Putative glycerate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerate kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H3E1_LEIBR

TriTrypDb:

LbrM.02.0480 , LBRM2903_020010600

Length:

950

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3E1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0031388	organic acid phosphorylation	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044281	small molecule metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008887	glycerate kinase activity	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.367
CLV_C14_Caspase3-7	364	368	PF00656	0.403
CLV_NRD_NRD_1	282	284	PF00675	0.308
CLV_NRD_NRD_1	676	678	PF00675	0.666
CLV_NRD_NRD_1	69	71	PF00675	0.582
CLV_NRD_NRD_1	715	717	PF00675	0.427
CLV_NRD_NRD_1	77	79	PF00675	0.543
CLV_NRD_NRD_1	865	867	PF00675	0.452
CLV_NRD_NRD_1	929	931	PF00675	0.487
CLV_NRD_NRD_1	96	98	PF00675	0.533
CLV_PCSK_KEX2_1	282	284	PF00082	0.323
CLV_PCSK_KEX2_1	467	469	PF00082	0.659
CLV_PCSK_KEX2_1	676	678	PF00082	0.680
CLV_PCSK_KEX2_1	685	687	PF00082	0.611
CLV_PCSK_KEX2_1	69	71	PF00082	0.613
CLV_PCSK_KEX2_1	715	717	PF00082	0.408
CLV_PCSK_KEX2_1	77	79	PF00082	0.543
CLV_PCSK_KEX2_1	865	867	PF00082	0.452
CLV_PCSK_KEX2_1	929	931	PF00082	0.487
CLV_PCSK_KEX2_1	95	97	PF00082	0.546
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.556
CLV_PCSK_PC1ET2_1	685	687	PF00082	0.698
CLV_PCSK_SKI1_1	282	286	PF00082	0.328
CLV_PCSK_SKI1_1	319	323	PF00082	0.403
CLV_PCSK_SKI1_1	355	359	PF00082	0.324
CLV_PCSK_SKI1_1	448	452	PF00082	0.311
CLV_PCSK_SKI1_1	506	510	PF00082	0.318
CLV_PCSK_SKI1_1	637	641	PF00082	0.358
CLV_PCSK_SKI1_1	783	787	PF00082	0.486
CLV_PCSK_SKI1_1	813	817	PF00082	0.343
DEG_APCC_DBOX_1	318	326	PF00400	0.403
DEG_Nend_UBRbox_3	1	3	PF02207	0.585
DOC_CKS1_1	658	663	PF01111	0.429
DOC_CKS1_1	83	88	PF01111	0.579
DOC_CKS1_1	897	902	PF01111	0.509
DOC_CYCLIN_RxL_1	192	203	PF00134	0.235
DOC_CYCLIN_RxL_1	810	821	PF00134	0.362
DOC_MAPK_gen_1	77	83	PF00069	0.569
DOC_MAPK_gen_1	780	790	PF00069	0.429
DOC_MAPK_MEF2A_6	282	289	PF00069	0.318
DOC_MAPK_NFAT4_5	282	290	PF00069	0.235
DOC_PP2B_LxvP_1	171	174	PF13499	0.683
DOC_PP2B_LxvP_1	197	200	PF13499	0.228
DOC_PP2B_LxvP_1	63	66	PF13499	0.574
DOC_PP2B_LxvP_1	815	818	PF13499	0.404
DOC_PP4_FxxP_1	695	698	PF00568	0.534
DOC_PP4_FxxP_1	903	906	PF00568	0.617
DOC_USP7_MATH_1	268	272	PF00917	0.232
DOC_USP7_MATH_1	403	407	PF00917	0.759
DOC_USP7_MATH_1	476	480	PF00917	0.712
DOC_USP7_MATH_1	537	541	PF00917	0.559
DOC_USP7_MATH_1	542	546	PF00917	0.631
DOC_USP7_MATH_1	558	562	PF00917	0.471
DOC_USP7_MATH_1	68	72	PF00917	0.580
DOC_USP7_MATH_1	717	721	PF00917	0.404
DOC_USP7_MATH_1	818	822	PF00917	0.511
DOC_USP7_MATH_1	831	835	PF00917	0.560
DOC_USP7_MATH_1	875	879	PF00917	0.395
DOC_USP7_MATH_1	941	945	PF00917	0.472
DOC_USP7_MATH_2	155	161	PF00917	0.632
DOC_WW_Pin1_4	100	105	PF00397	0.511
DOC_WW_Pin1_4	160	165	PF00397	0.644
DOC_WW_Pin1_4	340	345	PF00397	0.469
DOC_WW_Pin1_4	36	41	PF00397	0.560
DOC_WW_Pin1_4	45	50	PF00397	0.657
DOC_WW_Pin1_4	457	462	PF00397	0.603
DOC_WW_Pin1_4	477	482	PF00397	0.637
DOC_WW_Pin1_4	532	537	PF00397	0.604
DOC_WW_Pin1_4	620	625	PF00397	0.310
DOC_WW_Pin1_4	657	662	PF00397	0.425
DOC_WW_Pin1_4	670	675	PF00397	0.586
DOC_WW_Pin1_4	82	87	PF00397	0.654
DOC_WW_Pin1_4	829	834	PF00397	0.494
DOC_WW_Pin1_4	896	901	PF00397	0.485
LIG_14-3-3_CanoR_1	308	313	PF00244	0.390
LIG_14-3-3_CanoR_1	388	395	PF00244	0.360
LIG_14-3-3_CanoR_1	440	450	PF00244	0.306
LIG_14-3-3_CanoR_1	506	514	PF00244	0.318
LIG_14-3-3_CanoR_1	590	596	PF00244	0.426
LIG_14-3-3_CanoR_1	69	73	PF00244	0.639
LIG_14-3-3_CanoR_1	783	791	PF00244	0.451
LIG_14-3-3_CanoR_1	859	865	PF00244	0.345
LIG_14-3-3_CanoR_1	892	896	PF00244	0.389
LIG_14-3-3_CanoR_1	929	939	PF00244	0.602
LIG_14-3-3_CanoR_1	95	105	PF00244	0.518
LIG_Actin_WH2_2	916	934	PF00022	0.384
LIG_APCC_ABBA_1	378	383	PF00400	0.403
LIG_APCC_ABBA_1	835	840	PF00400	0.486
LIG_BRCT_BRCA1_1	632	636	PF00533	0.341
LIG_BRCT_BRCA1_1	860	864	PF00533	0.427
LIG_EH1_1	311	319	PF00400	0.318
LIG_eIF4E_1	312	318	PF01652	0.318
LIG_eIF4E_1	723	729	PF01652	0.314
LIG_FHA_1	151	157	PF00498	0.531
LIG_FHA_1	176	182	PF00498	0.528
LIG_FHA_1	211	217	PF00498	0.235
LIG_FHA_1	395	401	PF00498	0.495
LIG_FHA_1	56	62	PF00498	0.618
LIG_FHA_1	587	593	PF00498	0.361
LIG_FHA_1	658	664	PF00498	0.443
LIG_FHA_1	722	728	PF00498	0.424
LIG_FHA_1	784	790	PF00498	0.462
LIG_FHA_1	812	818	PF00498	0.476
LIG_FHA_1	897	903	PF00498	0.517
LIG_FHA_2	818	824	PF00498	0.499
LIG_GBD_Chelix_1	591	599	PF00786	0.311
LIG_Integrin_RGD_1	690	692	PF01839	0.612
LIG_LIR_Apic_2	692	698	PF02991	0.534
LIG_LIR_Apic_2	886	891	PF02991	0.473
LIG_LIR_Gen_1	798	808	PF02991	0.487
LIG_LIR_Nem_3	594	599	PF02991	0.404
LIG_LIR_Nem_3	633	639	PF02991	0.344
LIG_LIR_Nem_3	798	803	PF02991	0.439
LIG_MLH1_MIPbox_1	632	636	PF16413	0.341
LIG_MYND_1	900	904	PF01753	0.639
LIG_NRBOX	616	622	PF00104	0.400
LIG_PDZ_Class_1	945	950	PF00595	0.546
LIG_REV1ctd_RIR_1	633	641	PF16727	0.350
LIG_SH2_CRK	320	324	PF00017	0.235
LIG_SH2_CRK	888	892	PF00017	0.466
LIG_SH2_CRK	913	917	PF00017	0.485
LIG_SH2_NCK_1	320	324	PF00017	0.377
LIG_SH2_SRC	242	245	PF00017	0.318
LIG_SH2_SRC	644	647	PF00017	0.377
LIG_SH2_STAP1	320	324	PF00017	0.386
LIG_SH2_STAP1	723	727	PF00017	0.329
LIG_SH2_STAT3	638	641	PF00017	0.363
LIG_SH2_STAT5	242	245	PF00017	0.318
LIG_SH2_STAT5	453	456	PF00017	0.511
LIG_SH2_STAT5	488	491	PF00017	0.403
LIG_SH2_STAT5	638	641	PF00017	0.387
LIG_SH2_STAT5	644	647	PF00017	0.348
LIG_SH2_STAT5	723	726	PF00017	0.338
LIG_SH2_STAT5	765	768	PF00017	0.445
LIG_SH2_STAT5	800	803	PF00017	0.433
LIG_SH2_STAT5	854	857	PF00017	0.391
LIG_SH2_STAT5	888	891	PF00017	0.381
LIG_SH3_3	149	155	PF00018	0.622
LIG_SH3_3	161	167	PF00018	0.634
LIG_SH3_3	169	175	PF00018	0.478
LIG_SH3_3	179	185	PF00018	0.567
LIG_SH3_3	238	244	PF00018	0.318
LIG_SH3_3	449	455	PF00018	0.571
LIG_SH3_3	478	484	PF00018	0.678
LIG_SH3_3	58	64	PF00018	0.662
LIG_SH3_3	69	75	PF00018	0.691
LIG_SH3_3	80	86	PF00018	0.597
LIG_SH3_3	894	900	PF00018	0.449
LIG_SH3_CIN85_PxpxPR_1	64	69	PF14604	0.577
LIG_SUMO_SIM_anti_2	786	792	PF11976	0.380
LIG_SUMO_SIM_par_1	283	288	PF11976	0.318
LIG_SUMO_SIM_par_1	813	821	PF11976	0.373
LIG_TRAF2_1	155	158	PF00917	0.697
LIG_TYR_ITIM	318	323	PF00017	0.235
LIG_WW_3	482	486	PF00397	0.467
MOD_CDC14_SPxK_1	103	106	PF00782	0.441
MOD_CDC14_SPxK_1	673	676	PF00782	0.513
MOD_CDK_SPK_2	657	662	PF00069	0.345
MOD_CDK_SPK_2	82	87	PF00069	0.579
MOD_CDK_SPxK_1	100	106	PF00069	0.491
MOD_CDK_SPxK_1	670	676	PF00069	0.515
MOD_CDK_SPxxK_3	670	677	PF00069	0.518
MOD_CDK_SPxxK_3	829	836	PF00069	0.458
MOD_CK1_1	160	166	PF00069	0.642
MOD_CK1_1	229	235	PF00069	0.235
MOD_CK1_1	343	349	PF00069	0.417
MOD_CK1_1	5	11	PF00069	0.586
MOD_CK1_1	669	675	PF00069	0.573
MOD_CK1_1	742	748	PF00069	0.402
MOD_CK2_1	541	547	PF00069	0.555
MOD_CK2_1	607	613	PF00069	0.480
MOD_CMANNOS	132	135	PF00535	0.552
MOD_GlcNHglycan	140	143	PF01048	0.601
MOD_GlcNHglycan	186	189	PF01048	0.529
MOD_GlcNHglycan	20	24	PF01048	0.603
MOD_GlcNHglycan	260	264	PF01048	0.319
MOD_GlcNHglycan	405	408	PF01048	0.670
MOD_GlcNHglycan	443	446	PF01048	0.409
MOD_GlcNHglycan	544	547	PF01048	0.759
MOD_GlcNHglycan	608	612	PF01048	0.412
MOD_GlcNHglycan	632	635	PF01048	0.342
MOD_GlcNHglycan	668	671	PF01048	0.611
MOD_GlcNHglycan	729	732	PF01048	0.372
MOD_GlcNHglycan	879	882	PF01048	0.460
MOD_GlcNHglycan	917	920	PF01048	0.452
MOD_GlcNHglycan	932	935	PF01048	0.513
MOD_GSK3_1	110	117	PF00069	0.494
MOD_GSK3_1	158	165	PF00069	0.645
MOD_GSK3_1	19	26	PF00069	0.608
MOD_GSK3_1	208	215	PF00069	0.311
MOD_GSK3_1	222	229	PF00069	0.337
MOD_GSK3_1	252	259	PF00069	0.333
MOD_GSK3_1	268	275	PF00069	0.364
MOD_GSK3_1	28	35	PF00069	0.537
MOD_GSK3_1	457	464	PF00069	0.585
MOD_GSK3_1	524	531	PF00069	0.575
MOD_GSK3_1	537	544	PF00069	0.633
MOD_GSK3_1	666	673	PF00069	0.476
MOD_GSK3_1	703	710	PF00069	0.642
MOD_GSK3_1	717	724	PF00069	0.368
MOD_GSK3_1	727	734	PF00069	0.376
MOD_GSK3_1	798	805	PF00069	0.420
MOD_GSK3_1	941	948	PF00069	0.480
MOD_GSK3_1	96	103	PF00069	0.582
MOD_LATS_1	94	100	PF00433	0.577
MOD_N-GLC_1	10	15	PF02516	0.563
MOD_N-GLC_1	477	482	PF02516	0.528
MOD_N-GLC_2	887	889	PF02516	0.308
MOD_NEK2_1	114	119	PF00069	0.484
MOD_NEK2_1	176	181	PF00069	0.611
MOD_NEK2_1	19	24	PF00069	0.625
MOD_NEK2_1	208	213	PF00069	0.318
MOD_NEK2_1	227	232	PF00069	0.235
MOD_NEK2_1	32	37	PF00069	0.504
MOD_NEK2_1	528	533	PF00069	0.503
MOD_NEK2_1	666	671	PF00069	0.471
MOD_NEK2_1	803	808	PF00069	0.294
MOD_NEK2_1	924	929	PF00069	0.453
MOD_NEK2_2	110	115	PF00069	0.503
MOD_NEK2_2	717	722	PF00069	0.365
MOD_PIKK_1	394	400	PF00454	0.509
MOD_PKA_1	96	102	PF00069	0.546
MOD_PKA_2	307	313	PF00069	0.390
MOD_PKA_2	387	393	PF00069	0.490
MOD_PKA_2	441	447	PF00069	0.305
MOD_PKA_2	5	11	PF00069	0.701
MOD_PKA_2	68	74	PF00069	0.677
MOD_PKA_2	717	723	PF00069	0.366
MOD_PKA_2	858	864	PF00069	0.332
MOD_PKA_2	891	897	PF00069	0.394
MOD_PKA_2	96	102	PF00069	0.546
MOD_Plk_1	157	163	PF00069	0.630
MOD_Plk_1	736	742	PF00069	0.432
MOD_Plk_1	798	804	PF00069	0.441
MOD_Plk_1	875	881	PF00069	0.380
MOD_Plk_1	924	930	PF00069	0.542
MOD_Plk_4	176	182	PF00069	0.612
MOD_Plk_4	28	34	PF00069	0.530
MOD_Plk_4	524	530	PF00069	0.650
MOD_Plk_4	591	597	PF00069	0.474
MOD_Plk_4	717	723	PF00069	0.387
MOD_Plk_4	736	742	PF00069	0.473
MOD_Plk_4	803	809	PF00069	0.398
MOD_Plk_4	891	897	PF00069	0.401
MOD_Plk_4	935	941	PF00069	0.462
MOD_ProDKin_1	100	106	PF00069	0.502
MOD_ProDKin_1	160	166	PF00069	0.642
MOD_ProDKin_1	340	346	PF00069	0.469
MOD_ProDKin_1	36	42	PF00069	0.562
MOD_ProDKin_1	45	51	PF00069	0.655
MOD_ProDKin_1	457	463	PF00069	0.608
MOD_ProDKin_1	477	483	PF00069	0.632
MOD_ProDKin_1	532	538	PF00069	0.606
MOD_ProDKin_1	620	626	PF00069	0.304
MOD_ProDKin_1	657	663	PF00069	0.423
MOD_ProDKin_1	670	676	PF00069	0.588
MOD_ProDKin_1	82	88	PF00069	0.653
MOD_ProDKin_1	829	835	PF00069	0.495
MOD_ProDKin_1	896	902	PF00069	0.494
TRG_DiLeu_BaEn_1	281	286	PF01217	0.403
TRG_DiLeu_BaEn_4	157	163	PF01217	0.552
TRG_DiLeu_BaLyEn_6	745	750	PF01217	0.366
TRG_ENDOCYTIC_2	320	323	PF00928	0.235
TRG_ENDOCYTIC_2	800	803	PF00928	0.498
TRG_ENDOCYTIC_2	913	916	PF00928	0.494
TRG_ER_diArg_1	282	284	PF00400	0.302
TRG_ER_diArg_1	440	443	PF00400	0.304
TRG_ER_diArg_1	68	70	PF00400	0.584
TRG_ER_diArg_1	714	716	PF00400	0.432
TRG_ER_diArg_1	76	78	PF00400	0.542
TRG_ER_diArg_1	864	866	PF00400	0.418
TRG_ER_diArg_1	928	930	PF00400	0.480
TRG_ER_diArg_1	95	97	PF00400	0.543
TRG_NES_CRM1_1	433	446	PF08389	0.394
TRG_Pf-PMV_PEXEL_1	283	288	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	783	787	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L9	Leptomonas seymouri	45%	100%
A0A3S5H505	Leishmania donovani	69%	100%
A4HRP5	Leishmania infantum	69%	100%
E9ACC4	Leishmania major	69%	100%
E9AJL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%