Putative peptidyl dipeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl dipeptidase, putative

Species:

Leishmania braziliensis

UniProt:

A4H3G0_LEIBR

TriTrypDb:

LbrM.02.0670 , LBRM2903_270035200

Length:

193

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3G0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0019538	protein metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004175	endopeptidase activity	4	3
GO:0004222	metalloendopeptidase activity	5	3
GO:0005488	binding	1	3
GO:0008233	peptidase activity	3	3
GO:0008237	metallopeptidase activity	4	3
GO:0016787	hydrolase activity	2	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	176	178	PF00675	0.549
CLV_PCSK_SKI1_1	17	21	PF00082	0.549
CLV_PCSK_SKI1_1	182	186	PF00082	0.375
DEG_Nend_Nbox_1	1	3	PF02207	0.549
DOC_USP7_UBL2_3	178	182	PF12436	0.549
LIG_14-3-3_CanoR_1	157	162	PF00244	0.462
LIG_14-3-3_CanoR_1	85	92	PF00244	0.462
LIG_BRCT_BRCA1_1	107	111	PF00533	0.549
LIG_FHA_1	68	74	PF00498	0.384
LIG_FHA_2	13	19	PF00498	0.375
LIG_LIR_Gen_1	108	119	PF02991	0.358
LIG_LIR_Gen_1	127	132	PF02991	0.394
LIG_LIR_Gen_1	18	26	PF02991	0.549
LIG_LIR_Nem_3	108	114	PF02991	0.368
LIG_LIR_Nem_3	121	126	PF02991	0.386
LIG_LIR_Nem_3	127	131	PF02991	0.405
LIG_LIR_Nem_3	18	22	PF02991	0.549
LIG_LIR_Nem_3	28	33	PF02991	0.375
LIG_MLH1_MIPbox_1	107	111	PF16413	0.549
LIG_PTB_Apo_2	1	8	PF02174	0.549
LIG_PTB_Phospho_1	1	7	PF10480	0.549
LIG_SH2_CRK	33	37	PF00017	0.441
LIG_SH2_CRK	7	11	PF00017	0.549
LIG_SH2_STAP1	119	123	PF00017	0.549
LIG_SH2_STAP1	171	175	PF00017	0.549
LIG_SH2_STAP1	33	37	PF00017	0.412
LIG_SH2_STAP1	40	44	PF00017	0.337
LIG_SH2_STAT5	110	113	PF00017	0.549
LIG_SH2_STAT5	124	127	PF00017	0.305
LIG_SH2_STAT5	78	81	PF00017	0.549
LIG_SUMO_SIM_par_1	69	74	PF11976	0.462
LIG_TRAF2_1	86	89	PF00917	0.462
LIG_TRAF2_2	23	28	PF00917	0.462
LIG_TYR_ITIM	5	10	PF00017	0.549
LIG_WW_1	103	106	PF00397	0.549
LIG_WW_3	102	106	PF00397	0.549
MOD_CK1_1	8	14	PF00069	0.549
MOD_Cter_Amidation	175	178	PF01082	0.549
MOD_GlcNHglycan	10	13	PF01048	0.549
MOD_GlcNHglycan	107	110	PF01048	0.480
MOD_GlcNHglycan	142	145	PF01048	0.462
MOD_GSK3_1	140	147	PF00069	0.475
MOD_GSK3_1	157	164	PF00069	0.326
MOD_GSK3_1	6	13	PF00069	0.449
MOD_NEK2_1	140	145	PF00069	0.476
MOD_NEK2_1	5	10	PF00069	0.402
MOD_PIKK_1	21	27	PF00454	0.549
MOD_PK_1	157	163	PF00069	0.462
MOD_PKA_2	84	90	PF00069	0.527
MOD_PKB_1	155	163	PF00069	0.462
TRG_ENDOCYTIC_2	171	174	PF00928	0.549
TRG_ENDOCYTIC_2	33	36	PF00928	0.441
TRG_ENDOCYTIC_2	7	10	PF00928	0.549
TRG_ENDOCYTIC_2	78	81	PF00928	0.549
TRG_ER_diArg_1	154	157	PF00400	0.462
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AH08	Leishmania infantum	85%	95%