Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3C5_LEIBR

TriTrypDb:

LbrM.02.0320 , LBRM2903_020009800

Length:

1023

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 0
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4H3C5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3C5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	622	626	PF00656	0.660
CLV_C14_Caspase3-7	63	67	PF00656	0.603
CLV_NRD_NRD_1	204	206	PF00675	0.447
CLV_NRD_NRD_1	24	26	PF00675	0.613
CLV_NRD_NRD_1	381	383	PF00675	0.536
CLV_NRD_NRD_1	697	699	PF00675	0.478
CLV_NRD_NRD_1	8	10	PF00675	0.838
CLV_NRD_NRD_1	846	848	PF00675	0.578
CLV_PCSK_FUR_1	202	206	PF00082	0.439
CLV_PCSK_FUR_1	379	383	PF00082	0.470
CLV_PCSK_FUR_1	678	682	PF00082	0.427
CLV_PCSK_KEX2_1	204	206	PF00082	0.447
CLV_PCSK_KEX2_1	24	26	PF00082	0.602
CLV_PCSK_KEX2_1	251	253	PF00082	0.466
CLV_PCSK_KEX2_1	381	383	PF00082	0.540
CLV_PCSK_KEX2_1	680	682	PF00082	0.417
CLV_PCSK_KEX2_1	7	9	PF00082	0.840
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.462
CLV_PCSK_PC1ET2_1	680	682	PF00082	0.532
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.821
CLV_PCSK_SKI1_1	325	329	PF00082	0.435
CLV_PCSK_SKI1_1	450	454	PF00082	0.501
CLV_PCSK_SKI1_1	459	463	PF00082	0.568
CLV_PCSK_SKI1_1	467	471	PF00082	0.473
CLV_PCSK_SKI1_1	608	612	PF00082	0.476
CLV_PCSK_SKI1_1	698	702	PF00082	0.497
CLV_PCSK_SKI1_1	720	724	PF00082	0.516
CLV_PCSK_SKI1_1	727	731	PF00082	0.353
CLV_PCSK_SKI1_1	797	801	PF00082	0.472
DEG_APCC_DBOX_1	466	474	PF00400	0.762
DEG_SPOP_SBC_1	667	671	PF00917	0.642
DOC_CDC14_PxL_1	470	478	PF14671	0.768
DOC_CKS1_1	637	642	PF01111	0.659
DOC_CYCLIN_RxL_1	463	471	PF00134	0.762
DOC_CYCLIN_RxL_1	605	615	PF00134	0.675
DOC_CYCLIN_yCln2_LP_2	68	71	PF00134	0.610
DOC_MAPK_DCC_7	1009	1019	PF00069	0.658
DOC_MAPK_gen_1	305	312	PF00069	0.768
DOC_MAPK_gen_1	889	899	PF00069	0.724
DOC_MAPK_HePTP_8	893	905	PF00069	0.455
DOC_MAPK_MEF2A_6	325	333	PF00069	0.636
DOC_MAPK_MEF2A_6	454	462	PF00069	0.612
DOC_MAPK_MEF2A_6	892	901	PF00069	0.721
DOC_PP1_RVXF_1	890	896	PF00149	0.542
DOC_PP2B_LxvP_1	68	71	PF13499	0.610
DOC_PP2B_PxIxI_1	909	915	PF00149	0.530
DOC_PP4_MxPP_1	69	72	PF00568	0.605
DOC_USP7_MATH_1	283	287	PF00917	0.648
DOC_USP7_MATH_1	417	421	PF00917	0.653
DOC_USP7_MATH_1	585	589	PF00917	0.764
DOC_USP7_MATH_1	596	600	PF00917	0.697
DOC_USP7_MATH_1	653	657	PF00917	0.738
DOC_USP7_MATH_1	851	855	PF00917	0.768
DOC_USP7_MATH_1	960	964	PF00917	0.594
DOC_USP7_MATH_1	976	980	PF00917	0.620
DOC_WW_Pin1_4	1010	1015	PF00397	0.714
DOC_WW_Pin1_4	221	226	PF00397	0.755
DOC_WW_Pin1_4	234	239	PF00397	0.783
DOC_WW_Pin1_4	261	266	PF00397	0.801
DOC_WW_Pin1_4	39	44	PF00397	0.716
DOC_WW_Pin1_4	411	416	PF00397	0.717
DOC_WW_Pin1_4	542	547	PF00397	0.665
DOC_WW_Pin1_4	571	576	PF00397	0.721
DOC_WW_Pin1_4	636	641	PF00397	0.840
DOC_WW_Pin1_4	981	986	PF00397	0.704
LIG_14-3-3_CanoR_1	24	30	PF00244	0.727
LIG_14-3-3_CanoR_1	282	292	PF00244	0.689
LIG_14-3-3_CanoR_1	454	458	PF00244	0.728
LIG_14-3-3_CanoR_1	465	470	PF00244	0.682
LIG_14-3-3_CanoR_1	56	62	PF00244	0.490
LIG_14-3-3_CanoR_1	797	802	PF00244	0.676
LIG_14-3-3_CanoR_1	96	100	PF00244	0.485
LIG_APCC_ABBAyCdc20_2	702	708	PF00400	0.723
LIG_BIR_III_4	532	536	PF00653	0.654
LIG_BRCT_BRCA1_1	419	423	PF00533	0.639
LIG_BRCT_BRCA1_1	591	595	PF00533	0.766
LIG_BRCT_BRCA1_1	816	820	PF00533	0.713
LIG_BRCT_BRCA1_1	853	857	PF00533	0.734
LIG_CtBP_PxDLS_1	330	334	PF00389	0.530
LIG_CtBP_PxDLS_1	952	956	PF00389	0.542
LIG_EH1_1	927	935	PF00400	0.530
LIG_eIF4E_1	358	364	PF01652	0.530
LIG_eIF4E_1	928	934	PF01652	0.530
LIG_FHA_1	148	154	PF00498	0.483
LIG_FHA_1	287	293	PF00498	0.644
LIG_FHA_1	453	459	PF00498	0.792
LIG_FHA_1	537	543	PF00498	0.694
LIG_FHA_1	584	590	PF00498	0.696
LIG_FHA_1	592	598	PF00498	0.784
LIG_FHA_1	605	611	PF00498	0.656
LIG_FHA_1	613	619	PF00498	0.778
LIG_FHA_1	63	69	PF00498	0.607
LIG_FHA_1	667	673	PF00498	0.666
LIG_FHA_1	682	688	PF00498	0.674
LIG_FHA_1	750	756	PF00498	0.548
LIG_FHA_1	804	810	PF00498	0.546
LIG_FHA_1	99	105	PF00498	0.436
LIG_FHA_2	113	119	PF00498	0.581
LIG_FHA_2	429	435	PF00498	0.665
LIG_FHA_2	565	571	PF00498	0.828
LIG_FHA_2	669	675	PF00498	0.781
LIG_FHA_2	798	804	PF00498	0.684
LIG_FHA_2	809	815	PF00498	0.573
LIG_FHA_2	81	87	PF00498	0.576
LIG_FHA_2	886	892	PF00498	0.740
LIG_GBD_Chelix_1	770	778	PF00786	0.530
LIG_LIR_Apic_2	839	843	PF02991	0.693
LIG_LIR_Gen_1	1006	1015	PF02991	0.661
LIG_LIR_Gen_1	132	143	PF02991	0.596
LIG_LIR_Gen_1	356	367	PF02991	0.406
LIG_LIR_Gen_1	455	464	PF02991	0.783
LIG_LIR_Gen_1	725	735	PF02991	0.636
LIG_LIR_Gen_1	751	759	PF02991	0.556
LIG_LIR_Gen_1	800	810	PF02991	0.712
LIG_LIR_Gen_1	817	826	PF02991	0.493
LIG_LIR_Gen_1	963	973	PF02991	0.632
LIG_LIR_Nem_3	1006	1010	PF02991	0.668
LIG_LIR_Nem_3	132	138	PF02991	0.594
LIG_LIR_Nem_3	356	362	PF02991	0.406
LIG_LIR_Nem_3	455	460	PF02991	0.783
LIG_LIR_Nem_3	725	731	PF02991	0.636
LIG_LIR_Nem_3	751	757	PF02991	0.551
LIG_LIR_Nem_3	800	805	PF02991	0.701
LIG_LIR_Nem_3	817	823	PF02991	0.495
LIG_LIR_Nem_3	854	860	PF02991	0.708
LIG_LIR_Nem_3	865	869	PF02991	0.555
LIG_LIR_Nem_3	894	898	PF02991	0.537
LIG_LYPXL_SIV_4	925	933	PF13949	0.530
LIG_NRBOX	729	735	PF00104	0.530
LIG_PCNA_yPIPBox_3	789	802	PF02747	0.494
LIG_PCNA_yPIPBox_3	82	95	PF02747	0.552
LIG_Pex14_2	122	126	PF04695	0.578
LIG_Pex14_2	194	198	PF04695	0.610
LIG_Pex14_2	369	373	PF04695	0.277
LIG_Pex14_2	866	870	PF04695	0.678
LIG_SH2_CRK	630	634	PF00017	0.657
LIG_SH2_CRK	714	718	PF00017	0.520
LIG_SH2_NCK_1	714	718	PF00017	0.520
LIG_SH2_NCK_1	802	806	PF00017	0.544
LIG_SH2_PTP2	754	757	PF00017	0.353
LIG_SH2_PTP2	898	901	PF00017	0.277
LIG_SH2_SRC	754	757	PF00017	0.367
LIG_SH2_SRC	926	929	PF00017	0.530
LIG_SH2_STAT3	479	482	PF00017	0.797
LIG_SH2_STAT3	988	991	PF00017	0.661
LIG_SH2_STAT5	154	157	PF00017	0.441
LIG_SH2_STAT5	178	181	PF00017	0.530
LIG_SH2_STAT5	358	361	PF00017	0.455
LIG_SH2_STAT5	367	370	PF00017	0.331
LIG_SH2_STAT5	376	379	PF00017	0.542
LIG_SH2_STAT5	388	391	PF00017	0.580
LIG_SH2_STAT5	457	460	PF00017	0.797
LIG_SH2_STAT5	630	633	PF00017	0.657
LIG_SH2_STAT5	754	757	PF00017	0.353
LIG_SH2_STAT5	791	794	PF00017	0.660
LIG_SH2_STAT5	869	872	PF00017	0.693
LIG_SH2_STAT5	898	901	PF00017	0.277
LIG_SH2_STAT5	926	929	PF00017	0.530
LIG_SH3_2	1015	1020	PF14604	0.656
LIG_SH3_2	2	7	PF14604	0.552
LIG_SH3_2	268	273	PF14604	0.673
LIG_SH3_3	1012	1018	PF00018	0.652
LIG_SH3_3	262	268	PF00018	0.687
LIG_SH3_3	308	314	PF00018	0.670
LIG_SH3_3	38	44	PF00018	0.501
LIG_SH3_3	540	546	PF00018	0.653
LIG_SH3_3	603	609	PF00018	0.831
LIG_SH3_3	659	665	PF00018	0.661
LIG_SH3_3	802	808	PF00018	0.543
LIG_SH3_3	872	878	PF00018	0.721
LIG_SH3_3	904	910	PF00018	0.530
LIG_SH3_3	970	976	PF00018	0.834
LIG_SUMO_SIM_anti_2	332	339	PF11976	0.530
LIG_SUMO_SIM_anti_2	361	366	PF11976	0.413
LIG_SUMO_SIM_anti_2	539	545	PF11976	0.655
LIG_SUMO_SIM_anti_2	750	760	PF11976	0.361
LIG_SUMO_SIM_par_1	337	345	PF11976	0.496
LIG_SUMO_SIM_par_1	489	494	PF11976	0.647
LIG_SUMO_SIM_par_1	539	545	PF11976	0.655
LIG_SUMO_SIM_par_1	742	748	PF11976	0.530
LIG_SUMO_SIM_par_1	755	760	PF11976	0.402
LIG_SUMO_SIM_par_1	780	786	PF11976	0.503
LIG_SUMO_SIM_par_1	796	804	PF11976	0.519
LIG_SUMO_SIM_par_1	931	938	PF11976	0.530
LIG_TRAF2_1	430	433	PF00917	0.665
LIG_TYR_ITSM	750	757	PF00017	0.441
LIG_TYR_ITSM	798	805	PF00017	0.609
LIG_WRC_WIRS_1	343	348	PF05994	0.530
LIG_WW_3	279	283	PF00397	0.576
MOD_CK1_1	1008	1014	PF00069	0.621
MOD_CK1_1	147	153	PF00069	0.727
MOD_CK1_1	23	29	PF00069	0.510
MOD_CK1_1	286	292	PF00069	0.642
MOD_CK1_1	426	432	PF00069	0.680
MOD_CK1_1	438	444	PF00069	0.630
MOD_CK1_1	55	61	PF00069	0.586
MOD_CK1_1	588	594	PF00069	0.823
MOD_CK1_1	620	626	PF00069	0.677
MOD_CK1_1	747	753	PF00069	0.680
MOD_CK1_1	760	766	PF00069	0.315
MOD_CK1_1	80	86	PF00069	0.733
MOD_CK1_1	885	891	PF00069	0.684
MOD_CK1_1	958	964	PF00069	0.467
MOD_CK1_1	979	985	PF00069	0.771
MOD_CK2_1	112	118	PF00069	0.742
MOD_CK2_1	426	432	PF00069	0.795
MOD_CK2_1	668	674	PF00069	0.504
MOD_CK2_1	797	803	PF00069	0.593
MOD_CK2_1	80	86	PF00069	0.733
MOD_Cter_Amidation	249	252	PF01082	0.585
MOD_DYRK1A_RPxSP_1	234	238	PF00069	0.560
MOD_GlcNHglycan	1010	1013	PF01048	0.574
MOD_GlcNHglycan	144	147	PF01048	0.451
MOD_GlcNHglycan	207	210	PF01048	0.557
MOD_GlcNHglycan	226	229	PF01048	0.791
MOD_GlcNHglycan	25	28	PF01048	0.506
MOD_GlcNHglycan	253	256	PF01048	0.569
MOD_GlcNHglycan	285	288	PF01048	0.562
MOD_GlcNHglycan	402	405	PF01048	0.665
MOD_GlcNHglycan	415	418	PF01048	0.729
MOD_GlcNHglycan	419	422	PF01048	0.664
MOD_GlcNHglycan	425	428	PF01048	0.671
MOD_GlcNHglycan	598	601	PF01048	0.653
MOD_GlcNHglycan	633	636	PF01048	0.720
MOD_GlcNHglycan	647	650	PF01048	0.632
MOD_GlcNHglycan	655	658	PF01048	0.676
MOD_GlcNHglycan	759	762	PF01048	0.675
MOD_GlcNHglycan	830	833	PF01048	0.441
MOD_GlcNHglycan	960	963	PF01048	0.470
MOD_GSK3_1	142	149	PF00069	0.529
MOD_GSK3_1	282	289	PF00069	0.687
MOD_GSK3_1	290	297	PF00069	0.579
MOD_GSK3_1	342	349	PF00069	0.530
MOD_GSK3_1	396	403	PF00069	0.603
MOD_GSK3_1	409	416	PF00069	0.757
MOD_GSK3_1	419	426	PF00069	0.642
MOD_GSK3_1	566	573	PF00069	0.656
MOD_GSK3_1	585	592	PF00069	0.696
MOD_GSK3_1	614	621	PF00069	0.603
MOD_GSK3_1	645	652	PF00069	0.660
MOD_GSK3_1	668	675	PF00069	0.524
MOD_GSK3_1	687	694	PF00069	0.637
MOD_GSK3_1	745	752	PF00069	0.411
MOD_GSK3_1	797	804	PF00069	0.598
MOD_GSK3_1	810	817	PF00069	0.412
MOD_GSK3_1	86	93	PF00069	0.725
MOD_GSK3_1	94	101	PF00069	0.618
MOD_GSK3_1	942	949	PF00069	0.389
MOD_GSK3_1	977	984	PF00069	0.679
MOD_GSK3_1	986	993	PF00069	0.738
MOD_GSK3_1	994	1001	PF00069	0.640
MOD_N-GLC_1	450	455	PF02516	0.497
MOD_N-GLC_1	87	92	PF02516	0.720
MOD_N-GLC_2	49	51	PF02516	0.762
MOD_NEK2_1	142	147	PF00069	0.619
MOD_NEK2_1	171	176	PF00069	0.530
MOD_NEK2_1	20	25	PF00069	0.766
MOD_NEK2_1	335	340	PF00069	0.530
MOD_NEK2_1	346	351	PF00069	0.413
MOD_NEK2_1	423	428	PF00069	0.543
MOD_NEK2_1	452	457	PF00069	0.612
MOD_NEK2_1	564	569	PF00069	0.575
MOD_NEK2_1	611	616	PF00069	0.590
MOD_NEK2_1	701	706	PF00069	0.627
MOD_NEK2_1	712	717	PF00069	0.413
MOD_NEK2_1	744	749	PF00069	0.642
MOD_NEK2_1	759	764	PF00069	0.422
MOD_NEK2_1	934	939	PF00069	0.530
MOD_NEK2_1	955	960	PF00069	0.419
MOD_NEK2_1	990	995	PF00069	0.566
MOD_NEK2_2	180	185	PF00069	0.695
MOD_NEK2_2	474	479	PF00069	0.504
MOD_NEK2_2	910	915	PF00069	0.530
MOD_OFUCOSY	240	245	PF10250	0.548
MOD_OFUCOSY	78	84	PF10250	0.723
MOD_PIKK_1	121	127	PF00454	0.476
MOD_PIKK_1	144	150	PF00454	0.467
MOD_PIKK_1	409	415	PF00454	0.558
MOD_PIKK_1	942	948	PF00454	0.384
MOD_PK_1	157	163	PF00069	0.530
MOD_PKA_1	251	257	PF00069	0.573
MOD_PKA_2	20	26	PF00069	0.761
MOD_PKA_2	241	247	PF00069	0.618
MOD_PKA_2	251	257	PF00069	0.670
MOD_PKA_2	453	459	PF00069	0.496
MOD_PKA_2	55	61	PF00069	0.757
MOD_PKA_2	882	888	PF00069	0.442
MOD_PKA_2	95	101	PF00069	0.599
MOD_PKB_1	463	471	PF00069	0.746
MOD_Plk_1	474	480	PF00069	0.504
MOD_Plk_1	750	756	PF00069	0.702
MOD_Plk_1	813	819	PF00069	0.627
MOD_Plk_1	87	93	PF00069	0.720
MOD_Plk_4	171	177	PF00069	0.530
MOD_Plk_4	287	293	PF00069	0.622
MOD_Plk_4	336	342	PF00069	0.486
MOD_Plk_4	419	425	PF00069	0.646
MOD_Plk_4	453	459	PF00069	0.588
MOD_Plk_4	474	480	PF00069	0.504
MOD_Plk_4	537	543	PF00069	0.567
MOD_Plk_4	559	565	PF00069	0.576
MOD_Plk_4	701	707	PF00069	0.638
MOD_Plk_4	750	756	PF00069	0.429
MOD_Plk_4	87	93	PF00069	0.720
MOD_Plk_4	935	941	PF00069	0.530
MOD_Plk_4	960	966	PF00069	0.522
MOD_ProDKin_1	1010	1016	PF00069	0.640
MOD_ProDKin_1	221	227	PF00069	0.697
MOD_ProDKin_1	234	240	PF00069	0.735
MOD_ProDKin_1	261	267	PF00069	0.760
MOD_ProDKin_1	39	45	PF00069	0.718
MOD_ProDKin_1	411	417	PF00069	0.644
MOD_ProDKin_1	542	548	PF00069	0.571
MOD_ProDKin_1	571	577	PF00069	0.647
MOD_ProDKin_1	636	642	PF00069	0.816
MOD_ProDKin_1	981	987	PF00069	0.623
MOD_SUMO_for_1	706	709	PF00179	0.403
MOD_SUMO_rev_2	841	850	PF00179	0.713
TRG_DiLeu_BaEn_1	683	688	PF01217	0.652
TRG_DiLeu_BaEn_1	725	730	PF01217	0.629
TRG_DiLeu_BaLyEn_6	606	611	PF01217	0.606
TRG_DiLeu_BaLyEn_6	794	799	PF01217	0.592
TRG_ENDOCYTIC_2	178	181	PF00928	0.530
TRG_ENDOCYTIC_2	191	194	PF00928	0.527
TRG_ENDOCYTIC_2	457	460	PF00928	0.756
TRG_ENDOCYTIC_2	754	757	PF00928	0.433
TRG_ENDOCYTIC_2	802	805	PF00928	0.644
TRG_ENDOCYTIC_2	826	829	PF00928	0.655
TRG_ENDOCYTIC_2	869	872	PF00928	0.611
TRG_ENDOCYTIC_2	898	901	PF00928	0.277
TRG_ENDOCYTIC_2	926	929	PF00928	0.530
TRG_ER_diArg_1	203	205	PF00400	0.778
TRG_ER_diArg_1	378	381	PF00400	0.594
TRG_ER_diArg_1	462	465	PF00400	0.755
TRG_NES_CRM1_1	862	876	PF08389	0.621
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	467	471	PF00026	0.750
TRG_Pf-PMV_PEXEL_1	941	946	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H500	Leishmania donovani	66%	100%
A4HRN9	Leishmania infantum	66%	100%
E9ACB7	Leishmania major	65%	97%
E9AJK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%