Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3E4_LEIBR

TriTrypDb:

LbrM.02.0510 , LBRM2903_020011100

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4H3E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3E4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	439	443	PF00656	0.575
CLV_C14_Caspase3-7	476	480	PF00656	0.598
CLV_NRD_NRD_1	207	209	PF00675	0.412
CLV_NRD_NRD_1	468	470	PF00675	0.351
CLV_NRD_NRD_1	589	591	PF00675	0.391
CLV_PCSK_FUR_1	587	591	PF00082	0.330
CLV_PCSK_KEX2_1	207	209	PF00082	0.416
CLV_PCSK_KEX2_1	468	470	PF00082	0.351
CLV_PCSK_KEX2_1	567	569	PF00082	0.303
CLV_PCSK_KEX2_1	589	591	PF00082	0.391
CLV_PCSK_KEX2_1	592	594	PF00082	0.406
CLV_PCSK_PC1ET2_1	567	569	PF00082	0.303
CLV_PCSK_PC1ET2_1	592	594	PF00082	0.334
CLV_PCSK_PC7_1	585	591	PF00082	0.334
CLV_PCSK_SKI1_1	139	143	PF00082	0.567
CLV_PCSK_SKI1_1	152	156	PF00082	0.540
CLV_PCSK_SKI1_1	340	344	PF00082	0.208
CLV_PCSK_SKI1_1	564	568	PF00082	0.368
CLV_PCSK_SKI1_1	637	641	PF00082	0.199
CLV_PCSK_SKI1_1	666	670	PF00082	0.385
DEG_APCC_DBOX_1	138	146	PF00400	0.367
DEG_SPOP_SBC_1	391	395	PF00917	0.394
DOC_CYCLIN_RxL_1	149	159	PF00134	0.366
DOC_CYCLIN_RxL_1	337	345	PF00134	0.208
DOC_CYCLIN_yCln2_LP_2	179	185	PF00134	0.208
DOC_CYCLIN_yCln2_LP_2	230	236	PF00134	0.199
DOC_MAPK_DCC_7	139	147	PF00069	0.367
DOC_MAPK_gen_1	564	573	PF00069	0.509
DOC_MAPK_MEF2A_6	139	147	PF00069	0.367
DOC_MAPK_MEF2A_6	518	525	PF00069	0.199
DOC_MAPK_MEF2A_6	52	61	PF00069	0.581
DOC_PP1_RVXF_1	338	345	PF00149	0.208
DOC_PP2B_LxvP_1	163	166	PF13499	0.357
DOC_PP2B_LxvP_1	179	182	PF13499	0.161
DOC_PP2B_LxvP_1	230	233	PF13499	0.199
DOC_PP2B_LxvP_1	660	663	PF13499	0.291
DOC_PP4_FxxP_1	99	102	PF00568	0.208
DOC_USP7_MATH_1	15	19	PF00917	0.532
DOC_USP7_MATH_1	224	228	PF00917	0.368
DOC_USP7_MATH_1	242	246	PF00917	0.220
DOC_USP7_MATH_1	263	267	PF00917	0.371
DOC_USP7_MATH_1	280	284	PF00917	0.445
DOC_USP7_MATH_1	286	290	PF00917	0.451
DOC_USP7_MATH_1	291	295	PF00917	0.435
DOC_USP7_MATH_1	391	395	PF00917	0.463
DOC_USP7_MATH_1	399	403	PF00917	0.469
DOC_USP7_MATH_1	603	607	PF00917	0.554
DOC_USP7_MATH_1	65	69	PF00917	0.756
DOC_USP7_MATH_1	673	677	PF00917	0.199
DOC_USP7_UBL2_3	666	670	PF12436	0.185
DOC_WW_Pin1_4	114	119	PF00397	0.359
DOC_WW_Pin1_4	161	166	PF00397	0.360
DOC_WW_Pin1_4	173	178	PF00397	0.332
DOC_WW_Pin1_4	395	400	PF00397	0.505
DOC_WW_Pin1_4	40	45	PF00397	0.768
DOC_WW_Pin1_4	411	416	PF00397	0.402
DOC_WW_Pin1_4	482	487	PF00397	0.729
DOC_WW_Pin1_4	490	495	PF00397	0.767
LIG_14-3-3_CanoR_1	156	162	PF00244	0.386
LIG_14-3-3_CanoR_1	171	177	PF00244	0.433
LIG_14-3-3_CanoR_1	314	320	PF00244	0.319
LIG_14-3-3_CanoR_1	39	47	PF00244	0.589
LIG_14-3-3_CanoR_1	505	515	PF00244	0.597
LIG_BH_BH3_1	504	520	PF00452	0.533
LIG_BIR_III_4	613	617	PF00653	0.554
LIG_BRCT_BRCA1_1	112	116	PF00533	0.417
LIG_BRCT_BRCA1_1	189	193	PF00533	0.208
LIG_BRCT_BRCA1_1	561	565	PF00533	0.341
LIG_BRCT_BRCA1_1	635	639	PF00533	0.455
LIG_BRCT_BRCA1_2	561	567	PF00533	0.347
LIG_CSL_BTD_1	230	233	PF09270	0.199
LIG_EH1_1	642	650	PF00400	0.199
LIG_FHA_1	102	108	PF00498	0.234
LIG_FHA_1	136	142	PF00498	0.395
LIG_FHA_1	174	180	PF00498	0.345
LIG_FHA_1	306	312	PF00498	0.346
LIG_FHA_1	32	38	PF00498	0.561
LIG_FHA_1	350	356	PF00498	0.301
LIG_FHA_1	405	411	PF00498	0.439
LIG_FHA_1	74	80	PF00498	0.583
LIG_GBD_Chelix_1	421	429	PF00786	0.208
LIG_GBD_Chelix_1	649	657	PF00786	0.199
LIG_LIR_Apic_2	97	102	PF02991	0.208
LIG_LIR_Gen_1	190	198	PF02991	0.208
LIG_LIR_Gen_1	255	263	PF02991	0.364
LIG_LIR_Gen_1	352	360	PF02991	0.304
LIG_LIR_Gen_1	417	426	PF02991	0.232
LIG_LIR_Gen_1	456	465	PF02991	0.519
LIG_LIR_Gen_1	517	525	PF02991	0.385
LIG_LIR_Nem_3	17	22	PF02991	0.536
LIG_LIR_Nem_3	190	196	PF02991	0.208
LIG_LIR_Nem_3	255	260	PF02991	0.364
LIG_LIR_Nem_3	318	324	PF02991	0.315
LIG_LIR_Nem_3	352	357	PF02991	0.336
LIG_LIR_Nem_3	377	382	PF02991	0.199
LIG_LIR_Nem_3	417	423	PF02991	0.232
LIG_LIR_Nem_3	427	433	PF02991	0.394
LIG_LIR_Nem_3	449	455	PF02991	0.524
LIG_LIR_Nem_3	456	461	PF02991	0.514
LIG_LIR_Nem_3	517	523	PF02991	0.385
LIG_LIR_Nem_3	527	533	PF02991	0.199
LIG_LIR_Nem_3	562	566	PF02991	0.362
LIG_LIR_Nem_3	640	646	PF02991	0.199
LIG_LIR_Nem_3	97	101	PF02991	0.391
LIG_NRBOX	191	197	PF00104	0.208
LIG_PDZ_Class_3	685	690	PF00595	0.357
LIG_Pex14_1	379	383	PF04695	0.204
LIG_Pex14_2	325	329	PF04695	0.272
LIG_Pex14_2	639	643	PF04695	0.199
LIG_SH2_CRK	317	321	PF00017	0.312
LIG_SH2_CRK	520	524	PF00017	0.199
LIG_SH2_CRK	558	562	PF00017	0.199
LIG_SH2_CRK	563	567	PF00017	0.497
LIG_SH2_NCK_1	234	238	PF00017	0.199
LIG_SH2_NCK_1	383	387	PF00017	0.327
LIG_SH2_PTP2	323	326	PF00017	0.296
LIG_SH2_PTP2	58	61	PF00017	0.570
LIG_SH2_STAP1	234	238	PF00017	0.199
LIG_SH2_STAP1	317	321	PF00017	0.312
LIG_SH2_STAP1	458	462	PF00017	0.519
LIG_SH2_STAT5	130	133	PF00017	0.373
LIG_SH2_STAT5	240	243	PF00017	0.254
LIG_SH2_STAT5	323	326	PF00017	0.296
LIG_SH2_STAT5	354	357	PF00017	0.447
LIG_SH2_STAT5	365	368	PF00017	0.204
LIG_SH2_STAT5	383	386	PF00017	0.315
LIG_SH2_STAT5	558	561	PF00017	0.199
LIG_SH2_STAT5	58	61	PF00017	0.570
LIG_SH3_3	112	118	PF00018	0.362
LIG_SH3_3	137	143	PF00018	0.367
LIG_SH3_3	174	180	PF00018	0.345
LIG_SH3_3	245	251	PF00018	0.294
LIG_SH3_3	41	47	PF00018	0.765
LIG_SUMO_SIM_anti_2	552	557	PF11976	0.199
LIG_SUMO_SIM_anti_2	625	630	PF11976	0.555
LIG_SUMO_SIM_par_1	101	106	PF11976	0.208
LIG_SUMO_SIM_par_1	421	427	PF11976	0.199
LIG_SUMO_SIM_par_1	549	554	PF11976	0.204
LIG_SUMO_SIM_par_1	627	633	PF11976	0.532
LIG_TRFH_1	98	102	PF08558	0.208
LIG_TYR_ITIM	499	504	PF00017	0.566
LIG_TYR_ITIM	556	561	PF00017	0.199
LIG_TYR_ITSM	350	357	PF00017	0.289
LIG_UBA3_1	192	199	PF00899	0.362
LIG_UBA3_1	429	438	PF00899	0.199
LIG_WRC_WIRS_1	373	378	PF05994	0.231
LIG_WRC_WIRS_1	95	100	PF05994	0.208
LIG_WW_2	177	180	PF00397	0.331
LIG_WW_3	164	168	PF00397	0.362
MOD_CDC14_SPxK_1	164	167	PF00782	0.360
MOD_CDK_SPxK_1	161	167	PF00069	0.362
MOD_CK1_1	159	165	PF00069	0.364
MOD_CK1_1	200	206	PF00069	0.635
MOD_CK1_1	258	264	PF00069	0.399
MOD_CK1_1	282	288	PF00069	0.466
MOD_CK1_1	289	295	PF00069	0.503
MOD_CK1_1	297	303	PF00069	0.424
MOD_CK1_1	31	37	PF00069	0.648
MOD_CK1_1	385	391	PF00069	0.429
MOD_CK1_1	393	399	PF00069	0.458
MOD_CK1_1	401	407	PF00069	0.471
MOD_CK1_1	414	420	PF00069	0.444
MOD_CK1_1	424	430	PF00069	0.290
MOD_CK1_1	482	488	PF00069	0.626
MOD_CK1_1	493	499	PF00069	0.738
MOD_CK1_1	94	100	PF00069	0.289
MOD_CK2_1	114	120	PF00069	0.360
MOD_GlcNHglycan	126	129	PF01048	0.565
MOD_GlcNHglycan	202	205	PF01048	0.407
MOD_GlcNHglycan	244	247	PF01048	0.491
MOD_GlcNHglycan	257	260	PF01048	0.539
MOD_GlcNHglycan	272	275	PF01048	0.664
MOD_GlcNHglycan	282	285	PF01048	0.570
MOD_GlcNHglycan	293	296	PF01048	0.537
MOD_GlcNHglycan	34	37	PF01048	0.491
MOD_GlcNHglycan	344	347	PF01048	0.208
MOD_GlcNHglycan	376	379	PF01048	0.415
MOD_GlcNHglycan	384	387	PF01048	0.619
MOD_GlcNHglycan	401	404	PF01048	0.651
MOD_GlcNHglycan	411	414	PF01048	0.618
MOD_GlcNHglycan	430	433	PF01048	0.267
MOD_GlcNHglycan	481	484	PF01048	0.479
MOD_GlcNHglycan	495	498	PF01048	0.362
MOD_GlcNHglycan	573	576	PF01048	0.367
MOD_GlcNHglycan	579	582	PF01048	0.409
MOD_GlcNHglycan	675	678	PF01048	0.199
MOD_GSK3_1	110	117	PF00069	0.589
MOD_GSK3_1	131	138	PF00069	0.395
MOD_GSK3_1	157	164	PF00069	0.365
MOD_GSK3_1	199	206	PF00069	0.674
MOD_GSK3_1	207	214	PF00069	0.662
MOD_GSK3_1	242	249	PF00069	0.265
MOD_GSK3_1	26	33	PF00069	0.547
MOD_GSK3_1	264	271	PF00069	0.366
MOD_GSK3_1	278	285	PF00069	0.379
MOD_GSK3_1	286	293	PF00069	0.527
MOD_GSK3_1	349	356	PF00069	0.260
MOD_GSK3_1	381	388	PF00069	0.412
MOD_GSK3_1	390	397	PF00069	0.481
MOD_GSK3_1	424	431	PF00069	0.301
MOD_GSK3_1	46	53	PF00069	0.626
MOD_GSK3_1	482	489	PF00069	0.645
MOD_GSK3_1	571	578	PF00069	0.577
MOD_GSK3_1	633	640	PF00069	0.564
MOD_GSK3_1	74	81	PF00069	0.584
MOD_GSK3_1	90	97	PF00069	0.532
MOD_LATS_1	503	509	PF00433	0.551
MOD_N-GLC_1	66	71	PF02516	0.521
MOD_NEK2_1	131	136	PF00069	0.367
MOD_NEK2_1	172	177	PF00069	0.364
MOD_NEK2_1	223	228	PF00069	0.199
MOD_NEK2_1	253	258	PF00069	0.353
MOD_NEK2_1	26	31	PF00069	0.535
MOD_NEK2_1	270	275	PF00069	0.482
MOD_NEK2_1	279	284	PF00069	0.446
MOD_NEK2_1	290	295	PF00069	0.439
MOD_NEK2_1	342	347	PF00069	0.405
MOD_NEK2_1	382	387	PF00069	0.322
MOD_NEK2_1	409	414	PF00069	0.352
MOD_NEK2_1	421	426	PF00069	0.199
MOD_NEK2_1	506	511	PF00069	0.646
MOD_NEK2_1	551	556	PF00069	0.212
MOD_NEK2_1	571	576	PF00069	0.555
MOD_NEK2_1	638	643	PF00069	0.199
MOD_NEK2_1	655	660	PF00069	0.344
MOD_NEK2_1	74	79	PF00069	0.730
MOD_NEK2_2	353	358	PF00069	0.297
MOD_OFUCOSY	108	114	PF10250	0.453
MOD_OFUCOSY	184	191	PF10250	0.208
MOD_PIKK_1	404	410	PF00454	0.389
MOD_PKA_1	207	213	PF00069	0.608
MOD_PKA_2	200	206	PF00069	0.546
MOD_PKA_2	207	213	PF00069	0.591
MOD_PKA_2	31	37	PF00069	0.555
MOD_PKA_2	38	44	PF00069	0.577
MOD_PKA_2	446	452	PF00069	0.527
MOD_PKA_2	467	473	PF00069	0.563
MOD_PKA_2	504	510	PF00069	0.633
MOD_PKA_2	571	577	PF00069	0.534
MOD_PKA_2	88	94	PF00069	0.572
MOD_Plk_1	286	292	PF00069	0.368
MOD_Plk_1	66	72	PF00069	0.570
MOD_Plk_2-3	215	221	PF00069	0.509
MOD_Plk_4	15	21	PF00069	0.521
MOD_Plk_4	224	230	PF00069	0.199
MOD_Plk_4	315	321	PF00069	0.362
MOD_Plk_4	333	339	PF00069	0.199
MOD_Plk_4	349	355	PF00069	0.199
MOD_Plk_4	385	391	PF00069	0.350
MOD_Plk_4	414	420	PF00069	0.321
MOD_Plk_4	421	427	PF00069	0.340
MOD_Plk_4	551	557	PF00069	0.217
MOD_Plk_4	8	14	PF00069	0.538
MOD_Plk_4	94	100	PF00069	0.391
MOD_ProDKin_1	114	120	PF00069	0.360
MOD_ProDKin_1	161	167	PF00069	0.362
MOD_ProDKin_1	173	179	PF00069	0.328
MOD_ProDKin_1	395	401	PF00069	0.504
MOD_ProDKin_1	40	46	PF00069	0.767
MOD_ProDKin_1	411	417	PF00069	0.393
MOD_ProDKin_1	482	488	PF00069	0.725
MOD_ProDKin_1	490	496	PF00069	0.762
MOD_SUMO_for_1	82	85	PF00179	0.602
MOD_SUMO_rev_2	439	446	PF00179	0.497
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.367
TRG_DiLeu_BaLyEn_6	450	455	PF01217	0.530
TRG_ENDOCYTIC_2	19	22	PF00928	0.540
TRG_ENDOCYTIC_2	317	320	PF00928	0.314
TRG_ENDOCYTIC_2	321	324	PF00928	0.308
TRG_ENDOCYTIC_2	354	357	PF00928	0.447
TRG_ENDOCYTIC_2	458	461	PF00928	0.521
TRG_ENDOCYTIC_2	501	504	PF00928	0.566
TRG_ENDOCYTIC_2	520	523	PF00928	0.199
TRG_ENDOCYTIC_2	558	561	PF00928	0.199
TRG_ENDOCYTIC_2	563	566	PF00928	0.497
TRG_ENDOCYTIC_2	58	61	PF00928	0.570
TRG_ER_diArg_1	311	314	PF00400	0.391
TRG_ER_diArg_1	467	469	PF00400	0.550
TRG_ER_diArg_1	587	590	PF00400	0.532
TRG_NES_CRM1_1	618	630	PF08389	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2R3	Leptomonas seymouri	51%	100%