Voltage-dependent anion-selective channel protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial outer membrane protein porin, putative

Species:

Leishmania braziliensis

UniProt:

A4H3D7_LEIBR

TriTrypDb:

LbrM.02.0440 , LBRM2903_020010100

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	17
GO:0016020	membrane	2	17
GO:0019867	outer membrane	3	17
GO:0031090	organelle membrane	3	17
GO:0031966	mitochondrial membrane	4	17
GO:0031968	organelle outer membrane	4	17
GO:0098588	bounding membrane of organelle	4	17
GO:0110165	cellular anatomical entity	1	17
GO:0005739	mitochondrion	5	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0020022	acidocalcisome	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0046930	pore complex	3	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4H3D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3D7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	1
GO:0006839	mitochondrial transport	4	2
GO:0009987	cellular process	1	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	17
GO:0005216	monoatomic ion channel activity	4	17
GO:0005244	voltage-gated monoatomic ion channel activity	4	17
GO:0005253	monoatomic anion channel activity	5	17
GO:0008308	voltage-gated monoatomic anion channel activity	5	17
GO:0008509	monoatomic anion transmembrane transporter activity	4	17
GO:0015075	monoatomic ion transmembrane transporter activity	3	17
GO:0015103	inorganic anion transmembrane transporter activity	4	17
GO:0015267	channel activity	4	17
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	17
GO:0022803	passive transmembrane transporter activity	3	17
GO:0022832	voltage-gated channel activity	6	17
GO:0022836	gated channel activity	5	17
GO:0022857	transmembrane transporter activity	2	17
GO:0015288	porin activity	6	1
GO:0022829	wide pore channel activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	92	96	PF00082	0.548
DOC_CKS1_1	16	21	PF01111	0.532
DOC_PP4_FxxP_1	57	60	PF00568	0.422
DOC_USP7_UBL2_3	23	27	PF12436	0.391
DOC_WW_Pin1_4	138	143	PF00397	0.506
DOC_WW_Pin1_4	15	20	PF00397	0.568
DOC_WW_Pin1_4	84	89	PF00397	0.469
LIG_Actin_WH2_2	68	85	PF00022	0.486
LIG_BIR_II_1	1	5	PF00653	0.683
LIG_BRCT_BRCA1_1	199	203	PF00533	0.443
LIG_EH1_1	104	112	PF00400	0.498
LIG_eIF4E_1	16	22	PF01652	0.523
LIG_FHA_1	10	16	PF00498	0.426
LIG_FHA_1	234	240	PF00498	0.356
LIG_FHA_1	27	33	PF00498	0.501
LIG_FHA_1	40	46	PF00498	0.522
LIG_FHA_1	53	59	PF00498	0.527
LIG_FHA_1	85	91	PF00498	0.474
LIG_LIR_Apic_2	54	60	PF02991	0.408
LIG_LIR_Gen_1	202	209	PF02991	0.270
LIG_LIR_Nem_3	20	25	PF02991	0.408
LIG_LRP6_Inhibitor_1	246	252	PF00058	0.374
LIG_Pex14_1	261	265	PF04695	0.355
LIG_Pex14_2	203	207	PF04695	0.271
LIG_PTB_Apo_2	31	38	PF02174	0.267
LIG_SH2_CRK	16	20	PF00017	0.542
LIG_SH2_NCK_1	16	20	PF00017	0.542
LIG_SH2_SRC	120	123	PF00017	0.447
LIG_SH2_STAP1	205	209	PF00017	0.377
LIG_SH2_STAT5	100	103	PF00017	0.526
LIG_SH2_STAT5	265	268	PF00017	0.357
LIG_SH2_STAT5	74	77	PF00017	0.350
LIG_SH3_3	241	247	PF00018	0.522
LIG_UBA3_1	90	95	PF00899	0.419
MOD_CK1_1	123	129	PF00069	0.440
MOD_CK1_1	17	23	PF00069	0.352
MOD_CK1_1	6	12	PF00069	0.493
MOD_CK2_1	132	138	PF00069	0.442
MOD_CK2_1	275	281	PF00069	0.344
MOD_GlcNHglycan	199	202	PF01048	0.453
MOD_GlcNHglycan	64	67	PF01048	0.392
MOD_GSK3_1	128	135	PF00069	0.464
MOD_GSK3_1	193	200	PF00069	0.382
MOD_GSK3_1	94	101	PF00069	0.499
MOD_N-GLC_1	25	30	PF02516	0.402
MOD_N-GLC_1	62	67	PF02516	0.285
MOD_N-GLC_2	116	118	PF02516	0.320
MOD_N-GLC_2	166	168	PF02516	0.497
MOD_N-GLC_2	170	172	PF02516	0.492
MOD_N-GLC_2	212	214	PF02516	0.384
MOD_NEK2_1	8	13	PF00069	0.493
MOD_NEK2_1	82	87	PF00069	0.467
MOD_NEK2_1	94	99	PF00069	0.308
MOD_NEK2_2	247	252	PF00069	0.486
MOD_NEK2_2	52	57	PF00069	0.472
MOD_NEK2_2	98	103	PF00069	0.293
MOD_PK_1	132	138	PF00069	0.485
MOD_Plk_1	3	9	PF00069	0.469
MOD_Plk_4	17	23	PF00069	0.411
MOD_Plk_4	203	209	PF00069	0.510
MOD_Plk_4	261	267	PF00069	0.461
MOD_Plk_4	39	45	PF00069	0.292
MOD_Plk_4	52	58	PF00069	0.497
MOD_ProDKin_1	138	144	PF00069	0.504
MOD_ProDKin_1	15	21	PF00069	0.556
MOD_ProDKin_1	84	90	PF00069	0.479
MOD_SUMO_rev_2	89	97	PF00179	0.522
TRG_ENDOCYTIC_2	205	208	PF00928	0.281

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUD3	Leptomonas seymouri	70%	99%
A0A0N1IIR1	Leptomonas seymouri	34%	100%
A0A0S4JQ02	Bodo saltans	35%	100%
A0A1X0NJX9	Trypanosomatidae	42%	100%
A0A3R7M1M0	Trypanosoma rangeli	43%	100%
A0A3S5H502	Leishmania donovani	31%	100%
A0A3S5H503	Leishmania donovani	78%	100%
A0A422NPQ5	Trypanosoma rangeli	44%	100%
A4HRP1	Leishmania infantum	31%	100%
A4HRP2	Leishmania infantum	78%	100%
C9ZJ24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ACB9	Leishmania major	30%	98%
E9ACC0	Leishmania major	75%	100%
E9AJK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AJK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%