Putative mitochondrial carrier protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H3F8_LEIBR

TriTrypDb:

LbrM.02.0650 , LBRM2903_020012400

Length:

313

Annotations

LeishMANIAdb annotations

Homologous to Eukaryotic mitochondrial and chloroplast transporters for folate or nicotinic acid. Has no canonical mitochondrial target signal, only a Leishmaniid-specific C-terminal extension. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H3F8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3F8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0001409	guanine nucleotide transmembrane transporter activity	6	1
GO:0005215	transporter activity	1	1
GO:0015215	nucleotide transmembrane transporter activity	4	1
GO:0015216	purine nucleotide transmembrane transporter activity	5	1
GO:0015605	organophosphate ester transmembrane transporter activity	3	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	80	82	PF00675	0.518
CLV_PCSK_KEX2_1	124	126	PF00082	0.550
CLV_PCSK_KEX2_1	45	47	PF00082	0.315
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.569
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.324
CLV_PCSK_SKI1_1	112	116	PF00082	0.456
CLV_PCSK_SKI1_1	280	284	PF00082	0.317
CLV_PCSK_SKI1_1	292	296	PF00082	0.275
CLV_PCSK_SKI1_1	4	8	PF00082	0.615
DOC_CDC14_PxL_1	287	295	PF14671	0.315
DOC_PP1_RVXF_1	290	296	PF00149	0.297
DOC_PP4_FxxP_1	36	39	PF00568	0.446
DOC_WW_Pin1_4	280	285	PF00397	0.315
DOC_WW_Pin1_4	4	9	PF00397	0.515
LIG_14-3-3_CanoR_1	253	257	PF00244	0.403
LIG_AP2alpha_1	14	18	PF02296	0.560
LIG_BIR_II_1	1	5	PF00653	0.636
LIG_BRCT_BRCA1_1	275	279	PF00533	0.298
LIG_BRCT_BRCA1_1	75	79	PF00533	0.263
LIG_Clathr_ClatBox_1	150	154	PF01394	0.303
LIG_FHA_1	281	287	PF00498	0.277
LIG_FHA_2	253	259	PF00498	0.445
LIG_FHA_2	296	302	PF00498	0.403
LIG_LIR_Apic_2	33	39	PF02991	0.448
LIG_LIR_Gen_1	198	207	PF02991	0.294
LIG_LIR_Gen_1	222	232	PF02991	0.360
LIG_LIR_Gen_1	90	99	PF02991	0.423
LIG_LIR_Nem_3	121	126	PF02991	0.447
LIG_LIR_Nem_3	198	202	PF02991	0.294
LIG_LIR_Nem_3	276	282	PF02991	0.362
LIG_LIR_Nem_3	300	306	PF02991	0.364
LIG_LIR_Nem_3	90	95	PF02991	0.399
LIG_MLH1_MIPbox_1	275	279	PF16413	0.192
LIG_PCNA_PIPBox_1	108	117	PF02747	0.435
LIG_PCNA_yPIPBox_3	101	115	PF02747	0.513
LIG_PCNA_yPIPBox_3	176	184	PF02747	0.239
LIG_Pex14_2	123	127	PF04695	0.370
LIG_Pex14_2	14	18	PF04695	0.498
LIG_Pex14_2	36	40	PF04695	0.450
LIG_REV1ctd_RIR_1	276	283	PF16727	0.403
LIG_REV1ctd_RIR_1	301	309	PF16727	0.398
LIG_SH2_CRK	92	96	PF00017	0.368
LIG_SH2_NCK_1	92	96	PF00017	0.440
LIG_SH2_SRC	85	88	PF00017	0.370
LIG_SH2_STAP1	92	96	PF00017	0.352
LIG_SH2_STAT5	126	129	PF00017	0.525
LIG_SH2_STAT5	211	214	PF00017	0.462
LIG_SH2_STAT5	297	300	PF00017	0.328
LIG_SH2_STAT5	85	88	PF00017	0.379
LIG_SH3_3	237	243	PF00018	0.209
LIG_SUMO_SIM_anti_2	147	152	PF11976	0.209
LIG_UBA3_1	149	157	PF00899	0.313
LIG_WRC_WIRS_1	275	280	PF05994	0.445
MOD_CDK_SPK_2	280	285	PF00069	0.315
MOD_CK1_1	10	16	PF00069	0.496
MOD_CK1_1	2	8	PF00069	0.649
MOD_CK2_1	252	258	PF00069	0.445
MOD_CK2_1	295	301	PF00069	0.343
MOD_GlcNHglycan	1	4	PF01048	0.706
MOD_GlcNHglycan	184	187	PF01048	0.358
MOD_GlcNHglycan	288	291	PF01048	0.342
MOD_GlcNHglycan	309	312	PF01048	0.527
MOD_GlcNHglycan	75	78	PF01048	0.392
MOD_GSK3_1	234	241	PF00069	0.246
MOD_GSK3_1	55	62	PF00069	0.413
MOD_N-GLC_1	307	312	PF02516	0.582
MOD_N-GLC_2	226	228	PF02516	0.360
MOD_NEK2_1	114	119	PF00069	0.499
MOD_NEK2_1	18	23	PF00069	0.541
MOD_NEK2_1	227	232	PF00069	0.321
MOD_NEK2_1	295	300	PF00069	0.310
MOD_NEK2_1	307	312	PF00069	0.444
MOD_NEK2_1	40	45	PF00069	0.386
MOD_NEK2_1	55	60	PF00069	0.402
MOD_NEK2_2	274	279	PF00069	0.445
MOD_PIKK_1	157	163	PF00454	0.328
MOD_PKA_2	252	258	PF00069	0.383
MOD_PKA_2	55	61	PF00069	0.536
MOD_Plk_1	10	16	PF00069	0.587
MOD_Plk_4	184	190	PF00069	0.322
MOD_Plk_4	219	225	PF00069	0.310
MOD_Plk_4	274	280	PF00069	0.428
MOD_Plk_4	50	56	PF00069	0.538
MOD_Plk_4	87	93	PF00069	0.466
MOD_ProDKin_1	280	286	PF00069	0.315
MOD_ProDKin_1	4	10	PF00069	0.514
MOD_SUMO_for_1	270	273	PF00179	0.431
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.445
TRG_ENDOCYTIC_2	92	95	PF00928	0.346
TRG_ENDOCYTIC_2	96	99	PF00928	0.330
TRG_NES_CRM1_1	147	161	PF08389	0.239

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0G2K309	Rattus norvegicus	23%	100%
A0A0N0P7Y4	Leptomonas seymouri	26%	100%
A0A0N1I2W5	Leptomonas seymouri	47%	88%
A0A0N1IMP5	Leptomonas seymouri	22%	93%
A0A0S4IMF4	Bodo saltans	25%	89%
A0A0S4IR49	Bodo saltans	49%	95%
A0A0S4JHF7	Bodo saltans	64%	99%
A0A0S4JM95	Bodo saltans	22%	100%
A0A1X0NJD2	Trypanosomatidae	26%	100%
A0A1X0NLB0	Trypanosomatidae	61%	98%
A0A1X0P6S2	Trypanosomatidae	21%	96%
A0A3R7RT89	Trypanosoma rangeli	27%	100%
A0A3S7WTS6	Leishmania donovani	24%	100%
A0A422N706	Trypanosoma rangeli	47%	90%
A0A422NAX9	Trypanosoma rangeli	65%	96%
A0A451EJK1	Leishmania donovani	85%	100%
A4HRR2	Leishmania infantum	85%	100%
A4HWR9	Leishmania infantum	24%	100%
B0DK57	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	25%	100%
C9ZJ51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ACE1	Leishmania major	85%	100%
E9AJM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AQH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AQH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	82%
O60029	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	100%
O74439	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
O77792	Bos taurus	27%	100%
O97562	Sus scrofa	25%	100%
P10566	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P32089	Rattus norvegicus	21%	100%
P38988	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	100%
P53007	Homo sapiens	21%	100%
P55851	Homo sapiens	25%	100%
P56500	Rattus norvegicus	24%	100%
P70406	Mus musculus	24%	100%
P79110	Bos taurus	22%	100%
Q03028	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
Q3MHI3	Bos taurus	25%	100%
Q3SZI5	Bos taurus	24%	100%
Q4QF00	Leishmania major	25%	100%
Q54B67	Dictyostelium discoideum	24%	100%
Q54FE6	Dictyostelium discoideum	25%	100%
Q55DY8	Dictyostelium discoideum	21%	100%
Q55E45	Dictyostelium discoideum	25%	100%
Q55GE2	Dictyostelium discoideum	24%	100%
Q59Q36	Candida albicans (strain SC5314 / ATCC MYA-2876)	22%	100%
Q5R5A8	Pongo abelii	26%	100%
Q6PGY3	Danio rerio	23%	87%
Q86AV5	Dictyostelium discoideum	25%	100%
Q8BW66	Mus musculus	23%	100%
Q8BZ09	Mus musculus	24%	100%
Q8JZU2	Mus musculus	22%	100%
Q94AG6	Arabidopsis thaliana	26%	96%
Q99297	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
Q99JD3	Rattus norvegicus	24%	100%
Q9BQT8	Homo sapiens	25%	100%
Q9DB41	Mus musculus	23%	98%
Q9N2J1	Canis lupus familiaris	24%	100%
Q9P3T7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9W720	Danio rerio	27%	100%
Q9W725	Cyprinus carpio	29%	100%
Q9WVD5	Mus musculus	24%	100%
V5B5N3	Trypanosoma cruzi	62%	95%
V5BDR1	Trypanosoma cruzi	25%	100%
V5BN90	Trypanosoma cruzi	46%	90%