Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H3E6_LEIBR

TriTrypDb:

LbrM.02.0530 , LBRM2903_020011300

Length:

835

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3E6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.578
CLV_C14_Caspase3-7	301	305	PF00656	0.519
CLV_C14_Caspase3-7	729	733	PF00656	0.583
CLV_NRD_NRD_1	237	239	PF00675	0.658
CLV_NRD_NRD_1	358	360	PF00675	0.786
CLV_NRD_NRD_1	380	382	PF00675	0.695
CLV_NRD_NRD_1	429	431	PF00675	0.637
CLV_NRD_NRD_1	510	512	PF00675	0.564
CLV_NRD_NRD_1	560	562	PF00675	0.772
CLV_NRD_NRD_1	583	585	PF00675	0.787
CLV_NRD_NRD_1	759	761	PF00675	0.701
CLV_NRD_NRD_1	814	816	PF00675	0.754
CLV_NRD_NRD_1	823	825	PF00675	0.738
CLV_PCSK_FUR_1	356	360	PF00082	0.786
CLV_PCSK_KEX2_1	237	239	PF00082	0.649
CLV_PCSK_KEX2_1	356	358	PF00082	0.787
CLV_PCSK_KEX2_1	380	382	PF00082	0.686
CLV_PCSK_KEX2_1	429	431	PF00082	0.637
CLV_PCSK_KEX2_1	510	512	PF00082	0.564
CLV_PCSK_KEX2_1	559	561	PF00082	0.773
CLV_PCSK_KEX2_1	583	585	PF00082	0.787
CLV_PCSK_KEX2_1	759	761	PF00082	0.716
CLV_PCSK_KEX2_1	823	825	PF00082	0.747
CLV_PCSK_SKI1_1	625	629	PF00082	0.565
CLV_PCSK_SKI1_1	82	86	PF00082	0.552
CLV_Separin_Metazoa	490	494	PF03568	0.706
DEG_APCC_DBOX_1	624	632	PF00400	0.679
DEG_COP1_1	301	311	PF00400	0.515
DEG_Nend_Nbox_1	1	3	PF02207	0.688
DEG_SCF_FBW7_1	668	675	PF00400	0.817
DOC_ANK_TNKS_1	494	501	PF00023	0.783
DOC_CKS1_1	226	231	PF01111	0.719
DOC_CKS1_1	669	674	PF01111	0.820
DOC_MAPK_gen_1	820	828	PF00069	0.743
DOC_PP1_RVXF_1	822	829	PF00149	0.745
DOC_PP4_FxxP_1	2	5	PF00568	0.529
DOC_PP4_FxxP_1	488	491	PF00568	0.728
DOC_PP4_FxxP_1	643	646	PF00568	0.574
DOC_PP4_FxxP_1	828	831	PF00568	0.733
DOC_USP7_MATH_1	257	261	PF00917	0.636
DOC_USP7_MATH_1	309	313	PF00917	0.761
DOC_USP7_MATH_1	431	435	PF00917	0.731
DOC_USP7_MATH_1	454	458	PF00917	0.770
DOC_USP7_MATH_1	524	528	PF00917	0.726
DOC_USP7_MATH_1	614	618	PF00917	0.563
DOC_USP7_MATH_1	62	66	PF00917	0.605
DOC_USP7_MATH_1	637	641	PF00917	0.733
DOC_USP7_MATH_1	652	656	PF00917	0.597
DOC_USP7_MATH_1	664	668	PF00917	0.783
DOC_USP7_MATH_1	672	676	PF00917	0.738
DOC_USP7_MATH_1	679	683	PF00917	0.792
DOC_USP7_MATH_1	692	696	PF00917	0.511
DOC_USP7_MATH_1	698	702	PF00917	0.725
DOC_USP7_MATH_1	709	713	PF00917	0.538
DOC_USP7_MATH_1	716	720	PF00917	0.660
DOC_USP7_MATH_1	769	773	PF00917	0.772
DOC_WW_Pin1_4	1	6	PF00397	0.533
DOC_WW_Pin1_4	141	146	PF00397	0.584
DOC_WW_Pin1_4	197	202	PF00397	0.661
DOC_WW_Pin1_4	225	230	PF00397	0.703
DOC_WW_Pin1_4	281	286	PF00397	0.643
DOC_WW_Pin1_4	335	340	PF00397	0.742
DOC_WW_Pin1_4	342	347	PF00397	0.611
DOC_WW_Pin1_4	383	388	PF00397	0.798
DOC_WW_Pin1_4	456	461	PF00397	0.605
DOC_WW_Pin1_4	47	52	PF00397	0.762
DOC_WW_Pin1_4	626	631	PF00397	0.563
DOC_WW_Pin1_4	632	637	PF00397	0.537
DOC_WW_Pin1_4	642	647	PF00397	0.509
DOC_WW_Pin1_4	668	673	PF00397	0.746
DOC_WW_Pin1_4	748	753	PF00397	0.621
LIG_14-3-3_CanoR_1	152	161	PF00244	0.681
LIG_14-3-3_CanoR_1	23	30	PF00244	0.700
LIG_14-3-3_CanoR_1	638	644	PF00244	0.661
LIG_14-3-3_CanoR_1	742	752	PF00244	0.800
LIG_14-3-3_CanoR_1	801	809	PF00244	0.588
LIG_14-3-3_CanoR_1	823	827	PF00244	0.745
LIG_Actin_WH2_2	191	208	PF00022	0.491
LIG_APCC_ABBA_1	40	45	PF00400	0.557
LIG_APCC_ABBA_1	684	689	PF00400	0.557
LIG_BIR_III_4	732	736	PF00653	0.579
LIG_BRCT_BRCA1_1	134	138	PF00533	0.565
LIG_BRCT_BRCA1_1	639	643	PF00533	0.816
LIG_eIF4E_1	155	161	PF01652	0.557
LIG_eIF4E_2	489	495	PF01652	0.668
LIG_EVH1_1	643	647	PF00568	0.573
LIG_FHA_1	154	160	PF00498	0.667
LIG_FHA_1	218	224	PF00498	0.668
LIG_FHA_1	226	232	PF00498	0.608
LIG_FHA_1	336	342	PF00498	0.559
LIG_FHA_1	48	54	PF00498	0.732
LIG_FHA_1	585	591	PF00498	0.552
LIG_FHA_1	669	675	PF00498	0.819
LIG_FHA_1	74	80	PF00498	0.653
LIG_FHA_1	749	755	PF00498	0.581
LIG_FHA_2	370	376	PF00498	0.653
LIG_FHA_2	772	778	PF00498	0.806
LIG_FHA_2	801	807	PF00498	0.839
LIG_Integrin_RGD_1	302	304	PF01839	0.667
LIG_LIR_Apic_2	485	491	PF02991	0.607
LIG_LIR_Apic_2	640	646	PF02991	0.696
LIG_LIR_Apic_2	825	831	PF02991	0.736
LIG_LIR_Gen_1	199	208	PF02991	0.595
LIG_LIR_Gen_1	591	600	PF02991	0.802
LIG_LIR_Nem_3	135	141	PF02991	0.665
LIG_LIR_Nem_3	199	205	PF02991	0.611
LIG_LIR_Nem_3	376	382	PF02991	0.772
LIG_LIR_Nem_3	591	595	PF02991	0.810
LIG_LIR_Nem_3	607	613	PF02991	0.517
LIG_LIR_Nem_3	680	686	PF02991	0.612
LIG_NRBOX	230	236	PF00104	0.598
LIG_NRBOX	85	91	PF00104	0.579
LIG_PCNA_yPIPBox_3	697	711	PF02747	0.563
LIG_Pex14_1	151	155	PF04695	0.630
LIG_Pex14_1	531	535	PF04695	0.627
LIG_SH2_CRK	279	283	PF00017	0.638
LIG_SH2_CRK	522	526	PF00017	0.628
LIG_SH2_CRK	574	578	PF00017	0.587
LIG_SH2_CRK	592	596	PF00017	0.738
LIG_SH2_CRK	683	687	PF00017	0.649
LIG_SH2_NCK_1	261	265	PF00017	0.745
LIG_SH2_NCK_1	522	526	PF00017	0.628
LIG_SH2_PTP2	537	540	PF00017	0.740
LIG_SH2_SRC	489	492	PF00017	0.786
LIG_SH2_STAP1	155	159	PF00017	0.669
LIG_SH2_STAP1	279	283	PF00017	0.638
LIG_SH2_STAP1	289	293	PF00017	0.632
LIG_SH2_STAP1	43	47	PF00017	0.553
LIG_SH2_STAP1	650	654	PF00017	0.589
LIG_SH2_STAT5	139	142	PF00017	0.555
LIG_SH2_STAT5	155	158	PF00017	0.571
LIG_SH2_STAT5	202	205	PF00017	0.625
LIG_SH2_STAT5	225	228	PF00017	0.704
LIG_SH2_STAT5	261	264	PF00017	0.605
LIG_SH2_STAT5	270	273	PF00017	0.681
LIG_SH2_STAT5	368	371	PF00017	0.783
LIG_SH2_STAT5	537	540	PF00017	0.740
LIG_SH2_STAT5	725	728	PF00017	0.566
LIG_SH3_2	147	152	PF14604	0.759
LIG_SH3_2	554	559	PF14604	0.840
LIG_SH3_3	144	150	PF00018	0.646
LIG_SH3_3	201	207	PF00018	0.656
LIG_SH3_3	282	288	PF00018	0.742
LIG_SH3_3	310	316	PF00018	0.703
LIG_SH3_3	447	453	PF00018	0.805
LIG_SH3_3	457	463	PF00018	0.619
LIG_SH3_3	551	557	PF00018	0.757
LIG_SH3_3	633	639	PF00018	0.796
LIG_SH3_3	641	647	PF00018	0.683
LIG_SH3_3	784	790	PF00018	0.578
LIG_SUMO_SIM_anti_2	101	108	PF11976	0.426
LIG_TRAF2_1	372	375	PF00917	0.647
LIG_TRFH_1	211	215	PF08558	0.653
LIG_TYR_ITIM	590	595	PF00017	0.577
LIG_WW_1	267	270	PF00397	0.761
LIG_WW_1	647	650	PF00397	0.578
LIG_WW_3	490	494	PF00397	0.716
MOD_CDC14_SPxK_1	635	638	PF00782	0.560
MOD_CDK_SPK_2	225	230	PF00069	0.732
MOD_CDK_SPxK_1	632	638	PF00069	0.561
MOD_CK1_1	25	31	PF00069	0.752
MOD_CK1_1	284	290	PF00069	0.720
MOD_CK1_1	36	42	PF00069	0.613
MOD_CK1_1	4	10	PF00069	0.538
MOD_CK1_1	409	415	PF00069	0.681
MOD_CK1_1	444	450	PF00069	0.718
MOD_CK1_1	46	52	PF00069	0.559
MOD_CK1_1	527	533	PF00069	0.726
MOD_CK1_1	591	597	PF00069	0.742
MOD_CK1_1	617	623	PF00069	0.740
MOD_CK1_1	642	648	PF00069	0.654
MOD_CK1_1	712	718	PF00069	0.580
MOD_CK1_1	719	725	PF00069	0.543
MOD_CK1_1	771	777	PF00069	0.673
MOD_CK1_1	818	824	PF00069	0.737
MOD_CK2_1	162	168	PF00069	0.648
MOD_CK2_1	253	259	PF00069	0.732
MOD_CK2_1	29	35	PF00069	0.796
MOD_CK2_1	309	315	PF00069	0.766
MOD_CK2_1	369	375	PF00069	0.658
MOD_CK2_1	475	481	PF00069	0.582
MOD_CK2_1	564	570	PF00069	0.701
MOD_CK2_1	690	696	PF00069	0.796
MOD_CK2_1	793	799	PF00069	0.720
MOD_Cter_Amidation	813	816	PF01082	0.592
MOD_DYRK1A_RPxSP_1	143	147	PF00069	0.616
MOD_DYRK1A_RPxSP_1	456	460	PF00069	0.598
MOD_GlcNHglycan	134	137	PF01048	0.565
MOD_GlcNHglycan	156	159	PF01048	0.562
MOD_GlcNHglycan	25	28	PF01048	0.779
MOD_GlcNHglycan	255	258	PF01048	0.737
MOD_GlcNHglycan	273	276	PF01048	0.458
MOD_GlcNHglycan	31	34	PF01048	0.730
MOD_GlcNHglycan	383	386	PF01048	0.609
MOD_GlcNHglycan	443	446	PF01048	0.676
MOD_GlcNHglycan	45	48	PF01048	0.475
MOD_GlcNHglycan	456	459	PF01048	0.655
MOD_GlcNHglycan	477	480	PF01048	0.642
MOD_GlcNHglycan	526	529	PF01048	0.649
MOD_GlcNHglycan	564	569	PF01048	0.726
MOD_GlcNHglycan	577	580	PF01048	0.605
MOD_GlcNHglycan	606	609	PF01048	0.774
MOD_GlcNHglycan	650	653	PF01048	0.761
MOD_GlcNHglycan	700	703	PF01048	0.758
MOD_GlcNHglycan	748	751	PF01048	0.828
MOD_GlcNHglycan	761	764	PF01048	0.817
MOD_GlcNHglycan	771	774	PF01048	0.697
MOD_GlcNHglycan	81	85	PF01048	0.597
MOD_GSK3_1	1	8	PF00069	0.690
MOD_GSK3_1	101	108	PF00069	0.426
MOD_GSK3_1	217	224	PF00069	0.667
MOD_GSK3_1	25	32	PF00069	0.726
MOD_GSK3_1	253	260	PF00069	0.673
MOD_GSK3_1	383	390	PF00069	0.806
MOD_GSK3_1	43	50	PF00069	0.529
MOD_GSK3_1	441	448	PF00069	0.663
MOD_GSK3_1	584	591	PF00069	0.549
MOD_GSK3_1	614	621	PF00069	0.681
MOD_GSK3_1	648	655	PF00069	0.741
MOD_GSK3_1	664	671	PF00069	0.782
MOD_GSK3_1	673	680	PF00069	0.689
MOD_GSK3_1	692	699	PF00069	0.723
MOD_GSK3_1	705	712	PF00069	0.534
MOD_GSK3_1	715	722	PF00069	0.541
MOD_GSK3_1	800	807	PF00069	0.817
MOD_GSK3_1	814	821	PF00069	0.640
MOD_GSK3_1	822	829	PF00069	0.743
MOD_LATS_1	616	622	PF00433	0.566
MOD_LATS_1	791	797	PF00433	0.595
MOD_N-GLC_1	329	334	PF02516	0.577
MOD_N-GLC_1	387	392	PF02516	0.562
MOD_N-GLC_1	696	701	PF02516	0.559
MOD_NEK2_1	181	186	PF00069	0.504
MOD_NEK2_1	22	27	PF00069	0.763
MOD_NEK2_1	271	276	PF00069	0.634
MOD_NEK2_1	475	480	PF00069	0.585
MOD_NEK2_1	541	546	PF00069	0.612
MOD_NEK2_1	549	554	PF00069	0.711
MOD_NEK2_1	590	595	PF00069	0.677
MOD_NEK2_1	604	609	PF00069	0.692
MOD_NEK2_1	673	678	PF00069	0.693
MOD_NEK2_1	782	787	PF00069	0.648
MOD_NEK2_1	800	805	PF00069	0.584
MOD_PIKK_1	584	590	PF00454	0.585
MOD_PIKK_1	637	643	PF00454	0.816
MOD_PIKK_1	652	658	PF00454	0.595
MOD_PIKK_1	793	799	PF00454	0.627
MOD_PK_1	396	402	PF00069	0.814
MOD_PKA_1	759	765	PF00069	0.566
MOD_PKA_1	815	821	PF00069	0.840
MOD_PKA_2	151	157	PF00069	0.494
MOD_PKA_2	189	195	PF00069	0.697
MOD_PKA_2	22	28	PF00069	0.676
MOD_PKA_2	409	415	PF00069	0.665
MOD_PKA_2	614	620	PF00069	0.734
MOD_PKA_2	637	643	PF00069	0.660
MOD_PKA_2	719	725	PF00069	0.571
MOD_PKA_2	759	765	PF00069	0.692
MOD_PKA_2	800	806	PF00069	0.849
MOD_PKA_2	814	820	PF00069	0.659
MOD_PKA_2	822	828	PF00069	0.739
MOD_PKB_1	394	402	PF00069	0.818
MOD_Plk_1	190	196	PF00069	0.662
MOD_Plk_1	309	315	PF00069	0.766
MOD_Plk_1	329	335	PF00069	0.499
MOD_Plk_1	696	702	PF00069	0.773
MOD_Plk_1	80	86	PF00069	0.562
MOD_Plk_1	826	832	PF00069	0.835
MOD_Plk_4	221	227	PF00069	0.656
MOD_Plk_4	309	315	PF00069	0.766
MOD_Plk_4	409	415	PF00069	0.631
MOD_Plk_4	422	428	PF00069	0.581
MOD_Plk_4	527	533	PF00069	0.624
MOD_Plk_4	543	549	PF00069	0.639
MOD_Plk_4	664	670	PF00069	0.819
MOD_ProDKin_1	1	7	PF00069	0.533
MOD_ProDKin_1	141	147	PF00069	0.591
MOD_ProDKin_1	197	203	PF00069	0.651
MOD_ProDKin_1	225	231	PF00069	0.697
MOD_ProDKin_1	281	287	PF00069	0.637
MOD_ProDKin_1	335	341	PF00069	0.741
MOD_ProDKin_1	342	348	PF00069	0.611
MOD_ProDKin_1	383	389	PF00069	0.800
MOD_ProDKin_1	456	462	PF00069	0.604
MOD_ProDKin_1	47	53	PF00069	0.764
MOD_ProDKin_1	626	632	PF00069	0.562
MOD_ProDKin_1	642	648	PF00069	0.509
MOD_ProDKin_1	668	674	PF00069	0.747
MOD_ProDKin_1	748	754	PF00069	0.621
MOD_SUMO_rev_2	32	39	PF00179	0.798
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.792
TRG_ENDOCYTIC_2	202	205	PF00928	0.684
TRG_ENDOCYTIC_2	279	282	PF00928	0.635
TRG_ENDOCYTIC_2	368	371	PF00928	0.783
TRG_ENDOCYTIC_2	432	435	PF00928	0.734
TRG_ENDOCYTIC_2	522	525	PF00928	0.641
TRG_ENDOCYTIC_2	574	577	PF00928	0.591
TRG_ENDOCYTIC_2	592	595	PF00928	0.738
TRG_ENDOCYTIC_2	683	686	PF00928	0.645
TRG_ER_diArg_1	119	122	PF00400	0.620
TRG_ER_diArg_1	236	238	PF00400	0.629
TRG_ER_diArg_1	356	359	PF00400	0.787
TRG_ER_diArg_1	379	381	PF00400	0.685
TRG_ER_diArg_1	492	495	PF00400	0.720
TRG_ER_diArg_1	559	561	PF00400	0.773
TRG_ER_diArg_1	582	584	PF00400	0.789
TRG_ER_diArg_1	758	760	PF00400	0.708
TRG_NLS_MonoExtC_3	239	244	PF00514	0.506
TRG_NLS_MonoExtN_4	237	244	PF00514	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYI3	Leptomonas seymouri	43%	94%
A0A3S5H507	Leishmania donovani	73%	99%
A4HRQ1	Leishmania infantum	73%	99%
E9ACD0	Leishmania major	73%	100%
E9AJL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	99%