Phosphoglycan beta 1,3 galactosyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoglycan beta 1,3 galactosyltransferase

Species:

Leishmania braziliensis

UniProt:

A4H3B4_LEIBR

TriTrypDb:

LbrM.02.0210 , LBRM2903_020006500

Length:

817

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 60

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 52
NetGPI	no	yes: 0, no: 52

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Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	14
GO:0016020	membrane	2	53
GO:0031090	organelle membrane	3	14
GO:0098588	bounding membrane of organelle	4	14
GO:0110165	cellular anatomical entity	1	53

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Expansion

Sequence features

A4H3B4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3B4

Function

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Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	53
GO:0006807	nitrogen compound metabolic process	2	53
GO:0008152	metabolic process	1	53
GO:0019538	protein metabolic process	3	53
GO:0036211	protein modification process	4	53
GO:0043170	macromolecule metabolic process	3	53
GO:0043412	macromolecule modification	4	53
GO:0043413	macromolecule glycosylation	3	53
GO:0044238	primary metabolic process	2	53
GO:0070085	glycosylation	2	53

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	53
GO:0008194	UDP-glycosyltransferase activity	4	14
GO:0016740	transferase activity	2	53
GO:0016757	glycosyltransferase activity	3	53
GO:0016758	hexosyltransferase activity	4	53

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	398	402	PF00656	0.339
CLV_NRD_NRD_1	12	14	PF00675	0.426
CLV_NRD_NRD_1	313	315	PF00675	0.536
CLV_NRD_NRD_1	325	327	PF00675	0.505
CLV_NRD_NRD_1	411	413	PF00675	0.656
CLV_NRD_NRD_1	416	418	PF00675	0.646
CLV_NRD_NRD_1	494	496	PF00675	0.676
CLV_NRD_NRD_1	667	669	PF00675	0.536
CLV_NRD_NRD_1	736	738	PF00675	0.506
CLV_NRD_NRD_1	754	756	PF00675	0.515

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGN9	Leishmania donovani	42%	100%
A0A3S5H4Y6	Leishmania donovani	59%	100%
A0A3S5H4Y9	Leishmania donovani	39%	82%
A0A3S7WT86	Leishmania donovani	40%	79%
A0A3S7WWA6	Leishmania donovani	42%	100%
A0A451EJD9	Leishmania donovani	40%	100%
A0A451EJF4	Leishmania donovani	67%	100%
A0A451EJF6	Leishmania donovani	60%	100%
A0A451EJF8	Leishmania donovani	54%	100%
A0A451EJF9	Leishmania donovani	51%	95%

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