Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3A3_LEIBR

TriTrypDb:

LbrM.02.0090 , LBRM2903_020005500

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3A3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.607
CLV_C14_Caspase3-7	215	219	PF00656	0.628
CLV_C14_Caspase3-7	230	234	PF00656	0.626
CLV_NRD_NRD_1	270	272	PF00675	0.360
CLV_NRD_NRD_1	286	288	PF00675	0.225
CLV_PCSK_KEX2_1	24	26	PF00082	0.329
CLV_PCSK_KEX2_1	286	288	PF00082	0.473
CLV_PCSK_KEX2_1	293	295	PF00082	0.322
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.329
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.353
CLV_PCSK_SKI1_1	14	18	PF00082	0.322
CLV_PCSK_SKI1_1	202	206	PF00082	0.541
CLV_PCSK_SKI1_1	237	241	PF00082	0.513
CLV_PCSK_SKI1_1	24	28	PF00082	0.389
CLV_PCSK_SKI1_1	286	290	PF00082	0.356
CLV_PCSK_SKI1_1	297	301	PF00082	0.346
CLV_PCSK_SKI1_1	3	7	PF00082	0.511
CLV_Separin_Metazoa	277	281	PF03568	0.440
DEG_Nend_Nbox_1	1	3	PF02207	0.650
DEG_SPOP_SBC_1	224	228	PF00917	0.673
DEG_SPOP_SBC_1	89	93	PF00917	0.651
DOC_MAPK_DCC_7	217	225	PF00069	0.469
DOC_MAPK_gen_1	293	300	PF00069	0.337
DOC_MAPK_MEF2A_6	217	225	PF00069	0.469
DOC_PP1_RVXF_1	295	301	PF00149	0.472
DOC_PP2B_LxvP_1	155	158	PF13499	0.400
DOC_USP7_MATH_1	178	182	PF00917	0.515
DOC_USP7_MATH_1	251	255	PF00917	0.487
DOC_USP7_MATH_1	261	265	PF00917	0.316
DOC_USP7_MATH_1	301	305	PF00917	0.436
DOC_USP7_MATH_1	95	99	PF00917	0.659
DOC_USP7_UBL2_3	3	7	PF12436	0.621
DOC_USP7_UBL2_3	370	374	PF12436	0.621
DOC_WW_Pin1_4	249	254	PF00397	0.480
LIG_14-3-3_CanoR_1	129	136	PF00244	0.483
LIG_14-3-3_CanoR_1	202	208	PF00244	0.431
LIG_14-3-3_CanoR_1	338	346	PF00244	0.442
LIG_14-3-3_CanoR_1	364	370	PF00244	0.683
LIG_Actin_WH2_2	303	319	PF00022	0.487
LIG_Clathr_ClatBox_1	172	176	PF01394	0.392
LIG_FHA_1	114	120	PF00498	0.400
LIG_FHA_1	13	19	PF00498	0.443
LIG_FHA_1	220	226	PF00498	0.700
LIG_FHA_1	322	328	PF00498	0.456
LIG_FHA_1	352	358	PF00498	0.460
LIG_FHA_1	44	50	PF00498	0.381
LIG_FHA_2	208	214	PF00498	0.585
LIG_FHA_2	226	232	PF00498	0.656
LIG_GBD_Chelix_1	147	155	PF00786	0.342
LIG_IRF3_LxIS_1	145	150	PF10401	0.233
LIG_LIR_Apic_2	388	393	PF02991	0.650
LIG_LIR_Gen_1	111	122	PF02991	0.580
LIG_LIR_Gen_1	252	262	PF02991	0.375
LIG_LIR_Gen_1	275	283	PF02991	0.507
LIG_LIR_Nem_3	111	117	PF02991	0.622
LIG_LIR_Nem_3	134	139	PF02991	0.446
LIG_LIR_Nem_3	166	172	PF02991	0.312
LIG_LIR_Nem_3	252	258	PF02991	0.434
LIG_NRBOX	203	209	PF00104	0.539
LIG_Pex14_1	136	140	PF04695	0.492
LIG_Pex14_2	164	168	PF04695	0.435
LIG_SH2_CRK	169	173	PF00017	0.324
LIG_SH2_CRK	255	259	PF00017	0.425
LIG_SH2_CRK	270	274	PF00017	0.316
LIG_SH2_GRB2like	57	60	PF00017	0.487
LIG_SH2_NCK_1	248	252	PF00017	0.510
LIG_SH2_PTP2	144	147	PF00017	0.268
LIG_SH2_PTP2	238	241	PF00017	0.286
LIG_SH2_SRC	52	55	PF00017	0.262
LIG_SH2_STAP1	255	259	PF00017	0.363
LIG_SH2_STAT5	140	143	PF00017	0.369
LIG_SH2_STAT5	144	147	PF00017	0.329
LIG_SH2_STAT5	238	241	PF00017	0.388
LIG_SH2_STAT5	248	251	PF00017	0.487
LIG_SH2_STAT5	28	31	PF00017	0.368
LIG_SH2_STAT5	320	323	PF00017	0.519
LIG_SH2_STAT5	57	60	PF00017	0.390
LIG_SH3_3	218	224	PF00018	0.629
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.446
LIG_SUMO_SIM_par_1	171	176	PF11976	0.469
LIG_SUMO_SIM_par_1	287	292	PF11976	0.355
LIG_TRAF2_1	381	384	PF00917	0.529
LIG_TYR_ITIM	236	241	PF00017	0.403
LIG_UBA3_1	288	293	PF00899	0.415
LIG_UBA3_1	77	84	PF00899	0.547
MOD_CK1_1	98	104	PF00069	0.636
MOD_CK2_1	128	134	PF00069	0.632
MOD_CK2_1	147	153	PF00069	0.408
MOD_CK2_1	209	215	PF00069	0.614
MOD_CK2_1	377	383	PF00069	0.576
MOD_Cter_Amidation	372	375	PF01082	0.504
MOD_GlcNHglycan	103	106	PF01048	0.666
MOD_GlcNHglycan	131	134	PF01048	0.503
MOD_GlcNHglycan	180	183	PF01048	0.443
MOD_GlcNHglycan	334	337	PF01048	0.584
MOD_GSK3_1	178	185	PF00069	0.542
MOD_GSK3_1	203	210	PF00069	0.482
MOD_GSK3_1	219	226	PF00069	0.530
MOD_GSK3_1	34	41	PF00069	0.486
MOD_GSK3_1	365	372	PF00069	0.624
MOD_GSK3_1	97	104	PF00069	0.638
MOD_N-GLC_1	101	106	PF02516	0.481
MOD_NEK2_1	147	152	PF00069	0.346
MOD_NEK2_1	207	212	PF00069	0.572
MOD_NEK2_1	246	251	PF00069	0.649
MOD_NEK2_1	321	326	PF00069	0.356
MOD_NEK2_1	332	337	PF00069	0.441
MOD_NEK2_1	369	374	PF00069	0.494
MOD_NEK2_2	365	370	PF00069	0.466
MOD_NEK2_2	43	48	PF00069	0.426
MOD_PK_1	287	293	PF00069	0.360
MOD_PKA_2	128	134	PF00069	0.508
MOD_PKA_2	363	369	PF00069	0.675
MOD_PKA_2	95	101	PF00069	0.725
MOD_Plk_2-3	34	40	PF00069	0.531
MOD_Plk_2-3	378	384	PF00069	0.604
MOD_Plk_4	203	209	PF00069	0.537
MOD_Plk_4	261	267	PF00069	0.355
MOD_Plk_4	38	44	PF00069	0.608
MOD_Plk_4	385	391	PF00069	0.718
MOD_ProDKin_1	249	255	PF00069	0.463
TRG_ENDOCYTIC_2	144	147	PF00928	0.326
TRG_ENDOCYTIC_2	169	172	PF00928	0.307
TRG_ENDOCYTIC_2	238	241	PF00928	0.388
TRG_ENDOCYTIC_2	255	258	PF00928	0.424
TRG_ENDOCYTIC_2	270	273	PF00928	0.369
TRG_ENDOCYTIC_2	276	279	PF00928	0.362
TRG_ENDOCYTIC_2	57	60	PF00928	0.434
TRG_ER_diArg_1	285	287	PF00400	0.446
TRG_NES_CRM1_1	50	62	PF08389	0.438
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	287	292	PF00026	0.207
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAV1	Leptomonas seymouri	61%	95%
A0A0S4JHJ5	Bodo saltans	32%	100%
A0A1X0NJT7	Trypanosomatidae	37%	100%
A0A3S5H4X8	Leishmania donovani	83%	100%
A0A3S5IQM7	Trypanosoma rangeli	35%	98%
A4HRK9	Leishmania infantum	83%	100%
E9AC81	Leishmania major	81%	100%
E9AJH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
V5BAQ0	Trypanosoma cruzi	36%	100%