Nop14-like_family

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Nop14-like_family

Gene product:

Nop14-like family, putative

Species:

Leishmania braziliensis

UniProt:

A4H3F7_LEIBR

TriTrypDb:

LbrM.02.0640 , LBRM2903_020012300

Length:

906

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	10
GO:0030684	preribosome	3	10
GO:0032040	small-subunit processome	4	10
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:1990904	ribonucleoprotein complex	2	10
GO:0030689	Noc complex	3	1
GO:0030692	Noc4p-Nop14p complex	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4H3F7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3F7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0022613	ribonucleoprotein complex biogenesis	4	9
GO:0042254	ribosome biogenesis	5	9
GO:0044085	cellular component biogenesis	3	9
GO:0071840	cellular component organization or biogenesis	2	9
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.753
CLV_C14_Caspase3-7	300	304	PF00656	0.695
CLV_C14_Caspase3-7	307	311	PF00656	0.608
CLV_C14_Caspase3-7	471	475	PF00656	0.620
CLV_C14_Caspase3-7	600	604	PF00656	0.233
CLV_C14_Caspase3-7	63	67	PF00656	0.534
CLV_C14_Caspase3-7	899	903	PF00656	0.551
CLV_NRD_NRD_1	130	132	PF00675	0.719
CLV_NRD_NRD_1	156	158	PF00675	0.657
CLV_NRD_NRD_1	230	232	PF00675	0.555
CLV_NRD_NRD_1	257	259	PF00675	0.621
CLV_NRD_NRD_1	371	373	PF00675	0.622
CLV_NRD_NRD_1	554	556	PF00675	0.444
CLV_NRD_NRD_1	841	843	PF00675	0.389
CLV_NRD_NRD_1	887	889	PF00675	0.631
CLV_PCSK_FUR_1	231	235	PF00082	0.450
CLV_PCSK_FUR_1	855	859	PF00082	0.485
CLV_PCSK_KEX2_1	130	132	PF00082	0.719
CLV_PCSK_KEX2_1	14	16	PF00082	0.607
CLV_PCSK_KEX2_1	156	158	PF00082	0.657
CLV_PCSK_KEX2_1	230	232	PF00082	0.577
CLV_PCSK_KEX2_1	233	235	PF00082	0.560
CLV_PCSK_KEX2_1	257	259	PF00082	0.621
CLV_PCSK_KEX2_1	371	373	PF00082	0.623
CLV_PCSK_KEX2_1	554	556	PF00082	0.444
CLV_PCSK_KEX2_1	819	821	PF00082	0.379
CLV_PCSK_KEX2_1	827	829	PF00082	0.386
CLV_PCSK_KEX2_1	841	843	PF00082	0.369
CLV_PCSK_KEX2_1	846	848	PF00082	0.369
CLV_PCSK_KEX2_1	857	859	PF00082	0.369
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.648
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.638
CLV_PCSK_PC1ET2_1	819	821	PF00082	0.379
CLV_PCSK_PC1ET2_1	827	829	PF00082	0.386
CLV_PCSK_PC1ET2_1	846	848	PF00082	0.369
CLV_PCSK_PC1ET2_1	857	859	PF00082	0.304
CLV_PCSK_PC7_1	823	829	PF00082	0.369
CLV_PCSK_PC7_1	842	848	PF00082	0.369
CLV_PCSK_SKI1_1	11	15	PF00082	0.693
CLV_PCSK_SKI1_1	238	242	PF00082	0.535
CLV_PCSK_SKI1_1	250	254	PF00082	0.563
CLV_PCSK_SKI1_1	263	267	PF00082	0.505
CLV_PCSK_SKI1_1	314	318	PF00082	0.615
CLV_PCSK_SKI1_1	378	382	PF00082	0.575
CLV_PCSK_SKI1_1	539	543	PF00082	0.356
CLV_PCSK_SKI1_1	547	551	PF00082	0.348
CLV_PCSK_SKI1_1	644	648	PF00082	0.344
CLV_PCSK_SKI1_1	705	709	PF00082	0.444
CLV_PCSK_SKI1_1	733	737	PF00082	0.485
CLV_PCSK_SKI1_1	816	820	PF00082	0.401
CLV_PCSK_SKI1_1	831	835	PF00082	0.401
DEG_APCC_DBOX_1	313	321	PF00400	0.627
DEG_APCC_DBOX_1	887	895	PF00400	0.527
DEG_COP1_1	397	405	PF00400	0.632
DEG_SCF_FBW7_1	676	682	PF00400	0.233
DEG_SPOP_SBC_1	894	898	PF00917	0.788
DOC_ANK_TNKS_1	61	68	PF00023	0.725
DOC_CKS1_1	582	587	PF01111	0.369
DOC_CKS1_1	676	681	PF01111	0.233
DOC_CKS1_1	754	759	PF01111	0.233
DOC_CYCLIN_RxL_1	257	270	PF00134	0.557
DOC_MAPK_DCC_7	399	407	PF00069	0.671
DOC_MAPK_MEF2A_6	399	407	PF00069	0.671
DOC_MAPK_MEF2A_6	559	566	PF00069	0.444
DOC_MAPK_MEF2A_6	722	729	PF00069	0.233
DOC_PP2B_LxvP_1	640	643	PF13499	0.344
DOC_PP2B_LxvP_1	657	660	PF13499	0.344
DOC_PP2B_LxvP_1	743	746	PF13499	0.477
DOC_USP7_MATH_1	103	107	PF00917	0.622
DOC_USP7_MATH_1	147	151	PF00917	0.771
DOC_USP7_MATH_1	25	29	PF00917	0.560
DOC_USP7_MATH_1	286	290	PF00917	0.694
DOC_USP7_MATH_1	295	299	PF00917	0.668
DOC_USP7_MATH_1	304	308	PF00917	0.644
DOC_USP7_MATH_1	324	328	PF00917	0.587
DOC_USP7_MATH_1	545	549	PF00917	0.369
DOC_USP7_MATH_1	604	608	PF00917	0.444
DOC_USP7_MATH_1	747	751	PF00917	0.352
DOC_USP7_MATH_1	895	899	PF00917	0.787
DOC_USP7_MATH_2	84	90	PF00917	0.530
DOC_USP7_UBL2_3	880	884	PF12436	0.583
DOC_WW_Pin1_4	145	150	PF00397	0.784
DOC_WW_Pin1_4	243	248	PF00397	0.550
DOC_WW_Pin1_4	581	586	PF00397	0.369
DOC_WW_Pin1_4	675	680	PF00397	0.296
DOC_WW_Pin1_4	699	704	PF00397	0.485
DOC_WW_Pin1_4	721	726	PF00397	0.419
DOC_WW_Pin1_4	753	758	PF00397	0.449
DOC_WW_Pin1_4	781	786	PF00397	0.369
DOC_WW_Pin1_4	97	102	PF00397	0.814
LIG_14-3-3_CanoR_1	124	132	PF00244	0.757
LIG_14-3-3_CanoR_1	24	34	PF00244	0.581
LIG_14-3-3_CanoR_1	352	361	PF00244	0.600
LIG_14-3-3_CanoR_1	559	563	PF00244	0.372
LIG_14-3-3_CanoR_1	74	81	PF00244	0.543
LIG_14-3-3_CanoR_1	831	839	PF00244	0.485
LIG_Actin_WH2_2	607	622	PF00022	0.444
LIG_BIR_II_1	1	5	PF00653	0.511
LIG_BRCT_BRCA1_1	103	107	PF00533	0.810
LIG_BRCT_BRCA1_1	269	273	PF00533	0.630
LIG_BRCT_BRCA1_1	304	308	PF00533	0.487
LIG_BRCT_BRCA1_1	569	573	PF00533	0.369
LIG_Clathr_ClatBox_1	540	544	PF01394	0.352
LIG_CSL_BTD_1	754	757	PF09270	0.485
LIG_EH_1	92	96	PF12763	0.749
LIG_FHA_1	127	133	PF00498	0.740
LIG_FHA_1	212	218	PF00498	0.505
LIG_FHA_1	244	250	PF00498	0.540
LIG_FHA_1	320	326	PF00498	0.588
LIG_FHA_1	582	588	PF00498	0.389
LIG_FHA_1	611	617	PF00498	0.446
LIG_FHA_1	722	728	PF00498	0.389
LIG_FHA_2	137	143	PF00498	0.691
LIG_FHA_2	182	188	PF00498	0.511
LIG_FHA_2	275	281	PF00498	0.653
LIG_FHA_2	292	298	PF00498	0.722
LIG_FHA_2	377	383	PF00498	0.562
LIG_FHA_2	414	420	PF00498	0.546
LIG_FHA_2	61	67	PF00498	0.532
LIG_FHA_2	676	682	PF00498	0.416
LIG_GBD_Chelix_1	611	619	PF00786	0.444
LIG_HP1_1	643	647	PF01393	0.444
LIG_LIR_Gen_1	357	366	PF02991	0.533
LIG_LIR_Gen_1	492	503	PF02991	0.566
LIG_LIR_Gen_1	584	594	PF02991	0.348
LIG_LIR_Gen_1	607	616	PF02991	0.378
LIG_LIR_Gen_1	856	866	PF02991	0.485
LIG_LIR_Nem_3	492	498	PF02991	0.564
LIG_LIR_Nem_3	535	541	PF02991	0.375
LIG_LIR_Nem_3	584	589	PF02991	0.349
LIG_LIR_Nem_3	607	611	PF02991	0.378
LIG_LIR_Nem_3	856	862	PF02991	0.401
LIG_MYND_3	659	663	PF01753	0.485
LIG_NRBOX	515	521	PF00104	0.444
LIG_NRBOX	610	616	PF00104	0.344
LIG_NRBOX	737	743	PF00104	0.444
LIG_SH2_CRK	81	85	PF00017	0.519
LIG_SH2_CRK	859	863	PF00017	0.485
LIG_SH2_GRB2like	859	862	PF00017	0.485
LIG_SH2_SRC	565	568	PF00017	0.444
LIG_SH2_STAT5	565	568	PF00017	0.401
LIG_SH2_STAT5	608	611	PF00017	0.385
LIG_SH3_1	722	728	PF00018	0.444
LIG_SH3_3	442	448	PF00018	0.713
LIG_SH3_3	579	585	PF00018	0.357
LIG_SH3_3	722	728	PF00018	0.444
LIG_SH3_3	751	757	PF00018	0.483
LIG_SH3_5	574	578	PF00018	0.344
LIG_Sin3_3	538	545	PF02671	0.352
LIG_SUMO_SIM_par_1	530	535	PF11976	0.414
LIG_SUMO_SIM_par_1	539	544	PF11976	0.317
LIG_TRAF2_1	327	330	PF00917	0.657
LIG_TRAF2_1	381	384	PF00917	0.525
LIG_TRAF2_1	467	470	PF00917	0.605
LIG_TRAF2_1	84	87	PF00917	0.642
LIG_TRAF2_1	903	906	PF00917	0.543
LIG_UBA3_1	562	571	PF00899	0.444
LIG_UBA3_1	615	620	PF00899	0.444
LIG_WRC_WIRS_1	166	171	PF05994	0.520
LIG_WRC_WIRS_1	363	368	PF05994	0.630
LIG_WRC_WIRS_1	788	793	PF05994	0.401
MOD_CDC14_SPxK_1	702	705	PF00782	0.485
MOD_CDK_SPxK_1	699	705	PF00069	0.485
MOD_CDK_SPxxK_3	243	250	PF00069	0.545
MOD_CK1_1	106	112	PF00069	0.636
MOD_CK1_1	125	131	PF00069	0.607
MOD_CK1_1	140	146	PF00069	0.737
MOD_CK1_1	148	154	PF00069	0.653
MOD_CK1_1	284	290	PF00069	0.690
MOD_CK1_1	4	10	PF00069	0.715
MOD_CK1_1	455	461	PF00069	0.632
MOD_CK1_1	672	678	PF00069	0.424
MOD_CK1_1	750	756	PF00069	0.425
MOD_CK2_1	181	187	PF00069	0.508
MOD_CK2_1	274	280	PF00069	0.648
MOD_CK2_1	291	297	PF00069	0.666
MOD_CK2_1	324	330	PF00069	0.650
MOD_CK2_1	34	40	PF00069	0.634
MOD_CK2_1	376	382	PF00069	0.573
MOD_CK2_1	413	419	PF00069	0.564
MOD_CK2_1	446	452	PF00069	0.758
MOD_CK2_1	675	681	PF00069	0.385
MOD_GlcNHglycan	103	106	PF01048	0.730
MOD_GlcNHglycan	112	115	PF01048	0.661
MOD_GlcNHglycan	139	142	PF01048	0.716
MOD_GlcNHglycan	161	166	PF01048	0.610
MOD_GlcNHglycan	172	178	PF01048	0.593
MOD_GlcNHglycan	221	224	PF01048	0.389
MOD_GlcNHglycan	243	246	PF01048	0.609
MOD_GlcNHglycan	269	272	PF01048	0.609
MOD_GlcNHglycan	27	30	PF01048	0.598
MOD_GlcNHglycan	288	291	PF01048	0.550
MOD_GlcNHglycan	297	300	PF01048	0.742
MOD_GlcNHglycan	487	490	PF01048	0.489
MOD_GlcNHglycan	501	504	PF01048	0.387
MOD_GlcNHglycan	591	594	PF01048	0.414
MOD_GlcNHglycan	672	675	PF01048	0.414
MOD_GlcNHglycan	749	752	PF01048	0.376
MOD_GlcNHglycan	76	79	PF01048	0.758
MOD_GlcNHglycan	891	894	PF01048	0.710
MOD_GlcNHglycan	899	902	PF01048	0.702
MOD_GSK3_1	106	113	PF00069	0.619
MOD_GSK3_1	122	129	PF00069	0.739
MOD_GSK3_1	136	143	PF00069	0.664
MOD_GSK3_1	161	168	PF00069	0.519
MOD_GSK3_1	263	270	PF00069	0.614
MOD_GSK3_1	282	289	PF00069	0.417
MOD_GSK3_1	291	298	PF00069	0.750
MOD_GSK3_1	30	37	PF00069	0.665
MOD_GSK3_1	452	459	PF00069	0.568
MOD_GSK3_1	56	63	PF00069	0.597
MOD_GSK3_1	675	682	PF00069	0.357
MOD_GSK3_1	746	753	PF00069	0.420
MOD_GSK3_1	831	838	PF00069	0.485
MOD_GSK3_1	889	896	PF00069	0.778
MOD_GSK3_1	97	104	PF00069	0.691
MOD_N-GLC_1	135	140	PF02516	0.781
MOD_N-GLC_1	7	12	PF02516	0.450
MOD_NEK2_1	1	6	PF00069	0.645
MOD_NEK2_1	135	140	PF00069	0.787
MOD_NEK2_1	241	246	PF00069	0.587
MOD_NEK2_1	252	257	PF00069	0.471
MOD_NEK2_1	267	272	PF00069	0.530
MOD_NEK2_1	34	39	PF00069	0.644
MOD_NEK2_1	362	367	PF00069	0.540
MOD_NEK2_1	410	415	PF00069	0.474
MOD_NEK2_1	558	563	PF00069	0.355
MOD_NEK2_1	589	594	PF00069	0.345
MOD_NEK2_1	669	674	PF00069	0.349
MOD_NEK2_1	696	701	PF00069	0.397
MOD_NEK2_1	720	725	PF00069	0.452
MOD_NEK2_1	875	880	PF00069	0.553
MOD_NEK2_2	787	792	PF00069	0.401
MOD_PIKK_1	34	40	PF00454	0.645
MOD_PIKK_1	387	393	PF00454	0.621
MOD_PIKK_1	410	416	PF00454	0.604
MOD_PIKK_1	47	53	PF00454	0.686
MOD_PIKK_1	861	867	PF00454	0.474
MOD_PKA_2	123	129	PF00069	0.662
MOD_PKA_2	209	215	PF00069	0.520
MOD_PKA_2	25	31	PF00069	0.648
MOD_PKA_2	282	288	PF00069	0.710
MOD_PKA_2	295	301	PF00069	0.535
MOD_PKA_2	325	331	PF00069	0.669
MOD_PKA_2	34	40	PF00069	0.608
MOD_PKA_2	4	10	PF00069	0.635
MOD_PKA_2	499	505	PF00069	0.416
MOD_PKA_2	558	564	PF00069	0.354
MOD_Plk_1	376	382	PF00069	0.629
MOD_Plk_1	410	416	PF00069	0.627
MOD_Plk_1	545	551	PF00069	0.427
MOD_Plk_1	835	841	PF00069	0.485
MOD_Plk_2-3	274	280	PF00069	0.595
MOD_Plk_4	148	154	PF00069	0.747
MOD_Plk_4	304	310	PF00069	0.625
MOD_Plk_4	558	564	PF00069	0.253
MOD_Plk_4	604	610	PF00069	0.408
MOD_Plk_4	652	658	PF00069	0.485
MOD_Plk_4	750	756	PF00069	0.233
MOD_ProDKin_1	145	151	PF00069	0.783
MOD_ProDKin_1	243	249	PF00069	0.547
MOD_ProDKin_1	581	587	PF00069	0.369
MOD_ProDKin_1	675	681	PF00069	0.296
MOD_ProDKin_1	699	705	PF00069	0.485
MOD_ProDKin_1	721	727	PF00069	0.419
MOD_ProDKin_1	753	759	PF00069	0.449
MOD_ProDKin_1	781	787	PF00069	0.369
MOD_ProDKin_1	97	103	PF00069	0.815
MOD_SUMO_for_1	811	814	PF00179	0.369
MOD_SUMO_rev_2	821	829	PF00179	0.369
TRG_DiLeu_BaEn_1	248	253	PF01217	0.553
TRG_DiLeu_BaEn_1	666	671	PF01217	0.449
TRG_DiLeu_BaEn_4	384	390	PF01217	0.501
TRG_DiLeu_BaEn_4	715	721	PF01217	0.485
TRG_DiLeu_BaLyEn_6	657	662	PF01217	0.444
TRG_DiLeu_BaLyEn_6	702	707	PF01217	0.385
TRG_DiLeu_BaLyEn_6	709	714	PF01217	0.315
TRG_DiLeu_BaLyEn_6	798	803	PF01217	0.369
TRG_DiLeu_BaLyEn_6	825	830	PF01217	0.415
TRG_ENDOCYTIC_2	608	611	PF00928	0.344
TRG_ENDOCYTIC_2	711	714	PF00928	0.344
TRG_ENDOCYTIC_2	859	862	PF00928	0.369
TRG_ER_diArg_1	130	132	PF00400	0.723
TRG_ER_diArg_1	155	157	PF00400	0.662
TRG_ER_diArg_1	229	231	PF00400	0.589
TRG_ER_diArg_1	256	258	PF00400	0.625
TRG_ER_diArg_1	370	372	PF00400	0.750
TRG_ER_diArg_1	553	555	PF00400	0.447
TRG_ER_diArg_1	791	794	PF00400	0.373
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	712	716	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	794	798	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	820	824	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	831	836	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1III2	Leptomonas seymouri	56%	100%
A0A1X0NK23	Trypanosomatidae	35%	92%
A0A3S5H513	Leishmania donovani	79%	100%
A4HRR1	Leishmania infantum	80%	100%
C9ZJ50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	95%
E9ACE0	Leishmania major	78%	100%
E9AJM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	97%
V5AQ76	Trypanosoma cruzi	40%	100%