Retrotransposable element SLACS

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Retrotransposable element SLACS

Species:

Leishmania braziliensis

UniProt:

A4H3E8_LEIBR

TriTrypDb:

LbrM.02.0550 , LBRM2903_160010900 , LBRM2903_160011000

Length:

1148

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3E8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3E8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0003964	RNA-directed DNA polymerase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034061	DNA polymerase activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1090	1094	PF00656	0.489
CLV_C14_Caspase3-7	550	554	PF00656	0.677
CLV_NRD_NRD_1	1145	1147	PF00675	0.744
CLV_NRD_NRD_1	137	139	PF00675	0.410
CLV_NRD_NRD_1	454	456	PF00675	0.562
CLV_NRD_NRD_1	498	500	PF00675	0.665
CLV_NRD_NRD_1	502	504	PF00675	0.631
CLV_NRD_NRD_1	55	57	PF00675	0.640
CLV_NRD_NRD_1	567	569	PF00675	0.529
CLV_NRD_NRD_1	648	650	PF00675	0.836
CLV_NRD_NRD_1	667	669	PF00675	0.371
CLV_NRD_NRD_1	670	672	PF00675	0.548
CLV_NRD_NRD_1	918	920	PF00675	0.433
CLV_PCSK_FUR_1	452	456	PF00082	0.694
CLV_PCSK_FUR_1	668	672	PF00082	0.560
CLV_PCSK_KEX2_1	1145	1147	PF00082	0.753
CLV_PCSK_KEX2_1	137	139	PF00082	0.410
CLV_PCSK_KEX2_1	3	5	PF00082	0.571
CLV_PCSK_KEX2_1	454	456	PF00082	0.564
CLV_PCSK_KEX2_1	498	500	PF00082	0.688
CLV_PCSK_KEX2_1	517	519	PF00082	0.480
CLV_PCSK_KEX2_1	55	57	PF00082	0.640
CLV_PCSK_KEX2_1	648	650	PF00082	0.830
CLV_PCSK_KEX2_1	667	669	PF00082	0.345
CLV_PCSK_KEX2_1	670	672	PF00082	0.500
CLV_PCSK_KEX2_1	740	742	PF00082	0.633
CLV_PCSK_KEX2_1	918	920	PF00082	0.433
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.597
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.694
CLV_PCSK_PC1ET2_1	740	742	PF00082	0.633
CLV_PCSK_SKI1_1	137	141	PF00082	0.452
CLV_PCSK_SKI1_1	608	612	PF00082	0.599
CLV_PCSK_SKI1_1	670	674	PF00082	0.598
CLV_PCSK_SKI1_1	686	690	PF00082	0.557
CLV_PCSK_SKI1_1	755	759	PF00082	0.421
CLV_PCSK_SKI1_1	809	813	PF00082	0.433
CLV_PCSK_SKI1_1	834	838	PF00082	0.433
CLV_PCSK_SKI1_1	886	890	PF00082	0.440
CLV_Separin_Metazoa	1061	1065	PF03568	0.513
CLV_Separin_Metazoa	469	473	PF03568	0.697
CLV_Separin_Metazoa	603	607	PF03568	0.630
DEG_APCC_DBOX_1	669	677	PF00400	0.639
DEG_APCC_DBOX_1	754	762	PF00400	0.419
DEG_Nend_Nbox_1	1	3	PF02207	0.500
DOC_ANK_TNKS_1	743	750	PF00023	0.520
DOC_CKS1_1	523	528	PF01111	0.758
DOC_CKS1_1	536	541	PF01111	0.780
DOC_CKS1_1	721	726	PF01111	0.647
DOC_CKS1_1	810	815	PF01111	0.433
DOC_CYCLIN_RxL_1	108	120	PF00134	0.373
DOC_CYCLIN_RxL_1	594	603	PF00134	0.625
DOC_MAPK_DCC_7	1004	1013	PF00069	0.404
DOC_MAPK_DCC_7	1072	1081	PF00069	0.496
DOC_MAPK_DCC_7	234	243	PF00069	0.496
DOC_MAPK_DCC_7	930	940	PF00069	0.365
DOC_MAPK_gen_1	667	678	PF00069	0.557
DOC_MAPK_gen_1	730	739	PF00069	0.539
DOC_MAPK_gen_1	927	935	PF00069	0.365
DOC_MAPK_MEF2A_6	1072	1081	PF00069	0.496
DOC_MAPK_MEF2A_6	234	243	PF00069	0.540
DOC_PP1_RVXF_1	1076	1082	PF00149	0.434
DOC_PP2B_LxvP_1	116	119	PF13499	0.529
DOC_PP2B_LxvP_1	757	760	PF13499	0.469
DOC_USP7_MATH_1	1019	1023	PF00917	0.496
DOC_USP7_MATH_1	11	15	PF00917	0.738
DOC_USP7_MATH_1	1122	1126	PF00917	0.455
DOC_USP7_MATH_1	265	269	PF00917	0.510
DOC_USP7_MATH_1	32	36	PF00917	0.529
DOC_USP7_MATH_1	696	700	PF00917	0.574
DOC_USP7_MATH_1	71	75	PF00917	0.483
DOC_USP7_MATH_1	860	864	PF00917	0.440
DOC_USP7_MATH_1	996	1000	PF00917	0.404
DOC_WW_Pin1_4	1123	1128	PF00397	0.498
DOC_WW_Pin1_4	118	123	PF00397	0.412
DOC_WW_Pin1_4	380	385	PF00397	0.761
DOC_WW_Pin1_4	50	55	PF00397	0.651
DOC_WW_Pin1_4	522	527	PF00397	0.731
DOC_WW_Pin1_4	532	537	PF00397	0.661
DOC_WW_Pin1_4	57	62	PF00397	0.586
DOC_WW_Pin1_4	627	632	PF00397	0.867
DOC_WW_Pin1_4	720	725	PF00397	0.641
DOC_WW_Pin1_4	802	807	PF00397	0.593
DOC_WW_Pin1_4	809	814	PF00397	0.433
DOC_WW_Pin1_4	933	938	PF00397	0.462
LIG_14-3-3_CanoR_1	1072	1079	PF00244	0.447
LIG_14-3-3_CanoR_1	1084	1091	PF00244	0.448
LIG_14-3-3_CanoR_1	1101	1107	PF00244	0.320
LIG_14-3-3_CanoR_1	351	355	PF00244	0.760
LIG_14-3-3_CanoR_1	483	492	PF00244	0.600
LIG_14-3-3_CanoR_1	518	526	PF00244	0.747
LIG_14-3-3_CanoR_1	648	657	PF00244	0.744
LIG_14-3-3_CanoR_1	695	705	PF00244	0.549
LIG_14-3-3_CanoR_1	895	899	PF00244	0.521
LIG_14-3-3_CterR_2	1145	1148	PF00244	0.528
LIG_Actin_WH2_2	1076	1094	PF00022	0.493
LIG_AP2alpha_1	833	837	PF02296	0.521
LIG_AP2alpha_2	347	349	PF02296	0.748
LIG_APCC_ABBA_1	215	220	PF00400	0.458
LIG_BRCT_BRCA1_1	185	189	PF00533	0.502
LIG_BRCT_BRCA1_1	783	787	PF00533	0.475
LIG_Clathr_ClatBox_1	867	871	PF01394	0.433
LIG_deltaCOP1_diTrp_1	1040	1044	PF00928	0.502
LIG_deltaCOP1_diTrp_1	553	560	PF00928	0.619
LIG_deltaCOP1_diTrp_1	571	575	PF00928	0.347
LIG_EVH1_1	717	721	PF00568	0.541
LIG_FHA_1	1078	1084	PF00498	0.425
LIG_FHA_1	1103	1109	PF00498	0.466
LIG_FHA_1	327	333	PF00498	0.782
LIG_FHA_1	399	405	PF00498	0.778
LIG_FHA_1	435	441	PF00498	0.661
LIG_FHA_1	457	463	PF00498	0.644
LIG_FHA_1	508	514	PF00498	0.639
LIG_FHA_1	600	606	PF00498	0.518
LIG_FHA_1	74	80	PF00498	0.397
LIG_FHA_1	752	758	PF00498	0.423
LIG_FHA_1	769	775	PF00498	0.433
LIG_FHA_1	895	901	PF00498	0.521
LIG_FHA_1	91	97	PF00498	0.467
LIG_FHA_1	924	930	PF00498	0.394
LIG_FHA_1	959	965	PF00498	0.374
LIG_FHA_2	104	110	PF00498	0.521
LIG_FHA_2	128	134	PF00498	0.429
LIG_FHA_2	18	24	PF00498	0.599
LIG_FHA_2	289	295	PF00498	0.640
LIG_FHA_2	389	395	PF00498	0.745
LIG_FHA_2	404	410	PF00498	0.562
LIG_FHA_2	416	422	PF00498	0.561
LIG_FHA_2	477	483	PF00498	0.612
LIG_FHA_2	548	554	PF00498	0.606
LIG_FHA_2	628	634	PF00498	0.797
LIG_FHA_2	661	667	PF00498	0.683
LIG_FHA_2	988	994	PF00498	0.435
LIG_IBAR_NPY_1	255	257	PF08397	0.525
LIG_LIR_Apic_2	167	173	PF02991	0.546
LIG_LIR_Apic_2	7	11	PF02991	0.583
LIG_LIR_Gen_1	1051	1062	PF02991	0.499
LIG_LIR_Gen_1	814	825	PF02991	0.521
LIG_LIR_Gen_1	873	884	PF02991	0.433
LIG_LIR_Nem_3	1047	1053	PF02991	0.436
LIG_LIR_Nem_3	186	192	PF02991	0.529
LIG_LIR_Nem_3	283	288	PF02991	0.514
LIG_LIR_Nem_3	814	820	PF02991	0.509
LIG_LIR_Nem_3	830	836	PF02991	0.264
LIG_LIR_Nem_3	873	879	PF02991	0.509
LIG_LIR_Nem_3	897	901	PF02991	0.454
LIG_NRBOX	1078	1084	PF00104	0.425
LIG_PCNA_yPIPBox_3	594	605	PF02747	0.480
LIG_Pex14_1	556	560	PF04695	0.628
LIG_Pex14_2	833	837	PF04695	0.433
LIG_PTAP_UEV_1	336	341	PF05743	0.781
LIG_Rb_LxCxE_1	482	494	PF01857	0.612
LIG_SH2_CRK	876	880	PF00017	0.433
LIG_SH2_GRB2like	31	34	PF00017	0.505
LIG_SH2_NCK_1	170	174	PF00017	0.557
LIG_SH2_NCK_1	586	590	PF00017	0.587
LIG_SH2_NCK_1	876	880	PF00017	0.424
LIG_SH2_STAP1	1050	1054	PF00017	0.479
LIG_SH2_STAP1	586	590	PF00017	0.675
LIG_SH2_STAT3	595	598	PF00017	0.634
LIG_SH2_STAT5	1053	1056	PF00017	0.488
LIG_SH2_STAT5	149	152	PF00017	0.547
LIG_SH2_STAT5	18	21	PF00017	0.641
LIG_SH2_STAT5	274	277	PF00017	0.491
LIG_SH2_STAT5	586	589	PF00017	0.530
LIG_SH2_STAT5	640	643	PF00017	0.859
LIG_SH2_STAT5	963	966	PF00017	0.365
LIG_SH3_1	807	813	PF00018	0.433
LIG_SH3_2	331	336	PF14604	0.790
LIG_SH3_2	341	346	PF14604	0.627
LIG_SH3_2	539	544	PF14604	0.810
LIG_SH3_2	612	617	PF14604	0.810
LIG_SH3_3	1013	1019	PF00018	0.482
LIG_SH3_3	116	122	PF00018	0.460
LIG_SH3_3	223	229	PF00018	0.456
LIG_SH3_3	233	239	PF00018	0.494
LIG_SH3_3	242	248	PF00018	0.320
LIG_SH3_3	294	300	PF00018	0.591
LIG_SH3_3	311	317	PF00018	0.625
LIG_SH3_3	328	334	PF00018	0.647
LIG_SH3_3	337	343	PF00018	0.557
LIG_SH3_3	371	377	PF00018	0.768
LIG_SH3_3	382	388	PF00018	0.719
LIG_SH3_3	440	446	PF00018	0.634
LIG_SH3_3	528	534	PF00018	0.802
LIG_SH3_3	536	542	PF00018	0.752
LIG_SH3_3	609	615	PF00018	0.736
LIG_SH3_3	715	721	PF00018	0.550
LIG_SH3_3	792	798	PF00018	0.468
LIG_SH3_3	800	806	PF00018	0.578
LIG_SH3_3	807	813	PF00018	0.433
LIG_SH3_3	826	832	PF00018	0.433
LIG_SH3_3	931	937	PF00018	0.365
LIG_SH3_3	966	972	PF00018	0.421
LIG_SUMO_SIM_anti_2	1105	1110	PF11976	0.485
LIG_SUMO_SIM_anti_2	965	971	PF11976	0.421
LIG_SUMO_SIM_par_1	865	871	PF11976	0.433
LIG_SUMO_SIM_par_1	899	904	PF11976	0.521
LIG_TRAF2_1	361	364	PF00917	0.763
LIG_TRAF2_1	616	619	PF00917	0.851
LIG_TRAF2_1	622	625	PF00917	0.759
LIG_TRAF2_1	663	666	PF00917	0.666
MOD_CDK_SPK_2	50	55	PF00069	0.628
MOD_CDK_SPK_2	522	527	PF00069	0.812
MOD_CDK_SPK_2	627	632	PF00069	0.867
MOD_CDK_SPK_2	802	807	PF00069	0.593
MOD_CDK_SPxK_1	50	56	PF00069	0.647
MOD_CDK_SPxxK_3	802	809	PF00069	0.433
MOD_CK1_1	1138	1144	PF00069	0.524
MOD_CK1_1	211	217	PF00069	0.605
MOD_CK1_1	398	404	PF00069	0.775
MOD_CK1_1	416	422	PF00069	0.781
MOD_CK1_1	50	56	PF00069	0.614
MOD_CK1_1	863	869	PF00069	0.433
MOD_CK2_1	103	109	PF00069	0.499
MOD_CK2_1	1084	1090	PF00069	0.494
MOD_CK2_1	388	394	PF00069	0.761
MOD_CK2_1	415	421	PF00069	0.827
MOD_CK2_1	483	489	PF00069	0.558
MOD_CK2_1	619	625	PF00069	0.727
MOD_CK2_1	627	633	PF00069	0.728
MOD_CK2_1	660	666	PF00069	0.700
MOD_CK2_1	901	907	PF00069	0.489
MOD_CMANNOS	572	575	PF00535	0.515
MOD_Cter_Amidation	501	504	PF01082	0.672
MOD_Cter_Amidation	916	919	PF01082	0.433
MOD_DYRK1A_RPxSP_1	809	813	PF00069	0.433
MOD_GlcNHglycan	1004	1007	PF01048	0.404
MOD_GlcNHglycan	1021	1024	PF01048	0.466
MOD_GlcNHglycan	1034	1037	PF01048	0.434
MOD_GlcNHglycan	1073	1076	PF01048	0.435
MOD_GlcNHglycan	1086	1089	PF01048	0.443
MOD_GlcNHglycan	1093	1096	PF01048	0.258
MOD_GlcNHglycan	192	195	PF01048	0.619
MOD_GlcNHglycan	210	213	PF01048	0.502
MOD_GlcNHglycan	49	52	PF01048	0.658
MOD_GlcNHglycan	493	496	PF01048	0.591
MOD_GlcNHglycan	783	786	PF01048	0.496
MOD_GlcNHglycan	862	865	PF01048	0.437
MOD_GSK3_1	202	209	PF00069	0.555
MOD_GSK3_1	246	253	PF00069	0.627
MOD_GSK3_1	288	295	PF00069	0.612
MOD_GSK3_1	304	311	PF00069	0.523
MOD_GSK3_1	376	383	PF00069	0.814
MOD_GSK3_1	457	464	PF00069	0.587
MOD_GSK3_1	518	525	PF00069	0.805
MOD_GSK3_1	540	547	PF00069	0.718
MOD_GSK3_1	65	72	PF00069	0.559
MOD_GSK3_1	86	93	PF00069	0.470
MOD_GSK3_1	99	106	PF00069	0.456
MOD_GSK3_1	996	1003	PF00069	0.404
MOD_N-GLC_1	32	37	PF02516	0.592
MOD_N-GLC_1	462	467	PF02516	0.596
MOD_N-GLC_1	781	786	PF02516	0.581
MOD_N-GLC_1	91	96	PF02516	0.354
MOD_NEK2_1	1002	1007	PF00069	0.244
MOD_NEK2_1	1032	1037	PF00069	0.526
MOD_NEK2_1	1071	1076	PF00069	0.437
MOD_NEK2_1	1082	1087	PF00069	0.423
MOD_NEK2_1	1091	1096	PF00069	0.257
MOD_NEK2_1	140	145	PF00069	0.481
MOD_NEK2_1	308	313	PF00069	0.615
MOD_NEK2_1	462	467	PF00069	0.614
MOD_NEK2_1	476	481	PF00069	0.342
MOD_NEK2_1	584	589	PF00069	0.529
MOD_NEK2_1	604	609	PF00069	0.286
MOD_NEK2_1	768	773	PF00069	0.579
MOD_NEK2_1	870	875	PF00069	0.418
MOD_NEK2_1	894	899	PF00069	0.467
MOD_NEK2_1	923	928	PF00069	0.390
MOD_NEK2_1	939	944	PF00069	0.433
MOD_NEK2_1	987	992	PF00069	0.462
MOD_NEK2_1	99	104	PF00069	0.548
MOD_NEK2_2	288	293	PF00069	0.616
MOD_NEK2_2	684	689	PF00069	0.530
MOD_PIKK_1	250	256	PF00454	0.602
MOD_PIKK_1	383	389	PF00454	0.844
MOD_PIKK_1	413	419	PF00454	0.848
MOD_PKA_2	1032	1038	PF00069	0.528
MOD_PKA_2	1071	1077	PF00069	0.457
MOD_PKA_2	1091	1097	PF00069	0.254
MOD_PKA_2	1141	1147	PF00069	0.673
MOD_PKA_2	332	338	PF00069	0.790
MOD_PKA_2	350	356	PF00069	0.522
MOD_PKA_2	547	553	PF00069	0.629
MOD_PKA_2	696	702	PF00069	0.564
MOD_PKA_2	855	861	PF00069	0.454
MOD_PKA_2	877	883	PF00069	0.421
MOD_PKA_2	894	900	PF00069	0.433
MOD_PKA_2	99	105	PF00069	0.520
MOD_Plk_1	769	775	PF00069	0.433
MOD_Plk_1	901	907	PF00069	0.521
MOD_Plk_1	91	97	PF00069	0.508
MOD_Plk_1	965	971	PF00069	0.356
MOD_Plk_2-3	301	307	PF00069	0.577
MOD_Plk_4	1077	1083	PF00069	0.427
MOD_Plk_4	1104	1110	PF00069	0.497
MOD_Plk_4	12	18	PF00069	0.622
MOD_Plk_4	211	217	PF00069	0.552
MOD_Plk_4	304	310	PF00069	0.542
MOD_Plk_4	579	585	PF00069	0.556
MOD_Plk_4	812	818	PF00069	0.509
MOD_Plk_4	863	869	PF00069	0.433
MOD_Plk_4	91	97	PF00069	0.595
MOD_Plk_4	965	971	PF00069	0.413
MOD_ProDKin_1	1123	1129	PF00069	0.503
MOD_ProDKin_1	118	124	PF00069	0.417
MOD_ProDKin_1	380	386	PF00069	0.762
MOD_ProDKin_1	50	56	PF00069	0.647
MOD_ProDKin_1	522	528	PF00069	0.734
MOD_ProDKin_1	532	538	PF00069	0.660
MOD_ProDKin_1	57	63	PF00069	0.587
MOD_ProDKin_1	627	633	PF00069	0.868
MOD_ProDKin_1	720	726	PF00069	0.640
MOD_ProDKin_1	802	808	PF00069	0.433
MOD_ProDKin_1	809	815	PF00069	0.433
MOD_ProDKin_1	933	939	PF00069	0.462
MOD_SUMO_for_1	729	732	PF00179	0.665
TRG_DiLeu_BaEn_1	763	768	PF01217	0.480
TRG_DiLeu_BaEn_1	770	775	PF01217	0.402
TRG_DiLeu_BaLyEn_6	934	939	PF01217	0.421
TRG_ENDOCYTIC_2	876	879	PF00928	0.381
TRG_ER_diArg_1	136	138	PF00400	0.407
TRG_ER_diArg_1	275	278	PF00400	0.341
TRG_ER_diArg_1	423	426	PF00400	0.842
TRG_ER_diArg_1	452	455	PF00400	0.690
TRG_ER_diArg_1	54	56	PF00400	0.632
TRG_ER_diArg_1	546	549	PF00400	0.728
TRG_ER_diArg_1	605	608	PF00400	0.604
TRG_ER_diArg_1	667	670	PF00400	0.570
TRG_ER_diArg_1	694	697	PF00400	0.580
TRG_ER_diArg_1	789	792	PF00400	0.455
TRG_ER_diArg_1	918	920	PF00400	0.521
TRG_NLS_Bipartite_1	503	521	PF00514	0.721
TRG_NLS_MonoExtC_3	516	522	PF00514	0.704
TRG_NLS_MonoExtN_4	514	521	PF00514	0.693
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	565	570	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	671	675	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	686	690	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	706	711	PF00026	0.665
TRG_Pf-PMV_PEXEL_1	834	838	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZG3	Leptomonas seymouri	56%	76%
A0A1X0NK65	Trypanosomatidae	30%	69%
A4H8H0	Leishmania braziliensis	97%	81%
A4H8H1	Leishmania braziliensis	99%	99%
A4H8K2	Leishmania braziliensis	97%	100%
A4H8U5	Leishmania braziliensis	97%	71%
P15594	Trypanosoma brucei gambiense	29%	97%