TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4H3F0_LEIBR

TriTrypDb:

LbrM.02.0570 , LBRM2903_020011600

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3F0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3F0

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	10
GO:0009987	cellular process	1	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0030544	Hsp70 protein binding	4	10
GO:0031072	heat shock protein binding	3	10
GO:0051879	Hsp90 protein binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.341
CLV_C14_Caspase3-7	428	432	PF00656	0.511
CLV_NRD_NRD_1	287	289	PF00675	0.603
CLV_NRD_NRD_1	319	321	PF00675	0.534
CLV_NRD_NRD_1	340	342	PF00675	0.562
CLV_NRD_NRD_1	422	424	PF00675	0.630
CLV_NRD_NRD_1	467	469	PF00675	0.704
CLV_NRD_NRD_1	517	519	PF00675	0.489
CLV_PCSK_KEX2_1	287	289	PF00082	0.623
CLV_PCSK_KEX2_1	319	321	PF00082	0.534
CLV_PCSK_KEX2_1	339	341	PF00082	0.582
CLV_PCSK_KEX2_1	353	355	PF00082	0.588
CLV_PCSK_KEX2_1	422	424	PF00082	0.630
CLV_PCSK_KEX2_1	466	468	PF00082	0.706
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.431
CLV_PCSK_SKI1_1	101	105	PF00082	0.809
CLV_PCSK_SKI1_1	288	292	PF00082	0.408
CLV_PCSK_SKI1_1	382	386	PF00082	0.721
CLV_PCSK_SKI1_1	48	52	PF00082	0.687
CLV_PCSK_SKI1_1	7	11	PF00082	0.552
DEG_APCC_KENBOX_2	145	149	PF00400	0.278
DEG_COP1_1	292	304	PF00400	0.449
DEG_SPOP_SBC_1	402	406	PF00917	0.501
DEG_SPOP_SBC_1	96	100	PF00917	0.636
DOC_CKS1_1	104	109	PF01111	0.600
DOC_CKS1_1	328	333	PF01111	0.518
DOC_PP1_RVXF_1	106	113	PF00149	0.709
DOC_PP1_RVXF_1	223	229	PF00149	0.373
DOC_PP2B_LxvP_1	258	261	PF13499	0.207
DOC_PP4_FxxP_1	104	107	PF00568	0.757
DOC_PP4_FxxP_1	485	488	PF00568	0.663
DOC_SPAK_OSR1_1	375	379	PF12202	0.436
DOC_USP7_MATH_1	176	180	PF00917	0.359
DOC_USP7_MATH_1	322	326	PF00917	0.684
DOC_USP7_MATH_1	401	405	PF00917	0.659
DOC_USP7_MATH_1	408	412	PF00917	0.763
DOC_USP7_MATH_1	488	492	PF00917	0.603
DOC_USP7_MATH_1	502	506	PF00917	0.658
DOC_USP7_MATH_1	55	59	PF00917	0.756
DOC_USP7_MATH_1	97	101	PF00917	0.670
DOC_USP7_MATH_2	496	502	PF00917	0.532
DOC_USP7_UBL2_3	519	523	PF12436	0.429
DOC_WW_Pin1_4	103	108	PF00397	0.616
DOC_WW_Pin1_4	118	123	PF00397	0.708
DOC_WW_Pin1_4	172	177	PF00397	0.360
DOC_WW_Pin1_4	294	299	PF00397	0.550
DOC_WW_Pin1_4	327	332	PF00397	0.600
DOC_WW_Pin1_4	382	387	PF00397	0.645
DOC_WW_Pin1_4	447	452	PF00397	0.697
DOC_WW_Pin1_4	469	474	PF00397	0.644
DOC_WW_Pin1_4	51	56	PF00397	0.702
LIG_14-3-3_CanoR_1	101	107	PF00244	0.753
LIG_14-3-3_CanoR_1	225	229	PF00244	0.413
LIG_14-3-3_CanoR_1	288	298	PF00244	0.570
LIG_14-3-3_CanoR_1	48	53	PF00244	0.699
LIG_14-3-3_CanoR_1	86	91	PF00244	0.502
LIG_14-3-3_CterR_2	518	523	PF00244	0.518
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_FHA_1	134	140	PF00498	0.489
LIG_FHA_1	164	170	PF00498	0.399
LIG_FHA_1	219	225	PF00498	0.506
LIG_FHA_1	295	301	PF00498	0.642
LIG_FHA_1	404	410	PF00498	0.509
LIG_FHA_1	86	92	PF00498	0.721
LIG_FHA_2	1	7	PF00498	0.592
LIG_FHA_2	15	21	PF00498	0.425
LIG_FHA_2	175	181	PF00498	0.351
LIG_FHA_2	310	316	PF00498	0.786
LIG_FHA_2	328	334	PF00498	0.684
LIG_FHA_2	357	363	PF00498	0.674
LIG_LIR_Apic_2	102	107	PF02991	0.674
LIG_LIR_Apic_2	483	488	PF02991	0.736
LIG_LIR_Apic_2	51	55	PF02991	0.510
LIG_LIR_Gen_1	450	457	PF02991	0.490
LIG_LIR_Nem_3	227	232	PF02991	0.410
LIG_LIR_Nem_3	237	242	PF02991	0.343
LIG_LYPXL_SIV_4	196	204	PF13949	0.287
LIG_MYND_1	298	302	PF01753	0.476
LIG_MYND_1	461	465	PF01753	0.685
LIG_Pex14_1	228	232	PF04695	0.290
LIG_RPA_C_Fungi	418	430	PF08784	0.513
LIG_SH2_CRK	52	56	PF00017	0.680
LIG_SH2_GRB2like	190	193	PF00017	0.404
LIG_SH2_NCK_1	52	56	PF00017	0.680
LIG_SH2_STAP1	165	169	PF00017	0.369
LIG_SH2_STAP1	211	215	PF00017	0.459
LIG_SH2_STAP1	252	256	PF00017	0.331
LIG_SH2_STAP1	397	401	PF00017	0.485
LIG_SH2_STAT3	232	235	PF00017	0.290
LIG_SH2_STAT3	368	371	PF00017	0.566
LIG_SH2_STAT5	165	168	PF00017	0.425
LIG_SH2_STAT5	197	200	PF00017	0.356
LIG_SH2_STAT5	239	242	PF00017	0.439
LIG_SH2_STAT5	41	44	PF00017	0.646
LIG_SH3_2	461	466	PF14604	0.688
LIG_SH3_3	325	331	PF00018	0.522
LIG_SH3_3	458	464	PF00018	0.712
LIG_SUMO_SIM_anti_2	182	187	PF11976	0.424
LIG_TRAF2_1	280	283	PF00917	0.518
LIG_WRC_WIRS_1	482	487	PF05994	0.544
LIG_WW_3	463	467	PF00397	0.695
MOD_CDK_SPK_2	103	108	PF00069	0.607
MOD_CK1_1	121	127	PF00069	0.699
MOD_CK1_1	133	139	PF00069	0.570
MOD_CK1_1	191	197	PF00069	0.344
MOD_CK1_1	292	298	PF00069	0.641
MOD_CK1_1	308	314	PF00069	0.796
MOD_CK1_1	34	40	PF00069	0.715
MOD_CK1_1	450	456	PF00069	0.760
MOD_CK1_1	58	64	PF00069	0.654
MOD_CK1_1	77	83	PF00069	0.632
MOD_CK1_1	89	95	PF00069	0.732
MOD_CK1_1	99	105	PF00069	0.632
MOD_CK2_1	176	182	PF00069	0.582
MOD_CK2_1	309	315	PF00069	0.703
MOD_CK2_1	356	362	PF00069	0.611
MOD_Cter_Amidation	337	340	PF01082	0.622
MOD_Cter_Amidation	420	423	PF01082	0.509
MOD_DYRK1A_RPxSP_1	327	331	PF00069	0.521
MOD_GlcNHglycan	132	135	PF01048	0.619
MOD_GlcNHglycan	166	169	PF01048	0.449
MOD_GlcNHglycan	193	196	PF01048	0.285
MOD_GlcNHglycan	205	208	PF01048	0.445
MOD_GlcNHglycan	307	310	PF01048	0.747
MOD_GlcNHglycan	341	344	PF01048	0.691
MOD_GlcNHglycan	410	413	PF01048	0.778
MOD_GlcNHglycan	447	450	PF01048	0.572
MOD_GlcNHglycan	452	455	PF01048	0.670
MOD_GlcNHglycan	490	493	PF01048	0.658
MOD_GlcNHglycan	500	503	PF01048	0.681
MOD_GlcNHglycan	504	507	PF01048	0.691
MOD_GlcNHglycan	65	68	PF01048	0.727
MOD_GlcNHglycan	91	94	PF01048	0.739
MOD_GSK3_1	114	121	PF00069	0.679
MOD_GSK3_1	129	136	PF00069	0.633
MOD_GSK3_1	172	179	PF00069	0.520
MOD_GSK3_1	289	296	PF00069	0.576
MOD_GSK3_1	305	312	PF00069	0.622
MOD_GSK3_1	31	38	PF00069	0.727
MOD_GSK3_1	378	385	PF00069	0.737
MOD_GSK3_1	467	474	PF00069	0.746
MOD_GSK3_1	498	505	PF00069	0.632
MOD_GSK3_1	51	58	PF00069	0.801
MOD_GSK3_1	61	68	PF00069	0.727
MOD_GSK3_1	70	77	PF00069	0.730
MOD_GSK3_1	81	88	PF00069	0.693
MOD_GSK3_1	91	98	PF00069	0.699
MOD_GSK3_1	99	106	PF00069	0.657
MOD_N-GLC_1	191	196	PF02516	0.320
MOD_N-GLC_1	86	91	PF02516	0.751
MOD_NEK2_1	224	229	PF00069	0.543
MOD_NEK2_1	269	274	PF00069	0.452
MOD_NEK2_1	290	295	PF00069	0.592
MOD_NEK2_1	63	68	PF00069	0.642
MOD_NEK2_1	78	83	PF00069	0.524
MOD_NEK2_1	85	90	PF00069	0.660
MOD_PIKK_1	121	127	PF00454	0.802
MOD_PIKK_1	309	315	PF00454	0.534
MOD_PIKK_1	31	37	PF00454	0.706
MOD_PIKK_1	322	328	PF00454	0.692
MOD_PKA_1	339	345	PF00069	0.602
MOD_PKA_1	467	473	PF00069	0.681
MOD_PKA_2	224	230	PF00069	0.433
MOD_PKA_2	339	345	PF00069	0.633
MOD_PKA_2	378	384	PF00069	0.672
MOD_PKA_2	467	473	PF00069	0.720
MOD_PKA_2	74	80	PF00069	0.678
MOD_PKA_2	85	91	PF00069	0.790
MOD_Plk_1	218	224	PF00069	0.492
MOD_Plk_1	86	92	PF00069	0.503
MOD_Plk_4	224	230	PF00069	0.460
MOD_Plk_4	235	241	PF00069	0.368
MOD_Plk_4	296	302	PF00069	0.483
MOD_Plk_4	74	80	PF00069	0.751
MOD_Plk_4	86	92	PF00069	0.513
MOD_ProDKin_1	103	109	PF00069	0.609
MOD_ProDKin_1	118	124	PF00069	0.708
MOD_ProDKin_1	172	178	PF00069	0.357
MOD_ProDKin_1	294	300	PF00069	0.555
MOD_ProDKin_1	327	333	PF00069	0.598
MOD_ProDKin_1	382	388	PF00069	0.646
MOD_ProDKin_1	447	453	PF00069	0.699
MOD_ProDKin_1	469	475	PF00069	0.642
MOD_ProDKin_1	51	57	PF00069	0.703
MOD_SUMO_for_1	352	355	PF00179	0.504
TRG_ENDOCYTIC_2	239	242	PF00928	0.375
TRG_ER_diArg_1	286	288	PF00400	0.609
TRG_ER_diArg_1	318	320	PF00400	0.518
TRG_ER_diArg_1	339	341	PF00400	0.582
TRG_ER_diArg_1	376	379	PF00400	0.600
TRG_ER_diArg_1	422	424	PF00400	0.624
TRG_ER_diArg_1	465	468	PF00400	0.703
TRG_ER_diArg_1	515	518	PF00400	0.483
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0B2	Leptomonas seymouri	45%	93%
A0A1X0NJW2	Trypanosomatidae	32%	100%
A0A3S5H509	Leishmania donovani	73%	100%
A4HRQ4	Leishmania infantum	73%	100%
C9ZJ44	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ACD3	Leishmania major	72%	98%
E9AJM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
V5B5N7	Trypanosoma cruzi	32%	100%