LeishMANIAdb
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Phosphoglycan beta 1,3 galactosyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoglycan beta 1,3 galactosyltransferase
Gene product:
phosphoglycan beta 1,3 galactosyltransferase
Species:
Leishmania braziliensis
UniProt:
A4H3A9_LEIBR
TriTrypDb:
LbrM.02.0160 , LBRM2903_020006500 *
Length:
716

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 53
NetGPI no yes: 0, no: 53
Cellular components
Term Name Level Count
GO:0016020 membrane 2 54
GO:0110165 cellular anatomical entity 1 54
GO:0000139 Golgi membrane 5 13
GO:0031090 organelle membrane 3 13
GO:0098588 bounding membrane of organelle 4 13

Expansion

Sequence features

A4H3A9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3A9

Function

Biological processes
Term Name Level Count
GO:0006486 protein glycosylation 4 54
GO:0006807 nitrogen compound metabolic process 2 54
GO:0008152 metabolic process 1 54
GO:0019538 protein metabolic process 3 54
GO:0036211 protein modification process 4 54
GO:0043170 macromolecule metabolic process 3 54
GO:0043412 macromolecule modification 4 54
GO:0043413 macromolecule glycosylation 3 54
GO:0044238 primary metabolic process 2 54
GO:0070085 glycosylation 2 54
GO:0071704 organic substance metabolic process 2 54
GO:1901564 organonitrogen compound metabolic process 3 54
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 54
GO:0016740 transferase activity 2 54
GO:0016757 glycosyltransferase activity 3 54
GO:0016758 hexosyltransferase activity 4 54
GO:0008194 UDP-glycosyltransferase activity 4 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 76 80 PF00656 0.389
CLV_NRD_NRD_1 211 213 PF00675 0.543
CLV_NRD_NRD_1 223 225 PF00675 0.534
CLV_NRD_NRD_1 24 26 PF00675 0.593
CLV_NRD_NRD_1 309 311 PF00675 0.764
CLV_NRD_NRD_1 314 316 PF00675 0.724
CLV_NRD_NRD_1 36 38 PF00675 0.597
CLV_NRD_NRD_1 393 395 PF00675 0.696
CLV_NRD_NRD_1 566 568 PF00675 0.541
CLV_NRD_NRD_1 635 637 PF00675 0.510
CLV_NRD_NRD_1 653 655 PF00675 0.522
CLV_PCSK_KEX2_1 223 225 PF00082 0.547
CLV_PCSK_KEX2_1 24 26 PF00082 0.616
CLV_PCSK_KEX2_1 29 31 PF00082 0.649
CLV_PCSK_KEX2_1 309 311 PF00082 0.762
CLV_PCSK_KEX2_1 314 316 PF00082 0.723
CLV_PCSK_KEX2_1 393 395 PF00082 0.627
CLV_PCSK_KEX2_1 566 568 PF00082 0.592
CLV_PCSK_KEX2_1 634 636 PF00082 0.578
CLV_PCSK_KEX2_1 653 655 PF00082 0.536
CLV_PCSK_KEX2_1 676 678 PF00082 0.581
CLV_PCSK_PC1ET2_1 29 31 PF00082 0.617
CLV_PCSK_PC1ET2_1 634 636 PF00082 0.578
CLV_PCSK_PC1ET2_1 676 678 PF00082 0.564
CLV_PCSK_PC7_1 25 31 PF00082 0.571
CLV_PCSK_PC7_1 310 316 PF00082 0.634
CLV_PCSK_PC7_1 562 568 PF00082 0.507
CLV_PCSK_SKI1_1 204 208 PF00082 0.574
CLV_PCSK_SKI1_1 256 260 PF00082 0.595
CLV_PCSK_SKI1_1 29 33 PF00082 0.589
CLV_PCSK_SKI1_1 310 314 PF00082 0.693
CLV_PCSK_SKI1_1 382 386 PF00082 0.512
CLV_PCSK_SKI1_1 418 422 PF00082 0.598
CLV_PCSK_SKI1_1 515 519 PF00082 0.500
CLV_PCSK_SKI1_1 673 677 PF00082 0.528
DEG_SCF_FBW7_1 354 361 PF00400 0.514
DOC_CKS1_1 355 360 PF01111 0.521
DOC_CYCLIN_RxL_1 24 36 PF00134 0.359
DOC_CYCLIN_yCln2_LP_2 352 358 PF00134 0.559
DOC_MAPK_MEF2A_6 138 146 PF00069 0.433
DOC_MAPK_MEF2A_6 382 389 PF00069 0.480
DOC_MAPK_MEF2A_6 521 530 PF00069 0.321
DOC_MAPK_RevD_3 10 25 PF00069 0.204
DOC_PP1_RVXF_1 380 387 PF00149 0.378
DOC_PP1_RVXF_1 416 423 PF00149 0.438
DOC_PP1_RVXF_1 574 580 PF00149 0.266
DOC_PP2B_LxvP_1 352 355 PF13499 0.558
DOC_PP4_FxxP_1 360 363 PF00568 0.403
DOC_USP7_MATH_1 145 149 PF00917 0.469
DOC_USP7_MATH_1 180 184 PF00917 0.444
DOC_USP7_MATH_1 473 477 PF00917 0.395
DOC_WW_Pin1_4 23 28 PF00397 0.373
DOC_WW_Pin1_4 267 272 PF00397 0.414
DOC_WW_Pin1_4 321 326 PF00397 0.491
DOC_WW_Pin1_4 354 359 PF00397 0.494
DOC_WW_Pin1_4 591 596 PF00397 0.350
DOC_WW_Pin1_4 606 611 PF00397 0.310
DOC_WW_Pin1_4 675 680 PF00397 0.353
LIG_14-3-3_CanoR_1 212 216 PF00244 0.468
LIG_14-3-3_CanoR_1 256 261 PF00244 0.425
LIG_14-3-3_CanoR_1 30 39 PF00244 0.363
LIG_14-3-3_CanoR_1 315 325 PF00244 0.436
LIG_14-3-3_CanoR_1 44 53 PF00244 0.422
LIG_14-3-3_CanoR_1 475 479 PF00244 0.399
LIG_14-3-3_CanoR_1 543 549 PF00244 0.331
LIG_14-3-3_CanoR_1 562 566 PF00244 0.319
LIG_14-3-3_CanoR_1 653 657 PF00244 0.344
LIG_14-3-3_CanoR_1 86 93 PF00244 0.367
LIG_Actin_WH2_2 152 168 PF00022 0.473
LIG_Actin_WH2_2 552 568 PF00022 0.294
LIG_BIR_II_1 1 5 PF00653 0.403
LIG_BIR_III_2 664 668 PF00653 0.291
LIG_BRCT_BRCA1_1 268 272 PF00533 0.407
LIG_Clathr_ClatBox_1 506 510 PF01394 0.217
LIG_CtBP_PxDLS_1 246 250 PF00389 0.381
LIG_eIF4E_1 501 507 PF01652 0.224
LIG_FHA_1 148 154 PF00498 0.598
LIG_FHA_1 227 233 PF00498 0.370
LIG_FHA_1 273 279 PF00498 0.433
LIG_FHA_1 34 40 PF00498 0.365
LIG_FHA_1 340 346 PF00498 0.457
LIG_FHA_1 45 51 PF00498 0.431
LIG_FHA_1 5 11 PF00498 0.262
LIG_FHA_1 94 100 PF00498 0.536
LIG_FHA_2 295 301 PF00498 0.374
LIG_FHA_2 592 598 PF00498 0.322
LIG_FHA_2 607 613 PF00498 0.292
LIG_FHA_2 702 708 PF00498 0.319
LIG_LIR_Apic_2 357 363 PF02991 0.410
LIG_LIR_Apic_2 404 410 PF02991 0.466
LIG_LIR_Apic_2 708 714 PF02991 0.275
LIG_LIR_Gen_1 441 451 PF02991 0.358
LIG_LIR_Gen_1 542 550 PF02991 0.388
LIG_LIR_Gen_1 597 605 PF02991 0.391
LIG_LIR_Gen_1 623 629 PF02991 0.276
LIG_LIR_Nem_3 171 176 PF02991 0.441
LIG_LIR_Nem_3 214 218 PF02991 0.468
LIG_LIR_Nem_3 441 447 PF02991 0.320
LIG_LIR_Nem_3 542 548 PF02991 0.416
LIG_LIR_Nem_3 597 603 PF02991 0.396
LIG_LIR_Nem_3 623 628 PF02991 0.304
LIG_NRBOX 508 514 PF00104 0.238
LIG_NRBOX 555 561 PF00104 0.279
LIG_NRBOX 9 15 PF00104 0.295
LIG_Pex14_1 699 703 PF04695 0.281
LIG_REV1ctd_RIR_1 617 626 PF16727 0.290
LIG_SH2_CRK 625 629 PF00017 0.290
LIG_SH2_CRK 711 715 PF00017 0.328
LIG_SH2_NCK_1 285 289 PF00017 0.449
LIG_SH2_NCK_1 681 685 PF00017 0.364
LIG_SH2_NCK_1 711 715 PF00017 0.293
LIG_SH2_PTP2 444 447 PF00017 0.311
LIG_SH2_SRC 218 221 PF00017 0.344
LIG_SH2_SRC 425 428 PF00017 0.394
LIG_SH2_SRC 615 618 PF00017 0.273
LIG_SH2_STAP1 113 117 PF00017 0.446
LIG_SH2_STAP1 425 429 PF00017 0.490
LIG_SH2_STAP1 625 629 PF00017 0.286
LIG_SH2_STAT5 190 193 PF00017 0.394
LIG_SH2_STAT5 236 239 PF00017 0.430
LIG_SH2_STAT5 347 350 PF00017 0.424
LIG_SH2_STAT5 366 369 PF00017 0.380
LIG_SH2_STAT5 444 447 PF00017 0.336
LIG_SH2_STAT5 456 459 PF00017 0.374
LIG_SH2_STAT5 615 618 PF00017 0.445
LIG_SH3_3 183 189 PF00018 0.466
LIG_SH3_3 240 246 PF00018 0.338
LIG_SH3_3 320 326 PF00018 0.402
LIG_SH3_3 352 358 PF00018 0.534
LIG_SH3_3 442 448 PF00018 0.317
LIG_SH3_3 462 468 PF00018 0.367
LIG_SH3_3 514 520 PF00018 0.339
LIG_SH3_5 610 614 PF00018 0.228
LIG_SUMO_SIM_anti_2 15 20 PF11976 0.271
LIG_SUMO_SIM_par_1 12 17 PF11976 0.238
LIG_SUMO_SIM_par_1 245 253 PF11976 0.389
LIG_TRAF2_1 217 220 PF00917 0.348
LIG_TYR_ITIM 216 221 PF00017 0.543
LIG_WW_3 184 188 PF00397 0.444
MOD_CDC14_SPxK_1 26 29 PF00782 0.428
MOD_CDK_SPxK_1 23 29 PF00069 0.433
MOD_CDK_SPxxK_3 23 30 PF00069 0.434
MOD_CK1_1 33 39 PF00069 0.406
MOD_CK1_1 334 340 PF00069 0.602
MOD_CK1_1 343 349 PF00069 0.481
MOD_CK2_1 112 118 PF00069 0.488
MOD_CK2_1 278 284 PF00069 0.679
MOD_CK2_1 359 365 PF00069 0.496
MOD_Cter_Amidation 22 25 PF01082 0.439
MOD_Cter_Amidation 632 635 PF01082 0.374
MOD_GlcNHglycan 114 117 PF01048 0.601
MOD_GlcNHglycan 131 134 PF01048 0.610
MOD_GlcNHglycan 170 173 PF01048 0.469
MOD_GlcNHglycan 182 185 PF01048 0.487
MOD_GlcNHglycan 256 259 PF01048 0.564
MOD_GlcNHglycan 318 321 PF01048 0.489
MOD_GlcNHglycan 32 35 PF01048 0.416
MOD_GlcNHglycan 333 336 PF01048 0.531
MOD_GlcNHglycan 342 345 PF01048 0.597
MOD_GlcNHglycan 371 374 PF01048 0.610
MOD_GlcNHglycan 502 505 PF01048 0.265
MOD_GlcNHglycan 630 633 PF01048 0.451
MOD_GlcNHglycan 75 78 PF01048 0.498
MOD_GlcNHglycan 87 90 PF01048 0.478
MOD_GSK3_1 105 112 PF00069 0.554
MOD_GSK3_1 248 255 PF00069 0.666
MOD_GSK3_1 291 298 PF00069 0.453
MOD_GSK3_1 330 337 PF00069 0.687
MOD_GSK3_1 339 346 PF00069 0.533
MOD_GSK3_1 350 357 PF00069 0.558
MOD_GSK3_1 44 51 PF00069 0.587
MOD_GSK3_1 624 631 PF00069 0.393
MOD_GSK3_1 69 76 PF00069 0.403
MOD_N-GLC_1 266 271 PF02516 0.534
MOD_N-GLC_1 295 300 PF02516 0.443
MOD_N-GLC_1 473 478 PF02516 0.494
MOD_N-GLC_1 63 68 PF02516 0.439
MOD_NEK2_1 1 6 PF00069 0.325
MOD_NEK2_1 12 17 PF00069 0.348
MOD_NEK2_1 129 134 PF00069 0.562
MOD_NEK2_1 272 277 PF00069 0.496
MOD_NEK2_1 331 336 PF00069 0.462
MOD_NEK2_1 628 633 PF00069 0.406
MOD_NEK2_1 63 68 PF00069 0.532
MOD_NEK2_2 489 494 PF00069 0.305
MOD_NEK2_2 93 98 PF00069 0.696
MOD_PIKK_1 413 419 PF00454 0.551
MOD_PIKK_1 44 50 PF00454 0.458
MOD_PKA_1 393 399 PF00069 0.641
MOD_PKA_2 211 217 PF00069 0.577
MOD_PKA_2 331 337 PF00069 0.637
MOD_PKA_2 393 399 PF00069 0.597
MOD_PKA_2 474 480 PF00069 0.436
MOD_PKA_2 561 567 PF00069 0.335
MOD_PKA_2 652 658 PF00069 0.386
MOD_PKA_2 69 75 PF00069 0.439
MOD_PKA_2 85 91 PF00069 0.428
MOD_Plk_1 473 479 PF00069 0.455
MOD_Plk_1 596 602 PF00069 0.420
MOD_Plk_2-3 248 254 PF00069 0.547
MOD_Plk_4 14 20 PF00069 0.312
MOD_Plk_4 211 217 PF00069 0.497
MOD_Plk_4 343 349 PF00069 0.468
MOD_Plk_4 599 605 PF00069 0.521
MOD_Plk_4 69 75 PF00069 0.394
MOD_ProDKin_1 23 29 PF00069 0.445
MOD_ProDKin_1 267 273 PF00069 0.496
MOD_ProDKin_1 321 327 PF00069 0.602
MOD_ProDKin_1 354 360 PF00069 0.611
MOD_ProDKin_1 591 597 PF00069 0.405
MOD_ProDKin_1 606 612 PF00069 0.350
MOD_ProDKin_1 675 681 PF00069 0.410
TRG_DiLeu_BaLyEn_6 27 32 PF01217 0.441
TRG_DiLeu_BaLyEn_6 508 513 PF01217 0.400
TRG_ENDOCYTIC_2 190 193 PF00928 0.473
TRG_ENDOCYTIC_2 218 221 PF00928 0.583
TRG_ENDOCYTIC_2 427 430 PF00928 0.627
TRG_ENDOCYTIC_2 444 447 PF00928 0.265
TRG_ENDOCYTIC_2 545 548 PF00928 0.507
TRG_ENDOCYTIC_2 625 628 PF00928 0.333
TRG_ER_diArg_1 308 310 PF00400 0.709
TRG_ER_diArg_1 313 315 PF00400 0.667
TRG_ER_diArg_1 393 395 PF00400 0.494
TRG_ER_diArg_1 565 567 PF00400 0.430
TRG_Pf-PMV_PEXEL_1 37 41 PF00026 0.395
TRG_Pf-PMV_PEXEL_1 399 403 PF00026 0.456

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IGN9 Leishmania donovani 42% 88%
A0A3S5H4Y6 Leishmania donovani 62% 89%
A0A3S5H4Y9 Leishmania donovani 38% 72%
A0A3S7WT86 Leishmania donovani 40% 70%
A0A3S7WWA6 Leishmania donovani 42% 88%
A0A451EJD9 Leishmania donovani 40% 88%
A0A451EJF4 Leishmania donovani 65% 88%
A0A451EJF6 Leishmania donovani 55% 100%
A0A451EJF8 Leishmania donovani 56% 93%
A0A451EJF9 Leishmania donovani 53% 83%
A4H3B4 Leishmania braziliensis 79% 88%
A4H3B5 Leishmania braziliensis 94% 100%
A4H3B6 Leishmania braziliensis 86% 99%
A4H3B7 Leishmania braziliensis 51% 67%
A4H3B8 Leishmania braziliensis 62% 86%
A4H3B9 Leishmania braziliensis 40% 80%
A4H4W8 Leishmania braziliensis 40% 88%
A4HJ20 Leishmania braziliensis 86% 88%
A4HNK3 Leishmania braziliensis 42% 100%
A4HNK6 Leishmania braziliensis 40% 90%
A4HRL9 Leishmania infantum 65% 88%
A4HRM0 Leishmania infantum 64% 97%
A4HRM1 Leishmania infantum 55% 100%
A4HRS1 Leishmania infantum 53% 83%
A4HRS3 Leishmania infantum 39% 72%
A4HRS5 Leishmania infantum 56% 93%
A4HZM0 Leishmania infantum 40% 88%
A4I7C7 Leishmania infantum 41% 88%
A4IAQ2 Leishmania infantum 40% 88%
E9AC91 Leishmania major 64% 100%
E9AC92 Leishmania major 63% 100%
E9AC95 Leishmania major 54% 100%
E9AC96 Leishmania major 55% 100%
E9AC98 Leishmania major 38% 72%
E9AEH8 Leishmania major 41% 100%
E9AHA6 Leishmania infantum 39% 88%
E9AIP8 Leishmania braziliensis 40% 100%
E9AJI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 88%
E9AJI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 90%
E9AJI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 93%
E9AJI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 72%
E9ALD6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 97%
E9ASB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 88%
E9AXX8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 88%
E9B2C0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 88%
Q4Q5T6 Leishmania major 41% 100%
Q4QCL8 Leishmania major 42% 100%
Q4QFJ3 Leishmania major 40% 70%
Q4QIG9 Leishmania major 42% 100%
Q7YXU9 Leishmania major 42% 100%
Q7YXV1 Leishmania major 42% 100%
Q7YXV2 Leishmania major 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS