C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3A7_LEIBR

TriTrypDb:

LbrM.02.0140 , LBRM2903_020006300

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	5
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005686	U2 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	5
GO:0071004	U2-type prespliceosome	5	1
GO:0071010	prespliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	5
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	5

Expansion

Sequence features

A4H3A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3A7

Function

Biological processes
Term	Name	Level	Count
GO:0000245	spliceosomal complex assembly	7	1
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006396	RNA processing	6	4
GO:0006397	mRNA processing	7	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0008380	RNA splicing	7	4
GO:0016070	RNA metabolic process	5	4
GO:0016071	mRNA metabolic process	6	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0046483	heterocycle metabolic process	3	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0005488	binding	1	5
GO:0008270	zinc ion binding	6	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0046914	transition metal ion binding	5	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.377
CLV_NRD_NRD_1	62	64	PF00675	0.511
CLV_NRD_NRD_1	87	89	PF00675	0.477
CLV_PCSK_KEX2_1	25	27	PF00082	0.415
CLV_PCSK_KEX2_1	62	64	PF00082	0.516
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.404
CLV_PCSK_SKI1_1	204	208	PF00082	0.337
DEG_SPOP_SBC_1	102	106	PF00917	0.587
DOC_CKS1_1	122	127	PF01111	0.377
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.344
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.313
DOC_MAPK_gen_1	139	148	PF00069	0.377
DOC_MAPK_gen_1	226	233	PF00069	0.209
DOC_MAPK_gen_1	62	73	PF00069	0.607
DOC_MAPK_gen_1	86	96	PF00069	0.532
DOC_MAPK_HePTP_8	136	148	PF00069	0.377
DOC_MAPK_MEF2A_6	139	148	PF00069	0.377
DOC_PP4_FxxP_1	122	125	PF00568	0.285
DOC_USP7_MATH_1	102	106	PF00917	0.565
DOC_USP7_MATH_1	108	112	PF00917	0.665
DOC_USP7_UBL2_3	193	197	PF12436	0.320
DOC_WW_Pin1_4	1	6	PF00397	0.689
DOC_WW_Pin1_4	121	126	PF00397	0.377
LIG_14-3-3_CanoR_1	160	169	PF00244	0.265
LIG_BIR_II_1	1	5	PF00653	0.466
LIG_BRCT_BRCA1_1	229	233	PF00533	0.226
LIG_CaM_IQ_9	55	71	PF13499	0.520
LIG_deltaCOP1_diTrp_1	216	222	PF00928	0.337
LIG_eIF4E_1	176	182	PF01652	0.377
LIG_FHA_1	104	110	PF00498	0.694
LIG_FHA_1	153	159	PF00498	0.368
LIG_FHA_1	187	193	PF00498	0.295
LIG_FHA_1	31	37	PF00498	0.385
LIG_FHA_1	53	59	PF00498	0.442
LIG_FHA_1	6	12	PF00498	0.468
LIG_FHA_2	129	135	PF00498	0.261
LIG_FHA_2	147	153	PF00498	0.337
LIG_FHA_2	79	85	PF00498	0.599
LIG_IBAR_NPY_1	21	23	PF08397	0.494
LIG_LIR_Gen_1	140	151	PF02991	0.266
LIG_LIR_Gen_1	174	183	PF02991	0.267
LIG_LIR_Gen_1	185	195	PF02991	0.249
LIG_LIR_Nem_3	140	146	PF02991	0.266
LIG_LIR_Nem_3	174	180	PF02991	0.267
LIG_LIR_Nem_3	185	190	PF02991	0.249
LIG_LIR_Nem_3	221	225	PF02991	0.263
LIG_LIR_Nem_3	230	235	PF02991	0.285
LIG_MLH1_MIPbox_1	229	233	PF16413	0.226
LIG_PTB_Apo_2	18	25	PF02174	0.494
LIG_Rb_LxCxE_1	35	57	PF01857	0.475
LIG_SH2_CRK	187	191	PF00017	0.320
LIG_SH2_NCK_1	12	16	PF00017	0.534
LIG_SH2_NCK_1	187	191	PF00017	0.320
LIG_SH2_SRC	12	15	PF00017	0.541
LIG_SH2_STAP1	187	191	PF00017	0.377
LIG_SH2_STAP1	229	233	PF00017	0.292
LIG_SH2_STAT5	176	179	PF00017	0.294
LIG_SH2_STAT5	23	26	PF00017	0.487
LIG_SH2_STAT5	40	43	PF00017	0.497
LIG_SH3_3	166	172	PF00018	0.320
LIG_SH3_5	172	176	PF00018	0.337
LIG_SUMO_SIM_par_1	90	97	PF11976	0.537
LIG_WRC_WIRS_1	126	131	PF05994	0.320
MOD_CK1_1	110	116	PF00069	0.665
MOD_CK1_1	128	134	PF00069	0.357
MOD_CK1_1	4	10	PF00069	0.517
MOD_CK2_1	146	152	PF00069	0.363
MOD_CK2_1	160	166	PF00069	0.184
MOD_CK2_1	210	216	PF00069	0.307
MOD_CK2_1	78	84	PF00069	0.600
MOD_CMANNOS	219	222	PF00535	0.337
MOD_GlcNHglycan	110	113	PF01048	0.644
MOD_GlcNHglycan	162	165	PF01048	0.285
MOD_GlcNHglycan	96	99	PF01048	0.582
MOD_GSK3_1	1	8	PF00069	0.504
MOD_GSK3_1	103	110	PF00069	0.613
MOD_GSK3_1	121	128	PF00069	0.327
MOD_GSK3_1	207	214	PF00069	0.313
MOD_N-GLC_1	198	203	PF02516	0.337
MOD_N-GLC_1	5	10	PF02516	0.473
MOD_NEK2_1	94	99	PF00069	0.496
MOD_NEK2_2	125	130	PF00069	0.320
MOD_PIKK_1	146	152	PF00454	0.337
MOD_PIKK_1	198	204	PF00454	0.397
MOD_Plk_4	227	233	PF00069	0.364
MOD_ProDKin_1	1	7	PF00069	0.682
MOD_ProDKin_1	121	127	PF00069	0.377
TRG_DiLeu_BaEn_2	42	48	PF01217	0.461
TRG_DiLeu_BaEn_4	43	49	PF01217	0.466
TRG_ENDOCYTIC_2	12	15	PF00928	0.541
TRG_ENDOCYTIC_2	179	182	PF00928	0.270
TRG_ENDOCYTIC_2	187	190	PF00928	0.249
TRG_ENDOCYTIC_2	229	232	PF00928	0.284
TRG_Pf-PMV_PEXEL_1	69	74	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I8	Leptomonas seymouri	72%	95%
A0A0S4J697	Bodo saltans	42%	100%
A0A3S5H4Y4	Leishmania donovani	87%	99%
A4HRL6	Leishmania infantum	87%	99%
C9ZJ05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AC87	Leishmania major	86%	100%
E9AJI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q07350	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	89%
Q54B65	Dictyostelium discoideum	28%	100%
Q9P7L8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
V5AQR9	Trypanosoma cruzi	50%	96%