Putative RNA-editing complex protein MP81

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinetoplastid RNA editing protein 1, putative

Species:

Leishmania braziliensis

UniProt:

A4H3D6_LEIBR

TriTrypDb:

LbrM.02.0430 , LBRM2903_020009700

Length:

1000

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0031019	mitochondrial mRNA editing complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045293	mRNA editing complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4H3D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3D6

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0070705	RNA nucleotide insertion	6	1
GO:0070706	RNA nucleotide deletion	6	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1900864	mitochondrial RNA modification	6	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045294	alpha-catenin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	757	761	PF00656	0.524
CLV_C14_Caspase3-7	837	841	PF00656	0.584
CLV_C14_Caspase3-7	842	846	PF00656	0.567
CLV_C14_Caspase3-7	851	855	PF00656	0.614
CLV_NRD_NRD_1	259	261	PF00675	0.465
CLV_NRD_NRD_1	318	320	PF00675	0.519
CLV_NRD_NRD_1	460	462	PF00675	0.770
CLV_NRD_NRD_1	611	613	PF00675	0.539
CLV_NRD_NRD_1	764	766	PF00675	0.447
CLV_NRD_NRD_1	978	980	PF00675	0.444
CLV_PCSK_KEX2_1	258	260	PF00082	0.458
CLV_PCSK_KEX2_1	459	461	PF00082	0.618
CLV_PCSK_KEX2_1	611	613	PF00082	0.539
CLV_PCSK_KEX2_1	764	766	PF00082	0.447
CLV_PCSK_KEX2_1	807	809	PF00082	0.612
CLV_PCSK_KEX2_1	978	980	PF00082	0.444
CLV_PCSK_PC1ET2_1	459	461	PF00082	0.611
CLV_PCSK_PC1ET2_1	807	809	PF00082	0.612
CLV_PCSK_PC7_1	255	261	PF00082	0.443
CLV_PCSK_SKI1_1	477	481	PF00082	0.619
CLV_PCSK_SKI1_1	611	615	PF00082	0.576
CLV_PCSK_SKI1_1	661	665	PF00082	0.513
CLV_PCSK_SKI1_1	789	793	PF00082	0.461
CLV_PCSK_SKI1_1	827	831	PF00082	0.546
DEG_APCC_DBOX_1	610	618	PF00400	0.535
DEG_APCC_DBOX_1	777	785	PF00400	0.550
DEG_SCF_FBW7_1	673	678	PF00400	0.520
DEG_SPOP_SBC_1	173	177	PF00917	0.657
DEG_SPOP_SBC_1	468	472	PF00917	0.499
DOC_ANK_TNKS_1	447	454	PF00023	0.603
DOC_MAPK_DCC_7	418	426	PF00069	0.600
DOC_MAPK_DCC_7	940	950	PF00069	0.458
DOC_MAPK_gen_1	258	267	PF00069	0.384
DOC_MAPK_gen_1	807	813	PF00069	0.511
DOC_MAPK_HePTP_8	976	988	PF00069	0.466
DOC_MAPK_MEF2A_6	418	426	PF00069	0.600
DOC_MAPK_MEF2A_6	543	552	PF00069	0.546
DOC_MAPK_MEF2A_6	90	97	PF00069	0.552
DOC_MAPK_MEF2A_6	979	988	PF00069	0.395
DOC_PP1_RVXF_1	787	793	PF00149	0.450
DOC_PP2B_LxvP_1	95	98	PF13499	0.574
DOC_PP4_FxxP_1	419	422	PF00568	0.534
DOC_PP4_MxPP_1	108	111	PF00568	0.526
DOC_SPAK_OSR1_1	418	422	PF12202	0.538
DOC_USP7_MATH_1	144	148	PF00917	0.549
DOC_USP7_MATH_1	203	207	PF00917	0.602
DOC_USP7_MATH_1	342	346	PF00917	0.756
DOC_USP7_MATH_1	411	415	PF00917	0.583
DOC_USP7_MATH_1	635	639	PF00917	0.594
DOC_USP7_MATH_1	679	683	PF00917	0.762
DOC_USP7_MATH_1	802	806	PF00917	0.562
DOC_USP7_MATH_1	848	852	PF00917	0.559
DOC_USP7_UBL2_3	141	145	PF12436	0.522
DOC_WW_Pin1_4	194	199	PF00397	0.558
DOC_WW_Pin1_4	210	215	PF00397	0.500
DOC_WW_Pin1_4	358	363	PF00397	0.578
DOC_WW_Pin1_4	447	452	PF00397	0.599
DOC_WW_Pin1_4	49	54	PF00397	0.804
DOC_WW_Pin1_4	530	535	PF00397	0.571
DOC_WW_Pin1_4	55	60	PF00397	0.584
DOC_WW_Pin1_4	671	676	PF00397	0.521
DOC_WW_Pin1_4	8	13	PF00397	0.679
DOC_WW_Pin1_4	843	848	PF00397	0.681
LIG_14-3-3_CanoR_1	149	157	PF00244	0.525
LIG_14-3-3_CanoR_1	295	300	PF00244	0.515
LIG_14-3-3_CanoR_1	37	42	PF00244	0.623
LIG_14-3-3_CanoR_1	44	53	PF00244	0.549
LIG_14-3-3_CanoR_1	460	466	PF00244	0.588
LIG_14-3-3_CanoR_1	54	59	PF00244	0.527
LIG_14-3-3_CanoR_1	650	655	PF00244	0.523
LIG_14-3-3_CanoR_1	7	12	PF00244	0.721
LIG_14-3-3_CanoR_1	956	962	PF00244	0.314
LIG_14-3-3_CanoR_1	978	986	PF00244	0.410
LIG_AP2alpha_1	68	72	PF02296	0.503
LIG_APCC_ABBA_1	546	551	PF00400	0.545
LIG_BIR_III_4	329	333	PF00653	0.550
LIG_BIR_III_4	343	347	PF00653	0.495
LIG_BRCT_BRCA1_1	422	426	PF00533	0.466
LIG_BRCT_BRCA1_1	958	962	PF00533	0.417
LIG_Clathr_ClatBox_1	81	85	PF01394	0.423
LIG_deltaCOP1_diTrp_1	591	599	PF00928	0.595
LIG_deltaCOP1_diTrp_1	706	710	PF00928	0.529
LIG_EH_1	527	531	PF12763	0.553
LIG_EH_1	546	550	PF12763	0.543
LIG_FHA_1	1	7	PF00498	0.671
LIG_FHA_1	177	183	PF00498	0.601
LIG_FHA_1	233	239	PF00498	0.588
LIG_FHA_1	69	75	PF00498	0.568
LIG_FHA_1	872	878	PF00498	0.398
LIG_FHA_1	958	964	PF00498	0.364
LIG_FHA_2	150	156	PF00498	0.655
LIG_FHA_2	17	23	PF00498	0.576
LIG_FHA_2	385	391	PF00498	0.488
LIG_FHA_2	511	517	PF00498	0.529
LIG_FHA_2	535	541	PF00498	0.497
LIG_FHA_2	578	584	PF00498	0.664
LIG_FHA_2	748	754	PF00498	0.615
LIG_FHA_2	755	761	PF00498	0.583
LIG_FHA_2	796	802	PF00498	0.615
LIG_FHA_2	828	834	PF00498	0.586
LIG_FHA_2	854	860	PF00498	0.746
LIG_FHA_2	877	883	PF00498	0.444
LIG_FHA_2	901	907	PF00498	0.530
LIG_LIR_Apic_2	356	362	PF02991	0.514
LIG_LIR_Apic_2	523	529	PF02991	0.580
LIG_LIR_Gen_1	206	214	PF02991	0.512
LIG_LIR_Gen_1	378	386	PF02991	0.489
LIG_LIR_Gen_1	753	761	PF02991	0.522
LIG_LIR_Nem_3	206	211	PF02991	0.521
LIG_LIR_Nem_3	378	384	PF02991	0.490
LIG_LIR_Nem_3	706	711	PF02991	0.523
LIG_LIR_Nem_3	753	758	PF02991	0.572
LIG_LIR_Nem_3	760	766	PF02991	0.502
LIG_LIR_Nem_3	980	986	PF02991	0.397
LIG_LYPXL_yS_3	983	986	PF13949	0.377
LIG_MYND_1	99	103	PF01753	0.595
LIG_PDZ_Class_2	995	1000	PF00595	0.474
LIG_Pex14_1	763	767	PF04695	0.566
LIG_Pex14_2	68	72	PF04695	0.573
LIG_SH2_CRK	359	363	PF00017	0.514
LIG_SH2_CRK	604	608	PF00017	0.525
LIG_SH2_CRK	755	759	PF00017	0.458
LIG_SH2_PTP2	985	988	PF00017	0.354
LIG_SH2_STAP1	69	73	PF00017	0.554
LIG_SH2_STAP1	711	715	PF00017	0.508
LIG_SH2_STAT5	359	362	PF00017	0.549
LIG_SH2_STAT5	896	899	PF00017	0.355
LIG_SH2_STAT5	985	988	PF00017	0.354
LIG_SH3_3	100	106	PF00018	0.595
LIG_SH3_3	108	114	PF00018	0.598
LIG_SH3_3	208	214	PF00018	0.606
LIG_SH3_3	278	284	PF00018	0.472
LIG_SH3_3	362	368	PF00018	0.546
LIG_SH3_3	542	548	PF00018	0.564
LIG_SH3_3	582	588	PF00018	0.660
LIG_SH3_3	620	626	PF00018	0.599
LIG_SH3_3	985	991	PF00018	0.377
LIG_SUMO_SIM_anti_2	933	940	PF11976	0.408
LIG_SUMO_SIM_par_1	293	302	PF11976	0.511
LIG_SUMO_SIM_par_1	80	86	PF11976	0.418
LIG_SUMO_SIM_par_1	873	879	PF11976	0.454
LIG_SUMO_SIM_par_1	896	904	PF11976	0.342
LIG_TRAF2_1	513	516	PF00917	0.533
LIG_TRAF2_1	922	925	PF00917	0.533
LIG_WRC_WIRS_1	69	74	PF05994	0.594
LIG_WW_3	361	365	PF00397	0.506
LIG_WW_3	41	45	PF00397	0.546
MOD_CDC14_SPxK_1	361	364	PF00782	0.509
MOD_CDK_SPK_2	49	54	PF00069	0.572
MOD_CDK_SPxK_1	358	364	PF00069	0.513
MOD_CDK_SPxxK_3	60	67	PF00069	0.524
MOD_CK1_1	10	16	PF00069	0.736
MOD_CK1_1	148	154	PF00069	0.531
MOD_CK1_1	210	216	PF00069	0.558
MOD_CK1_1	298	304	PF00069	0.541
MOD_CK1_1	353	359	PF00069	0.542
MOD_CK1_1	45	51	PF00069	0.577
MOD_CK1_1	463	469	PF00069	0.591
MOD_CK1_1	470	476	PF00069	0.552
MOD_CK1_1	58	64	PF00069	0.500
MOD_CK1_1	846	852	PF00069	0.646
MOD_CK1_1	853	859	PF00069	0.673
MOD_CK1_1	907	913	PF00069	0.570
MOD_CK1_1	977	983	PF00069	0.431
MOD_CK2_1	149	155	PF00069	0.658
MOD_CK2_1	215	221	PF00069	0.639
MOD_CK2_1	372	378	PF00069	0.412
MOD_CK2_1	510	516	PF00069	0.543
MOD_CK2_1	534	540	PF00069	0.559
MOD_CK2_1	577	583	PF00069	0.569
MOD_CK2_1	795	801	PF00069	0.631
MOD_CK2_1	853	859	PF00069	0.544
MOD_CK2_1	900	906	PF00069	0.507
MOD_CK2_1	909	915	PF00069	0.593
MOD_GlcNHglycan	205	208	PF01048	0.756
MOD_GlcNHglycan	217	220	PF01048	0.563
MOD_GlcNHglycan	276	279	PF01048	0.565
MOD_GlcNHglycan	323	328	PF01048	0.772
MOD_GlcNHglycan	343	347	PF01048	0.556
MOD_GlcNHglycan	350	353	PF01048	0.599
MOD_GlcNHglycan	354	358	PF01048	0.600
MOD_GlcNHglycan	39	42	PF01048	0.601
MOD_GlcNHglycan	44	47	PF01048	0.561
MOD_GlcNHglycan	495	498	PF01048	0.722
MOD_GlcNHglycan	572	575	PF01048	0.659
MOD_GlcNHglycan	637	640	PF01048	0.682
MOD_GlcNHglycan	657	660	PF01048	0.618
MOD_GlcNHglycan	798	801	PF01048	0.726
MOD_GlcNHglycan	804	807	PF01048	0.655
MOD_GlcNHglycan	840	844	PF01048	0.620
MOD_GlcNHglycan	850	853	PF01048	0.655
MOD_GlcNHglycan	869	872	PF01048	0.507
MOD_GlcNHglycan	911	914	PF01048	0.599
MOD_GSK3_1	144	151	PF00069	0.615
MOD_GSK3_1	172	179	PF00069	0.606
MOD_GSK3_1	189	196	PF00069	0.578
MOD_GSK3_1	203	210	PF00069	0.591
MOD_GSK3_1	228	235	PF00069	0.546
MOD_GSK3_1	295	302	PF00069	0.593
MOD_GSK3_1	45	52	PF00069	0.582
MOD_GSK3_1	460	467	PF00069	0.592
MOD_GSK3_1	530	537	PF00069	0.502
MOD_GSK3_1	54	61	PF00069	0.697
MOD_GSK3_1	559	566	PF00069	0.465
MOD_GSK3_1	633	640	PF00069	0.706
MOD_GSK3_1	657	664	PF00069	0.576
MOD_GSK3_1	671	678	PF00069	0.623
MOD_GSK3_1	68	75	PF00069	0.728
MOD_GSK3_1	7	14	PF00069	0.633
MOD_GSK3_1	791	798	PF00069	0.576
MOD_GSK3_1	835	842	PF00069	0.666
MOD_GSK3_1	846	853	PF00069	0.588
MOD_GSK3_1	867	874	PF00069	0.443
MOD_GSK3_1	900	907	PF00069	0.539
MOD_N-GLC_1	534	539	PF02516	0.502
MOD_N-GLC_1	827	832	PF02516	0.545
MOD_NEK2_1	174	179	PF00069	0.602
MOD_NEK2_1	189	194	PF00069	0.613
MOD_NEK2_1	24	29	PF00069	0.684
MOD_NEK2_1	372	377	PF00069	0.413
MOD_NEK2_1	469	474	PF00069	0.495
MOD_NEK2_1	68	73	PF00069	0.612
MOD_NEK2_1	876	881	PF00069	0.447
MOD_NEK2_1	888	893	PF00069	0.351
MOD_NEK2_1	957	962	PF00069	0.436
MOD_NEK2_2	411	416	PF00069	0.487
MOD_PIKK_1	118	124	PF00454	0.455
MOD_PIKK_1	559	565	PF00454	0.460
MOD_PIKK_1	568	574	PF00454	0.493
MOD_PIKK_1	791	797	PF00454	0.482
MOD_PIKK_1	904	910	PF00454	0.470
MOD_PK_1	295	301	PF00069	0.538
MOD_PK_1	461	467	PF00069	0.520
MOD_PKA_1	460	466	PF00069	0.655
MOD_PKA_2	148	154	PF00069	0.597
MOD_PKA_2	165	171	PF00069	0.607
MOD_PKA_2	348	354	PF00069	0.532
MOD_PKA_2	460	466	PF00069	0.635
MOD_PKA_2	900	906	PF00069	0.530
MOD_PKA_2	977	983	PF00069	0.431
MOD_Plk_1	242	248	PF00069	0.375
MOD_Plk_1	515	521	PF00069	0.514
MOD_Plk_1	534	540	PF00069	0.573
MOD_Plk_1	827	833	PF00069	0.544
MOD_Plk_2-3	754	760	PF00069	0.536
MOD_Plk_4	178	184	PF00069	0.530
MOD_Plk_4	242	248	PF00069	0.509
MOD_Plk_4	312	318	PF00069	0.514
MOD_Plk_4	372	378	PF00069	0.416
MOD_Plk_4	420	426	PF00069	0.600
MOD_Plk_4	464	470	PF00069	0.577
MOD_Plk_4	534	540	PF00069	0.711
MOD_Plk_4	68	74	PF00069	0.621
MOD_Plk_4	871	877	PF00069	0.416
MOD_Plk_4	957	963	PF00069	0.373
MOD_ProDKin_1	194	200	PF00069	0.558
MOD_ProDKin_1	210	216	PF00069	0.500
MOD_ProDKin_1	358	364	PF00069	0.579
MOD_ProDKin_1	447	453	PF00069	0.601
MOD_ProDKin_1	49	55	PF00069	0.799
MOD_ProDKin_1	530	536	PF00069	0.571
MOD_ProDKin_1	60	66	PF00069	0.558
MOD_ProDKin_1	671	677	PF00069	0.521
MOD_ProDKin_1	8	14	PF00069	0.679
MOD_ProDKin_1	843	849	PF00069	0.680
MOD_SUMO_rev_2	551	557	PF00179	0.486
TRG_DiLeu_BaEn_4	591	597	PF01217	0.475
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.630
TRG_DiLeu_BaLyEn_6	620	625	PF01217	0.598
TRG_DiLeu_BaLyEn_6	716	721	PF01217	0.522
TRG_ENDOCYTIC_2	69	72	PF00928	0.559
TRG_ENDOCYTIC_2	755	758	PF00928	0.466
TRG_ENDOCYTIC_2	788	791	PF00928	0.525
TRG_ENDOCYTIC_2	983	986	PF00928	0.377
TRG_ER_diArg_1	257	260	PF00400	0.444
TRG_ER_diArg_1	460	462	PF00400	0.772
TRG_ER_diArg_1	763	765	PF00400	0.448
TRG_NES_CRM1_1	374	390	PF08389	0.499
TRG_NLS_MonoExtN_4	456	463	PF00514	0.667
TRG_Pf-PMV_PEXEL_1	477	482	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	612	616	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0H5	Leptomonas seymouri	41%	94%
A0A3S5H4Z9	Leishmania donovani	65%	87%
A4HRN8	Leishmania infantum	65%	90%
E9AJK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	97%
Q6T446	Leishmania major	66%	97%