Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3B2_LEIBR

TriTrypDb:

LbrM.02.0190 , LBRM2903_020005800

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3B2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3B2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.569
CLV_C14_Caspase3-7	186	190	PF00656	0.686
CLV_NRD_NRD_1	117	119	PF00675	0.429
CLV_NRD_NRD_1	300	302	PF00675	0.485
CLV_NRD_NRD_1	31	33	PF00675	0.559
CLV_NRD_NRD_1	68	70	PF00675	0.610
CLV_NRD_NRD_1	73	75	PF00675	0.548
CLV_NRD_NRD_1	76	78	PF00675	0.526
CLV_NRD_NRD_1	8	10	PF00675	0.636
CLV_PCSK_FUR_1	349	353	PF00082	0.530
CLV_PCSK_FUR_1	74	78	PF00082	0.453
CLV_PCSK_KEX2_1	116	118	PF00082	0.442
CLV_PCSK_KEX2_1	348	350	PF00082	0.631
CLV_PCSK_KEX2_1	351	353	PF00082	0.649
CLV_PCSK_KEX2_1	61	63	PF00082	0.647
CLV_PCSK_KEX2_1	68	70	PF00082	0.606
CLV_PCSK_KEX2_1	73	75	PF00082	0.542
CLV_PCSK_KEX2_1	76	78	PF00082	0.542
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.630
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.655
CLV_PCSK_PC7_1	69	75	PF00082	0.658
CLV_PCSK_SKI1_1	110	114	PF00082	0.588
CLV_PCSK_SKI1_1	15	19	PF00082	0.503
CLV_PCSK_SKI1_1	61	65	PF00082	0.626
DOC_CKS1_1	283	288	PF01111	0.488
DOC_MAPK_gen_1	73	83	PF00069	0.572
DOC_MAPK_MEF2A_6	76	85	PF00069	0.537
DOC_USP7_MATH_1	161	165	PF00917	0.505
DOC_USP7_MATH_1	310	314	PF00917	0.675
DOC_USP7_MATH_1	320	324	PF00917	0.697
DOC_USP7_MATH_1	340	344	PF00917	0.657
DOC_USP7_MATH_1	45	49	PF00917	0.682
DOC_USP7_MATH_1	57	61	PF00917	0.785
DOC_USP7_UBL2_3	29	33	PF12436	0.602
DOC_WW_Pin1_4	144	149	PF00397	0.558
DOC_WW_Pin1_4	225	230	PF00397	0.566
DOC_WW_Pin1_4	282	287	PF00397	0.499
LIG_14-3-3_CanoR_1	222	229	PF00244	0.509
LIG_BIR_II_1	1	5	PF00653	0.615
LIG_BRCT_BRCA1_1	21	25	PF00533	0.576
LIG_FHA_1	263	269	PF00498	0.505
LIG_FHA_1	278	284	PF00498	0.465
LIG_FHA_1	62	68	PF00498	0.500
LIG_FHA_2	145	151	PF00498	0.552
LIG_FHA_2	203	209	PF00498	0.487
LIG_FHA_2	230	236	PF00498	0.550
LIG_FHA_2	312	318	PF00498	0.484
LIG_Integrin_isoDGR_2	108	110	PF01839	0.377
LIG_Integrin_isoDGR_2	37	39	PF01839	0.624
LIG_LIR_Gen_1	207	217	PF02991	0.407
LIG_LIR_Gen_1	22	30	PF02991	0.545
LIG_LIR_Gen_1	80	89	PF02991	0.503
LIG_LIR_Nem_3	207	212	PF02991	0.419
LIG_LIR_Nem_3	22	28	PF02991	0.579
LIG_LIR_Nem_3	294	299	PF02991	0.491
LIG_LIR_Nem_3	80	85	PF02991	0.520
LIG_NRP_CendR_1	350	353	PF00754	0.756
LIG_Pex14_2	292	296	PF04695	0.487
LIG_SH2_NCK_1	160	164	PF00017	0.381
LIG_SH2_STAT5	128	131	PF00017	0.420
LIG_SH2_STAT5	155	158	PF00017	0.395
LIG_SH2_STAT5	202	205	PF00017	0.630
LIG_SH2_STAT5	236	239	PF00017	0.544
LIG_SH2_STAT5	291	294	PF00017	0.471
LIG_TRAF2_1	11	14	PF00917	0.550
LIG_TRAF2_1	148	151	PF00917	0.497
LIG_UBA3_1	24	33	PF00899	0.541
MOD_CDK_SPK_2	282	287	PF00069	0.499
MOD_CK1_1	19	25	PF00069	0.545
MOD_CK1_1	323	329	PF00069	0.788
MOD_CK1_1	343	349	PF00069	0.645
MOD_CK1_1	93	99	PF00069	0.655
MOD_CK2_1	144	150	PF00069	0.511
MOD_CK2_1	202	208	PF00069	0.475
MOD_CK2_1	271	277	PF00069	0.410
MOD_CK2_1	311	317	PF00069	0.484
MOD_Cter_Amidation	346	349	PF01082	0.731
MOD_GlcNHglycan	130	133	PF01048	0.452
MOD_GlcNHglycan	185	188	PF01048	0.593
MOD_GlcNHglycan	225	228	PF01048	0.504
MOD_GlcNHglycan	303	307	PF01048	0.588
MOD_GlcNHglycan	322	325	PF01048	0.449
MOD_GlcNHglycan	345	348	PF01048	0.714
MOD_GlcNHglycan	48	51	PF01048	0.565
MOD_GSK3_1	140	147	PF00069	0.557
MOD_GSK3_1	174	181	PF00069	0.594
MOD_GSK3_1	225	232	PF00069	0.503
MOD_GSK3_1	249	256	PF00069	0.557
MOD_GSK3_1	277	284	PF00069	0.472
MOD_GSK3_1	320	327	PF00069	0.649
MOD_GSK3_1	338	345	PF00069	0.606
MOD_GSK3_1	57	64	PF00069	0.715
MOD_GSK3_1	68	75	PF00069	0.544
MOD_N-GLC_1	324	329	PF02516	0.556
MOD_N-GLC_1	341	346	PF02516	0.728
MOD_N-GLC_2	182	184	PF02516	0.417
MOD_NEK2_1	304	309	PF00069	0.558
MOD_PIKK_1	174	180	PF00454	0.540
MOD_PIKK_1	271	277	PF00454	0.587
MOD_PIKK_1	68	74	PF00454	0.712
MOD_PK_1	77	83	PF00069	0.640
MOD_PKA_1	61	67	PF00069	0.644
MOD_PKA_1	68	74	PF00069	0.596
MOD_PKA_2	169	175	PF00069	0.486
MOD_PKA_2	223	229	PF00069	0.463
MOD_PKA_2	271	277	PF00069	0.488
MOD_PKA_2	310	316	PF00069	0.481
MOD_PKA_2	61	67	PF00069	0.610
MOD_PKA_2	68	74	PF00069	0.589
MOD_Plk_1	19	25	PF00069	0.552
MOD_Plk_1	244	250	PF00069	0.652
MOD_Plk_4	77	83	PF00069	0.508
MOD_ProDKin_1	144	150	PF00069	0.560
MOD_ProDKin_1	225	231	PF00069	0.567
MOD_ProDKin_1	282	288	PF00069	0.492
TRG_DiLeu_BaEn_1	13	18	PF01217	0.554
TRG_DiLeu_BaEn_4	13	19	PF01217	0.572
TRG_ER_diArg_1	116	118	PF00400	0.409
TRG_ER_diArg_1	269	272	PF00400	0.453
TRG_ER_diArg_1	349	352	PF00400	0.695
TRG_ER_diArg_1	67	69	PF00400	0.715
TRG_ER_diArg_1	73	76	PF00400	0.696
TRG_NLS_MonoCore_2	347	352	PF00514	0.750
TRG_NLS_MonoExtC_3	347	352	PF00514	0.671
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWM5	Leptomonas seymouri	61%	100%
A0A0S4JHT8	Bodo saltans	27%	99%
A0A1X0NKG5	Trypanosomatidae	38%	90%
A0A3S5H4Y1	Leishmania donovani	77%	100%
A0A422N6Z1	Trypanosoma rangeli	39%	91%
A4HRL2	Leishmania infantum	77%	100%
C9ZJ00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	91%
E9AC84	Leishmania major	77%	100%
E9AJH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
V5B685	Trypanosoma cruzi	40%	90%