WD domain, G-beta repeat family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3F3_LEIBR

TriTrypDb:

LbrM.02.0600 , LBRM2903_020011900

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3F3

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0006448	regulation of translational elongation	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0017182	peptidyl-diphthamide metabolic process	7	1
GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018202	peptidyl-histidine modification	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1900247	regulation of cytoplasmic translational elongation	8	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0052689	carboxylic ester hydrolase activity	4	1
GO:0061685	diphthine methylesterase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.785
CLV_C14_Caspase3-7	39	43	PF00656	0.499
CLV_C14_Caspase3-7	85	89	PF00656	0.750
CLV_NRD_NRD_1	220	222	PF00675	0.396
CLV_NRD_NRD_1	353	355	PF00675	0.580
CLV_NRD_NRD_1	58	60	PF00675	0.528
CLV_PCSK_KEX2_1	16	18	PF00082	0.420
CLV_PCSK_KEX2_1	220	222	PF00082	0.386
CLV_PCSK_KEX2_1	353	355	PF00082	0.478
CLV_PCSK_KEX2_1	416	418	PF00082	0.705
CLV_PCSK_KEX2_1	532	534	PF00082	0.430
CLV_PCSK_KEX2_1	58	60	PF00082	0.405
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.313
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.754
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.309
CLV_PCSK_SKI1_1	371	375	PF00082	0.551
DEG_APCC_DBOX_1	58	66	PF00400	0.582
DEG_SCF_TRCP1_1	378	384	PF00400	0.689
DOC_CDC14_PxL_1	30	38	PF14671	0.368
DOC_CKS1_1	21	26	PF01111	0.458
DOC_CYCLIN_RxL_1	368	378	PF00134	0.563
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.365
DOC_MAPK_gen_1	368	376	PF00069	0.600
DOC_MAPK_gen_1	58	64	PF00069	0.537
DOC_PP1_RVXF_1	501	508	PF00149	0.393
DOC_PP2B_LxvP_1	31	34	PF13499	0.582
DOC_PP2B_LxvP_1	435	438	PF13499	0.385
DOC_USP7_MATH_1	254	258	PF00917	0.585
DOC_USP7_MATH_1	274	278	PF00917	0.711
DOC_USP7_MATH_1	381	385	PF00917	0.700
DOC_USP7_MATH_1	46	50	PF00917	0.726
DOC_USP7_MATH_1	473	477	PF00917	0.657
DOC_USP7_MATH_1	480	484	PF00917	0.714
DOC_USP7_MATH_1	525	529	PF00917	0.476
DOC_USP7_MATH_1	84	88	PF00917	0.713
DOC_WW_Pin1_4	173	178	PF00397	0.591
DOC_WW_Pin1_4	197	202	PF00397	0.511
DOC_WW_Pin1_4	20	25	PF00397	0.496
DOC_WW_Pin1_4	248	253	PF00397	0.648
DOC_WW_Pin1_4	314	319	PF00397	0.479
DOC_WW_Pin1_4	329	334	PF00397	0.535
DOC_WW_Pin1_4	48	53	PF00397	0.565
DOC_WW_Pin1_4	72	77	PF00397	0.554
LIG_14-3-3_CanoR_1	124	133	PF00244	0.587
LIG_14-3-3_CanoR_1	17	22	PF00244	0.500
LIG_14-3-3_CanoR_1	323	333	PF00244	0.399
LIG_14-3-3_CanoR_1	411	418	PF00244	0.709
LIG_14-3-3_CanoR_1	452	459	PF00244	0.593
LIG_BRCT_BRCA1_1	139	143	PF00533	0.553
LIG_BRCT_BRCA1_1	60	64	PF00533	0.314
LIG_DLG_GKlike_1	58	65	PF00625	0.336
LIG_FHA_1	124	130	PF00498	0.593
LIG_FHA_1	198	204	PF00498	0.552
LIG_FHA_1	207	213	PF00498	0.317
LIG_FHA_1	234	240	PF00498	0.457
LIG_FHA_1	309	315	PF00498	0.531
LIG_FHA_1	330	336	PF00498	0.407
LIG_FHA_1	429	435	PF00498	0.532
LIG_FHA_1	489	495	PF00498	0.454
LIG_FHA_2	261	267	PF00498	0.698
LIG_FHA_2	305	311	PF00498	0.340
LIG_FHA_2	337	343	PF00498	0.282
LIG_FHA_2	487	493	PF00498	0.607
LIG_LIR_Gen_1	287	294	PF02991	0.538
LIG_LIR_Gen_1	332	340	PF02991	0.420
LIG_LIR_Nem_3	140	146	PF02991	0.365
LIG_LIR_Nem_3	287	293	PF02991	0.538
LIG_LIR_Nem_3	332	337	PF02991	0.431
LIG_MLH1_MIPbox_1	139	143	PF16413	0.553
LIG_NRBOX	398	404	PF00104	0.683
LIG_REV1ctd_RIR_1	140	147	PF16727	0.376
LIG_SH2_CRK	104	108	PF00017	0.497
LIG_SH2_CRK	290	294	PF00017	0.540
LIG_SH2_NCK_1	215	219	PF00017	0.488
LIG_SH2_SRC	215	218	PF00017	0.514
LIG_SH2_STAP1	449	453	PF00017	0.559
LIG_SH2_STAP1	497	501	PF00017	0.391
LIG_SH2_STAP1	530	534	PF00017	0.514
LIG_SH2_STAT5	290	293	PF00017	0.540
LIG_SH2_STAT5	334	337	PF00017	0.442
LIG_SH2_STAT5	468	471	PF00017	0.467
LIG_SH2_STAT5	53	56	PF00017	0.480
LIG_SH3_3	166	172	PF00018	0.525
LIG_SH3_3	175	181	PF00018	0.532
LIG_SH3_3	18	24	PF00018	0.513
LIG_SH3_3	246	252	PF00018	0.606
LIG_SH3_3	31	37	PF00018	0.554
LIG_SH3_3	412	418	PF00018	0.497
LIG_SH3_3	498	504	PF00018	0.489
LIG_SH3_3	78	84	PF00018	0.685
LIG_SUMO_SIM_anti_2	342	348	PF11976	0.479
LIG_SUMO_SIM_par_1	171	176	PF11976	0.462
LIG_SUMO_SIM_par_1	310	317	PF11976	0.490
LIG_SUMO_SIM_par_1	345	351	PF11976	0.532
LIG_TRAF2_1	454	457	PF00917	0.537
LIG_TYR_ITSM	330	337	PF00017	0.504
MOD_CK1_1	134	140	PF00069	0.456
MOD_CK1_1	20	26	PF00069	0.412
MOD_CK1_1	206	212	PF00069	0.482
MOD_CK1_1	45	51	PF00069	0.715
MOD_CK1_1	6	12	PF00069	0.490
MOD_CK1_1	87	93	PF00069	0.636
MOD_CK2_1	260	266	PF00069	0.748
MOD_CK2_1	336	342	PF00069	0.391
MOD_CK2_1	451	457	PF00069	0.543
MOD_CK2_1	473	479	PF00069	0.631
MOD_CK2_1	525	531	PF00069	0.498
MOD_GlcNHglycan	126	129	PF01048	0.473
MOD_GlcNHglycan	136	139	PF01048	0.495
MOD_GlcNHglycan	149	152	PF01048	0.657
MOD_GlcNHglycan	205	208	PF01048	0.448
MOD_GlcNHglycan	245	248	PF01048	0.582
MOD_GlcNHglycan	256	259	PF01048	0.761
MOD_GlcNHglycan	276	279	PF01048	0.536
MOD_GlcNHglycan	283	286	PF01048	0.339
MOD_GlcNHglycan	378	381	PF01048	0.699
MOD_GlcNHglycan	404	407	PF01048	0.655
MOD_GlcNHglycan	44	47	PF01048	0.723
MOD_GlcNHglycan	453	456	PF01048	0.604
MOD_GlcNHglycan	48	51	PF01048	0.732
MOD_GlcNHglycan	482	485	PF01048	0.591
MOD_GlcNHglycan	5	8	PF01048	0.548
MOD_GlcNHglycan	518	522	PF01048	0.612
MOD_GSK3_1	134	141	PF00069	0.564
MOD_GSK3_1	298	305	PF00069	0.612
MOD_GSK3_1	308	315	PF00069	0.517
MOD_GSK3_1	325	332	PF00069	0.504
MOD_GSK3_1	336	343	PF00069	0.404
MOD_GSK3_1	38	45	PF00069	0.669
MOD_GSK3_1	482	489	PF00069	0.645
MOD_GSK3_1	65	72	PF00069	0.439
MOD_N-GLC_1	254	259	PF02516	0.532
MOD_N-GLC_1	260	265	PF02516	0.506
MOD_N-GLC_1	397	402	PF02516	0.686
MOD_N-GLC_1	422	427	PF02516	0.660
MOD_NEK2_1	142	147	PF00069	0.616
MOD_NEK2_1	189	194	PF00069	0.414
MOD_NEK2_1	203	208	PF00069	0.179
MOD_NEK2_1	25	30	PF00069	0.283
MOD_NEK2_1	281	286	PF00069	0.498
MOD_NEK2_1	293	298	PF00069	0.554
MOD_NEK2_1	336	341	PF00069	0.438
MOD_NEK2_1	376	381	PF00069	0.669
MOD_NEK2_1	402	407	PF00069	0.659
MOD_NEK2_1	5	10	PF00069	0.507
MOD_NEK2_1	71	76	PF00069	0.545
MOD_NEK2_2	525	530	PF00069	0.496
MOD_OFUCOSY	419	426	PF10250	0.455
MOD_PK_1	17	23	PF00069	0.554
MOD_PKA_1	58	64	PF00069	0.344
MOD_PKA_2	123	129	PF00069	0.608
MOD_PKA_2	274	280	PF00069	0.663
MOD_PKA_2	367	373	PF00069	0.445
MOD_PKA_2	410	416	PF00069	0.610
MOD_PKA_2	451	457	PF00069	0.609
MOD_PKA_2	58	64	PF00069	0.344
MOD_PKB_1	306	314	PF00069	0.321
MOD_Plk_1	397	403	PF00069	0.684
MOD_Plk_2-3	342	348	PF00069	0.533
MOD_Plk_4	138	144	PF00069	0.587
MOD_Plk_4	397	403	PF00069	0.684
MOD_Plk_4	525	531	PF00069	0.407
MOD_ProDKin_1	173	179	PF00069	0.587
MOD_ProDKin_1	197	203	PF00069	0.498
MOD_ProDKin_1	20	26	PF00069	0.493
MOD_ProDKin_1	248	254	PF00069	0.652
MOD_ProDKin_1	314	320	PF00069	0.483
MOD_ProDKin_1	329	335	PF00069	0.525
MOD_ProDKin_1	48	54	PF00069	0.561
MOD_ProDKin_1	72	78	PF00069	0.564
MOD_SUMO_rev_2	413	418	PF00179	0.645
MOD_SUMO_rev_2	8	18	PF00179	0.549
TRG_DiLeu_BaEn_1	342	347	PF01217	0.404
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.350
TRG_ENDOCYTIC_2	104	107	PF00928	0.488
TRG_ENDOCYTIC_2	290	293	PF00928	0.540
TRG_ENDOCYTIC_2	334	337	PF00928	0.416
TRG_ER_diArg_1	220	222	PF00400	0.393
TRG_ER_diArg_1	306	309	PF00400	0.550
TRG_ER_diArg_1	352	354	PF00400	0.576
TRG_ER_diArg_1	58	60	PF00400	0.613
TRG_Pf-PMV_PEXEL_1	183	188	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHU3	Leptomonas seymouri	50%	100%
A0A1X0NJL9	Trypanosomatidae	29%	100%
A0A3R7NH89	Trypanosoma rangeli	33%	100%
A0A3S7WNM2	Leishmania donovani	75%	96%
A4HRQ7	Leishmania infantum	75%	96%
C9ZJ47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ACD6	Leishmania major	72%	100%
E9AJM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	94%
V5BER3	Trypanosoma cruzi	28%	100%