Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol kinase related protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H3A6_LEIBR

TriTrypDb:

LbrM.02.0130 , LBRM2903_020006200

Length:

4924

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	6
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

A4H3A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	7
GO:0000077	DNA damage checkpoint signaling	5	7
GO:0000723	telomere maintenance	5	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006468	protein phosphorylation	5	1
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0004674	protein serine/threonine kinase activity	4	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1072	1076	PF00656	0.424
CLV_C14_Caspase3-7	1096	1100	PF00656	0.323
CLV_C14_Caspase3-7	1262	1266	PF00656	0.571
CLV_C14_Caspase3-7	1281	1285	PF00656	0.443
CLV_C14_Caspase3-7	1301	1305	PF00656	0.577
CLV_C14_Caspase3-7	1680	1684	PF00656	0.469
CLV_C14_Caspase3-7	2240	2244	PF00656	0.329
CLV_C14_Caspase3-7	2757	2761	PF00656	0.411
CLV_C14_Caspase3-7	3032	3036	PF00656	0.239
CLV_C14_Caspase3-7	3144	3148	PF00656	0.310

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAI1	Leptomonas seymouri	44%	100%
A0A451EJF0	Leishmania donovani	72%	100%
A4HRL5	Leishmania infantum	72%	100%
E9AC86	Leishmania major	72%	99%
E9AJH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%

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