Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania braziliensis

UniProt:

A4H3E3_LEIBR

TriTrypDb:

LbrM.02.0500 , LBRM2903_020011000

Length:

850

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3E3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3E3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	62	68	PF00089	0.626
CLV_NRD_NRD_1	206	208	PF00675	0.660
CLV_NRD_NRD_1	240	242	PF00675	0.475
CLV_NRD_NRD_1	301	303	PF00675	0.722
CLV_NRD_NRD_1	415	417	PF00675	0.601
CLV_NRD_NRD_1	492	494	PF00675	0.743
CLV_NRD_NRD_1	590	592	PF00675	0.730
CLV_NRD_NRD_1	740	742	PF00675	0.698
CLV_NRD_NRD_1	79	81	PF00675	0.528
CLV_PCSK_FUR_1	587	591	PF00082	0.572
CLV_PCSK_FUR_1	77	81	PF00082	0.516
CLV_PCSK_KEX2_1	206	208	PF00082	0.660
CLV_PCSK_KEX2_1	240	242	PF00082	0.475
CLV_PCSK_KEX2_1	300	302	PF00082	0.730
CLV_PCSK_KEX2_1	489	491	PF00082	0.745
CLV_PCSK_KEX2_1	589	591	PF00082	0.730
CLV_PCSK_KEX2_1	660	662	PF00082	0.520
CLV_PCSK_KEX2_1	79	81	PF00082	0.519
CLV_PCSK_PC1ET2_1	489	491	PF00082	0.745
CLV_PCSK_PC1ET2_1	660	662	PF00082	0.520
CLV_PCSK_SKI1_1	288	292	PF00082	0.558
CLV_PCSK_SKI1_1	417	421	PF00082	0.539
CLV_PCSK_SKI1_1	544	548	PF00082	0.696
CLV_PCSK_SKI1_1	79	83	PF00082	0.522
DEG_APCC_DBOX_1	206	214	PF00400	0.660
DEG_SCF_FBW7_1	382	387	PF00400	0.566
DEG_SCF_TRCP1_1	617	623	PF00400	0.533
DEG_SPOP_SBC_1	101	105	PF00917	0.535
DEG_SPOP_SBC_1	146	150	PF00917	0.635
DEG_SPOP_SBC_1	384	388	PF00917	0.685
DEG_SPOP_SBC_1	834	838	PF00917	0.524
DOC_MAPK_DCC_7	206	215	PF00069	0.658
DOC_MAPK_DCC_7	524	532	PF00069	0.528
DOC_MAPK_gen_1	206	213	PF00069	0.660
DOC_MAPK_MEF2A_6	206	215	PF00069	0.658
DOC_MAPK_MEF2A_6	524	532	PF00069	0.528
DOC_MAPK_MEF2A_6	703	711	PF00069	0.675
DOC_PP2B_LxvP_1	349	352	PF13499	0.668
DOC_PP2B_LxvP_1	530	533	PF13499	0.510
DOC_PP4_FxxP_1	675	678	PF00568	0.530
DOC_SPAK_OSR1_1	724	728	PF12202	0.677
DOC_USP7_MATH_1	100	104	PF00917	0.569
DOC_USP7_MATH_1	117	121	PF00917	0.537
DOC_USP7_MATH_1	125	129	PF00917	0.545
DOC_USP7_MATH_1	14	18	PF00917	0.673
DOC_USP7_MATH_1	146	150	PF00917	0.566
DOC_USP7_MATH_1	164	168	PF00917	0.703
DOC_USP7_MATH_1	220	224	PF00917	0.644
DOC_USP7_MATH_1	275	279	PF00917	0.547
DOC_USP7_MATH_1	29	33	PF00917	0.566
DOC_USP7_MATH_1	364	368	PF00917	0.701
DOC_USP7_MATH_1	400	404	PF00917	0.670
DOC_USP7_MATH_1	433	437	PF00917	0.610
DOC_USP7_MATH_1	471	475	PF00917	0.714
DOC_USP7_MATH_1	484	488	PF00917	0.625
DOC_USP7_MATH_1	576	580	PF00917	0.611
DOC_USP7_MATH_1	604	608	PF00917	0.594
DOC_USP7_MATH_1	609	613	PF00917	0.638
DOC_USP7_MATH_1	669	673	PF00917	0.691
DOC_USP7_MATH_1	688	692	PF00917	0.528
DOC_USP7_MATH_1	705	709	PF00917	0.530
DOC_USP7_MATH_1	73	77	PF00917	0.556
DOC_USP7_MATH_1	833	837	PF00917	0.695
DOC_USP7_MATH_1	89	93	PF00917	0.523
DOC_WW_Pin1_4	111	116	PF00397	0.721
DOC_WW_Pin1_4	160	165	PF00397	0.637
DOC_WW_Pin1_4	17	22	PF00397	0.556
DOC_WW_Pin1_4	2	7	PF00397	0.734
DOC_WW_Pin1_4	295	300	PF00397	0.633
DOC_WW_Pin1_4	380	385	PF00397	0.688
DOC_WW_Pin1_4	426	431	PF00397	0.654
DOC_WW_Pin1_4	488	493	PF00397	0.742
DOC_WW_Pin1_4	674	679	PF00397	0.698
LIG_14-3-3_CanoR_1	309	315	PF00244	0.586
LIG_14-3-3_CanoR_1	493	499	PF00244	0.570
LIG_14-3-3_CanoR_1	515	519	PF00244	0.703
LIG_14-3-3_CanoR_1	589	594	PF00244	0.718
LIG_14-3-3_CanoR_1	620	625	PF00244	0.623
LIG_14-3-3_CanoR_1	673	678	PF00244	0.528
LIG_14-3-3_CanoR_1	724	728	PF00244	0.651
LIG_Actin_WH2_2	324	342	PF00022	0.616
LIG_BIR_II_1	1	5	PF00653	0.741
LIG_BRCT_BRCA1_1	671	675	PF00533	0.526
LIG_BRCT_BRCA1_1	721	725	PF00533	0.668
LIG_eIF4E_1	205	211	PF01652	0.657
LIG_eIF4E_1	540	546	PF01652	0.691
LIG_FHA_1	13	19	PF00498	0.721
LIG_FHA_1	166	172	PF00498	0.575
LIG_FHA_1	292	298	PF00498	0.555
LIG_FHA_1	49	55	PF00498	0.666
LIG_FHA_1	520	526	PF00498	0.699
LIG_FHA_1	545	551	PF00498	0.702
LIG_FHA_1	601	607	PF00498	0.549
LIG_FHA_1	724	730	PF00498	0.667
LIG_FHA_1	818	824	PF00498	0.659
LIG_FHA_1	97	103	PF00498	0.530
LIG_FHA_2	135	141	PF00498	0.577
LIG_FHA_2	353	359	PF00498	0.680
LIG_GBD_Chelix_1	327	335	PF00786	0.611
LIG_LIR_Apic_2	672	678	PF02991	0.527
LIG_LIR_Gen_1	30	37	PF02991	0.665
LIG_LIR_Gen_1	333	344	PF02991	0.612
LIG_LIR_Gen_1	403	413	PF02991	0.680
LIG_LIR_Gen_1	802	812	PF02991	0.608
LIG_LIR_Nem_3	30	36	PF02991	0.663
LIG_LIR_Nem_3	333	339	PF02991	0.608
LIG_LIR_Nem_3	342	348	PF02991	0.544
LIG_LIR_Nem_3	403	409	PF02991	0.678
LIG_LIR_Nem_3	802	807	PF02991	0.604
LIG_LYPXL_yS_3	448	451	PF13949	0.504
LIG_PTAP_UEV_1	142	147	PF05743	0.583
LIG_Rb_LxCxE_1	405	424	PF01857	0.696
LIG_SH2_CRK	804	808	PF00017	0.602
LIG_SH2_NCK_1	434	438	PF00017	0.518
LIG_SH2_PTP2	406	409	PF00017	0.685
LIG_SH2_SRC	274	277	PF00017	0.551
LIG_SH2_STAP1	434	438	PF00017	0.518
LIG_SH2_STAP1	772	776	PF00017	0.645
LIG_SH2_STAP1	804	808	PF00017	0.602
LIG_SH2_STAT5	37	40	PF00017	0.672
LIG_SH2_STAT5	406	409	PF00017	0.685
LIG_SH3_1	489	495	PF00018	0.576
LIG_SH3_3	140	146	PF00018	0.589
LIG_SH3_3	427	433	PF00018	0.520
LIG_SH3_3	464	470	PF00018	0.510
LIG_SH3_3	489	495	PF00018	0.576
LIG_SH3_3	523	529	PF00018	0.693
LIG_SH3_3	543	549	PF00018	0.528
LIG_SH3_3	704	710	PF00018	0.672
LIG_SH3_4	548	555	PF00018	0.553
LIG_SUMO_SIM_anti_2	223	229	PF11976	0.462
LIG_SUMO_SIM_anti_2	774	781	PF11976	0.659
MOD_CDC14_SPxK_1	298	301	PF00782	0.549
MOD_CDC14_SPxK_1	491	494	PF00782	0.742
MOD_CDK_SPK_2	295	300	PF00069	0.578
MOD_CDK_SPK_2	488	493	PF00069	0.742
MOD_CDK_SPK_2	678	683	PF00069	0.540
MOD_CDK_SPxK_1	295	301	PF00069	0.579
MOD_CDK_SPxK_1	488	494	PF00069	0.743
MOD_CDK_SPxxK_3	295	302	PF00069	0.635
MOD_CK1_1	103	109	PF00069	0.698
MOD_CK1_1	148	154	PF00069	0.579
MOD_CK1_1	17	23	PF00069	0.554
MOD_CK1_1	2	8	PF00069	0.734
MOD_CK1_1	223	229	PF00069	0.631
MOD_CK1_1	265	271	PF00069	0.593
MOD_CK1_1	312	318	PF00069	0.671
MOD_CK1_1	396	402	PF00069	0.682
MOD_CK1_1	585	591	PF00069	0.585
MOD_CK1_1	612	618	PF00069	0.585
MOD_CK1_1	677	683	PF00069	0.709
MOD_CK1_1	75	81	PF00069	0.510
MOD_CK1_1	758	764	PF00069	0.657
MOD_CK2_1	134	140	PF00069	0.574
MOD_CK2_1	352	358	PF00069	0.771
MOD_CK2_1	449	455	PF00069	0.659
MOD_CK2_1	589	595	PF00069	0.723
MOD_CK2_1	64	70	PF00069	0.634
MOD_GlcNHglycan	1	4	PF01048	0.741
MOD_GlcNHglycan	127	130	PF01048	0.621
MOD_GlcNHglycan	143	146	PF01048	0.666
MOD_GlcNHglycan	150	153	PF01048	0.628
MOD_GlcNHglycan	155	158	PF01048	0.579
MOD_GlcNHglycan	315	318	PF01048	0.650
MOD_GlcNHglycan	319	322	PF01048	0.496
MOD_GlcNHglycan	367	370	PF01048	0.793
MOD_GlcNHglycan	395	398	PF01048	0.696
MOD_GlcNHglycan	402	405	PF01048	0.597
MOD_GlcNHglycan	435	438	PF01048	0.555
MOD_GlcNHglycan	451	454	PF01048	0.537
MOD_GlcNHglycan	486	489	PF01048	0.640
MOD_GlcNHglycan	540	543	PF01048	0.612
MOD_GlcNHglycan	552	555	PF01048	0.663
MOD_GlcNHglycan	567	570	PF01048	0.537
MOD_GlcNHglycan	572	575	PF01048	0.598
MOD_GlcNHglycan	584	587	PF01048	0.568
MOD_GlcNHglycan	605	609	PF01048	0.667
MOD_GlcNHglycan	617	620	PF01048	0.548
MOD_GlcNHglycan	629	632	PF01048	0.554
MOD_GlcNHglycan	690	693	PF01048	0.680
MOD_GlcNHglycan	711	714	PF01048	0.675
MOD_GlcNHglycan	752	755	PF01048	0.666
MOD_GlcNHglycan	761	764	PF01048	0.636
MOD_GlcNHglycan	829	832	PF01048	0.657
MOD_GlcNHglycan	85	88	PF01048	0.700
MOD_GSK3_1	141	148	PF00069	0.560
MOD_GSK3_1	16	23	PF00069	0.574
MOD_GSK3_1	160	167	PF00069	0.623
MOD_GSK3_1	170	177	PF00069	0.704
MOD_GSK3_1	24	31	PF00069	0.516
MOD_GSK3_1	291	298	PF00069	0.593
MOD_GSK3_1	309	316	PF00069	0.618
MOD_GSK3_1	380	387	PF00069	0.716
MOD_GSK3_1	396	403	PF00069	0.650
MOD_GSK3_1	433	440	PF00069	0.567
MOD_GSK3_1	44	51	PF00069	0.602
MOD_GSK3_1	484	491	PF00069	0.621
MOD_GSK3_1	561	568	PF00069	0.561
MOD_GSK3_1	570	577	PF00069	0.644
MOD_GSK3_1	578	585	PF00069	0.569
MOD_GSK3_1	600	607	PF00069	0.555
MOD_GSK3_1	640	647	PF00069	0.544
MOD_GSK3_1	669	676	PF00069	0.551
MOD_GSK3_1	677	684	PF00069	0.542
MOD_GSK3_1	705	712	PF00069	0.567
MOD_GSK3_1	719	726	PF00069	0.632
MOD_GSK3_1	728	735	PF00069	0.602
MOD_GSK3_1	750	757	PF00069	0.707
MOD_GSK3_1	8	15	PF00069	0.641
MOD_GSK3_1	96	103	PF00069	0.680
MOD_LATS_1	580	586	PF00433	0.576
MOD_N-GLC_1	449	454	PF02516	0.490
MOD_N-GLC_1	754	759	PF02516	0.680
MOD_NEK2_1	1	6	PF00069	0.569
MOD_NEK2_1	147	152	PF00069	0.658
MOD_NEK2_1	155	160	PF00069	0.624
MOD_NEK2_1	171	176	PF00069	0.600
MOD_NEK2_1	22	27	PF00069	0.670
MOD_NEK2_1	339	344	PF00069	0.679
MOD_NEK2_1	478	483	PF00069	0.539
MOD_NEK2_1	508	513	PF00069	0.666
MOD_NEK2_1	550	555	PF00069	0.663
MOD_NEK2_1	567	572	PF00069	0.564
MOD_NEK2_1	627	632	PF00069	0.532
MOD_NEK2_1	656	661	PF00069	0.525
MOD_NEK2_1	72	77	PF00069	0.501
MOD_PIKK_1	275	281	PF00454	0.569
MOD_PIKK_1	330	336	PF00454	0.639
MOD_PKA_1	589	595	PF00069	0.555
MOD_PKA_2	339	345	PF00069	0.714
MOD_PKA_2	478	484	PF00069	0.570
MOD_PKA_2	514	520	PF00069	0.704
MOD_PKA_2	589	595	PF00069	0.625
MOD_PKA_2	612	618	PF00069	0.540
MOD_PKA_2	64	70	PF00069	0.634
MOD_PKA_2	723	729	PF00069	0.646
MOD_PKB_1	587	595	PF00069	0.560
MOD_Plk_1	449	455	PF00069	0.551
MOD_Plk_1	462	468	PF00069	0.649
MOD_Plk_1	562	568	PF00069	0.564
MOD_Plk_1	644	650	PF00069	0.635
MOD_Plk_1	802	808	PF00069	0.604
MOD_Plk_2-3	644	650	PF00069	0.534
MOD_Plk_4	150	156	PF00069	0.556
MOD_Plk_4	211	217	PF00069	0.659
MOD_Plk_4	223	229	PF00069	0.506
MOD_Plk_4	29	35	PF00069	0.681
MOD_Plk_4	303	309	PF00069	0.553
MOD_Plk_4	402	408	PF00069	0.677
MOD_Plk_4	437	443	PF00069	0.678
MOD_Plk_4	462	468	PF00069	0.505
MOD_Plk_4	622	628	PF00069	0.532
MOD_Plk_4	802	808	PF00069	0.604
MOD_Plk_4	818	824	PF00069	0.493
MOD_ProDKin_1	111	117	PF00069	0.723
MOD_ProDKin_1	160	166	PF00069	0.637
MOD_ProDKin_1	17	23	PF00069	0.554
MOD_ProDKin_1	2	8	PF00069	0.734
MOD_ProDKin_1	295	301	PF00069	0.634
MOD_ProDKin_1	380	386	PF00069	0.688
MOD_ProDKin_1	426	432	PF00069	0.654
MOD_ProDKin_1	488	494	PF00069	0.743
MOD_ProDKin_1	674	680	PF00069	0.701
MOD_SUMO_rev_2	258	268	PF00179	0.526
TRG_DiLeu_BaEn_1	803	808	PF01217	0.601
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.692
TRG_ENDOCYTIC_2	406	409	PF00928	0.685
TRG_ENDOCYTIC_2	448	451	PF00928	0.504
TRG_ENDOCYTIC_2	804	807	PF00928	0.602
TRG_ER_diArg_1	205	207	PF00400	0.660
TRG_ER_diArg_1	239	241	PF00400	0.497
TRG_ER_diArg_1	299	302	PF00400	0.720
TRG_ER_diArg_1	587	590	PF00400	0.574
TRG_ER_diArg_1	77	80	PF00400	0.519
TRG_NLS_MonoCore_2	492	497	PF00514	0.575
TRG_NLS_MonoExtN_4	490	497	PF00514	0.718
TRG_Pf-PMV_PEXEL_1	591	595	PF00026	0.716

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJI8	Leishmania donovani	63%	98%
A4HRP8	Leishmania infantum	63%	98%
E9ACC7	Leishmania major	60%	99%
E9AJL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	98%