Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitogen-activated kinase kinase kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H3C7_LEIBR

TriTrypDb:

LbrM.02.0340 , LBRM2903_020008300

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 43
NetGPI	no	yes: 0, no: 43

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H3C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3C7

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	44
GO:0006793	phosphorus metabolic process	3	44
GO:0006796	phosphate-containing compound metabolic process	4	44
GO:0006807	nitrogen compound metabolic process	2	44
GO:0008152	metabolic process	1	44
GO:0009987	cellular process	1	44
GO:0016310	phosphorylation	5	44
GO:0019538	protein metabolic process	3	44
GO:0036211	protein modification process	4	44
GO:0043170	macromolecule metabolic process	3	44
GO:0043412	macromolecule modification	4	44
GO:0044237	cellular metabolic process	2	44
GO:0044238	primary metabolic process	2	44
GO:0071704	organic substance metabolic process	2	44
GO:1901564	organonitrogen compound metabolic process	3	44

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	44
GO:0003824	catalytic activity	1	44
GO:0004672	protein kinase activity	3	44
GO:0005488	binding	1	44
GO:0005524	ATP binding	5	44
GO:0016301	kinase activity	4	44
GO:0016740	transferase activity	2	44
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	44
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	44
GO:0017076	purine nucleotide binding	4	44
GO:0030554	adenyl nucleotide binding	5	44
GO:0032553	ribonucleotide binding	3	44
GO:0032555	purine ribonucleotide binding	4	44
GO:0032559	adenyl ribonucleotide binding	5	44
GO:0035639	purine ribonucleoside triphosphate binding	4	44
GO:0036094	small molecule binding	2	44
GO:0043167	ion binding	2	44
GO:0043168	anion binding	3	44
GO:0097159	organic cyclic compound binding	2	44
GO:0097367	carbohydrate derivative binding	2	44
GO:0140096	catalytic activity, acting on a protein	2	44
GO:1901265	nucleoside phosphate binding	3	44
GO:1901363	heterocyclic compound binding	2	44
GO:0004674	protein serine/threonine kinase activity	4	25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.461
CLV_NRD_NRD_1	447	449	PF00675	0.282
CLV_PCSK_KEX2_1	447	449	PF00082	0.286
CLV_PCSK_PC7_1	443	449	PF00082	0.291
CLV_PCSK_SKI1_1	210	214	PF00082	0.211
CLV_PCSK_SKI1_1	316	320	PF00082	0.320
CLV_PCSK_SKI1_1	447	451	PF00082	0.299
DEG_APCC_DBOX_1	202	210	PF00400	0.163
DEG_APCC_DBOX_1	442	450	PF00400	0.266
DEG_APCC_DBOX_1	455	463	PF00400	0.425
DEG_SPOP_SBC_1	119	123	PF00917	0.445
DOC_CDC14_PxL_1	358	366	PF14671	0.312
DOC_CKS1_1	270	275	PF01111	0.163
DOC_CYCLIN_RxL_1	386	397	PF00134	0.197
DOC_CYCLIN_yCln2_LP_2	488	494	PF00134	0.390
DOC_MAPK_gen_1	316	325	PF00069	0.316
DOC_PP4_FxxP_1	103	106	PF00568	0.475
DOC_USP7_MATH_1	119	123	PF00917	0.722
DOC_USP7_MATH_1	253	257	PF00917	0.276
DOC_USP7_MATH_1	303	307	PF00917	0.343
DOC_USP7_MATH_1	476	480	PF00917	0.650
DOC_USP7_MATH_1	483	487	PF00917	0.626
DOC_WW_Pin1_4	102	107	PF00397	0.480
DOC_WW_Pin1_4	174	179	PF00397	0.236
DOC_WW_Pin1_4	265	270	PF00397	0.388
DOC_WW_Pin1_4	353	358	PF00397	0.306
DOC_WW_Pin1_4	408	413	PF00397	0.364
DOC_WW_Pin1_4	63	68	PF00397	0.616
DOC_WW_Pin1_4	76	81	PF00397	0.538
DOC_WW_Pin1_4	88	93	PF00397	0.700
LIG_14-3-3_CanoR_1	45	55	PF00244	0.572
LIG_14-3-3_CanoR_1	477	485	PF00244	0.607
LIG_14-3-3_CanoR_1	490	498	PF00244	0.558
LIG_14-3-3_CterR_2	525	529	PF00244	0.397
LIG_Actin_WH2_2	195	212	PF00022	0.221
LIG_Actin_WH2_2	431	449	PF00022	0.247
LIG_BIR_III_2	227	231	PF00653	0.163
LIG_BRCT_BRCA1_1	424	428	PF00533	0.337
LIG_BRCT_BRCA1_1	82	86	PF00533	0.467
LIG_Clathr_ClatBox_1	435	439	PF01394	0.384
LIG_deltaCOP1_diTrp_1	375	383	PF00928	0.423
LIG_deltaCOP1_diTrp_1	6	10	PF00928	0.636
LIG_eIF4E_1	359	365	PF01652	0.337
LIG_FHA_1	177	183	PF00498	0.427
LIG_FHA_1	22	28	PF00498	0.474
LIG_FHA_1	329	335	PF00498	0.319
LIG_FHA_2	339	345	PF00498	0.378
LIG_HOMEOBOX	5	8	PF00046	0.486
LIG_LIR_Apic_2	356	362	PF02991	0.316
LIG_LIR_Gen_1	236	244	PF02991	0.291
LIG_LIR_Gen_1	294	304	PF02991	0.394
LIG_LIR_Gen_1	3	10	PF02991	0.644
LIG_LIR_Nem_3	294	300	PF02991	0.383
LIG_LIR_Nem_3	309	314	PF02991	0.289
LIG_LIR_Nem_3	425	431	PF02991	0.316
LIG_LIR_Nem_3	495	501	PF02991	0.388
LIG_LIR_Nem_3	6	10	PF02991	0.636
LIG_Rb_pABgroove_1	220	228	PF01858	0.343
LIG_SH2_CRK	311	315	PF00017	0.358
LIG_SH2_CRK	498	502	PF00017	0.342
LIG_SH2_PTP2	461	464	PF00017	0.226
LIG_SH2_SRC	221	224	PF00017	0.254
LIG_SH2_SRC	461	464	PF00017	0.494
LIG_SH2_STAP1	424	428	PF00017	0.380
LIG_SH2_STAT3	127	130	PF00017	0.578
LIG_SH2_STAT3	424	427	PF00017	0.343
LIG_SH2_STAT5	221	224	PF00017	0.310
LIG_SH2_STAT5	242	245	PF00017	0.354
LIG_SH2_STAT5	461	464	PF00017	0.354
LIG_SH3_2	472	477	PF14604	0.419
LIG_SH3_3	228	234	PF00018	0.460
LIG_SH3_3	267	273	PF00018	0.283
LIG_SH3_3	469	475	PF00018	0.513
LIG_SUMO_SIM_par_1	433	439	PF11976	0.319
LIG_SUMO_SIM_par_1	462	468	PF11976	0.395
LIG_TRAF2_1	195	198	PF00917	0.373
LIG_TRAF2_1	28	31	PF00917	0.458
LIG_TYR_ITIM	459	464	PF00017	0.227
MOD_CK1_1	256	262	PF00069	0.263
MOD_CK1_1	268	274	PF00069	0.287
MOD_CK1_1	306	312	PF00069	0.343
MOD_CK1_1	422	428	PF00069	0.346
MOD_CK1_1	434	440	PF00069	0.248
MOD_CK1_1	465	471	PF00069	0.470
MOD_CK1_1	479	485	PF00069	0.640
MOD_CK1_1	49	55	PF00069	0.715
MOD_CK1_1	88	94	PF00069	0.510
MOD_CK2_1	25	31	PF00069	0.585
MOD_CK2_1	394	400	PF00069	0.287
MOD_GlcNHglycan	111	114	PF01048	0.700
MOD_GlcNHglycan	122	125	PF01048	0.640
MOD_GlcNHglycan	131	134	PF01048	0.515
MOD_GlcNHglycan	14	17	PF01048	0.667
MOD_GlcNHglycan	141	144	PF01048	0.413
MOD_GlcNHglycan	170	175	PF01048	0.234
MOD_GlcNHglycan	255	258	PF01048	0.258
MOD_GlcNHglycan	27	30	PF01048	0.585
MOD_GlcNHglycan	396	399	PF01048	0.324
MOD_GlcNHglycan	481	484	PF01048	0.653
MOD_GlcNHglycan	492	495	PF01048	0.616
MOD_GlcNHglycan	56	59	PF01048	0.682
MOD_GlcNHglycan	82	85	PF01048	0.703
MOD_GlcNHglycan	87	90	PF01048	0.780
MOD_GSK3_1	170	177	PF00069	0.200
MOD_GSK3_1	21	28	PF00069	0.480
MOD_GSK3_1	264	271	PF00069	0.361
MOD_GSK3_1	274	281	PF00069	0.316
MOD_GSK3_1	418	425	PF00069	0.374
MOD_GSK3_1	430	437	PF00069	0.289
MOD_GSK3_1	45	52	PF00069	0.538
MOD_GSK3_1	479	486	PF00069	0.600
MOD_GSK3_1	76	83	PF00069	0.603
MOD_GSK3_1	84	91	PF00069	0.729
MOD_N-GLC_1	12	17	PF02516	0.536
MOD_NEK2_1	109	114	PF00069	0.473
MOD_NEK2_1	274	279	PF00069	0.334
MOD_NEK2_1	337	342	PF00069	0.311
MOD_NEK2_1	393	398	PF00069	0.291
MOD_NEK2_1	431	436	PF00069	0.233
MOD_NEK2_2	161	166	PF00069	0.270
MOD_NEK2_2	303	308	PF00069	0.328
MOD_PIKK_1	14	20	PF00454	0.460
MOD_PIKK_1	338	344	PF00454	0.195
MOD_PIKK_1	422	428	PF00454	0.297
MOD_PKA_2	442	448	PF00069	0.323
MOD_PKA_2	476	482	PF00069	0.654
MOD_Plk_4	161	167	PF00069	0.293
MOD_Plk_4	188	194	PF00069	0.377
MOD_Plk_4	233	239	PF00069	0.345
MOD_Plk_4	292	298	PF00069	0.316
MOD_Plk_4	431	437	PF00069	0.263
MOD_Plk_4	462	468	PF00069	0.372
MOD_ProDKin_1	102	108	PF00069	0.480
MOD_ProDKin_1	174	180	PF00069	0.236
MOD_ProDKin_1	265	271	PF00069	0.388
MOD_ProDKin_1	353	359	PF00069	0.306
MOD_ProDKin_1	408	414	PF00069	0.364
MOD_ProDKin_1	63	69	PF00069	0.618
MOD_ProDKin_1	76	82	PF00069	0.541
MOD_ProDKin_1	88	94	PF00069	0.701
TRG_DiLeu_BaEn_1	400	405	PF01217	0.195
TRG_ENDOCYTIC_2	311	314	PF00928	0.358
TRG_ENDOCYTIC_2	384	387	PF00928	0.301
TRG_ENDOCYTIC_2	461	464	PF00928	0.241
TRG_ENDOCYTIC_2	498	501	PF00928	0.324
TRG_ER_diArg_1	151	154	PF00400	0.342
TRG_ER_diArg_1	446	448	PF00400	0.299
TRG_NES_CRM1_1	328	342	PF08389	0.490
TRG_Pf-PMV_PEXEL_1	490	495	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D3	Leptomonas seymouri	50%	100%
A0A0S4J6L4	Bodo saltans	26%	100%
A0A0S4J757	Bodo saltans	27%	98%
A0A0S4JIJ6	Bodo saltans	26%	94%
A0A0S4JMY6	Bodo saltans	25%	69%
A0A1X0NIA0	Trypanosomatidae	33%	100%
A0A1X0NKA1	Trypanosomatidae	38%	100%
A0A1X0NNF5	Trypanosomatidae	29%	85%
A0A1X0P9C4	Trypanosomatidae	32%	100%
A0A2I0BVG8	Plasmodium falciparum (isolate NF54)	23%	100%
A0A3Q8IAQ1	Leishmania donovani	32%	100%
A0A3Q8IFK8	Leishmania donovani	28%	100%
A0A3Q8IFW0	Leishmania donovani	32%	100%
A0A3Q8IIG1	Leishmania donovani	29%	100%
A0A3Q8IPJ5	Leishmania donovani	26%	100%
A0A3R7KRP1	Trypanosoma rangeli	27%	100%
A0A3R7KZ44	Trypanosoma rangeli	29%	90%
A0A3R7RC77	Trypanosoma rangeli	25%	90%
A0A3S5H4Z4	Leishmania donovani	77%	100%
A0A3S7WWE7	Leishmania donovani	28%	100%
A0A3S7X6T8	Leishmania donovani	27%	100%
A0A3S7X7Y2	Leishmania donovani	26%	100%
A0A422N3U8	Trypanosoma rangeli	25%	73%
A0A422N3Y6	Trypanosoma rangeli	24%	100%
A0A422NUF0	Trypanosoma rangeli	27%	100%
A4HAS1	Leishmania braziliensis	26%	100%
A4HBL4	Leishmania braziliensis	28%	100%
A4HCE6	Leishmania braziliensis	32%	100%
A4HFA1	Leishmania braziliensis	26%	100%
A4HH03	Leishmania braziliensis	30%	100%
A4HJT5	Leishmania braziliensis	29%	100%
A4HJW2	Leishmania braziliensis	32%	100%
A4HLR0	Leishmania braziliensis	28%	100%
A4HRM6	Leishmania infantum	77%	100%
A4HZA2	Leishmania infantum	28%	100%
A4HZW8	Leishmania infantum	32%	100%
A4I2H8	Leishmania infantum	27%	100%
A4I435	Leishmania infantum	30%	100%
A4I7A1	Leishmania infantum	28%	100%
A4I7C4	Leishmania infantum	32%	100%
A4I960	Leishmania infantum	27%	100%
A4I9Y5	Leishmania infantum	26%	100%
C9ZIZ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZWI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ACA4	Leishmania major	76%	100%
E9AJJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	98%
E9AUY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AYN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B0C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B4Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
P05772	Oryctolagus cuniculus	22%	79%
P62343	Plasmodium falciparum (isolate K1 / Thailand)	23%	100%
P62344	Plasmodium falciparum (isolate 3D7)	23%	100%
P68403	Rattus norvegicus	22%	79%
P68404	Mus musculus	22%	79%
Q07832	Mus musculus	26%	88%
Q08942	Trypanosoma brucei brucei	27%	100%
Q13177	Homo sapiens	26%	100%
Q17941	Caenorhabditis elegans	24%	98%
Q4P5N0	Ustilago maydis (strain 521 / FGSC 9021)	23%	71%
Q4Q2Z2	Leishmania major	25%	100%
Q4Q3Y9	Leishmania major	27%	100%
Q4Q5T9	Leishmania major	32%	100%
Q4Q5W2	Leishmania major	29%	100%
Q4Q7W2	Leishmania major	30%	100%
Q4Q8T4	Leishmania major	27%	100%
Q4QBQ2	Leishmania major	33%	100%
Q4QCK0	Leishmania major	27%	100%
Q5VQQ5	Oryza sativa subsp. japonica	26%	100%
Q64303	Rattus norvegicus	27%	100%
Q6Z2M9	Oryza sativa subsp. japonica	27%	100%
Q8CIN4	Mus musculus	27%	100%
V5BSA6	Trypanosoma cruzi	27%	81%