Putative ARP2/3 complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ARP2/3 complex subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H3F1_LEIBR

TriTrypDb:

LbrM.02.0580 , LBRM2903_020011700

Length:

223

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0005885	Arp2/3 protein complex	2	9
GO:0032991	protein-containing complex	1	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4H3F1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3F1

Function

Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	9
GO:0008064	regulation of actin polymerization or depolymerization	6	9
GO:0008154	actin polymerization or depolymerization	6	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0022607	cellular component assembly	4	9
GO:0030041	actin filament polymerization	7	9
GO:0030832	regulation of actin filament length	5	9
GO:0030833	regulation of actin filament polymerization	7	9
GO:0032271	regulation of protein polymerization	6	9
GO:0032535	regulation of cellular component size	4	9
GO:0032956	regulation of actin cytoskeleton organization	5	9
GO:0032970	regulation of actin filament-based process	4	9
GO:0033043	regulation of organelle organization	5	9
GO:0034314	Arp2/3 complex-mediated actin nucleation	7	9
GO:0043254	regulation of protein-containing complex assembly	5	9
GO:0043933	protein-containing complex organization	4	9
GO:0044087	regulation of cellular component biogenesis	4	9
GO:0045010	actin nucleation	6	9
GO:0050789	regulation of biological process	2	9
GO:0050794	regulation of cellular process	3	9
GO:0051128	regulation of cellular component organization	4	9
GO:0051258	protein polymerization	6	9
GO:0051493	regulation of cytoskeleton organization	6	9
GO:0065003	protein-containing complex assembly	5	9
GO:0065007	biological regulation	1	9
GO:0065008	regulation of biological quality	2	9
GO:0071840	cellular component organization or biogenesis	2	9
GO:0090066	regulation of anatomical structure size	3	9
GO:0097435	supramolecular fiber organization	4	9
GO:0110053	regulation of actin filament organization	6	9
GO:1902903	regulation of supramolecular fiber organization	5	9

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	3
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0008092	cytoskeletal protein binding	3	3
GO:0044877	protein-containing complex binding	2	1
GO:0051015	actin filament binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.538
CLV_PCSK_SKI1_1	136	140	PF00082	0.171
CLV_PCSK_SKI1_1	14	18	PF00082	0.330
DEG_APCC_DBOX_1	13	21	PF00400	0.484
DEG_COP1_1	27	38	PF00400	0.440
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.432
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.346
DOC_MAPK_MEF2A_6	14	22	PF00069	0.432
DOC_PP1_RVXF_1	88	94	PF00149	0.416
DOC_PP4_FxxP_1	206	209	PF00568	0.602
DOC_USP7_MATH_1	201	205	PF00917	0.417
DOC_USP7_MATH_1	61	65	PF00917	0.393
DOC_WW_Pin1_4	39	44	PF00397	0.448
DOC_WW_Pin1_4	47	52	PF00397	0.445
LIG_14-3-3_CanoR_1	169	173	PF00244	0.500
LIG_14-3-3_CanoR_1	174	180	PF00244	0.496
LIG_14-3-3_CanoR_1	90	94	PF00244	0.429
LIG_BIR_II_1	1	5	PF00653	0.432
LIG_BIR_III_2	48	52	PF00653	0.539
LIG_BRCT_BRCA1_1	91	95	PF00533	0.422
LIG_eIF4E_1	153	159	PF01652	0.429
LIG_FHA_1	105	111	PF00498	0.496
LIG_FHA_1	122	128	PF00498	0.496
LIG_FHA_1	13	19	PF00498	0.522
LIG_FHA_2	43	49	PF00498	0.391
LIG_LIR_Apic_2	204	209	PF02991	0.389
LIG_LIR_Gen_1	111	117	PF02991	0.481
LIG_LIR_Gen_1	154	164	PF02991	0.484
LIG_LIR_Nem_3	111	116	PF02991	0.481
LIG_LIR_Nem_3	154	160	PF02991	0.484
LIG_LIR_Nem_3	204	208	PF02991	0.432
LIG_LIR_Nem_3	50	55	PF02991	0.371
LIG_Pex14_2	175	179	PF04695	0.410
LIG_SH2_NCK_1	9	13	PF00017	0.484
LIG_SH2_STAP1	153	157	PF00017	0.429
LIG_SH2_STAT5	113	116	PF00017	0.422
LIG_SH2_STAT5	44	47	PF00017	0.371
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.470
LIG_TRAF2_2	209	214	PF00917	0.402
LIG_TYR_ITIM	7	12	PF00017	0.410
LIG_WRC_WIRS_1	176	181	PF05994	0.410
LIG_WRC_WIRS_1	22	27	PF05994	0.484
MOD_CK1_1	193	199	PF00069	0.407
MOD_CK1_1	204	210	PF00069	0.435
MOD_CK1_1	24	30	PF00069	0.485
MOD_CK1_1	42	48	PF00069	0.474
MOD_CK1_1	64	70	PF00069	0.371
MOD_CK1_1	85	91	PF00069	0.454
MOD_CK2_1	73	79	PF00069	0.460
MOD_GlcNHglycan	196	199	PF01048	0.201
MOD_GlcNHglycan	75	78	PF01048	0.284
MOD_GSK3_1	104	111	PF00069	0.400
MOD_GSK3_1	190	197	PF00069	0.549
MOD_GSK3_1	57	64	PF00069	0.493
MOD_GSK3_1	82	89	PF00069	0.444
MOD_N-GLC_1	194	199	PF02516	0.171
MOD_N-GLC_1	86	91	PF02516	0.180
MOD_NEK2_1	116	121	PF00069	0.518
MOD_NEK2_1	175	180	PF00069	0.416
MOD_NEK2_1	190	195	PF00069	0.400
MOD_NEK2_1	72	77	PF00069	0.485
MOD_NEK2_1	86	91	PF00069	0.431
MOD_NEK2_2	201	206	PF00069	0.378
MOD_PIKK_1	104	110	PF00454	0.432
MOD_PKA_2	168	174	PF00069	0.402
MOD_PKA_2	89	95	PF00069	0.429
MOD_Plk_1	12	18	PF00069	0.496
MOD_Plk_1	153	159	PF00069	0.429
MOD_Plk_1	183	189	PF00069	0.401
MOD_Plk_1	61	67	PF00069	0.397
MOD_Plk_1	86	92	PF00069	0.460
MOD_Plk_4	153	159	PF00069	0.484
MOD_Plk_4	175	181	PF00069	0.440
MOD_Plk_4	201	207	PF00069	0.371
MOD_Plk_4	89	95	PF00069	0.485
MOD_ProDKin_1	39	45	PF00069	0.448
MOD_ProDKin_1	47	53	PF00069	0.445
TRG_DiLeu_BaEn_1	13	18	PF01217	0.432
TRG_ENDOCYTIC_2	113	116	PF00928	0.454
TRG_ENDOCYTIC_2	9	12	PF00928	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAU0	Leptomonas seymouri	45%	100%
A0A0S4KGM1	Bodo saltans	27%	100%
A0A1X0NJU3	Trypanosomatidae	29%	100%
A0A3R7MB12	Trypanosoma rangeli	26%	100%
A0A451EJJ5	Leishmania donovani	72%	100%
A4HRQ5	Leishmania infantum	71%	100%
C9ZJ46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AJM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
F4JUL9	Arabidopsis thaliana	28%	100%
O96625	Dictyostelium discoideum	25%	100%
P58798	Caenorhabditis elegans	28%	100%
P59998	Homo sapiens	28%	100%
P59999	Mus musculus	28%	100%
Q148J6	Bos taurus	28%	100%
Q19R45	Leishmania major	67%	100%
Q641G7	Xenopus laevis	28%	100%
Q92352	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%