Tautomerase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H3E5_LEIBR

TriTrypDb:

LbrM.02.0520 , LBRM2903_020011200

Length:

162

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3E5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.566
CLV_PCSK_SKI1_1	152	156	PF00082	0.424
CLV_PCSK_SKI1_1	52	56	PF00082	0.570
DOC_CYCLIN_RxL_1	46	59	PF00134	0.700
DOC_MAPK_gen_1	150	159	PF00069	0.565
DOC_MAPK_MEF2A_6	123	130	PF00069	0.478
DOC_MAPK_NFAT4_5	123	131	PF00069	0.489
DOC_PP1_RVXF_1	154	160	PF00149	0.418
DOC_PP4_FxxP_1	10	13	PF00568	0.458
DOC_PP4_FxxP_1	87	90	PF00568	0.539
DOC_USP7_MATH_1	105	109	PF00917	0.549
DOC_WW_Pin1_4	86	91	PF00397	0.666
LIG_14-3-3_CanoR_1	142	148	PF00244	0.522
LIG_Actin_WH2_2	127	144	PF00022	0.449
LIG_Clathr_ClatBox_1	128	132	PF01394	0.486
LIG_FHA_1	142	148	PF00498	0.517
LIG_FHA_1	153	159	PF00498	0.467
LIG_FHA_1	37	43	PF00498	0.618
LIG_LIR_Apic_2	7	13	PF02991	0.485
LIG_LIR_Apic_2	85	90	PF02991	0.541
LIG_LIR_Gen_1	124	134	PF02991	0.426
LIG_LIR_LC3C_4	144	149	PF02991	0.343
LIG_LIR_Nem_3	124	130	PF02991	0.427
LIG_SH2_STAT3	117	120	PF00017	0.490
LIG_SH2_STAT5	117	120	PF00017	0.470
LIG_SH3_2	47	52	PF14604	0.566
LIG_SH3_3	44	50	PF00018	0.698
LIG_SUMO_SIM_par_1	127	132	PF11976	0.519
LIG_TRAF2_1	133	136	PF00917	0.559
MOD_CK1_1	41	47	PF00069	0.603
MOD_GlcNHglycan	58	61	PF01048	0.743
MOD_GlcNHglycan	98	101	PF01048	0.622
MOD_GSK3_1	37	44	PF00069	0.528
MOD_GSK3_1	54	61	PF00069	0.473
MOD_GSK3_1	92	99	PF00069	0.812
MOD_N-GLC_1	92	97	PF02516	0.635
MOD_NEK2_1	121	126	PF00069	0.460
MOD_NEK2_1	141	146	PF00069	0.493
MOD_NEK2_1	53	58	PF00069	0.586
MOD_PIKK_1	41	47	PF00454	0.687
MOD_PKA_2	141	147	PF00069	0.497
MOD_PKA_2	45	51	PF00069	0.655
MOD_Plk_1	152	158	PF00069	0.472
MOD_Plk_4	143	149	PF00069	0.599
MOD_ProDKin_1	86	92	PF00069	0.668
TRG_DiLeu_BaEn_2	48	54	PF01217	0.545
TRG_DiLeu_BaEn_4	136	142	PF01217	0.569
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.449
TRG_NES_CRM1_1	119	135	PF08389	0.558
TRG_Pf-PMV_PEXEL_1	32	37	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D0	Leptomonas seymouri	61%	100%
A0A0N1HW96	Leptomonas seymouri	33%	100%
A0A0S4IPF2	Bodo saltans	30%	100%
A0A0S4JFI1	Bodo saltans	34%	100%
A0A1X0NKC2	Trypanosomatidae	32%	100%
A0A1X0P259	Trypanosomatidae	29%	100%
A0A3R7K0R9	Trypanosoma rangeli	29%	100%
A0A3S5H506	Leishmania donovani	76%	99%
A0A3S7X3W3	Leishmania donovani	33%	100%
A0A422NFX4	Trypanosoma rangeli	37%	100%
A4HIL9	Leishmania braziliensis	32%	100%
A4HRQ0	Leishmania infantum	76%	99%
A4I5W4	Leishmania infantum	33%	100%
C9ZJ38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZR85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ACC9	Leishmania major	77%	100%
E9AJL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
E9B159	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4Q707	Leishmania major	32%	70%
V5BMX8	Trypanosoma cruzi	32%	100%