DNA-directed RNA polymerase III subunit RPC3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3F9_LEIBR

TriTrypDb:

LbrM.02.0660 , LBRM2903_020012600

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	4
GO:0005666	RNA polymerase III complex	4	4
GO:0030880	RNA polymerase complex	3	4
GO:0032991	protein-containing complex	1	4
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	4
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	4
GO:0140513	nuclear protein-containing complex	2	4
GO:0140535	intracellular protein-containing complex	2	4
GO:1902494	catalytic complex	2	4
GO:1990234	transferase complex	3	4

Expansion

Sequence features

A4H3F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3F9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003677	DNA binding	4	4
GO:0003697	single-stranded DNA binding	5	4
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.579
CLV_NRD_NRD_1	37	39	PF00675	0.606
CLV_NRD_NRD_1	78	80	PF00675	0.452
CLV_PCSK_KEX2_1	16	18	PF00082	0.581
CLV_PCSK_KEX2_1	36	38	PF00082	0.606
CLV_PCSK_KEX2_1	78	80	PF00082	0.452
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.574
CLV_PCSK_SKI1_1	117	121	PF00082	0.554
CLV_PCSK_SKI1_1	163	167	PF00082	0.413
CLV_PCSK_SKI1_1	188	192	PF00082	0.399
CLV_PCSK_SKI1_1	193	197	PF00082	0.383
CLV_PCSK_SKI1_1	214	218	PF00082	0.610
CLV_PCSK_SKI1_1	238	242	PF00082	0.416
CLV_PCSK_SKI1_1	29	33	PF00082	0.594
CLV_PCSK_SKI1_1	307	311	PF00082	0.436
CLV_PCSK_SKI1_1	321	325	PF00082	0.307
CLV_Separin_Metazoa	204	208	PF03568	0.461
DEG_APCC_DBOX_1	187	195	PF00400	0.397
DEG_APCC_DBOX_1	77	85	PF00400	0.447
DEG_Nend_UBRbox_3	1	3	PF02207	0.568
DOC_CKS1_1	99	104	PF01111	0.594
DOC_CYCLIN_RxL_1	318	327	PF00134	0.404
DOC_CYCLIN_yCln2_LP_2	84	90	PF00134	0.558
DOC_MAPK_gen_1	214	222	PF00069	0.437
DOC_MAPK_gen_1	236	245	PF00069	0.414
DOC_MAPK_MEF2A_6	153	161	PF00069	0.523
DOC_MAPK_MEF2A_6	321	328	PF00069	0.413
DOC_PP4_FxxP_1	120	123	PF00568	0.428
DOC_USP7_MATH_1	103	107	PF00917	0.638
DOC_USP7_MATH_1	177	181	PF00917	0.579
DOC_USP7_MATH_1	206	210	PF00917	0.498
DOC_USP7_MATH_1	216	220	PF00917	0.361
DOC_USP7_MATH_1	23	27	PF00917	0.600
DOC_USP7_MATH_1	271	275	PF00917	0.593
DOC_USP7_UBL2_3	12	16	PF12436	0.562
DOC_WW_Pin1_4	104	109	PF00397	0.664
DOC_WW_Pin1_4	19	24	PF00397	0.576
DOC_WW_Pin1_4	267	272	PF00397	0.585
DOC_WW_Pin1_4	98	103	PF00397	0.652
LIG_14-3-3_CanoR_1	17	23	PF00244	0.649
LIG_14-3-3_CanoR_1	238	244	PF00244	0.407
LIG_AP2alpha_1	195	199	PF02296	0.425
LIG_BRCT_BRCA1_1	106	110	PF00533	0.650
LIG_Clathr_ClatBox_1	323	327	PF01394	0.400
LIG_FHA_1	114	120	PF00498	0.654
LIG_FHA_1	206	212	PF00498	0.511
LIG_FHA_1	240	246	PF00498	0.411
LIG_FHA_1	48	54	PF00498	0.574
LIG_FHA_1	64	70	PF00498	0.548
LIG_FHA_2	173	179	PF00498	0.411
LIG_LIR_Gen_1	107	118	PF02991	0.620
LIG_LIR_Gen_1	244	253	PF02991	0.422
LIG_LIR_Nem_3	152	157	PF02991	0.422
LIG_LIR_Nem_3	244	250	PF02991	0.420
LIG_NRBOX	318	324	PF00104	0.408
LIG_PCNA_yPIPBox_3	307	320	PF02747	0.418
LIG_PDZ_Class_3	324	329	PF00595	0.381
LIG_Pex14_2	195	199	PF04695	0.425
LIG_SH2_CRK	154	158	PF00017	0.384
LIG_SH2_STAT5	184	187	PF00017	0.608
LIG_SH2_STAT5	221	224	PF00017	0.379
LIG_SH3_3	257	263	PF00018	0.456
LIG_SH3_3	96	102	PF00018	0.582
LIG_SUMO_SIM_par_1	321	327	PF11976	0.406
MOD_CK1_1	180	186	PF00069	0.433
MOD_CK1_1	293	299	PF00069	0.434
MOD_CK1_1	68	74	PF00069	0.490
MOD_CK2_1	172	178	PF00069	0.410
MOD_GlcNHglycan	208	211	PF01048	0.602
MOD_GlcNHglycan	213	217	PF01048	0.491
MOD_GlcNHglycan	227	230	PF01048	0.272
MOD_GlcNHglycan	257	260	PF01048	0.628
MOD_GlcNHglycan	273	276	PF01048	0.551
MOD_GlcNHglycan	279	282	PF01048	0.551
MOD_GlcNHglycan	292	295	PF01048	0.374
MOD_GlcNHglycan	3	6	PF01048	0.547
MOD_GlcNHglycan	70	73	PF01048	0.512
MOD_GSK3_1	104	111	PF00069	0.723
MOD_GSK3_1	19	26	PF00069	0.617
MOD_GSK3_1	212	219	PF00069	0.476
MOD_GSK3_1	223	230	PF00069	0.310
MOD_GSK3_1	267	274	PF00069	0.706
MOD_GSK3_1	307	314	PF00069	0.429
MOD_GSK3_1	63	70	PF00069	0.532
MOD_N-GLC_1	1	6	PF02516	0.556
MOD_N-GLC_1	108	113	PF02516	0.729
MOD_NEK2_1	225	230	PF00069	0.403
MOD_NEK2_1	239	244	PF00069	0.310
MOD_NEK2_1	295	300	PF00069	0.574
MOD_NEK2_2	216	221	PF00069	0.431
MOD_PIKK_1	23	29	PF00454	0.674
MOD_PIKK_1	302	308	PF00454	0.379
MOD_PKA_2	206	212	PF00069	0.511
MOD_Plk_1	108	114	PF00069	0.541
MOD_Plk_1	133	139	PF00069	0.383
MOD_Plk_1	172	178	PF00069	0.410
MOD_Plk_2-3	172	178	PF00069	0.410
MOD_Plk_4	180	186	PF00069	0.617
MOD_Plk_4	216	222	PF00069	0.508
MOD_Plk_4	227	233	PF00069	0.505
MOD_Plk_4	315	321	PF00069	0.408
MOD_ProDKin_1	19	25	PF00069	0.575
MOD_ProDKin_1	267	273	PF00069	0.587
MOD_ProDKin_1	98	104	PF00069	0.656
MOD_SUMO_rev_2	26	33	PF00179	0.594
TRG_DiLeu_BaLyEn_6	160	165	PF01217	0.288
TRG_DiLeu_BaLyEn_6	318	323	PF01217	0.404
TRG_ENDOCYTIC_2	154	157	PF00928	0.392
TRG_ER_diArg_1	17	20	PF00400	0.593
TRG_ER_diArg_1	35	38	PF00400	0.605
TRG_ER_diArg_1	39	42	PF00400	0.581
TRG_ER_diArg_1	77	79	PF00400	0.456
TRG_NES_CRM1_1	189	204	PF08389	0.412
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HRS6	Leishmania infantum	84%	100%
E9ACE2	Leishmania major	83%	100%