RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania braziliensis

UniProt:

A4H3A8_LEIBR

TriTrypDb:

LbrM.02.0150 , LBRM2903_020006400

Length:

892

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3A8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016740	transferase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.551
CLV_C14_Caspase3-7	309	313	PF00656	0.404
CLV_C14_Caspase3-7	369	373	PF00656	0.748
CLV_NRD_NRD_1	304	306	PF00675	0.667
CLV_NRD_NRD_1	440	442	PF00675	0.567
CLV_NRD_NRD_1	569	571	PF00675	0.641
CLV_NRD_NRD_1	788	790	PF00675	0.677
CLV_PCSK_KEX2_1	788	790	PF00082	0.578
CLV_PCSK_SKI1_1	344	348	PF00082	0.532
CLV_PCSK_SKI1_1	523	527	PF00082	0.655
CLV_PCSK_SKI1_1	535	539	PF00082	0.500
CLV_PCSK_SKI1_1	61	65	PF00082	0.249
CLV_PCSK_SKI1_1	634	638	PF00082	0.547
CLV_PCSK_SKI1_1	756	760	PF00082	0.607
CLV_PCSK_SKI1_1	847	851	PF00082	0.430
CLV_PCSK_SKI1_1	885	889	PF00082	0.249
DEG_APCC_DBOX_1	45	53	PF00400	0.580
DEG_COP1_1	605	613	PF00400	0.522
DEG_Kelch_Keap1_1	720	725	PF01344	0.578
DEG_Nend_UBRbox_2	1	3	PF02207	0.537
DEG_SCF_FBXO31_1	886	892	PF12014	0.399
DEG_SPOP_SBC_1	137	141	PF00917	0.491
DEG_SPOP_SBC_1	688	692	PF00917	0.536
DOC_ANK_TNKS_1	215	222	PF00023	0.562
DOC_ANK_TNKS_1	3	10	PF00023	0.528
DOC_CKS1_1	105	110	PF01111	0.443
DOC_CKS1_1	282	287	PF01111	0.524
DOC_CKS1_1	356	361	PF01111	0.476
DOC_CKS1_1	806	811	PF01111	0.719
DOC_CYCLIN_yCln2_LP_2	298	304	PF00134	0.702
DOC_MAPK_gen_1	424	431	PF00069	0.549
DOC_MAPK_gen_1	557	566	PF00069	0.600
DOC_MAPK_gen_1	570	577	PF00069	0.656
DOC_MAPK_MEF2A_6	424	431	PF00069	0.474
DOC_MAPK_MEF2A_6	885	892	PF00069	0.405
DOC_PP2B_LxvP_1	298	301	PF13499	0.549
DOC_PP2B_LxvP_1	483	486	PF13499	0.615
DOC_PP2B_LxvP_1	575	578	PF13499	0.683
DOC_PP4_FxxP_1	215	218	PF00568	0.564
DOC_PP4_FxxP_1	806	809	PF00568	0.768
DOC_PP4_FxxP_1	875	878	PF00568	0.430
DOC_USP7_MATH_1	137	141	PF00917	0.408
DOC_USP7_MATH_1	155	159	PF00917	0.605
DOC_USP7_MATH_1	401	405	PF00917	0.689
DOC_USP7_MATH_1	417	421	PF00917	0.475
DOC_USP7_MATH_1	491	495	PF00917	0.634
DOC_USP7_MATH_1	527	531	PF00917	0.730
DOC_USP7_MATH_1	648	652	PF00917	0.546
DOC_USP7_MATH_1	654	658	PF00917	0.504
DOC_USP7_MATH_1	701	705	PF00917	0.774
DOC_USP7_MATH_1	740	744	PF00917	0.559
DOC_USP7_MATH_1	774	778	PF00917	0.680
DOC_USP7_MATH_1	782	786	PF00917	0.608
DOC_USP7_MATH_1	802	806	PF00917	0.710
DOC_USP7_MATH_1	828	832	PF00917	0.725
DOC_WW_Pin1_4	104	109	PF00397	0.364
DOC_WW_Pin1_4	247	252	PF00397	0.616
DOC_WW_Pin1_4	278	283	PF00397	0.532
DOC_WW_Pin1_4	355	360	PF00397	0.489
DOC_WW_Pin1_4	587	592	PF00397	0.779
DOC_WW_Pin1_4	637	642	PF00397	0.627
DOC_WW_Pin1_4	699	704	PF00397	0.732
DOC_WW_Pin1_4	724	729	PF00397	0.408
DOC_WW_Pin1_4	770	775	PF00397	0.785
DOC_WW_Pin1_4	805	810	PF00397	0.733
LIG_14-3-3_CanoR_1	125	135	PF00244	0.416
LIG_14-3-3_CanoR_1	511	521	PF00244	0.576
LIG_14-3-3_CanoR_1	535	540	PF00244	0.498
LIG_14-3-3_CanoR_1	581	591	PF00244	0.730
LIG_14-3-3_CanoR_1	830	838	PF00244	0.468
LIG_14-3-3_CanoR_1	865	874	PF00244	0.387
LIG_Actin_WH2_2	45	63	PF00022	0.249
LIG_Actin_WH2_2	519	537	PF00022	0.477
LIG_Actin_WH2_2	740	758	PF00022	0.538
LIG_APCC_ABBA_1	564	569	PF00400	0.556
LIG_APCC_ABBA_1	678	683	PF00400	0.426
LIG_BRCT_BRCA1_1	291	295	PF00533	0.702
LIG_BRCT_BRCA1_1	505	509	PF00533	0.748
LIG_EH1_1	340	348	PF00400	0.515
LIG_FHA_1	139	145	PF00498	0.573
LIG_FHA_1	168	174	PF00498	0.557
LIG_FHA_1	356	362	PF00498	0.468
LIG_FHA_1	464	470	PF00498	0.581
LIG_FHA_1	618	624	PF00498	0.704
LIG_FHA_1	673	679	PF00498	0.499
LIG_FHA_1	721	727	PF00498	0.559
LIG_FHA_1	9	15	PF00498	0.525
LIG_FHA_1	93	99	PF00498	0.409
LIG_FHA_2	645	651	PF00498	0.677
LIG_GBD_Chelix_1	97	105	PF00786	0.249
LIG_IRF3_LxIS_1	181	187	PF10401	0.551
LIG_LIR_Apic_2	354	359	PF02991	0.560
LIG_LIR_Apic_2	444	448	PF02991	0.529
LIG_LIR_Apic_2	487	493	PF02991	0.668
LIG_LIR_Apic_2	805	809	PF02991	0.787
LIG_LIR_Apic_2	872	878	PF02991	0.430
LIG_LIR_Gen_1	35	44	PF02991	0.436
LIG_LIR_Gen_1	459	469	PF02991	0.524
LIG_LIR_Gen_1	743	751	PF02991	0.525
LIG_LIR_Nem_3	279	283	PF02991	0.511
LIG_LIR_Nem_3	292	298	PF02991	0.735
LIG_LIR_Nem_3	330	335	PF02991	0.476
LIG_LIR_Nem_3	35	41	PF02991	0.431
LIG_LIR_Nem_3	354	360	PF02991	0.621
LIG_LIR_Nem_3	363	368	PF02991	0.472
LIG_LIR_Nem_3	419	425	PF02991	0.547
LIG_LIR_Nem_3	459	465	PF02991	0.504
LIG_LIR_Nem_3	743	748	PF02991	0.489
LIG_LIR_Nem_3	765	769	PF02991	0.676
LIG_MYND_1	728	732	PF01753	0.450
LIG_PCNA_TLS_4	885	892	PF02747	0.405
LIG_PDZ_Class_2	887	892	PF00595	0.577
LIG_SH2_CRK	357	361	PF00017	0.471
LIG_SH2_CRK	365	369	PF00017	0.543
LIG_SH2_CRK	38	42	PF00017	0.441
LIG_SH2_CRK	462	466	PF00017	0.483
LIG_SH2_CRK	490	494	PF00017	0.675
LIG_SH2_CRK	662	666	PF00017	0.563
LIG_SH2_CRK	745	749	PF00017	0.533
LIG_SH2_CRK	766	770	PF00017	0.445
LIG_SH2_NCK_1	365	369	PF00017	0.416
LIG_SH2_NCK_1	38	42	PF00017	0.489
LIG_SH2_NCK_1	662	666	PF00017	0.634
LIG_SH2_PTP2	445	448	PF00017	0.516
LIG_SH2_PTP2	563	566	PF00017	0.523
LIG_SH2_SRC	308	311	PF00017	0.652
LIG_SH2_SRC	365	368	PF00017	0.464
LIG_SH2_SRC	445	448	PF00017	0.516
LIG_SH2_SRC	563	566	PF00017	0.487
LIG_SH2_STAP1	583	587	PF00017	0.739
LIG_SH2_STAP1	745	749	PF00017	0.517
LIG_SH2_STAT3	838	841	PF00017	0.430
LIG_SH2_STAT5	100	103	PF00017	0.416
LIG_SH2_STAT5	334	337	PF00017	0.503
LIG_SH2_STAT5	349	352	PF00017	0.398
LIG_SH2_STAT5	357	360	PF00017	0.510
LIG_SH2_STAT5	38	41	PF00017	0.436
LIG_SH2_STAT5	422	425	PF00017	0.604
LIG_SH2_STAT5	445	448	PF00017	0.516
LIG_SH2_STAT5	468	471	PF00017	0.510
LIG_SH2_STAT5	553	556	PF00017	0.623
LIG_SH2_STAT5	563	566	PF00017	0.469
LIG_SH2_STAT5	59	62	PF00017	0.381
LIG_SH2_STAT5	669	672	PF00017	0.484
LIG_SH2_STAT5	838	841	PF00017	0.421
LIG_SH3_1	490	496	PF00018	0.678
LIG_SH3_1	794	800	PF00018	0.685
LIG_SH3_2	301	306	PF14604	0.671
LIG_SH3_3	22	28	PF00018	0.505
LIG_SH3_3	221	227	PF00018	0.641
LIG_SH3_3	279	285	PF00018	0.746
LIG_SH3_3	298	304	PF00018	0.754
LIG_SH3_3	361	367	PF00018	0.592
LIG_SH3_3	490	496	PF00018	0.678
LIG_SH3_3	674	680	PF00018	0.562
LIG_SH3_3	697	703	PF00018	0.678
LIG_SH3_3	794	800	PF00018	0.783
LIG_SUMO_SIM_par_1	358	363	PF11976	0.448
LIG_SUMO_SIM_par_1	481	488	PF11976	0.612
LIG_SxIP_EBH_1	166	180	PF03271	0.548
LIG_TRAF2_1	773	776	PF00917	0.729
LIG_TYR_ITIM	355	360	PF00017	0.489
LIG_TYR_ITIM	36	41	PF00017	0.481
LIG_TYR_ITIM	561	566	PF00017	0.520
LIG_WRC_WIRS_1	759	764	PF05994	0.554
LIG_WRC_WIRS_1	803	808	PF05994	0.600
LIG_WW_3	664	668	PF00397	0.493
MOD_CDC14_SPxK_1	640	643	PF00782	0.686
MOD_CDK_SPxK_1	637	643	PF00069	0.644
MOD_CK1_1	104	110	PF00069	0.400
MOD_CK1_1	197	203	PF00069	0.719
MOD_CK1_1	250	256	PF00069	0.612
MOD_CK1_1	290	296	PF00069	0.766
MOD_CK1_1	503	509	PF00069	0.771
MOD_CK1_1	702	708	PF00069	0.725
MOD_CK1_1	734	740	PF00069	0.574
MOD_CK1_1	805	811	PF00069	0.771
MOD_CK1_1	821	827	PF00069	0.618
MOD_CK2_1	644	650	PF00069	0.725
MOD_CK2_1	770	776	PF00069	0.612
MOD_GlcNHglycan	170	173	PF01048	0.684
MOD_GlcNHglycan	174	177	PF01048	0.676
MOD_GlcNHglycan	210	213	PF01048	0.829
MOD_GlcNHglycan	236	239	PF01048	0.677
MOD_GlcNHglycan	272	275	PF01048	0.753
MOD_GlcNHglycan	295	298	PF01048	0.748
MOD_GlcNHglycan	368	371	PF01048	0.725
MOD_GlcNHglycan	372	375	PF01048	0.738
MOD_GlcNHglycan	378	381	PF01048	0.690
MOD_GlcNHglycan	394	397	PF01048	0.732
MOD_GlcNHglycan	399	402	PF01048	0.694
MOD_GlcNHglycan	403	406	PF01048	0.565
MOD_GlcNHglycan	449	452	PF01048	0.544
MOD_GlcNHglycan	503	506	PF01048	0.771
MOD_GlcNHglycan	529	532	PF01048	0.656
MOD_GlcNHglycan	56	59	PF01048	0.457
MOD_GlcNHglycan	604	607	PF01048	0.779
MOD_GlcNHglycan	650	653	PF01048	0.545
MOD_GlcNHglycan	738	741	PF01048	0.664
MOD_GlcNHglycan	819	823	PF01048	0.734
MOD_GlcNHglycan	825	828	PF01048	0.697
MOD_GlcNHglycan	831	834	PF01048	0.653
MOD_GSK3_1	126	133	PF00069	0.454
MOD_GSK3_1	168	175	PF00069	0.574
MOD_GSK3_1	234	241	PF00069	0.842
MOD_GSK3_1	287	294	PF00069	0.729
MOD_GSK3_1	32	39	PF00069	0.451
MOD_GSK3_1	347	354	PF00069	0.569
MOD_GSK3_1	366	373	PF00069	0.408
MOD_GSK3_1	374	381	PF00069	0.774
MOD_GSK3_1	397	404	PF00069	0.684
MOD_GSK3_1	44	51	PF00069	0.536
MOD_GSK3_1	496	503	PF00069	0.728
MOD_GSK3_1	583	590	PF00069	0.678
MOD_GSK3_1	591	598	PF00069	0.668
MOD_GSK3_1	644	651	PF00069	0.535
MOD_GSK3_1	699	706	PF00069	0.768
MOD_GSK3_1	720	727	PF00069	0.402
MOD_GSK3_1	734	741	PF00069	0.606
MOD_GSK3_1	758	765	PF00069	0.543
MOD_GSK3_1	77	84	PF00069	0.339
MOD_GSK3_1	770	777	PF00069	0.690
MOD_GSK3_1	783	790	PF00069	0.531
MOD_GSK3_1	88	95	PF00069	0.333
MOD_LATS_1	533	539	PF00433	0.513
MOD_N-GLC_1	268	273	PF02516	0.556
MOD_N-GLC_1	290	295	PF02516	0.542
MOD_N-GLC_1	32	37	PF02516	0.513
MOD_N-GLC_1	401	406	PF02516	0.543
MOD_N-GLC_1	44	49	PF02516	0.587
MOD_N-GLC_1	496	501	PF02516	0.642
MOD_N-GLC_1	527	532	PF02516	0.475
MOD_N-GLC_1	77	82	PF02516	0.249
MOD_NEK2_1	101	106	PF00069	0.416
MOD_NEK2_1	268	273	PF00069	0.697
MOD_NEK2_1	289	294	PF00069	0.789
MOD_NEK2_1	36	41	PF00069	0.424
MOD_NEK2_1	397	402	PF00069	0.512
MOD_NEK2_1	410	415	PF00069	0.461
MOD_NEK2_1	437	442	PF00069	0.540
MOD_NEK2_1	501	506	PF00069	0.768
MOD_NEK2_1	687	692	PF00069	0.647
MOD_NEK2_1	707	712	PF00069	0.535
MOD_NEK2_1	762	767	PF00069	0.528
MOD_NEK2_1	88	93	PF00069	0.416
MOD_NEK2_2	351	356	PF00069	0.648
MOD_NEK2_2	417	422	PF00069	0.465
MOD_NEK2_2	59	64	PF00069	0.419
MOD_NEK2_2	740	745	PF00069	0.575
MOD_PIKK_1	194	200	PF00454	0.623
MOD_PIKK_1	226	232	PF00454	0.746
MOD_PIKK_1	403	409	PF00454	0.674
MOD_PIKK_1	496	502	PF00454	0.746
MOD_PIKK_1	731	737	PF00454	0.605
MOD_PKA_2	208	214	PF00069	0.755
MOD_PKA_2	351	357	PF00069	0.607
MOD_PKA_2	410	416	PF00069	0.648
MOD_PKA_2	720	726	PF00069	0.652
MOD_PKA_2	787	793	PF00069	0.569
MOD_PKA_2	829	835	PF00069	0.642
MOD_Plk_1	290	296	PF00069	0.774
MOD_Plk_1	32	38	PF00069	0.510
MOD_Plk_1	374	380	PF00069	0.601
MOD_Plk_1	496	502	PF00069	0.674
MOD_Plk_2-3	8	14	PF00069	0.556
MOD_Plk_4	130	136	PF00069	0.346
MOD_Plk_4	242	248	PF00069	0.600
MOD_Plk_4	250	256	PF00069	0.580
MOD_Plk_4	32	38	PF00069	0.460
MOD_Plk_4	351	357	PF00069	0.649
MOD_Plk_4	405	411	PF00069	0.555
MOD_Plk_4	417	423	PF00069	0.672
MOD_Plk_4	485	491	PF00069	0.478
MOD_Plk_4	517	523	PF00069	0.567
MOD_Plk_4	535	541	PF00069	0.527
MOD_Plk_4	740	746	PF00069	0.489
MOD_Plk_4	802	808	PF00069	0.594
MOD_Plk_4	93	99	PF00069	0.401
MOD_ProDKin_1	104	110	PF00069	0.364
MOD_ProDKin_1	247	253	PF00069	0.615
MOD_ProDKin_1	278	284	PF00069	0.531
MOD_ProDKin_1	355	361	PF00069	0.483
MOD_ProDKin_1	587	593	PF00069	0.774
MOD_ProDKin_1	637	643	PF00069	0.644
MOD_ProDKin_1	699	705	PF00069	0.723
MOD_ProDKin_1	724	730	PF00069	0.415
MOD_ProDKin_1	770	776	PF00069	0.789
MOD_ProDKin_1	805	811	PF00069	0.732
MOD_SUMO_rev_2	187	197	PF00179	0.681
MOD_SUMO_rev_2	568	573	PF00179	0.657
TRG_DiLeu_BaLyEn_6	479	484	PF01217	0.565
TRG_ENDOCYTIC_2	357	360	PF00928	0.477
TRG_ENDOCYTIC_2	365	368	PF00928	0.530
TRG_ENDOCYTIC_2	38	41	PF00928	0.436
TRG_ENDOCYTIC_2	462	465	PF00928	0.490
TRG_ENDOCYTIC_2	563	566	PF00928	0.523
TRG_ENDOCYTIC_2	745	748	PF00928	0.471
TRG_ENDOCYTIC_2	766	769	PF00928	0.425
TRG_ER_diArg_1	302	305	PF00400	0.698
TRG_NES_CRM1_1	463	478	PF08389	0.520
TRG_Pf-PMV_PEXEL_1	847	851	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB49	Leptomonas seymouri	53%	100%
A0A3R7M1K8	Trypanosoma rangeli	26%	100%
A0A3S7WNL7	Leishmania donovani	67%	100%
A4HRL7	Leishmania infantum	71%	100%
E9AC88	Leishmania major	66%	99%
E9AJI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%