Small GTP binding protein rab6-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small GTP binding protein rab6-like protein (fragment)

Species:

Leishmania braziliensis

UniProt:

A4H3C2_LEIBR

TriTrypDb:

LbrM.02.0290 , LBRM2903_020008000

Length:

118

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3C2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	4
GO:0003924	GTPase activity	7	4
GO:0005488	binding	1	5
GO:0005525	GTP binding	5	5
GO:0016462	pyrophosphatase activity	5	4
GO:0016787	hydrolase activity	2	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	4
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	4
GO:0017076	purine nucleotide binding	4	5
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	4
GO:0019001	guanyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032561	guanyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	26	30	PF00082	0.196
DEG_Nend_UBRbox_2	1	3	PF02207	0.441
DEG_SPOP_SBC_1	17	21	PF00917	0.361
DOC_PP2B_PxIxI_1	54	60	PF00149	0.178
DOC_USP7_MATH_1	17	21	PF00917	0.612
DOC_USP7_MATH_1	6	10	PF00917	0.473
LIG_14-3-3_CanoR_1	110	114	PF00244	0.178
LIG_14-3-3_CanoR_1	86	91	PF00244	0.190
LIG_14-3-3_CanoR_1	96	105	PF00244	0.190
LIG_BRCT_BRCA1_1	110	114	PF00533	0.178
LIG_FHA_1	36	42	PF00498	0.252
LIG_FHA_1	54	60	PF00498	0.352
LIG_FHA_1	63	69	PF00498	0.285
LIG_FHA_1	99	105	PF00498	0.410
LIG_LIR_Gen_1	85	95	PF02991	0.178
LIG_LIR_Nem_3	111	117	PF02991	0.353
LIG_LIR_Nem_3	85	90	PF02991	0.235
LIG_MLH1_MIPbox_1	110	114	PF16413	0.178
LIG_Pex14_2	113	117	PF04695	0.178
LIG_REV1ctd_RIR_1	59	68	PF16727	0.367
LIG_SH2_STAT5	94	97	PF00017	0.191
LIG_SUMO_SIM_par_1	26	32	PF11976	0.235
LIG_SUMO_SIM_par_1	98	106	PF11976	0.178
LIG_SxIP_EBH_1	86	97	PF03271	0.178
LIG_TRAF2_1	82	85	PF00917	0.361
LIG_WRC_WIRS_1	46	51	PF05994	0.178
MOD_CK1_1	10	16	PF00069	0.512
MOD_CK1_1	109	115	PF00069	0.182
MOD_CK1_1	18	24	PF00069	0.318
MOD_CK1_1	39	45	PF00069	0.178
MOD_CK1_1	98	104	PF00069	0.379
MOD_GlcNHglycan	15	18	PF01048	0.525
MOD_GlcNHglycan	2	5	PF01048	0.499
MOD_GlcNHglycan	98	101	PF01048	0.324
MOD_GSK3_1	105	112	PF00069	0.236
MOD_GSK3_1	31	38	PF00069	0.191
MOD_GSK3_1	6	13	PF00069	0.630
MOD_GSK3_1	86	93	PF00069	0.363
MOD_N-GLC_1	96	101	PF02516	0.293
MOD_NEK2_1	62	67	PF00069	0.346
MOD_NEK2_1	78	83	PF00069	0.400
MOD_PK_1	11	17	PF00069	0.405
MOD_PKA_2	109	115	PF00069	0.141
MOD_PKA_2	95	101	PF00069	0.293
MOD_Plk_1	31	37	PF00069	0.178
MOD_Plk_4	109	115	PF00069	0.276
MOD_Plk_4	18	24	PF00069	0.508
MOD_Plk_4	36	42	PF00069	0.132
MOD_Plk_4	86	92	PF00069	0.293
MOD_Plk_4	98	104	PF00069	0.287
TRG_ENDOCYTIC_2	46	49	PF00928	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IKT1	Bodo saltans	35%	100%
A0A0S4JNI6	Bodo saltans	36%	100%
A0A3R7MFJ7	Trypanosoma rangeli	30%	100%