Ribosome biogenesis protein slx9-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3D9_LEIBR

TriTrypDb:

LbrM.02.0460 , LBRM2903_020010400

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3D9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3D9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.514
CLV_C14_Caspase3-7	60	64	PF00656	0.464
CLV_NRD_NRD_1	117	119	PF00675	0.673
CLV_NRD_NRD_1	125	127	PF00675	0.687
CLV_NRD_NRD_1	17	19	PF00675	0.728
CLV_NRD_NRD_1	96	98	PF00675	0.822
CLV_PCSK_KEX2_1	117	119	PF00082	0.673
CLV_PCSK_KEX2_1	125	127	PF00082	0.687
CLV_PCSK_KEX2_1	195	197	PF00082	0.791
CLV_PCSK_KEX2_1	8	10	PF00082	0.699
CLV_PCSK_KEX2_1	96	98	PF00082	0.721
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.699
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.721
CLV_PCSK_SKI1_1	117	121	PF00082	0.689
CLV_PCSK_SKI1_1	126	130	PF00082	0.621
CLV_PCSK_SKI1_1	62	66	PF00082	0.573
CLV_PCSK_SKI1_1	97	101	PF00082	0.694
DEG_APCC_DBOX_1	125	133	PF00400	0.774
DOC_CKS1_1	179	184	PF01111	0.697
DOC_CKS1_1	42	47	PF01111	0.557
DOC_CYCLIN_RxL_1	122	133	PF00134	0.692
DOC_MAPK_gen_1	52	61	PF00069	0.518
DOC_MAPK_gen_1	71	80	PF00069	0.737
DOC_PP2B_LxvP_1	127	130	PF13499	0.660
DOC_USP7_MATH_1	14	18	PF00917	0.749
DOC_USP7_MATH_1	30	34	PF00917	0.688
DOC_USP7_MATH_1	83	87	PF00917	0.568
DOC_USP7_UBL2_3	15	19	PF12436	0.702
DOC_USP7_UBL2_3	98	102	PF12436	0.618
DOC_WW_Pin1_4	104	109	PF00397	0.564
DOC_WW_Pin1_4	178	183	PF00397	0.696
DOC_WW_Pin1_4	36	41	PF00397	0.763
DOC_WW_Pin1_4	46	51	PF00397	0.551
LIG_14-3-3_CanoR_1	117	122	PF00244	0.775
LIG_AP2alpha_2	161	163	PF02296	0.626
LIG_BIR_II_1	1	5	PF00653	0.700
LIG_FHA_1	111	117	PF00498	0.680
LIG_FHA_1	179	185	PF00498	0.633
LIG_FHA_2	131	137	PF00498	0.566
LIG_LIR_Gen_1	161	170	PF02991	0.628
LIG_LIR_Nem_3	161	166	PF02991	0.625
LIG_NRP_CendR_1	195	197	PF00754	0.555
LIG_SH3_3	176	182	PF00018	0.748
LIG_SH3_3	39	45	PF00018	0.557
LIG_TRAF2_1	134	137	PF00917	0.595
LIG_TRAF2_1	142	145	PF00917	0.601
MOD_CDC14_SPxK_1	49	52	PF00782	0.585
MOD_CDK_SPxK_1	46	52	PF00069	0.579
MOD_CK1_1	110	116	PF00069	0.771
MOD_CK1_1	34	40	PF00069	0.734
MOD_CK1_1	85	91	PF00069	0.562
MOD_CK2_1	130	136	PF00069	0.636
MOD_Cter_Amidation	193	196	PF01082	0.597
MOD_GlcNHglycan	25	28	PF01048	0.719
MOD_GlcNHglycan	33	36	PF01048	0.740
MOD_GlcNHglycan	91	94	PF01048	0.691
MOD_GSK3_1	106	113	PF00069	0.788
MOD_GSK3_1	30	37	PF00069	0.695
MOD_GSK3_1	44	51	PF00069	0.690
MOD_GSK3_1	81	88	PF00069	0.565
MOD_PIKK_1	107	113	PF00454	0.773
MOD_PIKK_1	86	92	PF00454	0.700
MOD_PKA_1	117	123	PF00069	0.693
MOD_PKA_1	97	103	PF00069	0.613
MOD_PKA_2	117	123	PF00069	0.776
MOD_PKA_2	86	92	PF00069	0.803
MOD_Plk_4	117	123	PF00069	0.776
MOD_ProDKin_1	104	110	PF00069	0.559
MOD_ProDKin_1	178	184	PF00069	0.696
MOD_ProDKin_1	36	42	PF00069	0.760
MOD_ProDKin_1	46	52	PF00069	0.552
TRG_ER_diArg_1	116	118	PF00400	0.680
TRG_ER_diArg_1	125	127	PF00400	0.687
TRG_ER_diArg_1	195	197	PF00400	0.751
TRG_ER_diArg_1	65	68	PF00400	0.633
TRG_ER_diArg_1	9	12	PF00400	0.555
TRG_NLS_MonoExtC_3	100	105	PF00514	0.577
TRG_NLS_MonoExtN_4	5	12	PF00514	0.802
TRG_NLS_MonoExtN_4	98	105	PF00514	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P478	Leptomonas seymouri	47%	90%
A0A451EJI4	Leishmania donovani	60%	98%
A4HRP3	Leishmania infantum	60%	98%
E9ACC2	Leishmania major	69%	100%
E9AJL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	98%