Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3F6_LEIBR

TriTrypDb:

LbrM.02.0630 , LBRM2903_020012200

Length:

294

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3F6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.701
CLV_NRD_NRD_1	113	115	PF00675	0.750
CLV_NRD_NRD_1	150	152	PF00675	0.633
CLV_PCSK_KEX2_1	113	115	PF00082	0.791
CLV_PCSK_KEX2_1	150	152	PF00082	0.658
CLV_PCSK_KEX2_1	37	39	PF00082	0.675
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.658
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.675
CLV_PCSK_SKI1_1	161	165	PF00082	0.590
CLV_PCSK_SKI1_1	274	278	PF00082	0.562
CLV_PCSK_SKI1_1	37	41	PF00082	0.558
CLV_PCSK_SKI1_1	75	79	PF00082	0.498
DEG_Nend_UBRbox_2	1	3	PF02207	0.529
DEG_SPOP_SBC_1	125	129	PF00917	0.701
DOC_CKS1_1	1	6	PF01111	0.772
DOC_MAPK_DCC_7	150	160	PF00069	0.583
DOC_MAPK_gen_1	181	189	PF00069	0.524
DOC_MAPK_gen_1	70	80	PF00069	0.696
DOC_MAPK_MEF2A_6	151	160	PF00069	0.579
DOC_USP7_MATH_1	13	17	PF00917	0.784
DOC_USP7_MATH_1	246	250	PF00917	0.716
DOC_WW_Pin1_4	105	110	PF00397	0.538
DOC_WW_Pin1_4	169	174	PF00397	0.627
DOC_WW_Pin1_4	19	24	PF00397	0.620
LIG_14-3-3_CanoR_1	133	143	PF00244	0.687
LIG_14-3-3_CanoR_1	230	235	PF00244	0.511
LIG_14-3-3_CanoR_1	38	46	PF00244	0.641
LIG_BRCT_BRCA1_1	206	210	PF00533	0.426
LIG_FHA_1	1	7	PF00498	0.766
LIG_FHA_1	170	176	PF00498	0.589
LIG_FHA_1	42	48	PF00498	0.591
LIG_FHA_2	115	121	PF00498	0.542
LIG_FHA_2	135	141	PF00498	0.801
LIG_FHA_2	16	22	PF00498	0.742
LIG_FHA_2	162	168	PF00498	0.564
LIG_LIR_Nem_3	198	204	PF02991	0.573
LIG_NRBOX	41	47	PF00104	0.516
LIG_PDZ_Class_3	289	294	PF00595	0.580
LIG_SH2_CRK	201	205	PF00017	0.589
LIG_SH2_STAT5	203	206	PF00017	0.532
LIG_SH3_2	146	151	PF14604	0.477
LIG_SH3_2	4	9	PF14604	0.536
LIG_SH3_3	1	7	PF00018	0.741
LIG_SH3_3	140	146	PF00018	0.733
LIG_SH3_3	20	26	PF00018	0.696
LIG_SUMO_SIM_anti_2	76	81	PF11976	0.589
LIG_TRAF2_1	116	119	PF00917	0.536
LIG_TRAF2_1	164	167	PF00917	0.649
LIG_TRAF2_1	52	55	PF00917	0.595
MOD_CDK_SPxxK_3	169	176	PF00069	0.652
MOD_CK1_1	136	142	PF00069	0.724
MOD_CK1_1	16	22	PF00069	0.770
MOD_CK2_1	113	119	PF00069	0.532
MOD_CK2_1	134	140	PF00069	0.799
MOD_CK2_1	161	167	PF00069	0.550
MOD_CK2_1	8	14	PF00069	0.817
MOD_CMANNOS	98	101	PF00535	0.626
MOD_GlcNHglycan	102	105	PF01048	0.529
MOD_GlcNHglycan	122	125	PF01048	0.664
MOD_GlcNHglycan	14	18	PF01048	0.662
MOD_GlcNHglycan	253	256	PF01048	0.728
MOD_GlcNHglycan	62	65	PF01048	0.626
MOD_GSK3_1	120	127	PF00069	0.688
MOD_GSK3_1	13	20	PF00069	0.733
MOD_GSK3_1	242	249	PF00069	0.593
MOD_GSK3_1	25	32	PF00069	0.736
MOD_GSK3_1	37	44	PF00069	0.595
MOD_GSK3_1	96	103	PF00069	0.511
MOD_NEK2_1	196	201	PF00069	0.633
MOD_NEK2_1	60	65	PF00069	0.614
MOD_PIKK_1	114	120	PF00454	0.630
MOD_PIKK_1	134	140	PF00454	0.727
MOD_PIKK_1	285	291	PF00454	0.532
MOD_PKA_1	113	119	PF00069	0.774
MOD_PKA_1	37	43	PF00069	0.649
MOD_PKA_2	113	119	PF00069	0.667
MOD_PKA_2	37	43	PF00069	0.649
MOD_Plk_1	196	202	PF00069	0.584
MOD_Plk_4	279	285	PF00069	0.598
MOD_Plk_4	41	47	PF00069	0.596
MOD_ProDKin_1	105	111	PF00069	0.546
MOD_ProDKin_1	169	175	PF00069	0.623
MOD_ProDKin_1	19	25	PF00069	0.616
MOD_SUMO_for_1	210	213	PF00179	0.614
MOD_SUMO_rev_2	32	39	PF00179	0.656
MOD_SUMO_rev_2	53	58	PF00179	0.657
TRG_DiLeu_BaEn_1	178	183	PF01217	0.520
TRG_DiLeu_BaEn_4	166	172	PF01217	0.648
TRG_ENDOCYTIC_2	201	204	PF00928	0.589
TRG_ER_diArg_1	112	114	PF00400	0.698
TRG_NLS_MonoCore_2	149	154	PF00514	0.674
TRG_NLS_MonoExtN_4	147	154	PF00514	0.627
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W5	Leptomonas seymouri	53%	98%
A0A0S4JF25	Bodo saltans	23%	100%
A0A1X0NJL7	Trypanosomatidae	37%	89%
A0A3S5H512	Leishmania donovani	77%	93%
A0A422NAY0	Trypanosoma rangeli	33%	89%
A4HRR0	Leishmania infantum	77%	93%
C9ZJ49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	98%
E9ACD9	Leishmania major	75%	100%
E9AJM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	94%
V5D620	Trypanosoma cruzi	38%	92%