Putative cytochrome b-domain protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b-domain protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H3A1_LEIBR

TriTrypDb:

LbrM.02.0070 , LBRM2903_020005300

Length:

218

Annotations

LeishMANIAdb annotations

This cluster contains a high variety of cytochrome b5 homologs. Although all membrane-anchored, some use the N-terminal [type-III] while others the C-terminal TM helix [type-IV]. The heme domain is assumed to be cytoplasmic.. Localization: ER (by homology) / Mitochondrial outer membrane (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H3A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3A1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0020037	heme binding	4	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046906	tetrapyrrole binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.426
CLV_NRD_NRD_1	82	84	PF00675	0.363
CLV_PCSK_KEX2_1	82	84	PF00082	0.365
CLV_PCSK_SKI1_1	122	126	PF00082	0.301
CLV_PCSK_SKI1_1	163	167	PF00082	0.465
CLV_PCSK_SKI1_1	63	67	PF00082	0.268
DEG_APCC_KENBOX_2	15	19	PF00400	0.418
DOC_MAPK_gen_1	66	74	PF00069	0.500
DOC_MAPK_gen_1	82	88	PF00069	0.574
DOC_MAPK_MEF2A_6	201	210	PF00069	0.403
DOC_USP7_MATH_1	93	97	PF00917	0.560
DOC_WW_Pin1_4	140	145	PF00397	0.418
LIG_14-3-3_CanoR_1	175	185	PF00244	0.757
LIG_14-3-3_CanoR_1	83	89	PF00244	0.619
LIG_FHA_1	110	116	PF00498	0.525
LIG_FHA_1	150	156	PF00498	0.418
LIG_FHA_1	178	184	PF00498	0.770
LIG_FHA_2	4	10	PF00498	0.439
LIG_LIR_Gen_1	112	119	PF02991	0.501
LIG_LIR_Gen_1	17	28	PF02991	0.561
LIG_LIR_Nem_3	112	117	PF02991	0.521
LIG_LIR_Nem_3	17	23	PF02991	0.493
LIG_LIR_Nem_3	53	59	PF02991	0.501
LIG_PTB_Apo_2	103	110	PF02174	0.501
LIG_PTB_Apo_2	22	29	PF02174	0.560
LIG_PTB_Phospho_1	103	109	PF10480	0.501
LIG_PTB_Phospho_1	22	28	PF10480	0.560
LIG_SH2_PTP2	85	88	PF00017	0.560
LIG_SH2_SRC	153	156	PF00017	0.445
LIG_SH2_SRC	34	37	PF00017	0.525
LIG_SH2_STAT5	5	8	PF00017	0.483
LIG_SH2_STAT5	85	88	PF00017	0.657
LIG_UBA3_1	192	201	PF00899	0.629
MOD_CK1_1	176	182	PF00069	0.616
MOD_CK2_1	184	190	PF00069	0.612
MOD_CK2_1	3	9	PF00069	0.442
MOD_CK2_1	75	81	PF00069	0.580
MOD_GlcNHglycan	174	178	PF01048	0.482
MOD_GlcNHglycan	186	189	PF01048	0.463
MOD_GlcNHglycan	95	98	PF01048	0.385
MOD_GSK3_1	131	138	PF00069	0.560
MOD_GSK3_1	165	172	PF00069	0.735
MOD_GSK3_1	173	180	PF00069	0.680
MOD_GSK3_1	184	191	PF00069	0.577
MOD_N-GLC_1	188	193	PF02516	0.503
MOD_N-GLC_1	23	28	PF02516	0.246
MOD_N-GLC_1	59	64	PF02516	0.325
MOD_NEK2_1	149	154	PF00069	0.418
MOD_PIKK_1	131	137	PF00454	0.558
MOD_PIKK_1	165	171	PF00454	0.745
MOD_Plk_1	188	194	PF00069	0.643
MOD_Plk_1	23	29	PF00069	0.446
MOD_Plk_4	188	194	PF00069	0.637
MOD_Plk_4	23	29	PF00069	0.430
MOD_ProDKin_1	140	146	PF00069	0.418
MOD_SUMO_rev_2	157	166	PF00179	0.634
MOD_SUMO_rev_2	70	74	PF00179	0.480
TRG_DiLeu_BaEn_1	17	22	PF01217	0.529
TRG_DiLeu_BaEn_2	161	167	PF01217	0.614
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.418
TRG_ENDOCYTIC_2	147	150	PF00928	0.546
TRG_ENDOCYTIC_2	85	88	PF00928	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I5	Leptomonas seymouri	71%	100%
A0A1X0NJR3	Trypanosomatidae	51%	98%
A0A3S5H4X7	Leishmania donovani	74%	100%
A0A422N6Z2	Trypanosoma rangeli	49%	96%
A4HRK7	Leishmania infantum	75%	100%
E9AC79	Leishmania major	75%	100%
E9AJH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%