LeishMANIAdb
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Putative serine peptidase, Clan S-, family S54

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative serine peptidase, Clan S-, family S54
Gene product:
serine peptidase, Clan S-, family S54, putative
Species:
Leishmania braziliensis
UniProt:
A4H3C4_LEIBR
TriTrypDb:
LbrM.02.0310 , LBRM2903_020010000
Length:
375

Annotations

LeishMANIAdb annotations

Despite the signature matches, it is both structurally and sequence-wise very dissimilar from rhomboids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 5, no: 5
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A4H3C4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3C4

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 2
GO:0006066 alcohol metabolic process 3 2
GO:0006071 glycerol metabolic process 5 2
GO:0008152 metabolic process 1 2
GO:0009987 cellular process 1 2
GO:0019400 alditol metabolic process 4 2
GO:0019751 polyol metabolic process 4 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0044262 obsolete cellular carbohydrate metabolic process 3 2
GO:0044281 small molecule metabolic process 2 2
GO:0071704 organic substance metabolic process 2 2
GO:1901615 organic hydroxy compound metabolic process 3 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0004175 endopeptidase activity 4 5
GO:0004252 serine-type endopeptidase activity 5 5
GO:0008233 peptidase activity 3 5
GO:0008236 serine-type peptidase activity 4 5
GO:0016787 hydrolase activity 2 5
GO:0017171 serine hydrolase activity 3 5
GO:0140096 catalytic activity, acting on a protein 2 5
GO:0004371 glycerone kinase activity 5 2
GO:0016301 kinase activity 4 2
GO:0016740 transferase activity 2 2
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 2
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 172 174 PF00675 0.561
CLV_NRD_NRD_1 300 302 PF00675 0.508
CLV_NRD_NRD_1 339 341 PF00675 0.386
CLV_NRD_NRD_1 343 345 PF00675 0.360
CLV_NRD_NRD_1 353 355 PF00675 0.276
CLV_NRD_NRD_1 371 373 PF00675 0.448
CLV_PCSK_KEX2_1 172 174 PF00082 0.508
CLV_PCSK_KEX2_1 300 302 PF00082 0.507
CLV_PCSK_KEX2_1 343 345 PF00082 0.346
CLV_PCSK_KEX2_1 353 355 PF00082 0.315
CLV_PCSK_KEX2_1 371 373 PF00082 0.449
CLV_PCSK_PC7_1 349 355 PF00082 0.400
CLV_PCSK_SKI1_1 107 111 PF00082 0.428
CLV_PCSK_SKI1_1 121 125 PF00082 0.503
CLV_PCSK_SKI1_1 208 212 PF00082 0.555
CLV_PCSK_SKI1_1 258 262 PF00082 0.494
CLV_PCSK_SKI1_1 300 304 PF00082 0.507
CLV_PCSK_SKI1_1 362 366 PF00082 0.322
CLV_PCSK_SKI1_1 54 58 PF00082 0.446
DEG_APCC_DBOX_1 299 307 PF00400 0.187
DEG_APCC_DBOX_1 343 351 PF00400 0.475
DEG_Nend_UBRbox_1 1 4 PF02207 0.575
DOC_CDC14_PxL_1 10 18 PF14671 0.500
DOC_CYCLIN_yCln2_LP_2 360 366 PF00134 0.519
DOC_MAPK_gen_1 353 361 PF00069 0.514
DOC_MAPK_gen_1 37 47 PF00069 0.561
DOC_MAPK_MEF2A_6 11 19 PF00069 0.442
DOC_MAPK_MEF2A_6 54 63 PF00069 0.502
DOC_PP2B_LxvP_1 265 268 PF13499 0.339
DOC_USP7_MATH_1 113 117 PF00917 0.624
DOC_USP7_MATH_1 302 306 PF00917 0.307
DOC_USP7_MATH_1 89 93 PF00917 0.571
LIG_14-3-3_CanoR_1 208 214 PF00244 0.387
LIG_14-3-3_CanoR_1 258 267 PF00244 0.304
LIG_14-3-3_CanoR_1 301 307 PF00244 0.322
LIG_14-3-3_CanoR_1 40 46 PF00244 0.644
LIG_14-3-3_CanoR_1 54 63 PF00244 0.538
LIG_APCC_ABBA_1 45 50 PF00400 0.516
LIG_BRCT_BRCA1_1 220 224 PF00533 0.261
LIG_BRCT_BRCA1_1 69 73 PF00533 0.590
LIG_FHA_1 272 278 PF00498 0.308
LIG_FHA_1 64 70 PF00498 0.501
LIG_FHA_2 28 34 PF00498 0.561
LIG_FHA_2 76 82 PF00498 0.492
LIG_FHA_2 98 104 PF00498 0.664
LIG_LIR_Gen_1 249 259 PF02991 0.280
LIG_LIR_Gen_1 57 68 PF02991 0.571
LIG_LIR_Nem_3 249 254 PF02991 0.280
LIG_LIR_Nem_3 57 63 PF02991 0.573
LIG_NBox_RRM_1 263 273 PF00076 0.187
LIG_PDZ_Class_1 370 375 PF00595 0.669
LIG_Pex14_2 56 60 PF04695 0.529
LIG_RPA_C_Fungi 168 180 PF08784 0.492
LIG_RPA_C_Fungi 349 361 PF08784 0.354
LIG_SH2_CRK 256 260 PF00017 0.298
LIG_SH2_STAP1 220 224 PF00017 0.306
LIG_SH2_STAT3 281 284 PF00017 0.201
LIG_SH2_STAT5 281 284 PF00017 0.415
LIG_SH2_STAT5 333 336 PF00017 0.370
LIG_SH3_3 306 312 PF00018 0.201
LIG_SH3_3 85 91 PF00018 0.419
LIG_TRAF2_1 227 230 PF00917 0.455
LIG_UBA3_1 202 211 PF00899 0.469
LIG_WRC_WIRS_1 164 169 PF05994 0.327
LIG_WRC_WIRS_1 72 77 PF05994 0.430
MOD_CK1_1 116 122 PF00069 0.351
MOD_CK1_1 249 255 PF00069 0.370
MOD_CK1_1 98 104 PF00069 0.482
MOD_CK2_1 194 200 PF00069 0.483
MOD_CK2_1 224 230 PF00069 0.559
MOD_CK2_1 291 297 PF00069 0.398
MOD_CK2_1 75 81 PF00069 0.341
MOD_CMANNOS 342 345 PF00535 0.388
MOD_GlcNHglycan 110 113 PF01048 0.518
MOD_GlcNHglycan 141 144 PF01048 0.421
MOD_GlcNHglycan 191 194 PF01048 0.493
MOD_GlcNHglycan 196 199 PF01048 0.427
MOD_GlcNHglycan 226 229 PF01048 0.477
MOD_GlcNHglycan 23 26 PF01048 0.536
MOD_GlcNHglycan 241 244 PF01048 0.197
MOD_GlcNHglycan 248 251 PF01048 0.285
MOD_GlcNHglycan 372 375 PF01048 0.428
MOD_GlcNHglycan 91 94 PF01048 0.544
MOD_GSK3_1 63 70 PF00069 0.468
MOD_GSK3_1 71 78 PF00069 0.392
MOD_N-GLC_1 83 88 PF02516 0.515
MOD_NEK2_1 163 168 PF00069 0.337
MOD_NEK2_1 224 229 PF00069 0.513
MOD_NEK2_1 75 80 PF00069 0.360
MOD_NEK2_1 97 102 PF00069 0.631
MOD_PIKK_1 116 122 PF00454 0.501
MOD_PKA_2 95 101 PF00069 0.706
MOD_Plk_1 131 137 PF00069 0.374
MOD_Plk_4 209 215 PF00069 0.407
MOD_Plk_4 302 308 PF00069 0.201
MOD_Plk_4 75 81 PF00069 0.297
TRG_ENDOCYTIC_2 164 167 PF00928 0.491
TRG_ENDOCYTIC_2 333 336 PF00928 0.370
TRG_ER_diArg_1 171 173 PF00400 0.433
TRG_ER_diArg_1 307 310 PF00400 0.201
TRG_ER_diArg_1 342 344 PF00400 0.443
TRG_NLS_MonoExtC_3 339 344 PF00514 0.520

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IG61 Leptomonas seymouri 53% 100%
A0A1X0NK02 Trypanosomatidae 31% 100%
A0A3R7KGS4 Trypanosoma rangeli 30% 100%
A0A3S5H501 Leishmania donovani 66% 100%
A4HRP0 Leishmania infantum 66% 100%
C9ZJ23 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9ACB8 Leishmania major 67% 99%
E9AJK6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 65% 100%
V5BCY2 Trypanosoma cruzi 30% 72%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS