Soluble_NSF_attachment_protein_-_SNAP_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Soluble NSF attachment protein, SNAP, putative

Species:

Leishmania braziliensis

UniProt:

A4H3C9_LEIBR

TriTrypDb:

LbrM.02.0360 , LBRM2903_020008800

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4H3C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3C9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0006886	intracellular protein transport	4	6
GO:0008104	protein localization	4	6
GO:0009987	cellular process	1	6
GO:0015031	protein transport	4	6
GO:0033036	macromolecule localization	2	6
GO:0045184	establishment of protein localization	3	6
GO:0046907	intracellular transport	3	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051641	cellular localization	2	6
GO:0051649	establishment of localization in cell	3	6
GO:0070727	cellular macromolecule localization	3	6
GO:0071702	organic substance transport	4	6
GO:0071705	nitrogen compound transport	4	6
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0035494	SNARE complex disassembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005483	soluble NSF attachment protein activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	495	499	PF00656	0.588
CLV_C14_Caspase3-7	524	528	PF00656	0.500
CLV_C14_Caspase3-7	615	619	PF00656	0.396
CLV_NRD_NRD_1	432	434	PF00675	0.572
CLV_NRD_NRD_1	693	695	PF00675	0.585
CLV_PCSK_FUR_1	429	433	PF00082	0.437
CLV_PCSK_KEX2_1	431	433	PF00082	0.567
CLV_PCSK_KEX2_1	693	695	PF00082	0.585
CLV_PCSK_KEX2_1	91	93	PF00082	0.674
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.449
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.629
CLV_PCSK_SKI1_1	232	236	PF00082	0.549
CLV_PCSK_SKI1_1	303	307	PF00082	0.420
CLV_PCSK_SKI1_1	324	328	PF00082	0.420
CLV_PCSK_SKI1_1	407	411	PF00082	0.420
CLV_PCSK_SKI1_1	523	527	PF00082	0.417
CLV_PCSK_SKI1_1	565	569	PF00082	0.457
CLV_PCSK_SKI1_1	630	634	PF00082	0.487
CLV_PCSK_SKI1_1	652	656	PF00082	0.480
CLV_PCSK_SKI1_1	694	698	PF00082	0.577
DEG_APCC_DBOX_1	529	537	PF00400	0.456
DEG_APCC_KENBOX_2	645	649	PF00400	0.505
DEG_SPOP_SBC_1	246	250	PF00917	0.520
DOC_CYCLIN_RxL_1	321	330	PF00134	0.420
DOC_CYCLIN_RxL_1	562	571	PF00134	0.428
DOC_CYCLIN_RxL_1	690	701	PF00134	0.570
DOC_MAPK_gen_1	530	537	PF00069	0.457
DOC_MAPK_MEF2A_6	354	362	PF00069	0.420
DOC_MAPK_MEF2A_6	530	537	PF00069	0.457
DOC_PP1_RVXF_1	301	308	PF00149	0.420
DOC_PP2B_LxvP_1	13	16	PF13499	0.568
DOC_PP2B_LxvP_1	476	479	PF13499	0.538
DOC_PP2B_LxvP_1	559	562	PF13499	0.377
DOC_PP2B_PxIxI_1	357	363	PF00149	0.420
DOC_USP7_MATH_1	171	175	PF00917	0.685
DOC_USP7_MATH_1	2	6	PF00917	0.542
DOC_USP7_MATH_1	208	212	PF00917	0.709
DOC_USP7_MATH_1	228	232	PF00917	0.685
DOC_USP7_MATH_1	246	250	PF00917	0.502
DOC_USP7_MATH_1	25	29	PF00917	0.618
DOC_USP7_MATH_1	335	339	PF00917	0.251
DOC_USP7_MATH_1	41	45	PF00917	0.568
DOC_USP7_MATH_1	600	604	PF00917	0.562
DOC_USP7_MATH_1	613	617	PF00917	0.442
DOC_USP7_MATH_1	72	76	PF00917	0.675
DOC_WW_Pin1_4	233	238	PF00397	0.769
DOC_WW_Pin1_4	261	266	PF00397	0.635
DOC_WW_Pin1_4	434	439	PF00397	0.578
LIG_14-3-3_CanoR_1	202	208	PF00244	0.611
LIG_14-3-3_CanoR_1	226	231	PF00244	0.559
LIG_14-3-3_CanoR_1	279	288	PF00244	0.491
LIG_14-3-3_CanoR_1	334	343	PF00244	0.251
LIG_14-3-3_CanoR_1	500	506	PF00244	0.556
LIG_14-3-3_CanoR_1	516	522	PF00244	0.544
LIG_14-3-3_CanoR_1	523	531	PF00244	0.418
LIG_14-3-3_CanoR_1	577	583	PF00244	0.548
LIG_14-3-3_CanoR_1	62	68	PF00244	0.575
LIG_14-3-3_CanoR_1	659	664	PF00244	0.558
LIG_14-3-3_CanoR_1	693	697	PF00244	0.451
LIG_Actin_WH2_2	339	356	PF00022	0.420
LIG_APCC_ABBA_1	410	415	PF00400	0.420
LIG_BIR_III_2	146	150	PF00653	0.547
LIG_BRCT_BRCA1_1	205	209	PF00533	0.653
LIG_BRCT_BRCA1_1	503	507	PF00533	0.684
LIG_deltaCOP1_diTrp_1	297	306	PF00928	0.490
LIG_deltaCOP1_diTrp_1	76	84	PF00928	0.540
LIG_eIF4E_1	626	632	PF01652	0.309
LIG_FHA_1	150	156	PF00498	0.659
LIG_FHA_1	300	306	PF00498	0.420
LIG_FHA_1	492	498	PF00498	0.611
LIG_FHA_1	562	568	PF00498	0.463
LIG_FHA_1	569	575	PF00498	0.405
LIG_FHA_2	264	270	PF00498	0.406
LIG_FHA_2	280	286	PF00498	0.467
LIG_FHA_2	448	454	PF00498	0.674
LIG_FHA_2	480	486	PF00498	0.628
LIG_LIR_Apic_2	204	208	PF02991	0.544
LIG_LIR_Gen_1	629	639	PF02991	0.421
LIG_LIR_Gen_1	695	704	PF02991	0.478
LIG_LIR_Nem_3	564	569	PF02991	0.479
LIG_LIR_Nem_3	629	635	PF02991	0.407
LIG_LIR_Nem_3	672	676	PF02991	0.450
LIG_LYPXL_SIV_4	280	288	PF13949	0.471
LIG_MYND_1	11	15	PF01753	0.568
LIG_NRBOX	532	538	PF00104	0.449
LIG_PCNA_yPIPBox_3	23	34	PF02747	0.552
LIG_Pex14_1	205	209	PF04695	0.546
LIG_PTB_Apo_2	330	337	PF02174	0.420
LIG_PTB_Apo_2	83	90	PF02174	0.534
LIG_SH2_CRK	569	573	PF00017	0.438
LIG_SH2_NCK_1	281	285	PF00017	0.464
LIG_SH2_SRC	543	546	PF00017	0.474
LIG_SH2_STAT5	281	284	PF00017	0.514
LIG_SH2_STAT5	372	375	PF00017	0.251
LIG_SH2_STAT5	566	569	PF00017	0.488
LIG_SH2_STAT5	621	624	PF00017	0.484
LIG_SH3_3	12	18	PF00018	0.670
LIG_SH3_3	165	171	PF00018	0.501
LIG_SH3_3	19	25	PF00018	0.662
LIG_SH3_3	231	237	PF00018	0.602
LIG_SH3_3	259	265	PF00018	0.496
LIG_SH3_3	313	319	PF00018	0.251
LIG_SH3_3	502	508	PF00018	0.616
LIG_SUMO_SIM_anti_2	63	69	PF11976	0.546
LIG_SUMO_SIM_par_1	487	496	PF11976	0.535
LIG_SUMO_SIM_par_1	532	538	PF11976	0.419
LIG_TYR_ITIM	567	572	PF00017	0.439
LIG_WW_1	512	515	PF00397	0.641
MOD_CDK_SPK_2	434	439	PF00069	0.487
MOD_CK1_1	211	217	PF00069	0.703
MOD_CK1_1	233	239	PF00069	0.681
MOD_CK1_1	492	498	PF00069	0.571
MOD_CK1_1	5	11	PF00069	0.551
MOD_CK1_1	587	593	PF00069	0.596
MOD_CK1_1	603	609	PF00069	0.489
MOD_CK1_1	63	69	PF00069	0.583
MOD_CK2_1	263	269	PF00069	0.421
MOD_CK2_1	279	285	PF00069	0.466
MOD_CK2_1	335	341	PF00069	0.251
MOD_CK2_1	479	485	PF00069	0.630
MOD_CK2_1	692	698	PF00069	0.444
MOD_GlcNHglycan	138	141	PF01048	0.604
MOD_GlcNHglycan	171	174	PF01048	0.738
MOD_GlcNHglycan	191	194	PF01048	0.610
MOD_GlcNHglycan	211	214	PF01048	0.746
MOD_GlcNHglycan	239	243	PF01048	0.625
MOD_GlcNHglycan	249	252	PF01048	0.520
MOD_GlcNHglycan	43	46	PF01048	0.738
MOD_GlcNHglycan	586	589	PF01048	0.550
MOD_GlcNHglycan	79	82	PF01048	0.711
MOD_GlcNHglycan	8	11	PF01048	0.711
MOD_GSK3_1	1	8	PF00069	0.664
MOD_GSK3_1	185	192	PF00069	0.565
MOD_GSK3_1	222	229	PF00069	0.675
MOD_GSK3_1	342	349	PF00069	0.420
MOD_GSK3_1	463	470	PF00069	0.643
MOD_GSK3_1	485	492	PF00069	0.607
MOD_GSK3_1	49	56	PF00069	0.714
MOD_GSK3_1	517	524	PF00069	0.567
MOD_GSK3_1	553	560	PF00069	0.561
MOD_GSK3_1	601	608	PF00069	0.600
MOD_N-GLC_1	136	141	PF02516	0.567
MOD_N-GLC_2	86	88	PF02516	0.535
MOD_NEK2_1	185	190	PF00069	0.536
MOD_NEK2_1	209	214	PF00069	0.608
MOD_NEK2_1	245	250	PF00069	0.570
MOD_NEK2_1	327	332	PF00069	0.420
MOD_NEK2_1	353	358	PF00069	0.420
MOD_NEK2_1	467	472	PF00069	0.568
MOD_NEK2_1	568	573	PF00069	0.447
MOD_NEK2_1	612	617	PF00069	0.508
MOD_NEK2_2	621	626	PF00069	0.442
MOD_NEK2_2	692	697	PF00069	0.444
MOD_PIKK_1	413	419	PF00454	0.251
MOD_PK_1	226	232	PF00069	0.560
MOD_PKA_2	201	207	PF00069	0.734
MOD_PKA_2	515	521	PF00069	0.601
MOD_PKA_2	600	606	PF00069	0.550
MOD_PKA_2	61	67	PF00069	0.642
MOD_PKA_2	692	698	PF00069	0.444
MOD_Plk_1	463	469	PF00069	0.737
MOD_Plk_1	638	644	PF00069	0.538
MOD_Plk_2-3	117	123	PF00069	0.559
MOD_Plk_4	25	31	PF00069	0.674
MOD_Plk_4	327	333	PF00069	0.260
MOD_Plk_4	463	469	PF00069	0.536
MOD_Plk_4	621	627	PF00069	0.443
MOD_Plk_4	63	69	PF00069	0.546
MOD_ProDKin_1	233	239	PF00069	0.770
MOD_ProDKin_1	261	267	PF00069	0.625
MOD_ProDKin_1	434	440	PF00069	0.585
MOD_SUMO_for_1	135	138	PF00179	0.559
MOD_SUMO_rev_2	393	401	PF00179	0.265
TRG_DiLeu_BaEn_1	269	274	PF01217	0.537
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.593
TRG_ENDOCYTIC_2	121	124	PF00928	0.613
TRG_ENDOCYTIC_2	543	546	PF00928	0.337
TRG_ENDOCYTIC_2	569	572	PF00928	0.475
TRG_ER_diArg_1	432	434	PF00400	0.561
TRG_Pf-PMV_PEXEL_1	523	527	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	694	698	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4Z6	Leishmania donovani	63%	100%
A4HRM8	Leishmania infantum	63%	100%
E9ACA6	Leishmania major	61%	100%
E9AJJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%