Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3E2_LEIBR

TriTrypDb:

LbrM.02.0490 , LBRM2903_020010700

Length:

170

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3E2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.401
CLV_NRD_NRD_1	58	60	PF00675	0.618
CLV_PCSK_KEX2_1	109	111	PF00082	0.401
CLV_PCSK_KEX2_1	58	60	PF00082	0.618
CLV_PCSK_SKI1_1	109	113	PF00082	0.567
CLV_PCSK_SKI1_1	80	84	PF00082	0.548
DEG_Nend_UBRbox_1	1	4	PF02207	0.489
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.587
DOC_PP1_RVXF_1	14	20	PF00149	0.482
DOC_USP7_MATH_1	66	70	PF00917	0.496
DOC_USP7_MATH_1	85	89	PF00917	0.596
DOC_WW_Pin1_4	69	74	PF00397	0.638
LIG_14-3-3_CanoR_1	16	20	PF00244	0.584
LIG_14-3-3_CanoR_1	58	64	PF00244	0.567
LIG_Actin_WH2_2	44	60	PF00022	0.661
LIG_BIR_III_4	117	121	PF00653	0.602
LIG_deltaCOP1_diTrp_1	107	111	PF00928	0.555
LIG_FHA_1	58	64	PF00498	0.527
LIG_FHA_1	76	82	PF00498	0.555
LIG_FHA_2	143	149	PF00498	0.573
LIG_FHA_2	91	97	PF00498	0.611
LIG_LIR_Nem_3	107	111	PF02991	0.669
LIG_LIR_Nem_3	29	35	PF02991	0.647
LIG_RPA_C_Fungi	54	66	PF08784	0.478
LIG_SH2_STAP1	161	165	PF00017	0.464
LIG_SH3_3	27	33	PF00018	0.556
LIG_TRAF2_1	93	96	PF00917	0.617
MOD_CK1_1	69	75	PF00069	0.615
MOD_CK2_1	142	148	PF00069	0.622
MOD_CK2_1	23	29	PF00069	0.647
MOD_CK2_1	90	96	PF00069	0.619
MOD_GlcNHglycan	68	71	PF01048	0.621
MOD_GSK3_1	65	72	PF00069	0.595
MOD_NEK2_1	57	62	PF00069	0.572
MOD_NEK2_1	6	11	PF00069	0.565
MOD_PK_1	59	65	PF00069	0.481
MOD_PKA_2	15	21	PF00069	0.484
MOD_PKA_2	57	63	PF00069	0.566
MOD_PKA_2	90	96	PF00069	0.558
MOD_Plk_2-3	142	148	PF00069	0.424
MOD_Plk_4	15	21	PF00069	0.493
MOD_ProDKin_1	69	75	PF00069	0.639
TRG_DiLeu_BaEn_2	106	112	PF01217	0.561
TRG_ER_diArg_1	1	4	PF00400	0.489
TRG_ER_diArg_1	108	110	PF00400	0.409
TRG_ER_diArg_1	57	59	PF00400	0.612
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.675

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJI7	Leishmania donovani	73%	100%
A4HRP6	Leishmania infantum	73%	100%
E9ACC5	Leishmania major	69%	100%
E9AJL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%