Glyco_transf_41 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosyltransferase (GlcNAc), putative

Species:

Leishmania braziliensis

UniProt:

A4H3C0_LEIBR

TriTrypDb:

LbrM.02.0270 , LBRM2903_020007800

Length:

863

Annotations

LeishMANIAdb annotations

A conserved glycosyltransferase enzyme. Only expanded in T cruzi lineage.. Localization: Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

A4H3C0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3C0

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	468	472	PF00656	0.423
CLV_MEL_PAP_1	389	395	PF00089	0.425
CLV_NRD_NRD_1	111	113	PF00675	0.437
CLV_NRD_NRD_1	123	125	PF00675	0.356
CLV_NRD_NRD_1	189	191	PF00675	0.504
CLV_NRD_NRD_1	294	296	PF00675	0.556
CLV_NRD_NRD_1	362	364	PF00675	0.413
CLV_NRD_NRD_1	430	432	PF00675	0.346
CLV_NRD_NRD_1	653	655	PF00675	0.223
CLV_NRD_NRD_1	88	90	PF00675	0.506

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2W0	Leptomonas seymouri	54%	90%
A0A3S5H4Z0	Leishmania donovani	75%	96%
A4HRS4	Leishmania infantum	75%	96%
E9AC99	Leishmania major	75%	100%
E9AJI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	96%

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