Putative proteasome regulatory non-ATPase subunit 6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATPase subunit 6, putative

Species:

Leishmania braziliensis

UniProt:

A4H3D3_LEIBR

TriTrypDb:

LbrM.02.0400 , LBRM2903_020009400

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	10
GO:0032991	protein-containing complex	1	11
GO:0140535	intracellular protein-containing complex	2	10
GO:1902494	catalytic complex	2	10
GO:1905368	peptidase complex	3	10
GO:1905369	endopeptidase complex	4	10
GO:0005737	cytoplasm	2	1
GO:0008541	proteasome regulatory particle, lid subcomplex	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3D3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.514
CLV_C14_Caspase3-7	43	47	PF00656	0.511
CLV_C14_Caspase3-7	503	507	PF00656	0.698
CLV_C14_Caspase3-7	516	520	PF00656	0.655
CLV_NRD_NRD_1	122	124	PF00675	0.319
CLV_NRD_NRD_1	126	128	PF00675	0.302
CLV_NRD_NRD_1	146	148	PF00675	0.249
CLV_NRD_NRD_1	163	165	PF00675	0.320
CLV_NRD_NRD_1	25	27	PF00675	0.206
CLV_NRD_NRD_1	254	256	PF00675	0.399
CLV_NRD_NRD_1	339	341	PF00675	0.288
CLV_NRD_NRD_1	390	392	PF00675	0.358
CLV_NRD_NRD_1	493	495	PF00675	0.673
CLV_NRD_NRD_1	94	96	PF00675	0.255
CLV_PCSK_KEX2_1	126	128	PF00082	0.257
CLV_PCSK_KEX2_1	163	165	PF00082	0.421
CLV_PCSK_KEX2_1	25	27	PF00082	0.204
CLV_PCSK_KEX2_1	254	256	PF00082	0.520
CLV_PCSK_KEX2_1	339	341	PF00082	0.288
CLV_PCSK_KEX2_1	497	499	PF00082	0.762
CLV_PCSK_KEX2_1	530	532	PF00082	0.643
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.757
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.648
CLV_PCSK_PC7_1	526	532	PF00082	0.672
CLV_PCSK_SKI1_1	127	131	PF00082	0.268
CLV_PCSK_SKI1_1	168	172	PF00082	0.362
CLV_PCSK_SKI1_1	192	196	PF00082	0.371
CLV_PCSK_SKI1_1	280	284	PF00082	0.391
CLV_PCSK_SKI1_1	29	33	PF00082	0.255
CLV_PCSK_SKI1_1	352	356	PF00082	0.312
CLV_PCSK_SKI1_1	481	485	PF00082	0.694
CLV_PCSK_SKI1_1	79	83	PF00082	0.259
CLV_PCSK_SKI1_1	95	99	PF00082	0.255
CLV_Separin_Metazoa	336	340	PF03568	0.550
DEG_APCC_DBOX_1	132	140	PF00400	0.575
DEG_APCC_DBOX_1	167	175	PF00400	0.353
DEG_APCC_DBOX_1	253	261	PF00400	0.363
DEG_APCC_DBOX_1	28	36	PF00400	0.455
DEG_APCC_DBOX_1	351	359	PF00400	0.468
DEG_APCC_KENBOX_2	485	489	PF00400	0.458
DEG_SCF_TRCP1_1	519	525	PF00400	0.532
DOC_CYCLIN_RxL_1	25	34	PF00134	0.501
DOC_CYCLIN_RxL_1	399	410	PF00134	0.415
DOC_CYCLIN_RxL_1	89	99	PF00134	0.468
DOC_MAPK_gen_1	254	262	PF00069	0.392
DOC_MAPK_MEF2A_6	168	176	PF00069	0.330
DOC_USP7_MATH_1	151	155	PF00917	0.439
DOC_USP7_MATH_1	194	198	PF00917	0.477
DOC_USP7_MATH_1	253	257	PF00917	0.413
DOC_USP7_MATH_1	3	7	PF00917	0.532
DOC_USP7_MATH_1	319	323	PF00917	0.501
DOC_USP7_MATH_1	367	371	PF00917	0.555
DOC_USP7_MATH_1	412	416	PF00917	0.742
DOC_USP7_UBL2_3	464	468	PF12436	0.458
DOC_USP7_UBL2_3	92	96	PF12436	0.511
DOC_WW_Pin1_4	266	271	PF00397	0.430
DOC_WW_Pin1_4	356	361	PF00397	0.550
LIG_14-3-3_CanoR_1	126	130	PF00244	0.550
LIG_14-3-3_CanoR_1	199	206	PF00244	0.518
LIG_14-3-3_CanoR_1	25	32	PF00244	0.528
LIG_14-3-3_CanoR_1	254	258	PF00244	0.415
LIG_Actin_WH2_2	342	358	PF00022	0.511
LIG_Actin_WH2_2	380	396	PF00022	0.511
LIG_APCC_ABBA_1	404	409	PF00400	0.536
LIG_Clathr_ClatBox_1	372	376	PF01394	0.455
LIG_Clathr_ClatBox_1	404	408	PF01394	0.511
LIG_eIF4E_1	56	62	PF01652	0.511
LIG_FHA_1	10	16	PF00498	0.521
LIG_FHA_1	167	173	PF00498	0.475
LIG_FHA_1	328	334	PF00498	0.550
LIG_FHA_1	35	41	PF00498	0.544
LIG_FHA_1	89	95	PF00498	0.456
LIG_FHA_2	25	31	PF00498	0.540
LIG_FHA_2	315	321	PF00498	0.514
LIG_FHA_2	346	352	PF00498	0.501
LIG_FHA_2	447	453	PF00498	0.504
LIG_LIR_Apic_2	204	209	PF02991	0.397
LIG_LIR_Gen_1	231	240	PF02991	0.349
LIG_LIR_Gen_1	241	250	PF02991	0.390
LIG_LIR_Gen_1	256	265	PF02991	0.337
LIG_LIR_Gen_1	305	313	PF02991	0.468
LIG_LIR_Gen_1	344	354	PF02991	0.466
LIG_LIR_Gen_1	359	369	PF02991	0.433
LIG_LIR_Gen_1	452	462	PF02991	0.428
LIG_LIR_Nem_3	179	185	PF02991	0.324
LIG_LIR_Nem_3	231	236	PF02991	0.397
LIG_LIR_Nem_3	238	243	PF02991	0.387
LIG_LIR_Nem_3	256	262	PF02991	0.336
LIG_LIR_Nem_3	305	311	PF02991	0.468
LIG_LIR_Nem_3	344	349	PF02991	0.457
LIG_LIR_Nem_3	359	364	PF02991	0.463
LIG_LIR_Nem_3	452	457	PF02991	0.429
LIG_LIR_Nem_3	459	465	PF02991	0.430
LIG_NRBOX	154	160	PF00104	0.404
LIG_NRBOX	272	278	PF00104	0.412
LIG_NRBOX	57	63	PF00104	0.485
LIG_NRP_CendR_1	530	532	PF00754	0.536
LIG_PCNA_yPIPBox_3	455	468	PF02747	0.577
LIG_Rb_pABgroove_1	456	464	PF01858	0.448
LIG_SH2_CRK	206	210	PF00017	0.401
LIG_SH2_CRK	233	237	PF00017	0.435
LIG_SH2_CRK	259	263	PF00017	0.337
LIG_SH2_CRK	346	350	PF00017	0.455
LIG_SH2_CRK	361	365	PF00017	0.455
LIG_SH2_CRK	454	458	PF00017	0.436
LIG_SH2_GRB2like	426	429	PF00017	0.676
LIG_SH2_NCK_1	361	365	PF00017	0.468
LIG_SH2_NCK_1	426	430	PF00017	0.675
LIG_SH2_PTP2	138	141	PF00017	0.470
LIG_SH2_SRC	138	141	PF00017	0.470
LIG_SH2_SRC	426	429	PF00017	0.676
LIG_SH2_SRC	444	447	PF00017	0.473
LIG_SH2_STAP1	233	237	PF00017	0.435
LIG_SH2_STAP1	426	430	PF00017	0.675
LIG_SH2_STAT3	300	303	PF00017	0.481
LIG_SH2_STAT5	138	141	PF00017	0.506
LIG_SH2_STAT5	175	178	PF00017	0.419
LIG_SH2_STAT5	206	209	PF00017	0.427
LIG_SH2_STAT5	235	238	PF00017	0.406
LIG_SH2_STAT5	368	371	PF00017	0.497
LIG_SH3_3	354	360	PF00018	0.550
LIG_SH3_3	521	527	PF00018	0.529
LIG_SUMO_SIM_par_1	11	18	PF11976	0.526
LIG_SUMO_SIM_par_1	166	173	PF11976	0.481
LIG_SUMO_SIM_par_1	60	65	PF11976	0.486
LIG_TYR_ITIM	136	141	PF00017	0.473
LIG_TYR_ITIM	257	262	PF00017	0.337
LIG_UBA3_1	307	314	PF00899	0.368
LIG_UBA3_1	461	468	PF00899	0.463
MOD_CDK_SPxxK_3	356	363	PF00069	0.423
MOD_CK1_1	197	203	PF00069	0.499
MOD_CK1_1	263	269	PF00069	0.424
MOD_CK1_1	278	284	PF00069	0.460
MOD_CK1_1	34	40	PF00069	0.332
MOD_CK2_1	208	214	PF00069	0.504
MOD_CK2_1	24	30	PF00069	0.456
MOD_CK2_1	266	272	PF00069	0.428
MOD_CK2_1	278	284	PF00069	0.370
MOD_CK2_1	314	320	PF00069	0.212
MOD_CK2_1	345	351	PF00069	0.333
MOD_CK2_1	446	452	PF00069	0.510
MOD_GlcNHglycan	155	158	PF01048	0.496
MOD_GlcNHglycan	196	199	PF01048	0.497
MOD_GlcNHglycan	218	221	PF01048	0.345
MOD_GlcNHglycan	320	324	PF01048	0.353
MOD_GlcNHglycan	519	522	PF01048	0.728
MOD_GSK3_1	194	201	PF00069	0.417
MOD_GSK3_1	260	267	PF00069	0.561
MOD_GSK3_1	272	279	PF00069	0.449
MOD_GSK3_1	31	38	PF00069	0.434
MOD_N-GLC_1	228	233	PF02516	0.408
MOD_NEK2_1	176	181	PF00069	0.312
MOD_NEK2_1	260	265	PF00069	0.404
MOD_NEK2_1	276	281	PF00069	0.409
MOD_NEK2_1	31	36	PF00069	0.437
MOD_NEK2_1	345	350	PF00069	0.308
MOD_NEK2_2	253	258	PF00069	0.412
MOD_PIKK_1	208	214	PF00454	0.504
MOD_PIKK_1	382	388	PF00454	0.302
MOD_PKA_2	125	131	PF00069	0.423
MOD_PKA_2	198	204	PF00069	0.506
MOD_PKA_2	24	30	PF00069	0.370
MOD_PKA_2	253	259	PF00069	0.410
MOD_Plk_1	166	172	PF00069	0.507
MOD_Plk_1	228	234	PF00069	0.411
MOD_Plk_4	201	207	PF00069	0.389
MOD_Plk_4	231	237	PF00069	0.431
MOD_Plk_4	272	278	PF00069	0.527
MOD_Plk_4	31	37	PF00069	0.379
MOD_Plk_4	345	351	PF00069	0.313
MOD_Plk_4	368	374	PF00069	0.322
MOD_Plk_4	439	445	PF00069	0.489
MOD_Plk_4	453	459	PF00069	0.419
MOD_ProDKin_1	266	272	PF00069	0.435
MOD_ProDKin_1	356	362	PF00069	0.423
MOD_SUMO_rev_2	173	181	PF00179	0.450
MOD_SUMO_rev_2	225	232	PF00179	0.379
MOD_SUMO_rev_2	278	288	PF00179	0.472
MOD_SUMO_rev_2	376	385	PF00179	0.352
TRG_DiLeu_BaEn_1	272	277	PF01217	0.408
TRG_DiLeu_BaEn_2	124	130	PF01217	0.308
TRG_ENDOCYTIC_2	138	141	PF00928	0.504
TRG_ENDOCYTIC_2	182	185	PF00928	0.331
TRG_ENDOCYTIC_2	233	236	PF00928	0.403
TRG_ENDOCYTIC_2	237	240	PF00928	0.393
TRG_ENDOCYTIC_2	259	262	PF00928	0.385
TRG_ENDOCYTIC_2	346	349	PF00928	0.313
TRG_ENDOCYTIC_2	361	364	PF00928	0.373
TRG_ENDOCYTIC_2	454	457	PF00928	0.442
TRG_ER_diArg_1	130	133	PF00400	0.312
TRG_ER_diArg_1	162	164	PF00400	0.397
TRG_ER_diArg_1	338	340	PF00400	0.339
TRG_NES_CRM1_1	30	46	PF08389	0.354
TRG_NES_CRM1_1	365	376	PF08389	0.308
TRG_NLS_MonoExtC_3	493	498	PF00514	0.679
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L4	Leptomonas seymouri	77%	100%
A0A0S4JHD2	Bodo saltans	55%	100%
A0A1X0NKK6	Trypanosomatidae	59%	94%
A0A3R7KIY0	Trypanosoma rangeli	57%	100%
A0A3S5H4Z8	Leishmania donovani	93%	100%
A4HRN4	Leishmania infantum	93%	100%
A8X379	Caenorhabditis briggsae	31%	100%
C9ZJ16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9ACB2	Leishmania major	91%	99%
E9AJK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
F1LMZ8	Rattus norvegicus	41%	100%
F1QGH9	Danio rerio	42%	100%
F6P3G4	Danio rerio	42%	100%
F6XBL2	Xenopus tropicalis	41%	100%
O00231	Homo sapiens	41%	100%
P34481	Caenorhabditis elegans	32%	100%
Q12377	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
Q20938	Caenorhabditis elegans	38%	100%
Q2KI42	Bos taurus	41%	100%
Q54UB5	Dictyostelium discoideum	37%	100%
Q7KLV9	Drosophila melanogaster	38%	100%
Q8BG32	Mus musculus	41%	100%
Q9LP45	Arabidopsis thaliana	46%	100%
Q9P7S2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%