SRP9-21 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3C6_LEIBR

TriTrypDb:

LbrM.02.0330 , LBRM2903_020008200

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	4
GO:0048500	signal recognition particle	3	4
GO:1990904	ribonucleoprotein complex	2	4

Expansion

Sequence features

A4H3C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3C6

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	4
GO:0006612	protein targeting to membrane	5	4
GO:0006613	cotranslational protein targeting to membrane	6	4
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	4
GO:0006810	transport	3	4
GO:0006886	intracellular protein transport	4	4
GO:0008104	protein localization	4	4
GO:0009987	cellular process	1	4
GO:0015031	protein transport	4	4
GO:0033036	macromolecule localization	2	4
GO:0033365	protein localization to organelle	5	4
GO:0045047	protein targeting to ER	6	4
GO:0045184	establishment of protein localization	3	4
GO:0046907	intracellular transport	3	4
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0051641	cellular localization	2	4
GO:0051649	establishment of localization in cell	3	4
GO:0051668	localization within membrane	3	4
GO:0070727	cellular macromolecule localization	3	4
GO:0070972	protein localization to endoplasmic reticulum	6	4
GO:0071702	organic substance transport	4	4
GO:0071705	nitrogen compound transport	4	4
GO:0072594	establishment of protein localization to organelle	4	4
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	4
GO:0072657	protein localization to membrane	4	4
GO:0090150	establishment of protein localization to membrane	4	4

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003723	RNA binding	4	4
GO:0005488	binding	1	4
GO:0008312	7S RNA binding	5	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.695
CLV_NRD_NRD_1	165	167	PF00675	0.684
CLV_NRD_NRD_1	36	38	PF00675	0.461
CLV_PCSK_FUR_1	21	25	PF00082	0.430
CLV_PCSK_KEX2_1	165	167	PF00082	0.644
CLV_PCSK_KEX2_1	23	25	PF00082	0.482
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.455
CLV_PCSK_SKI1_1	26	30	PF00082	0.437
CLV_PCSK_SKI1_1	37	41	PF00082	0.338
DEG_Nend_UBRbox_1	1	4	PF02207	0.427
DOC_MAPK_gen_1	21	31	PF00069	0.472
DOC_MAPK_MEF2A_6	21	29	PF00069	0.480
DOC_MAPK_NFAT4_5	24	32	PF00069	0.440
DOC_USP7_MATH_1	105	109	PF00917	0.558
DOC_USP7_MATH_1	11	15	PF00917	0.426
DOC_USP7_MATH_1	134	138	PF00917	0.654
DOC_USP7_MATH_1	145	149	PF00917	0.631
DOC_USP7_MATH_1	150	154	PF00917	0.556
DOC_USP7_MATH_1	33	37	PF00917	0.558
DOC_USP7_MATH_1	90	94	PF00917	0.707
DOC_USP7_MATH_1	96	100	PF00917	0.602
DOC_WW_Pin1_4	79	84	PF00397	0.755
LIG_14-3-3_CanoR_1	48	52	PF00244	0.440
LIG_14-3-3_CanoR_1	77	81	PF00244	0.607
LIG_FHA_1	50	56	PF00498	0.442
LIG_FHA_2	51	57	PF00498	0.456
LIG_SH3_3	77	83	PF00018	0.701
MOD_CK1_1	136	142	PF00069	0.543
MOD_CK1_1	148	154	PF00069	0.648
MOD_CK1_1	73	79	PF00069	0.479
MOD_CK2_1	50	56	PF00069	0.416
MOD_CK2_1	88	94	PF00069	0.652
MOD_Cter_Amidation	160	163	PF01082	0.624
MOD_GlcNHglycan	136	139	PF01048	0.644
MOD_GlcNHglycan	90	93	PF01048	0.756
MOD_GlcNHglycan	98	101	PF01048	0.641
MOD_GSK3_1	145	152	PF00069	0.598
MOD_GSK3_1	84	91	PF00069	0.737
MOD_NEK2_1	63	68	PF00069	0.526
MOD_NEK2_2	11	16	PF00069	0.425
MOD_PIKK_1	145	151	PF00454	0.600
MOD_PKA_2	126	132	PF00069	0.529
MOD_PKA_2	47	53	PF00069	0.439
MOD_PKA_2	76	82	PF00069	0.604
MOD_Plk_4	63	69	PF00069	0.482
MOD_ProDKin_1	79	85	PF00069	0.756
TRG_DiLeu_BaEn_2	3	9	PF01217	0.480
TRG_ER_diArg_1	24	27	PF00400	0.450
TRG_ER_diArg_1	29	32	PF00400	0.427
TRG_NLS_MonoExtC_3	161	166	PF00514	0.596
TRG_NLS_MonoExtN_4	160	166	PF00514	0.597
TRG_NLS_MonoExtN_4	21	27	PF00514	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT10	Leptomonas seymouri	50%	100%
A0A451EJG5	Leishmania donovani	67%	99%
A4HRM5	Leishmania infantum	67%	99%
E9ACA3	Leishmania major	70%	99%
E9AJJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%