Putative serine peptidase, Clan S-, family S54

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine peptidase, Clan S-, family S54, putative

Species:

Leishmania braziliensis

UniProt:

A4H3C4_LEIBR

TriTrypDb:

LbrM.02.0310 , LBRM2903_020010000

Length:

375

Annotations

LeishMANIAdb annotations

Despite the signature matches, it is both structurally and sequence-wise very dissimilar from rhomboids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 5
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Previous1Next

Expansion

Sequence features

A4H3C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3C4

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	2
GO:0006066	alcohol metabolic process	3	2
GO:0006071	glycerol metabolic process	5	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0019400	alditol metabolic process	4	2
GO:0019751	polyol metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044262	obsolete cellular carbohydrate metabolic process	3	2

Previous1 2Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004175	endopeptidase activity	4	5
GO:0004252	serine-type endopeptidase activity	5	5
GO:0004371	glycerone kinase activity	5	2
GO:0008233	peptidase activity	3	5
GO:0008236	serine-type peptidase activity	4	5
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2

Previous1 2Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	172	174	PF00675	0.561
CLV_NRD_NRD_1	300	302	PF00675	0.508
CLV_NRD_NRD_1	339	341	PF00675	0.386
CLV_NRD_NRD_1	343	345	PF00675	0.360
CLV_NRD_NRD_1	353	355	PF00675	0.276
CLV_NRD_NRD_1	371	373	PF00675	0.448
CLV_PCSK_KEX2_1	172	174	PF00082	0.508
CLV_PCSK_KEX2_1	300	302	PF00082	0.507
CLV_PCSK_KEX2_1	343	345	PF00082	0.346
CLV_PCSK_KEX2_1	353	355	PF00082	0.315

Previous1 2 3 4 5…11Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IG61	Leptomonas seymouri	53%	100%
A0A1X0NK02	Trypanosomatidae	31%	100%
A0A3R7KGS4	Trypanosoma rangeli	30%	100%
A0A3S5H501	Leishmania donovani	66%	100%
A4HRP0	Leishmania infantum	66%	100%
C9ZJ23	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ACB8	Leishmania major	67%	99%
E9AJK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
V5BCY2	Trypanosoma cruzi	30%	72%

Previous1Next