Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3A4_LEIBR

TriTrypDb:

LbrM.02.0100 , LBRM2903_020005600

Length:

818

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3A4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3A4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.719
CLV_C14_Caspase3-7	233	237	PF00656	0.361
CLV_NRD_NRD_1	277	279	PF00675	0.489
CLV_NRD_NRD_1	487	489	PF00675	0.372
CLV_NRD_NRD_1	568	570	PF00675	0.589
CLV_NRD_NRD_1	716	718	PF00675	0.537
CLV_PCSK_FUR_1	714	718	PF00082	0.559
CLV_PCSK_KEX2_1	277	279	PF00082	0.489
CLV_PCSK_KEX2_1	487	489	PF00082	0.372
CLV_PCSK_KEX2_1	568	570	PF00082	0.712
CLV_PCSK_KEX2_1	716	718	PF00082	0.563
CLV_PCSK_SKI1_1	155	159	PF00082	0.465
CLV_PCSK_SKI1_1	248	252	PF00082	0.468
CLV_PCSK_SKI1_1	264	268	PF00082	0.522
CLV_PCSK_SKI1_1	309	313	PF00082	0.589
CLV_PCSK_SKI1_1	414	418	PF00082	0.442
CLV_PCSK_SKI1_1	419	423	PF00082	0.452
CLV_PCSK_SKI1_1	43	47	PF00082	0.582
CLV_PCSK_SKI1_1	51	55	PF00082	0.487
CLV_PCSK_SKI1_1	568	572	PF00082	0.614
DEG_APCC_DBOX_1	247	255	PF00400	0.464
DEG_COP1_1	770	780	PF00400	0.564
DEG_Nend_Nbox_1	1	3	PF02207	0.487
DEG_SCF_FBW7_2	654	660	PF00400	0.686
DEG_SPOP_SBC_1	28	32	PF00917	0.503
DEG_SPOP_SBC_1	381	385	PF00917	0.360
DEG_SPOP_SBC_1	504	508	PF00917	0.406
DEG_SPOP_SBC_1	633	637	PF00917	0.674
DOC_CKS1_1	337	342	PF01111	0.604
DOC_CKS1_1	441	446	PF01111	0.543
DOC_CKS1_1	654	659	PF01111	0.684
DOC_CYCLIN_RxL_1	40	50	PF00134	0.520
DOC_CYCLIN_yCln2_LP_2	441	447	PF00134	0.534
DOC_MAPK_gen_1	198	206	PF00069	0.405
DOC_MAPK_MEF2A_6	51	60	PF00069	0.394
DOC_MAPK_RevD_3	474	488	PF00069	0.330
DOC_PP1_RVXF_1	41	47	PF00149	0.414
DOC_PP1_RVXF_1	461	468	PF00149	0.402
DOC_PP2B_LxvP_1	45	48	PF13499	0.390
DOC_USP7_MATH_1	164	168	PF00917	0.705
DOC_USP7_MATH_1	179	183	PF00917	0.564
DOC_USP7_MATH_1	186	190	PF00917	0.682
DOC_USP7_MATH_1	28	32	PF00917	0.595
DOC_USP7_MATH_1	304	308	PF00917	0.324
DOC_USP7_MATH_1	381	385	PF00917	0.401
DOC_USP7_MATH_1	505	509	PF00917	0.605
DOC_USP7_MATH_1	530	534	PF00917	0.766
DOC_USP7_MATH_1	619	623	PF00917	0.593
DOC_USP7_MATH_1	631	635	PF00917	0.756
DOC_USP7_MATH_1	670	674	PF00917	0.684
DOC_USP7_MATH_1	739	743	PF00917	0.566
DOC_USP7_MATH_1	756	760	PF00917	0.645
DOC_USP7_MATH_1	778	782	PF00917	0.833
DOC_USP7_MATH_1	792	796	PF00917	0.590
DOC_USP7_MATH_1	798	802	PF00917	0.443
DOC_WW_Pin1_4	182	187	PF00397	0.651
DOC_WW_Pin1_4	336	341	PF00397	0.599
DOC_WW_Pin1_4	440	445	PF00397	0.577
DOC_WW_Pin1_4	653	658	PF00397	0.510
DOC_WW_Pin1_4	668	673	PF00397	0.668
DOC_WW_Pin1_4	787	792	PF00397	0.686
LIG_14-3-3_CanoR_1	127	133	PF00244	0.491
LIG_14-3-3_CanoR_1	155	160	PF00244	0.538
LIG_14-3-3_CanoR_1	187	193	PF00244	0.675
LIG_14-3-3_CanoR_1	277	281	PF00244	0.504
LIG_14-3-3_CanoR_1	299	304	PF00244	0.505
LIG_14-3-3_CanoR_1	309	314	PF00244	0.423
LIG_14-3-3_CanoR_1	348	353	PF00244	0.495
LIG_14-3-3_CanoR_1	419	424	PF00244	0.555
LIG_14-3-3_CanoR_1	463	468	PF00244	0.678
LIG_14-3-3_CanoR_1	740	744	PF00244	0.526
LIG_14-3-3_CanoR_1	745	749	PF00244	0.542
LIG_Actin_WH2_2	217	232	PF00022	0.620
LIG_Actin_WH2_2	251	266	PF00022	0.322
LIG_Actin_WH2_2	471	489	PF00022	0.334
LIG_BRCT_BRCA1_1	383	387	PF00533	0.599
LIG_deltaCOP1_diTrp_1	660	665	PF00928	0.550
LIG_FHA_1	132	138	PF00498	0.507
LIG_FHA_1	191	197	PF00498	0.486
LIG_FHA_1	201	207	PF00498	0.418
LIG_FHA_1	358	364	PF00498	0.357
LIG_FHA_1	374	380	PF00498	0.681
LIG_FHA_1	413	419	PF00498	0.445
LIG_FHA_1	473	479	PF00498	0.352
LIG_FHA_1	504	510	PF00498	0.380
LIG_FHA_1	587	593	PF00498	0.761
LIG_FHA_1	619	625	PF00498	0.513
LIG_FHA_1	678	684	PF00498	0.664
LIG_FHA_1	716	722	PF00498	0.528
LIG_FHA_1	97	103	PF00498	0.549
LIG_FHA_2	112	118	PF00498	0.550
LIG_FHA_2	3	9	PF00498	0.702
LIG_FHA_2	537	543	PF00498	0.579
LIG_FHA_2	609	615	PF00498	0.765
LIG_GBD_Chelix_1	223	231	PF00786	0.506
LIG_LIR_Apic_2	545	550	PF02991	0.641
LIG_LIR_Gen_1	135	146	PF02991	0.478
LIG_LIR_Gen_1	219	229	PF02991	0.476
LIG_LIR_Gen_1	265	276	PF02991	0.602
LIG_LIR_Gen_1	312	321	PF02991	0.507
LIG_LIR_Gen_1	384	395	PF02991	0.495
LIG_LIR_Gen_1	415	425	PF02991	0.552
LIG_LIR_Gen_1	596	605	PF02991	0.627
LIG_LIR_Nem_3	135	141	PF02991	0.498
LIG_LIR_Nem_3	219	224	PF02991	0.498
LIG_LIR_Nem_3	265	271	PF02991	0.609
LIG_LIR_Nem_3	312	317	PF02991	0.489
LIG_LIR_Nem_3	384	390	PF02991	0.483
LIG_LIR_Nem_3	415	420	PF02991	0.399
LIG_LIR_Nem_3	552	558	PF02991	0.577
LIG_LIR_Nem_3	596	600	PF02991	0.617
LIG_NRBOX	40	46	PF00104	0.423
LIG_PDZ_Class_2	813	818	PF00595	0.531
LIG_REV1ctd_RIR_1	414	423	PF16727	0.408
LIG_SH2_CRK	138	142	PF00017	0.710
LIG_SH2_CRK	149	153	PF00017	0.509
LIG_SH2_CRK	547	551	PF00017	0.382
LIG_SH2_NCK_1	138	142	PF00017	0.488
LIG_SH2_NCK_1	208	212	PF00017	0.400
LIG_SH2_STAP1	108	112	PF00017	0.689
LIG_SH2_STAP1	116	120	PF00017	0.540
LIG_SH2_STAP1	149	153	PF00017	0.585
LIG_SH2_STAT3	723	726	PF00017	0.604
LIG_SH2_STAT5	151	154	PF00017	0.687
LIG_SH2_STAT5	228	231	PF00017	0.485
LIG_SH2_STAT5	268	271	PF00017	0.594
LIG_SH2_STAT5	547	550	PF00017	0.635
LIG_SH2_STAT5	615	618	PF00017	0.494
LIG_SH3_3	651	657	PF00018	0.613
LIG_SH3_3	686	692	PF00018	0.637
LIG_SH3_3	785	791	PF00018	0.559
LIG_SH3_3	805	811	PF00018	0.607
LIG_TRAF2_1	326	329	PF00917	0.507
LIG_TRAF2_1	5	8	PF00917	0.698
LIG_TRAF2_1	512	515	PF00917	0.597
LIG_TRAF2_1	611	614	PF00917	0.766
LIG_TYR_ITIM	147	152	PF00017	0.689
LIG_UBA3_1	392	396	PF00899	0.631
LIG_WRC_WIRS_1	268	273	PF05994	0.329
MOD_CDK_SPK_2	182	187	PF00069	0.528
MOD_CK1_1	118	124	PF00069	0.512
MOD_CK1_1	131	137	PF00069	0.483
MOD_CK1_1	163	169	PF00069	0.524
MOD_CK1_1	173	179	PF00069	0.774
MOD_CK1_1	182	188	PF00069	0.656
MOD_CK1_1	191	197	PF00069	0.495
MOD_CK1_1	435	441	PF00069	0.454
MOD_CK1_1	466	472	PF00069	0.555
MOD_CK1_1	494	500	PF00069	0.563
MOD_CK1_1	609	615	PF00069	0.641
MOD_CK1_1	622	628	PF00069	0.577
MOD_CK1_1	634	640	PF00069	0.783
MOD_CK1_1	673	679	PF00069	0.596
MOD_CK1_1	779	785	PF00069	0.828
MOD_CK1_1	83	89	PF00069	0.643
MOD_CK2_1	111	117	PF00069	0.594
MOD_CK2_1	2	8	PF00069	0.614
MOD_CK2_1	267	273	PF00069	0.360
MOD_CK2_1	608	614	PF00069	0.762
MOD_CK2_1	679	685	PF00069	0.661
MOD_CK2_1	798	804	PF00069	0.490
MOD_GlcNHglycan	117	120	PF01048	0.678
MOD_GlcNHglycan	162	165	PF01048	0.662
MOD_GlcNHglycan	174	178	PF01048	0.654
MOD_GlcNHglycan	282	285	PF01048	0.587
MOD_GlcNHglycan	434	437	PF01048	0.464
MOD_GlcNHglycan	455	458	PF01048	0.516
MOD_GlcNHglycan	468	471	PF01048	0.604
MOD_GlcNHglycan	501	504	PF01048	0.511
MOD_GlcNHglycan	572	575	PF01048	0.628
MOD_GlcNHglycan	608	611	PF01048	0.598
MOD_GlcNHglycan	621	624	PF01048	0.568
MOD_GlcNHglycan	641	644	PF01048	0.632
MOD_GlcNHglycan	668	671	PF01048	0.670
MOD_GlcNHglycan	754	757	PF01048	0.599
MOD_GlcNHglycan	778	781	PF01048	0.837
MOD_GlcNHglycan	794	797	PF01048	0.546
MOD_GlcNHglycan	800	803	PF01048	0.625
MOD_GlcNHglycan	86	89	PF01048	0.706
MOD_GSK3_1	103	110	PF00069	0.584
MOD_GSK3_1	111	118	PF00069	0.551
MOD_GSK3_1	128	135	PF00069	0.616
MOD_GSK3_1	160	167	PF00069	0.482
MOD_GSK3_1	182	189	PF00069	0.650
MOD_GSK3_1	190	197	PF00069	0.600
MOD_GSK3_1	2	9	PF00069	0.641
MOD_GSK3_1	23	30	PF00069	0.685
MOD_GSK3_1	276	283	PF00069	0.562
MOD_GSK3_1	305	312	PF00069	0.389
MOD_GSK3_1	315	322	PF00069	0.418
MOD_GSK3_1	348	355	PF00069	0.609
MOD_GSK3_1	435	442	PF00069	0.487
MOD_GSK3_1	491	498	PF00069	0.711
MOD_GSK3_1	499	506	PF00069	0.630
MOD_GSK3_1	578	585	PF00069	0.555
MOD_GSK3_1	618	625	PF00069	0.611
MOD_GSK3_1	631	638	PF00069	0.749
MOD_GSK3_1	666	673	PF00069	0.679
MOD_GSK3_1	677	684	PF00069	0.636
MOD_GSK3_1	752	759	PF00069	0.462
MOD_GSK3_1	798	805	PF00069	0.754
MOD_GSK3_1	80	87	PF00069	0.601
MOD_N-GLC_1	28	33	PF02516	0.549
MOD_N-GLC_1	381	386	PF02516	0.407
MOD_N-GLC_1	463	468	PF02516	0.487
MOD_N-GLC_1	798	803	PF02516	0.582
MOD_NEK2_1	115	120	PF00069	0.667
MOD_NEK2_1	132	137	PF00069	0.495
MOD_NEK2_1	147	152	PF00069	0.689
MOD_NEK2_1	280	285	PF00069	0.510
MOD_NEK2_1	570	575	PF00069	0.510
MOD_NEK2_1	578	583	PF00069	0.489
MOD_NEK2_1	666	671	PF00069	0.759
MOD_NEK2_1	744	749	PF00069	0.607
MOD_NEK2_1	752	757	PF00069	0.541
MOD_NEK2_2	200	205	PF00069	0.420
MOD_NEK2_2	412	417	PF00069	0.450
MOD_NEK2_2	739	744	PF00069	0.551
MOD_NEK2_2	802	807	PF00069	0.444
MOD_PIKK_1	285	291	PF00454	0.347
MOD_PIKK_1	491	497	PF00454	0.725
MOD_PIKK_1	609	615	PF00454	0.765
MOD_PK_1	299	305	PF00069	0.300
MOD_PKA_2	160	166	PF00069	0.478
MOD_PKA_2	186	192	PF00069	0.681
MOD_PKA_2	200	206	PF00069	0.601
MOD_PKA_2	276	282	PF00069	0.505
MOD_PKA_2	639	645	PF00069	0.599
MOD_PKA_2	715	721	PF00069	0.636
MOD_PKA_2	739	745	PF00069	0.536
MOD_Plk_1	179	185	PF00069	0.543
MOD_Plk_1	412	418	PF00069	0.448
MOD_Plk_1	463	469	PF00069	0.669
MOD_Plk_2-3	111	117	PF00069	0.445
MOD_Plk_4	103	109	PF00069	0.517
MOD_Plk_4	111	117	PF00069	0.588
MOD_Plk_4	147	153	PF00069	0.538
MOD_Plk_4	264	270	PF00069	0.515
MOD_Plk_4	309	315	PF00069	0.588
MOD_Plk_4	348	354	PF00069	0.535
MOD_Plk_4	419	425	PF00069	0.487
MOD_Plk_4	505	511	PF00069	0.635
MOD_Plk_4	542	548	PF00069	0.657
MOD_Plk_4	69	75	PF00069	0.378
MOD_Plk_4	739	745	PF00069	0.546
MOD_Plk_4	802	808	PF00069	0.652
MOD_Plk_4	810	816	PF00069	0.601
MOD_Plk_4	90	96	PF00069	0.760
MOD_ProDKin_1	182	188	PF00069	0.650
MOD_ProDKin_1	336	342	PF00069	0.598
MOD_ProDKin_1	440	446	PF00069	0.568
MOD_ProDKin_1	653	659	PF00069	0.507
MOD_ProDKin_1	668	674	PF00069	0.674
MOD_ProDKin_1	787	793	PF00069	0.686
MOD_SUMO_rev_2	391	398	PF00179	0.637
TRG_DiLeu_BaEn_3	565	571	PF01217	0.713
TRG_DiLeu_BaLyEn_6	202	207	PF01217	0.415
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.432
TRG_DiLeu_BaLyEn_6	573	578	PF01217	0.464
TRG_ENDOCYTIC_2	138	141	PF00928	0.742
TRG_ENDOCYTIC_2	149	152	PF00928	0.570
TRG_ENDOCYTIC_2	228	231	PF00928	0.443
TRG_ENDOCYTIC_2	268	271	PF00928	0.594
TRG_ER_diArg_1	276	278	PF00400	0.369
TRG_ER_diArg_1	486	488	PF00400	0.356
TRG_ER_diArg_1	568	570	PF00400	0.589
TRG_ER_diArg_1	714	717	PF00400	0.561
TRG_Pf-PMV_PEXEL_1	556	561	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	750	754	PF00026	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K8	Leptomonas seymouri	36%	68%
A0A3S5H4X9	Leishmania donovani	71%	82%
A4HRL0	Leishmania infantum	71%	82%
E9AC82	Leishmania major	73%	100%
E9AJH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	82%