Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3A2_LEIBR

TriTrypDb:

LbrM.02.0080 , LBRM2903_020005400

Length:

194

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3A2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_Nbox_1	1	3	PF02207	0.482
DEG_SPOP_SBC_1	124	128	PF00917	0.438
DOC_CKS1_1	1	6	PF01111	0.466
DOC_MAPK_gen_1	33	43	PF00069	0.537
DOC_MAPK_MEF2A_6	36	45	PF00069	0.521
DOC_PP2B_LxvP_1	2	5	PF13499	0.461
DOC_USP7_MATH_1	117	121	PF00917	0.670
DOC_WW_Pin1_4	65	70	PF00397	0.679
LIG_14-3-3_CanoR_1	157	162	PF00244	0.447
LIG_14-3-3_CanoR_1	36	40	PF00244	0.730
LIG_14-3-3_CanoR_1	94	103	PF00244	0.679
LIG_CtBP_PxDLS_1	40	44	PF00389	0.447
LIG_FHA_1	10	16	PF00498	0.616
LIG_FHA_1	144	150	PF00498	0.609
LIG_FHA_1	182	188	PF00498	0.397
LIG_FHA_1	77	83	PF00498	0.605
LIG_GBD_Chelix_1	133	141	PF00786	0.553
LIG_LIR_Gen_1	183	189	PF02991	0.493
LIG_LIR_Gen_1	47	56	PF02991	0.614
LIG_LIR_Nem_3	173	179	PF02991	0.630
LIG_LIR_Nem_3	183	188	PF02991	0.608
LIG_LIR_Nem_3	47	53	PF02991	0.625
LIG_LIR_Nem_3	58	63	PF02991	0.586
LIG_Pex14_2	170	174	PF04695	0.592
LIG_Pex14_2	56	60	PF04695	0.632
LIG_SH2_GRB2like	148	151	PF00017	0.655
LIG_SH2_STAT5	148	151	PF00017	0.524
LIG_SH3_3	12	18	PF00018	0.660
LIG_SH3_3	2	8	PF00018	0.685
MOD_CK1_1	120	126	PF00069	0.596
MOD_CK1_1	68	74	PF00069	0.490
MOD_CK1_1	96	102	PF00069	0.692
MOD_GlcNHglycan	112	116	PF01048	0.498
MOD_GlcNHglycan	122	125	PF01048	0.468
MOD_GlcNHglycan	167	170	PF01048	0.646
MOD_GlcNHglycan	37	40	PF01048	0.670
MOD_GSK3_1	116	123	PF00069	0.670
MOD_GSK3_1	157	164	PF00069	0.565
MOD_GSK3_1	63	70	PF00069	0.551
MOD_GSK3_1	93	100	PF00069	0.676
MOD_N-GLC_1	117	122	PF02516	0.683
MOD_NEK2_1	125	130	PF00069	0.528
MOD_NEK2_1	170	175	PF00069	0.533
MOD_OFUCOSY	73	80	PF10250	0.450
MOD_PIKK_1	127	133	PF00454	0.588
MOD_PIKK_1	140	146	PF00454	0.697
MOD_PIKK_1	68	74	PF00454	0.452
MOD_PKA_2	181	187	PF00069	0.394
MOD_PKA_2	35	41	PF00069	0.721
MOD_PKA_2	93	99	PF00069	0.674
MOD_Plk_1	117	123	PF00069	0.648
MOD_Plk_1	170	176	PF00069	0.540
MOD_Plk_4	143	149	PF00069	0.621
MOD_Plk_4	157	163	PF00069	0.689
MOD_Plk_4	97	103	PF00069	0.504
MOD_ProDKin_1	65	71	PF00069	0.680
TRG_DiLeu_BaEn_1	183	188	PF01217	0.555
TRG_NES_CRM1_1	42	52	PF08389	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ46	Leptomonas seymouri	57%	99%
A0A1X0NKM1	Trypanosomatidae	36%	93%
A0A422N6X4	Trypanosoma rangeli	28%	100%
A0A451EJE3	Leishmania donovani	79%	100%
A4HRK8	Leishmania infantum	79%	100%
C9ZIZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AC80	Leishmania major	78%	100%
E9AJH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	91%
V5BFA7	Trypanosoma cruzi	32%	100%