LeishMANIAdb
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Gamma-glutamyl phosphate reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Gamma-glutamyl phosphate reductase-like protein
Gene product:
gamma-glutamyl phosphate reductase-like protein
Species:
Leishmania braziliensis
UniProt:
A4H3F4_LEIBR
TriTrypDb:
LbrM.02.0610 , LBRM2903_020012000 *
Length:
659

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3F4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3F4

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 4
GO:0006520 amino acid metabolic process 3 4
GO:0006560 proline metabolic process 6 4
GO:0006561 proline biosynthetic process 7 4
GO:0006807 nitrogen compound metabolic process 2 4
GO:0008152 metabolic process 1 4
GO:0008652 amino acid biosynthetic process 4 4
GO:0009058 biosynthetic process 2 4
GO:0009064 glutamine family amino acid metabolic process 5 4
GO:0009084 glutamine family amino acid biosynthetic process 6 4
GO:0009987 cellular process 1 4
GO:0016053 organic acid biosynthetic process 4 4
GO:0018130 heterocycle biosynthetic process 4 4
GO:0019752 carboxylic acid metabolic process 5 4
GO:0043436 oxoacid metabolic process 4 4
GO:0044237 cellular metabolic process 2 4
GO:0044238 primary metabolic process 2 4
GO:0044249 cellular biosynthetic process 3 4
GO:0044281 small molecule metabolic process 2 4
GO:0044283 small molecule biosynthetic process 3 4
GO:0046394 carboxylic acid biosynthetic process 5 4
GO:0046483 heterocycle metabolic process 3 4
GO:0055129 L-proline biosynthetic process 5 4
GO:0071704 organic substance metabolic process 2 4
GO:1901360 organic cyclic compound metabolic process 3 4
GO:1901362 organic cyclic compound biosynthetic process 4 4
GO:1901564 organonitrogen compound metabolic process 3 4
GO:1901566 organonitrogen compound biosynthetic process 4 4
GO:1901576 organic substance biosynthetic process 3 4
GO:1901605 alpha-amino acid metabolic process 4 4
GO:1901607 alpha-amino acid biosynthetic process 5 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0016491 oxidoreductase activity 2 10
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4 10
GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3 10
GO:0004350 glutamate-5-semialdehyde dehydrogenase activity 5 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 305 309 PF00656 0.576
CLV_NRD_NRD_1 148 150 PF00675 0.679
CLV_NRD_NRD_1 322 324 PF00675 0.589
CLV_NRD_NRD_1 333 335 PF00675 0.481
CLV_NRD_NRD_1 36 38 PF00675 0.448
CLV_NRD_NRD_1 395 397 PF00675 0.423
CLV_NRD_NRD_1 643 645 PF00675 0.489
CLV_PCSK_KEX2_1 148 150 PF00082 0.679
CLV_PCSK_KEX2_1 322 324 PF00082 0.589
CLV_PCSK_KEX2_1 333 335 PF00082 0.481
CLV_PCSK_KEX2_1 36 38 PF00082 0.448
CLV_PCSK_KEX2_1 395 397 PF00082 0.423
CLV_PCSK_SKI1_1 37 41 PF00082 0.440
CLV_PCSK_SKI1_1 395 399 PF00082 0.426
DEG_APCC_DBOX_1 36 44 PF00400 0.429
DEG_Nend_Nbox_1 1 3 PF02207 0.625
DEG_SPOP_SBC_1 156 160 PF00917 0.534
DEG_SPOP_SBC_1 180 184 PF00917 0.534
DEG_SPOP_SBC_1 624 628 PF00917 0.423
DOC_ANK_TNKS_1 286 293 PF00023 0.514
DOC_CKS1_1 131 136 PF01111 0.540
DOC_CKS1_1 247 252 PF01111 0.578
DOC_CYCLIN_yCln2_LP_2 255 261 PF00134 0.495
DOC_CYCLIN_yCln2_LP_2 343 349 PF00134 0.414
DOC_MAPK_DCC_7 115 124 PF00069 0.527
DOC_MAPK_gen_1 330 340 PF00069 0.527
DOC_MAPK_gen_1 355 362 PF00069 0.429
DOC_MAPK_MEF2A_6 115 124 PF00069 0.527
DOC_MAPK_MEF2A_6 355 362 PF00069 0.485
DOC_MAPK_MEF2A_6 504 512 PF00069 0.407
DOC_MAPK_MEF2A_6 633 640 PF00069 0.451
DOC_MAPK_MEF2A_6 72 79 PF00069 0.648
DOC_PP2B_LxvP_1 343 346 PF13499 0.425
DOC_PP2B_PxIxI_1 357 363 PF00149 0.419
DOC_USP7_MATH_1 120 124 PF00917 0.535
DOC_USP7_MATH_1 125 129 PF00917 0.552
DOC_USP7_MATH_1 139 143 PF00917 0.610
DOC_USP7_MATH_1 180 184 PF00917 0.670
DOC_USP7_MATH_1 194 198 PF00917 0.685
DOC_USP7_MATH_1 200 204 PF00917 0.600
DOC_USP7_MATH_1 209 213 PF00917 0.549
DOC_USP7_MATH_1 21 25 PF00917 0.454
DOC_USP7_MATH_1 29 33 PF00917 0.404
DOC_USP7_MATH_1 309 313 PF00917 0.625
DOC_USP7_MATH_1 389 393 PF00917 0.497
DOC_USP7_MATH_1 417 421 PF00917 0.439
DOC_USP7_MATH_1 84 88 PF00917 0.655
DOC_USP7_MATH_1 89 93 PF00917 0.629
DOC_WW_Pin1_4 103 108 PF00397 0.529
DOC_WW_Pin1_4 130 135 PF00397 0.667
DOC_WW_Pin1_4 143 148 PF00397 0.574
DOC_WW_Pin1_4 246 251 PF00397 0.654
DOC_WW_Pin1_4 254 259 PF00397 0.570
DOC_WW_Pin1_4 312 317 PF00397 0.647
DOC_WW_Pin1_4 71 76 PF00397 0.624
LIG_14-3-3_CanoR_1 148 154 PF00244 0.677
LIG_14-3-3_CanoR_1 3 7 PF00244 0.570
LIG_14-3-3_CanoR_1 36 40 PF00244 0.431
LIG_14-3-3_CanoR_1 396 405 PF00244 0.423
LIG_14-3-3_CanoR_1 419 427 PF00244 0.406
LIG_14-3-3_CanoR_1 504 512 PF00244 0.407
LIG_14-3-3_CanoR_1 610 617 PF00244 0.441
LIG_14-3-3_CanoR_1 633 639 PF00244 0.449
LIG_14-3-3_CanoR_1 649 655 PF00244 0.352
LIG_APCC_ABBA_1 47 52 PF00400 0.340
LIG_APCC_ABBA_1 496 501 PF00400 0.560
LIG_BIR_III_2 308 312 PF00653 0.576
LIG_BRCT_BRCA1_1 468 472 PF00533 0.408
LIG_Clathr_ClatBox_1 569 573 PF01394 0.420
LIG_DCNL_PONY_1 1 4 PF03556 0.620
LIG_eIF4E_1 385 391 PF01652 0.298
LIG_FHA_1 157 163 PF00498 0.533
LIG_FHA_1 226 232 PF00498 0.543
LIG_FHA_1 333 339 PF00498 0.601
LIG_FHA_1 372 378 PF00498 0.387
LIG_FHA_1 398 404 PF00498 0.410
LIG_FHA_1 449 455 PF00498 0.423
LIG_FHA_1 492 498 PF00498 0.560
LIG_FHA_1 504 510 PF00498 0.380
LIG_FHA_1 554 560 PF00498 0.567
LIG_FHA_1 641 647 PF00498 0.466
LIG_FHA_1 72 78 PF00498 0.646
LIG_FHA_2 187 193 PF00498 0.666
LIG_FHA_2 233 239 PF00498 0.687
LIG_FHA_2 264 270 PF00498 0.502
LIG_FHA_2 522 528 PF00498 0.535
LIG_FHA_2 584 590 PF00498 0.454
LIG_FXI_DFP_1 499 503 PF00024 0.419
LIG_LIR_Gen_1 382 391 PF02991 0.306
LIG_LIR_Gen_1 421 431 PF02991 0.576
LIG_LIR_Gen_1 458 466 PF02991 0.348
LIG_LIR_Gen_1 482 492 PF02991 0.439
LIG_LIR_LC3C_4 643 648 PF02991 0.353
LIG_LIR_Nem_3 106 111 PF02991 0.530
LIG_LIR_Nem_3 421 427 PF02991 0.571
LIG_LIR_Nem_3 428 433 PF02991 0.461
LIG_LIR_Nem_3 458 464 PF02991 0.359
LIG_LIR_Nem_3 482 487 PF02991 0.436
LIG_LIR_Nem_3 500 505 PF02991 0.266
LIG_LIR_Nem_3 539 545 PF02991 0.485
LIG_Pex14_1 285 289 PF04695 0.495
LIG_Pex14_2 571 575 PF04695 0.426
LIG_PTB_Apo_2 478 485 PF02174 0.413
LIG_SH2_CRK 542 546 PF00017 0.548
LIG_SH2_GRB2like 385 388 PF00017 0.307
LIG_SH2_PTP2 430 433 PF00017 0.357
LIG_SH2_SRC 289 292 PF00017 0.514
LIG_SH2_STAP1 341 345 PF00017 0.440
LIG_SH2_STAP1 385 389 PF00017 0.302
LIG_SH2_STAP1 505 509 PF00017 0.447
LIG_SH2_STAT3 465 468 PF00017 0.395
LIG_SH2_STAT3 594 597 PF00017 0.308
LIG_SH2_STAT5 155 158 PF00017 0.702
LIG_SH2_STAT5 270 273 PF00017 0.463
LIG_SH2_STAT5 385 388 PF00017 0.330
LIG_SH2_STAT5 430 433 PF00017 0.357
LIG_SH2_STAT5 465 468 PF00017 0.555
LIG_SH2_STAT5 505 508 PF00017 0.400
LIG_SH2_STAT5 53 56 PF00017 0.341
LIG_SH2_STAT5 594 597 PF00017 0.432
LIG_SH3_3 128 134 PF00018 0.536
LIG_SH3_3 313 319 PF00018 0.666
LIG_SH3_3 433 439 PF00018 0.401
LIG_SH3_3 74 80 PF00018 0.661
LIG_SUMO_SIM_anti_2 432 437 PF11976 0.409
LIG_SUMO_SIM_anti_2 599 606 PF11976 0.423
LIG_SUMO_SIM_par_1 373 378 PF11976 0.387
LIG_SUMO_SIM_par_1 494 501 PF11976 0.406
LIG_SUMO_SIM_par_1 532 541 PF11976 0.460
LIG_SUMO_SIM_par_1 634 639 PF11976 0.453
LIG_SxIP_EBH_1 445 456 PF03271 0.542
LIG_TRAF2_1 524 527 PF00917 0.399
LIG_TRAF2_1 537 540 PF00917 0.427
LIG_UBA3_1 255 263 PF00899 0.495
LIG_WRC_WIRS_1 572 577 PF05994 0.434
MOD_CDC14_SPxK_1 146 149 PF00782 0.677
MOD_CDC14_SPxK_1 257 260 PF00782 0.501
MOD_CDK_SPK_2 143 148 PF00069 0.685
MOD_CDK_SPxK_1 143 149 PF00069 0.684
MOD_CDK_SPxK_1 254 260 PF00069 0.643
MOD_CK1_1 142 148 PF00069 0.688
MOD_CK1_1 227 233 PF00069 0.615
MOD_CK1_1 312 318 PF00069 0.576
MOD_CK1_1 447 453 PF00069 0.443
MOD_CK1_1 574 580 PF00069 0.562
MOD_CK1_1 650 656 PF00069 0.359
MOD_CK1_1 91 97 PF00069 0.584
MOD_CK2_1 148 154 PF00069 0.565
MOD_CK2_1 186 192 PF00069 0.664
MOD_CK2_1 207 213 PF00069 0.566
MOD_CK2_1 232 238 PF00069 0.686
MOD_CK2_1 263 269 PF00069 0.589
MOD_CK2_1 417 423 PF00069 0.455
MOD_CK2_1 521 527 PF00069 0.539
MOD_CK2_1 535 541 PF00069 0.410
MOD_CK2_1 583 589 PF00069 0.451
MOD_GlcNHglycan 127 130 PF01048 0.583
MOD_GlcNHglycan 141 144 PF01048 0.665
MOD_GlcNHglycan 219 222 PF01048 0.571
MOD_GlcNHglycan 295 298 PF01048 0.690
MOD_GlcNHglycan 319 322 PF01048 0.641
MOD_GlcNHglycan 4 7 PF01048 0.573
MOD_GlcNHglycan 405 408 PF01048 0.421
MOD_GlcNHglycan 427 430 PF01048 0.311
MOD_GlcNHglycan 467 471 PF01048 0.407
MOD_GlcNHglycan 612 615 PF01048 0.424
MOD_GlcNHglycan 86 89 PF01048 0.656
MOD_GlcNHglycan 94 97 PF01048 0.609
MOD_GSK3_1 125 132 PF00069 0.579
MOD_GSK3_1 139 146 PF00069 0.670
MOD_GSK3_1 157 164 PF00069 0.511
MOD_GSK3_1 181 188 PF00069 0.632
MOD_GSK3_1 190 197 PF00069 0.712
MOD_GSK3_1 23 30 PF00069 0.477
MOD_GSK3_1 379 386 PF00069 0.511
MOD_GSK3_1 444 451 PF00069 0.470
MOD_GSK3_1 455 462 PF00069 0.534
MOD_GSK3_1 605 612 PF00069 0.425
MOD_GSK3_1 623 630 PF00069 0.290
MOD_GSK3_1 71 78 PF00069 0.639
MOD_GSK3_1 84 91 PF00069 0.551
MOD_N-GLC_1 200 205 PF02516 0.538
MOD_N-GLC_1 605 610 PF02516 0.531
MOD_NEK2_1 161 166 PF00069 0.586
MOD_NEK2_1 190 195 PF00069 0.683
MOD_NEK2_1 2 7 PF00069 0.589
MOD_NEK2_1 219 224 PF00069 0.535
MOD_NEK2_1 225 230 PF00069 0.528
MOD_NEK2_1 28 33 PF00069 0.464
MOD_NEK2_1 383 388 PF00069 0.507
MOD_NEK2_1 390 395 PF00069 0.488
MOD_NEK2_1 425 430 PF00069 0.309
MOD_NEK2_1 571 576 PF00069 0.427
MOD_NEK2_1 623 628 PF00069 0.543
MOD_NEK2_1 640 645 PF00069 0.463
MOD_NEK2_2 379 384 PF00069 0.433
MOD_PIKK_1 161 167 PF00454 0.541
MOD_PIKK_1 194 200 PF00454 0.541
MOD_PIKK_1 444 450 PF00454 0.312
MOD_PIKK_1 89 95 PF00454 0.532
MOD_PKA_1 148 154 PF00069 0.657
MOD_PKA_2 148 154 PF00069 0.657
MOD_PKA_2 2 8 PF00069 0.591
MOD_PKA_2 329 335 PF00069 0.567
MOD_PKA_2 35 41 PF00069 0.439
MOD_PKA_2 358 364 PF00069 0.411
MOD_PKA_2 418 424 PF00069 0.432
MOD_PKA_2 455 461 PF00069 0.484
MOD_PKA_2 503 509 PF00069 0.535
MOD_PKA_2 609 615 PF00069 0.429
MOD_Plk_1 341 347 PF00069 0.433
MOD_Plk_2-3 535 541 PF00069 0.493
MOD_Plk_4 157 163 PF00069 0.533
MOD_Plk_4 371 377 PF00069 0.433
MOD_Plk_4 379 385 PF00069 0.454
MOD_Plk_4 460 466 PF00069 0.454
MOD_Plk_4 492 498 PF00069 0.546
MOD_ProDKin_1 103 109 PF00069 0.531
MOD_ProDKin_1 130 136 PF00069 0.668
MOD_ProDKin_1 143 149 PF00069 0.574
MOD_ProDKin_1 246 252 PF00069 0.650
MOD_ProDKin_1 254 260 PF00069 0.567
MOD_ProDKin_1 312 318 PF00069 0.646
MOD_ProDKin_1 71 77 PF00069 0.632
TRG_DiLeu_BaEn_4 540 546 PF01217 0.512
TRG_DiLeu_BaLyEn_6 450 455 PF01217 0.289
TRG_ENDOCYTIC_2 385 388 PF00928 0.468
TRG_ENDOCYTIC_2 430 433 PF00928 0.454
TRG_ENDOCYTIC_2 505 508 PF00928 0.406
TRG_ENDOCYTIC_2 542 545 PF00928 0.475
TRG_ER_diArg_1 147 149 PF00400 0.674
TRG_ER_diArg_1 322 324 PF00400 0.548
TRG_ER_diArg_1 356 359 PF00400 0.444
TRG_ER_diArg_1 394 396 PF00400 0.422
TRG_Pf-PMV_PEXEL_1 8 12 PF00026 0.431

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ITL0 Leishmania donovani 28% 100%
A0A451EJJ7 Leishmania donovani 83% 100%
A4HRQ8 Leishmania infantum 82% 100%
A4I8D9 Leishmania infantum 28% 100%
E9ACD7 Leishmania major 82% 100%
E9AJM5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
E9B397 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
Q4Q4V8 Leishmania major 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS