltransferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoglycan beta 1,3 galactosyltransferase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H3H1_LEIBR

TriTrypDb:

LbrM.02.0790 , LBRM2903_020007500

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3H1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3H1

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043413	macromolecule glycosylation	3	1
GO:0044238	primary metabolic process	2	1
GO:0070085	glycosylation	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016740	transferase activity	2	4
GO:0016757	glycosyltransferase activity	3	4
GO:0016758	hexosyltransferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.315
CLV_NRD_NRD_1	122	124	PF00675	0.355
CLV_NRD_NRD_1	47	49	PF00675	0.317
CLV_NRD_NRD_1	64	66	PF00675	0.482
CLV_PCSK_FUR_1	117	121	PF00082	0.326
CLV_PCSK_KEX2_1	115	117	PF00082	0.326
CLV_PCSK_KEX2_1	119	121	PF00082	0.327
CLV_PCSK_KEX2_1	122	124	PF00082	0.353
CLV_PCSK_KEX2_1	47	49	PF00082	0.317
CLV_PCSK_KEX2_1	64	66	PF00082	0.482
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.300
CLV_PCSK_PC7_1	115	121	PF00082	0.296
CLV_PCSK_SKI1_1	149	153	PF00082	0.382
CLV_PCSK_SKI1_1	47	51	PF00082	0.324
DOC_CKS1_1	182	187	PF01111	0.471
DOC_MAPK_gen_1	47	54	PF00069	0.329
DOC_MAPK_gen_1	64	71	PF00069	0.357
DOC_MAPK_gen_1	73	82	PF00069	0.393
DOC_MAPK_MEF2A_6	47	54	PF00069	0.301
DOC_MAPK_MEF2A_6	64	71	PF00069	0.284
DOC_MAPK_MEF2A_6	76	84	PF00069	0.289
DOC_PP1_RVXF_1	147	154	PF00149	0.438
DOC_USP7_MATH_1	204	208	PF00917	0.475
DOC_USP7_MATH_1	74	78	PF00917	0.560
DOC_WW_Pin1_4	181	186	PF00397	0.519
LIG_14-3-3_CanoR_1	149	154	PF00244	0.391
LIG_14-3-3_CanoR_1	5	12	PF00244	0.542
LIG_14-3-3_CanoR_1	73	82	PF00244	0.325
LIG_14-3-3_CterR_2	265	268	PF00244	0.343
LIG_Actin_WH2_2	136	151	PF00022	0.571
LIG_BRCT_BRCA1_1	206	210	PF00533	0.383
LIG_FHA_1	224	230	PF00498	0.433
LIG_FHA_2	19	25	PF00498	0.462
LIG_LIR_Gen_1	135	143	PF02991	0.512
LIG_LIR_Gen_1	152	158	PF02991	0.368
LIG_LIR_Gen_1	89	98	PF02991	0.382
LIG_LIR_Nem_3	135	140	PF02991	0.394
LIG_LIR_Nem_3	152	156	PF02991	0.375
LIG_LIR_Nem_3	165	171	PF02991	0.409
LIG_LIR_Nem_3	258	264	PF02991	0.372
LIG_LIR_Nem_3	89	93	PF02991	0.456
LIG_RPA_C_Fungi	59	71	PF08784	0.389
LIG_SH2_CRK	30	34	PF00017	0.443
LIG_SH2_SRC	235	238	PF00017	0.488
LIG_SH2_STAP1	246	250	PF00017	0.456
LIG_SH2_STAT3	171	174	PF00017	0.344
LIG_SH2_STAT5	132	135	PF00017	0.486
LIG_SH2_STAT5	167	170	PF00017	0.485
LIG_SH2_STAT5	172	175	PF00017	0.477
LIG_SH2_STAT5	235	238	PF00017	0.469
LIG_SH3_1	30	36	PF00018	0.422
LIG_SH3_3	30	36	PF00018	0.429
LIG_SH3_3	90	96	PF00018	0.318
LIG_SUMO_SIM_anti_2	81	86	PF11976	0.328
LIG_SUMO_SIM_par_1	220	226	PF11976	0.453
LIG_SUMO_SIM_par_1	83	89	PF11976	0.357
LIG_TRAF2_1	86	89	PF00917	0.412
LIG_WW_3	2	6	PF00397	0.616
MOD_CK2_1	177	183	PF00069	0.505
MOD_CK2_1	18	24	PF00069	0.466
MOD_CK2_1	31	37	PF00069	0.483
MOD_GlcNHglycan	100	103	PF01048	0.302
MOD_GlcNHglycan	207	210	PF01048	0.505
MOD_GlcNHglycan	229	232	PF01048	0.580
MOD_GlcNHglycan	255	258	PF01048	0.295
MOD_GlcNHglycan	76	79	PF01048	0.377
MOD_GSK3_1	11	18	PF00069	0.577
MOD_GSK3_1	177	184	PF00069	0.410
MOD_GSK3_1	223	230	PF00069	0.476
MOD_GSK3_1	253	260	PF00069	0.428
MOD_GSK3_1	31	38	PF00069	0.423
MOD_N-GLC_1	227	232	PF02516	0.533
MOD_NEK2_1	12	17	PF00069	0.531
MOD_NEK2_1	210	215	PF00069	0.604
MOD_PIKK_1	15	21	PF00454	0.554
MOD_PK_1	31	37	PF00069	0.416
MOD_PKA_2	4	10	PF00069	0.548
MOD_PKA_2	98	104	PF00069	0.476
MOD_PKB_1	147	155	PF00069	0.333
MOD_Plk_1	126	132	PF00069	0.317
MOD_Plk_4	152	158	PF00069	0.448
MOD_Plk_4	18	24	PF00069	0.466
MOD_ProDKin_1	181	187	PF00069	0.520
MOD_SUMO_rev_2	34	41	PF00179	0.360
TRG_ENDOCYTIC_2	137	140	PF00928	0.566
TRG_ER_diArg_1	114	117	PF00400	0.316
TRG_ER_diArg_1	120	123	PF00400	0.337
TRG_ER_diArg_1	160	163	PF00400	0.419
TRG_ER_diArg_1	47	49	PF00400	0.317
TRG_ER_diArg_1	64	66	PF00400	0.482
TRG_NLS_MonoExtC_3	118	123	PF00514	0.305
TRG_NLS_MonoExtN_4	116	123	PF00514	0.303
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.302
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I172	Leptomonas seymouri	37%	100%
A0A0N1IG10	Leptomonas seymouri	29%	100%
E8NHL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	94%
E9AI30	Leishmania braziliensis	26%	77%